Amino acid dipepetide frequency for Candidatus Kentron sp. G

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.296AlaAla: 9.296 ± 0.12
1.079AlaCys: 1.079 ± 0.031
4.945AlaAsp: 4.945 ± 0.065
5.568AlaGlu: 5.568 ± 0.086
3.683AlaPhe: 3.683 ± 0.073
8.574AlaGly: 8.574 ± 0.094
2.167AlaHis: 2.167 ± 0.053
5.827AlaIle: 5.827 ± 0.079
3.438AlaLys: 3.438 ± 0.068
10.494AlaLeu: 10.494 ± 0.124
2.539AlaMet: 2.539 ± 0.05
2.72AlaAsn: 2.72 ± 0.051
4.315AlaPro: 4.315 ± 0.091
2.998AlaGln: 2.998 ± 0.059
7.543AlaArg: 7.543 ± 0.12
4.898AlaSer: 4.898 ± 0.078
4.405AlaThr: 4.405 ± 0.077
6.323AlaVal: 6.323 ± 0.092
1.352AlaTrp: 1.352 ± 0.043
2.258AlaTyr: 2.258 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.034CysAla: 1.034 ± 0.036
0.185CysCys: 0.185 ± 0.019
0.505CysAsp: 0.505 ± 0.023
0.57CysGlu: 0.57 ± 0.026
0.496CysPhe: 0.496 ± 0.02
0.936CysGly: 0.936 ± 0.031
0.403CysHis: 0.403 ± 0.025
0.579CysIle: 0.579 ± 0.024
0.357CysLys: 0.357 ± 0.019
1.245CysLeu: 1.245 ± 0.041
0.209CysMet: 0.209 ± 0.016
0.411CysAsn: 0.411 ± 0.021
0.833CysPro: 0.833 ± 0.036
0.373CysGln: 0.373 ± 0.021
0.986CysArg: 0.986 ± 0.033
0.614CysSer: 0.614 ± 0.028
0.513CysThr: 0.513 ± 0.021
0.785CysVal: 0.785 ± 0.033
0.137CysTrp: 0.137 ± 0.012
0.379CysTyr: 0.379 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.205AspAla: 5.205 ± 0.085
0.582AspCys: 0.582 ± 0.031
3.018AspAsp: 3.018 ± 0.069
3.428AspGlu: 3.428 ± 0.063
2.334AspPhe: 2.334 ± 0.049
4.649AspGly: 4.649 ± 0.093
1.218AspHis: 1.218 ± 0.03
3.565AspIle: 3.565 ± 0.058
2.489AspLys: 2.489 ± 0.06
5.078AspLeu: 5.078 ± 0.074
1.101AspMet: 1.101 ± 0.039
1.734AspAsn: 1.734 ± 0.054
3.17AspPro: 3.17 ± 0.056
1.362AspGln: 1.362 ± 0.04
4.163AspArg: 4.163 ± 0.081
2.948AspSer: 2.948 ± 0.053
3.255AspThr: 3.255 ± 0.07
3.534AspVal: 3.534 ± 0.066
0.98AspTrp: 0.98 ± 0.032
1.788AspTyr: 1.788 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.936GluAla: 5.936 ± 0.084
0.58GluCys: 0.58 ± 0.024
3.155GluAsp: 3.155 ± 0.058
4.767GluGlu: 4.767 ± 0.088
2.192GluPhe: 2.192 ± 0.049
4.575GluGly: 4.575 ± 0.079
1.65GluHis: 1.65 ± 0.042
4.31GluIle: 4.31 ± 0.069
3.501GluLys: 3.501 ± 0.071
5.898GluLeu: 5.898 ± 0.083
1.682GluMet: 1.682 ± 0.04
2.407GluAsn: 2.407 ± 0.046
2.91GluPro: 2.91 ± 0.062
2.856GluGln: 2.856 ± 0.061
5.362GluArg: 5.362 ± 0.082
3.316GluSer: 3.316 ± 0.055
3.544GluThr: 3.544 ± 0.058
3.599GluVal: 3.599 ± 0.067
0.761GluTrp: 0.761 ± 0.028
