Amino acid dipepetide frequency for Rhizobacter sp. Root1221

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.551AlaAla: 18.551 ± 0.149	1.226AlaCys: 1.226 ± 0.028	6.932AlaAsp: 6.932 ± 0.068	6.561AlaGlu: 6.561 ± 0.071	4.201AlaPhe: 4.201 ± 0.051	11.363AlaGly: 11.363 ± 0.09	2.805AlaHis: 2.805 ± 0.045	4.786AlaIle: 4.786 ± 0.054	3.562AlaLys: 3.562 ± 0.062	14.735AlaLeu: 14.735 ± 0.121	3.436AlaMet: 3.436 ± 0.046	2.938AlaAsn: 2.938 ± 0.047	6.641AlaPro: 6.641 ± 0.089	5.05AlaGln: 5.05 ± 0.064	9.467AlaArg: 9.467 ± 0.089	7.01AlaSer: 7.01 ± 0.065	6.835AlaThr: 6.835 ± 0.083	10.036AlaVal: 10.036 ± 0.099	2.085AlaTrp: 2.085 ± 0.038	2.414AlaTyr: 2.414 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	1.116CysAla: 1.116 ± 0.026	0.094CysCys: 0.094 ± 0.007	0.525CysAsp: 0.525 ± 0.017	0.464CysGlu: 0.464 ± 0.017	0.296CysPhe: 0.296 ± 0.014	0.897CysGly: 0.897 ± 0.022	0.244CysHis: 0.244 ± 0.012	0.338CysIle: 0.338 ± 0.014	0.167CysLys: 0.167 ± 0.009	0.808CysLeu: 0.808 ± 0.025	0.176CysMet: 0.176 ± 0.01	0.197CysAsn: 0.197 ± 0.008	0.419CysPro: 0.419 ± 0.017	0.241CysGln: 0.241 ± 0.01	0.586CysArg: 0.586 ± 0.022	0.48CysSer: 0.48 ± 0.017	0.491CysThr: 0.491 ± 0.017	0.674CysVal: 0.674 ± 0.018	0.119CysTrp: 0.119 ± 0.008	0.157CysTyr: 0.157 ± 0.009	0.001CysXaa: 0.001 ± 0.001
Asp	7.431AspAla: 7.431 ± 0.079	0.402AspCys: 0.402 ± 0.016	3.177AspAsp: 3.177 ± 0.042	3.062AspGlu: 3.062 ± 0.041	1.902AspPhe: 1.902 ± 0.032	5.198AspGly: 5.198 ± 0.07	1.309AspHis: 1.309 ± 0.028	2.266AspIle: 2.266 ± 0.036	1.496AspLys: 1.496 ± 0.035	5.801AspLeu: 5.801 ± 0.064	1.041AspMet: 1.041 ± 0.025	1.322AspAsn: 1.322 ± 0.028	3.304AspPro: 3.304 ± 0.041	1.72AspGln: 1.72 ± 0.034	3.937AspArg: 3.937 ± 0.048	2.334AspSer: 2.334 ± 0.036	3.293AspThr: 3.293 ± 0.044	4.568AspVal: 4.568 ± 0.049	0.9AspTrp: 0.9 ± 0.021	1.231AspTyr: 1.231 ± 0.025	0.003AspXaa: 0.003 ± 0.001
Glu	6.823GluAla: 6.823 ± 0.077	0.348GluCys: 0.348 ± 0.016	2.081GluAsp: 2.081 ± 0.036	2.16GluGlu: 2.16 ± 0.044	1.707GluPhe: 1.707 ± 0.034	3.591GluGly: 3.591 ± 0.05	1.317GluHis: 1.317 ± 0.026	2.248GluIle: 2.248 ± 0.046	1.449GluLys: 1.449 ± 0.028	5.453GluLeu: 5.453 ± 0.065	1.175GluMet: 1.175 ± 0.025	1.108GluAsn: 1.108 ± 0.026	2.723GluPro: 2.723 ± 0.041	2.204GluGln: 2.204 ± 0.035	4.569GluArg: 4.569 ± 0.058	2.472GluSer: 2.472 ± 0.035	2.491GluThr: 2.491 ± 0.038	4.123GluVal: 4.123 ± 0.056	0.658GluTrp: 0.658 ± 0.018	0.884GluTyr: 0.884 ± 0.025	0.004GluXaa: 0.004 ± 0.002