1.879GluTyr: 1.879 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.369PheAla: 3.369 ± 0.068
0.559PheCys: 0.559 ± 0.024
2.683PheAsp: 2.683 ± 0.056
2.43PheGlu: 2.43 ± 0.046
1.943PhePhe: 1.943 ± 0.055
3.371PheGly: 3.371 ± 0.061
1.078PheHis: 1.078 ± 0.033
1.942PheIle: 1.942 ± 0.046
1.073PheLys: 1.073 ± 0.034
4.187PheLeu: 4.187 ± 0.077
0.848PheMet: 0.848 ± 0.03
0.979PheAsn: 0.979 ± 0.032
2.055PhePro: 2.055 ± 0.049
1.311PheGln: 1.311 ± 0.032
2.708PheArg: 2.708 ± 0.054
2.942PheSer: 2.942 ± 0.059
1.982PheThr: 1.982 ± 0.044
2.64PheVal: 2.64 ± 0.057
0.486PheTrp: 0.486 ± 0.022
1.119PheTyr: 1.119 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.383GlyAla: 7.383 ± 0.094
1.096GlyCys: 1.096 ± 0.038
4.006GlyAsp: 4.006 ± 0.078
5.369GlyGlu: 5.369 ± 0.087
3.705GlyPhe: 3.705 ± 0.073
5.855GlyGly: 5.855 ± 0.101
2.113GlyHis: 2.113 ± 0.06
5.269GlyIle: 5.269 ± 0.083
4.278GlyLys: 4.278 ± 0.078
7.39GlyLeu: 7.39 ± 0.09
2.173GlyMet: 2.173 ± 0.053
2.994GlyAsn: 2.994 ± 0.069
2.83GlyPro: 2.83 ± 0.063
2.884GlyGln: 2.884 ± 0.06
6.188GlyArg: 6.188 ± 0.091
4.362GlySer: 4.362 ± 0.072
3.879GlyThr: 3.879 ± 0.093
5.229GlyVal: 5.229 ± 0.079
1.219GlyTrp: 1.219 ± 0.038
2.475GlyTyr: 2.475 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.116HisAla: 2.116 ± 0.047
0.411HisCys: 0.411 ± 0.021
1.229HisAsp: 1.229 ± 0.036
1.496HisGlu: 1.496 ± 0.04
1.03HisPhe: 1.03 ± 0.033
2.348HisGly: 2.348 ± 0.05
0.703HisHis: 0.703 ± 0.032
1.327HisIle: 1.327 ± 0.043
0.8HisLys: 0.8 ± 0.03
2.491HisLeu: 2.491 ± 0.055
0.467HisMet: 0.467 ± 0.022
0.731HisAsn: 0.731 ± 0.026
1.687HisPro: 1.687 ± 0.041
0.734HisGln: 0.734 ± 0.028
1.957HisArg: 1.957 ± 0.049
1.21HisSer: 1.21 ± 0.04
1.174HisThr: 1.174 ± 0.044
1.443HisVal: 1.443 ± 0.043
0.397HisTrp: 0.397 ± 0.021
0.852HisTyr: 0.852 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.972IleAla: 5.972 ± 0.092
0.595IleCys: 0.595 ± 0.023
3.748IleAsp: 3.748 ± 0.056
4.031IleGlu: 4.031 ± 0.072
1.989IlePhe: 1.989 ± 0.049
4.841IleGly: 4.841 ± 0.083
1.558IleHis: 1.558 ± 0.04
2.961IleIle: 2.961 ± 0.065
1.963IleLys: 1.963 ± 0.049
5.385IleLeu: 5.385 ± 0.082
1.128IleMet: 1.128 ± 0.035
1.45IleAsn: 1.45 ± 0.043
3.277IlePro: 3.277 ± 0.072
1.751IleGln: 1.751 ± 0.045
4.597IleArg: 4.597 ± 0.082
3.313IleSer: 3.313 ± 0.056
3.349IleThr: 3.349 ± 0.085
3.971IleVal: 3.971 ± 0.068
0.62IleTrp: 0.62 ± 0.027
1.409IleTyr: 1.409 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
3.696LysAla: 3.696 ± 0.067
0.508LysCys: 0.508 ± 0.023
2.093LysAsp: 2.093 ± 0.055
2.714LysGlu: 2.714 ± 0.065
1.161LysPhe: 1.161 ± 0.033
2.752LysGly: 2.752 ± 0.06
0.822LysHis: 0.822 ± 0.03
2.368LysIle: 2.368 ± 0.052
2.332LysLys: 2.332 ± 0.064
3.51LysLeu: 3.51 ± 0.07
0.996LysMet: 0.996 ± 0.036
1.519LysAsn: 1.519 ± 0.04
2.042LysPro: 2.042 ± 0.047
1.513LysGln: 1.513 ± 0.047
2.87LysArg: 2.87 ± 0.058
2.26LysSer: 2.26 ± 0.051
2.501LysThr: 2.501 ± 0.049
2.416LysVal: 2.416 ± 0.059
0.462LysTrp: 0.462 ± 0.027
0.991LysTyr: 0.991 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
10.866LeuAla: 10.866 ± 0.138
1.136LeuCys: 1.136 ± 0.034
6.041LeuAsp: 6.041 ± 0.079
6.264LeuGlu: 6.264 ± 0.089
4.239LeuPhe: 4.239 ± 0.084
7.928LeuGly: 7.928 ± 0.087
2.254LeuHis: 2.254 ± 0.052
5.076LeuIle: 5.076 ± 0.076
3.339LeuLys: 3.339 ± 0.067
10.567LeuLeu: 10.567 ± 0.15
2.373LeuMet: 2.373 ± 0.053
2.596LeuAsn: 2.596 ± 0.056
5.551LeuPro: 5.551 ± 0.081
2.997LeuGln: 2.997 ± 0.06
7.499LeuArg: 7.499 ± 0.108
6.29LeuSer: 6.29 ± 0.097
5.308LeuThr: 5.308 ± 0.078
6.65LeuVal: 6.65 ± 0.098
1.369LeuTrp: 1.369 ± 0.049
2.867LeuTyr: 2.867 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.719MetAla: 2.719 ± 0.056
0.155MetCys: 0.155 ± 0.013
1.393MetAsp: 1.393 ± 0.039
1.674MetGlu: 1.674 ± 0.048
0.65MetPhe: 0.65 ± 0.026
2.047MetGly: 2.047 ± 0.054
0.441MetHis: 0.441 ± 0.022
1.255MetIle: 1.255 ± 0.042
1.141MetLys: 1.141 ± 0.034
2.124MetLeu: 2.124 ± 0.043
0.573MetMet: 0.573 ± 0.027
0.922MetAsn: 0.922 ± 0.032
1.215MetPro: 1.215 ± 0.037
0.767MetGln: 0.767 ± 0.028
1.515MetArg: 1.515 ± 0.043
1.429MetSer: 1.429 ± 0.039
1.5MetThr: 1.5 ± 0.04
1.567MetVal: 1.567 ± 0.04
0.177MetTrp: 0.177 ± 0.015
0.381MetTyr: 0.381 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.835AsnAla: 2.835 ± 0.06
0.384AsnCys: 0.384 ± 0.022
1.611AsnAsp: 1.611 ± 0.045
1.677AsnGlu: 1.677 ± 0.044
1.122AsnPhe: 1.122 ± 0.032
2.321AsnGly: 2.321 ± 0.054
0.913AsnHis: 0.913 ± 0.032
1.914AsnIle: 1.914 ± 0.048
1.093AsnLys: 1.093 ± 0.033
3.18AsnLeu: 3.18 ± 0.064
0.602AsnMet: 0.602 ± 0.027
1.251AsnAsn: 1.251 ± 0.043
2.234AsnPro: 2.234 ± 0.055
0.935AsnGln: 0.935 ± 0.034
2.584AsnArg: 2.584 ± 0.053
1.675AsnSer: 1.675 ± 0.043
1.893AsnThr: 1.893 ± 0.051
1.865AsnVal: 1.865 ± 0.051
0.472AsnTrp: 0.472 ± 0.023
0.884AsnTyr: 0.884 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