Phe	4.178PheAla: 4.178 ± 0.05	0.328PheCys: 0.328 ± 0.015	2.702PheAsp: 2.702 ± 0.039	2.126PheGlu: 2.126 ± 0.035	1.238PhePhe: 1.238 ± 0.029	3.42PheGly: 3.42 ± 0.041	0.773PheHis: 0.773 ± 0.02	1.354PheIle: 1.354 ± 0.024	1.079PheLys: 1.079 ± 0.028	2.871PheLeu: 2.871 ± 0.046	0.725PheMet: 0.725 ± 0.019	1.077PheAsn: 1.077 ± 0.026	1.464PhePro: 1.464 ± 0.024	1.058PheGln: 1.058 ± 0.024	2.058PheArg: 2.058 ± 0.032	2.079PheSer: 2.079 ± 0.034	2.041PheThr: 2.041 ± 0.036	2.802PheVal: 2.802 ± 0.04	0.47PheTrp: 0.47 ± 0.016	0.76PheTyr: 0.76 ± 0.021	0.001PheXaa: 0.001 ± 0.001
Gly	9.783GlyAla: 9.783 ± 0.069	0.833GlyCys: 0.833 ± 0.021	4.441GlyAsp: 4.441 ± 0.051	4.336GlyGlu: 4.336 ± 0.057	3.209GlyPhe: 3.209 ± 0.046	7.35GlyGly: 7.35 ± 0.099	2.138GlyHis: 2.138 ± 0.037	3.679GlyIle: 3.679 ± 0.047	2.812GlyLys: 2.812 ± 0.045	9.039GlyLeu: 9.039 ± 0.08	2.095GlyMet: 2.095 ± 0.038	2.288GlyAsn: 2.288 ± 0.061	3.398GlyPro: 3.398 ± 0.043	3.297GlyGln: 3.297 ± 0.046	6.038GlyArg: 6.038 ± 0.062	4.706GlySer: 4.706 ± 0.064	5.186GlyThr: 5.186 ± 0.092	6.832GlyVal: 6.832 ± 0.073	1.513GlyTrp: 1.513 ± 0.027	2.087GlyTyr: 2.087 ± 0.035	0.003GlyXaa: 0.003 ± 0.001
His	2.999HisAla: 2.999 ± 0.047	0.248HisCys: 0.248 ± 0.012	1.367HisAsp: 1.367 ± 0.03	1.226HisGlu: 1.226 ± 0.027	0.862HisPhe: 0.862 ± 0.022	2.272HisGly: 2.272 ± 0.039	0.704HisHis: 0.704 ± 0.022	0.806HisIle: 0.806 ± 0.021	0.491HisLys: 0.491 ± 0.016	2.524HisLeu: 2.524 ± 0.043	0.45HisMet: 0.45 ± 0.016	0.48HisAsn: 0.48 ± 0.016	1.576HisPro: 1.576 ± 0.031	0.772HisGln: 0.772 ± 0.018	1.729HisArg: 1.729 ± 0.035	0.929HisSer: 0.929 ± 0.022	1.221HisThr: 1.221 ± 0.026	1.863HisVal: 1.863 ± 0.032	0.414HisTrp: 0.414 ± 0.017	0.541HisTyr: 0.541 ± 0.017	0.001HisXaa: 0.001 ± 0.001
Ile	5.542IleAla: 5.542 ± 0.061	0.308IleCys: 0.308 ± 0.012	3.136IleAsp: 3.136 ± 0.037	2.819IleGlu: 2.819 ± 0.045	1.03IlePhe: 1.03 ± 0.024	3.891IleGly: 3.891 ± 0.044	0.789IleHis: 0.789 ± 0.022	1.143IleIle: 1.143 ± 0.029	1.201IleLys: 1.201 ± 0.027	2.766IleLeu: 2.766 ± 0.047	0.579IleMet: 0.579 ± 0.02	1.202IleAsn: 1.202 ± 0.029	1.777IlePro: 1.777 ± 0.037	1.106IleGln: 1.106 ± 0.023	2.377IleArg: 2.377 ± 0.036	2.089IleSer: 2.089 ± 0.035	2.298IleThr: 2.298 ± 0.04	3.368IleVal: 3.368 ± 0.044	0.36IleTrp: 0.36 ± 0.015	0.76IleTyr: 0.76 ± 0.02	0.002IleXaa: 0.002 ± 0.001