5.18ProAla: 5.18 ± 0.088
0.564ProCys: 0.564 ± 0.026
3.701ProAsp: 3.701 ± 0.071
4.073ProGlu: 4.073 ± 0.078
1.88ProPhe: 1.88 ± 0.042
4.596ProGly: 4.596 ± 0.081
1.133ProHis: 1.133 ± 0.035
2.659ProIle: 2.659 ± 0.06
1.96ProLys: 1.96 ± 0.048
4.623ProLeu: 4.623 ± 0.076
1.327ProMet: 1.327 ± 0.041
1.732ProAsn: 1.732 ± 0.039
2.767ProPro: 2.767 ± 0.074
1.359ProGln: 1.359 ± 0.041
3.361ProArg: 3.361 ± 0.067
2.867ProSer: 2.867 ± 0.064
2.187ProThr: 2.187 ± 0.055
3.792ProVal: 3.792 ± 0.068
0.785ProTrp: 0.785 ± 0.029
1.335ProTyr: 1.335 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.227GlnAla: 3.227 ± 0.066
0.405GlnCys: 0.405 ± 0.021
1.587GlnAsp: 1.587 ± 0.047
2.246GlnGlu: 2.246 ± 0.054
0.998GlnPhe: 0.998 ± 0.033
2.803GlnGly: 2.803 ± 0.055
0.762GlnHis: 0.762 ± 0.031
1.627GlnIle: 1.627 ± 0.041
1.402GlnLys: 1.402 ± 0.044
3.019GlnLeu: 3.019 ± 0.06
0.73GlnMet: 0.73 ± 0.03
0.929GlnAsn: 0.929 ± 0.03
1.655GlnPro: 1.655 ± 0.046
1.253GlnGln: 1.253 ± 0.041
2.625GlnArg: 2.625 ± 0.066
1.811GlnSer: 1.811 ± 0.049
1.717GlnThr: 1.717 ± 0.048
2.325GlnVal: 2.325 ± 0.049
0.531GlnTrp: 0.531 ± 0.024
0.886GlnTyr: 0.886 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
6.522ArgAla: 6.522 ± 0.095
0.812ArgCys: 0.812 ± 0.03
3.829ArgAsp: 3.829 ± 0.069
5.714ArgGlu: 5.714 ± 0.095
3.422ArgPhe: 3.422 ± 0.065
5.01ArgGly: 5.01 ± 0.085
2.046ArgHis: 2.046 ± 0.043
5.079ArgIle: 5.079 ± 0.078
3.058ArgLys: 3.058 ± 0.059
8.292ArgLeu: 8.292 ± 0.125
2.036ArgMet: 2.036 ± 0.045
2.892ArgAsn: 2.892 ± 0.057
3.417ArgPro: 3.417 ± 0.07
2.925ArgGln: 2.925 ± 0.058
5.679ArgArg: 5.679 ± 0.097
3.359ArgSer: 3.359 ± 0.064
3.337ArgThr: 3.337 ± 0.066
4.679ArgVal: 4.679 ± 0.063
1.064ArgTrp: 1.064 ± 0.035
2.831ArgTyr: 2.831 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.996SerAla: 4.996 ± 0.064
0.763SerCys: 0.763 ± 0.033
3.031SerAsp: 3.031 ± 0.059
3.312SerGlu: 3.312 ± 0.056
2.213SerPhe: 2.213 ± 0.061
5.196SerGly: 5.196 ± 0.093
1.423SerHis: 1.423 ± 0.037
3.009SerIle: 3.009 ± 0.059
1.877SerLys: 1.877 ± 0.051
5.905SerLeu: 5.905 ± 0.084
1.349SerMet: 1.349 ± 0.041
1.677SerAsn: 1.677 ± 0.041
3.236SerPro: 3.236 ± 0.067
1.482SerGln: 1.482 ± 0.03
4.161SerArg: 4.161 ± 0.07
3.438SerSer: 3.438 ± 0.077
2.638SerThr: 2.638 ± 0.053
3.636SerVal: 3.636 ± 0.069
0.761SerTrp: 0.761 ± 0.028
1.411SerTyr: 1.411 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.637ThrAla: 4.637 ± 0.091