Lys	3.848LysAla: 3.848 ± 0.051	0.141LysCys: 0.141 ± 0.009	1.498LysAsp: 1.498 ± 0.034	1.265LysGlu: 1.265 ± 0.033	0.924LysPhe: 0.924 ± 0.023	2.244LysGly: 2.244 ± 0.04	0.609LysHis: 0.609 ± 0.017	1.138LysIle: 1.138 ± 0.029	1.093LysLys: 1.093 ± 0.036	3.103LysLeu: 3.103 ± 0.051	0.654LysMet: 0.654 ± 0.02	0.775LysAsn: 0.775 ± 0.022	1.843LysPro: 1.843 ± 0.035	1.088LysGln: 1.088 ± 0.025	2.037LysArg: 2.037 ± 0.037	1.573LysSer: 1.573 ± 0.032	1.643LysThr: 1.643 ± 0.03	2.504LysVal: 2.504 ± 0.042	0.33LysTrp: 0.33 ± 0.015	0.615LysTyr: 0.615 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.962LeuAla: 14.962 ± 0.107	0.963LeuCys: 0.963 ± 0.024	6.219LeuAsp: 6.219 ± 0.066	4.765LeuGlu: 4.765 ± 0.058	3.347LeuPhe: 3.347 ± 0.05	8.703LeuGly: 8.703 ± 0.068	2.395LeuHis: 2.395 ± 0.036	3.762LeuIle: 3.762 ± 0.049	3.493LeuLys: 3.493 ± 0.05	10.804LeuLeu: 10.804 ± 0.11	2.359LeuMet: 2.359 ± 0.039	2.655LeuAsn: 2.655 ± 0.035	6.144LeuPro: 6.144 ± 0.063	4.013LeuGln: 4.013 ± 0.051	7.909LeuArg: 7.909 ± 0.085	6.376LeuSer: 6.376 ± 0.069	5.661LeuThr: 5.661 ± 0.063	8.425LeuVal: 8.425 ± 0.08	1.308LeuTrp: 1.308 ± 0.031	1.921LeuTyr: 1.921 ± 0.033	0.005LeuXaa: 0.005 ± 0.001
Met	2.893MetAla: 2.893 ± 0.039	0.153MetCys: 0.153 ± 0.008	1.048MetAsp: 1.048 ± 0.026	0.838MetGlu: 0.838 ± 0.023	0.697MetPhe: 0.697 ± 0.021	1.704MetGly: 1.704 ± 0.031	0.515MetHis: 0.515 ± 0.017	0.848MetIle: 0.848 ± 0.023	0.923MetLys: 0.923 ± 0.025	2.473MetLeu: 2.473 ± 0.041	0.484MetMet: 0.484 ± 0.018	0.861MetAsn: 0.861 ± 0.021	1.439MetPro: 1.439 ± 0.028	0.904MetGln: 0.904 ± 0.022	1.62MetArg: 1.62 ± 0.03	1.555MetSer: 1.555 ± 0.032	1.542MetThr: 1.542 ± 0.028	1.677MetVal: 1.677 ± 0.029	0.208MetTrp: 0.208 ± 0.009	0.356MetTyr: 0.356 ± 0.014	0.002MetXaa: 0.002 ± 0.001
Asn	3.28AsnAla: 3.28 ± 0.043	0.234AsnCys: 0.234 ± 0.01	1.503AsnAsp: 1.503 ± 0.035	1.229AsnGlu: 1.229 ± 0.024	0.895AsnPhe: 0.895 ± 0.023	2.347AsnGly: 2.347 ± 0.044	0.545AsnHis: 0.545 ± 0.016	0.991AsnIle: 0.991 ± 0.026	0.712AsnLys: 0.712 ± 0.022	2.588AsnLeu: 2.588 ± 0.038	0.506AsnMet: 0.506 ± 0.016	0.754AsnAsn: 0.754 ± 0.027	1.686AsnPro: 1.686 ± 0.029	0.889AsnGln: 0.889 ± 0.024	1.649AsnArg: 1.649 ± 0.033	1.111AsnSer: 1.111 ± 0.03	1.466AsnThr: 1.466 ± 0.038	2.014AsnVal: 2.014 ± 0.035	0.364AsnTrp: 0.364 ± 0.011	0.601AsnTyr: 0.601 ± 0.018	0.001AsnXaa: 0.001 ± 0.001
Pro	7.863ProAla: 7.863 ± 0.086	0.352ProCys: 0.352 ± 0.016	3.366ProAsp: 3.366 ± 0.041	3.078ProGlu: 3.078 ± 0.043	1.864ProPhe: 1.864 ± 0.028	4.999ProGly: 4.999 ± 0.054	1.213ProHis: 1.213 ± 0.028	1.738ProIle: 1.738 ± 0.026	1.499ProLys: 1.499 ± 0.031	5.359ProLeu: 5.359 ± 0.056	1.273ProMet: 1.273 ± 0.026	1.274ProAsn: 1.274 ± 0.024	3.