0.513ThrCys: 0.513 ± 0.022
2.94ThrAsp: 2.94 ± 0.074
3.038ThrGlu: 3.038 ± 0.06
1.868ThrPhe: 1.868 ± 0.047
5.178ThrGly: 5.178 ± 0.102
1.26ThrHis: 1.26 ± 0.041
2.981ThrIle: 2.981 ± 0.069
1.675ThrLys: 1.675 ± 0.043
5.742ThrLeu: 5.742 ± 0.082
1.154ThrMet: 1.154 ± 0.037
1.476ThrAsn: 1.476 ± 0.043
3.11ThrPro: 3.11 ± 0.047
1.653ThrGln: 1.653 ± 0.046
3.556ThrArg: 3.556 ± 0.064
2.6ThrSer: 2.6 ± 0.061
2.601ThrThr: 2.601 ± 0.072
3.891ThrVal: 3.891 ± 0.071
0.621ThrTrp: 0.621 ± 0.029
1.203ThrTyr: 1.203 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.22ValAla: 6.22 ± 0.096
0.753ValCys: 0.753 ± 0.027
3.827ValAsp: 3.827 ± 0.065
4.163ValGlu: 4.163 ± 0.061
2.884ValPhe: 2.884 ± 0.06
4.681ValGly: 4.681 ± 0.084
1.564ValHis: 1.564 ± 0.039
4.103ValIle: 4.103 ± 0.072
2.4ValLys: 2.4 ± 0.058
7.082ValLeu: 7.082 ± 0.077
1.587ValMet: 1.587 ± 0.039
1.832ValAsn: 1.832 ± 0.051
3.078ValPro: 3.078 ± 0.06
1.824ValGln: 1.824 ± 0.046
4.655ValArg: 4.655 ± 0.071
3.952ValSer: 3.952 ± 0.06
3.906ValThr: 3.906 ± 0.084
4.648ValVal: 4.648 ± 0.085
0.848ValTrp: 0.848 ± 0.03
1.633ValTyr: 1.633 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.939TrpAla: 0.939 ± 0.034
0.16TrpCys: 0.16 ± 0.012
0.832TrpAsp: 0.832 ± 0.042
0.939TrpGlu: 0.939 ± 0.037
0.544TrpPhe: 0.544 ± 0.027
0.888TrpGly: 0.888 ± 0.037
0.324TrpHis: 0.324 ± 0.02
0.796TrpIle: 0.796 ± 0.034
0.554TrpLys: 0.554 ± 0.025
1.665TrpLeu: 1.665 ± 0.05
0.317TrpMet: 0.317 ± 0.017
0.464TrpAsn: 0.464 ± 0.026
0.631TrpPro: 0.631 ± 0.024
0.602TrpGln: 0.602 ± 0.03
1.182TrpArg: 1.182 ± 0.037
0.808TrpSer: 0.808 ± 0.034
0.612TrpThr: 0.612 ± 0.029
0.871TrpVal: 0.871 ± 0.03
0.205TrpTrp: 0.205 ± 0.014
0.376TrpTyr: 0.376 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.275TyrAla: 2.275 ± 0.052
0.309TyrCys: 0.309 ± 0.016
1.426TyrAsp: 1.426 ± 0.058
1.411TyrGlu: 1.411 ± 0.039
1.354TyrPhe: 1.354 ± 0.044
2.149TyrGly: 2.149 ± 0.054
0.772TyrHis: 0.772 ± 0.028
1.261TyrIle: 1.261 ± 0.04
0.795TyrLys: 0.795 ± 0.028
3.333TyrLeu: 3.333 ± 0.056
0.451TyrMet: 0.451 ± 0.022
0.726TyrAsn: 0.726 ± 0.026
1.869TyrPro: 1.869 ± 0.049
0.96TyrGln: 0.96 ± 0.033
2.81TyrArg: 2.81 ± 0.056
1.421TyrSer: 1.421 ± 0.041
1.399TyrThr: 1.399 ± 0.046
1.773TyrVal: 1.773 ± 0.047
0.461TyrTrp: 0.461 ± 0.023
0.87TyrTyr: 0.87 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3885 proteins (952963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski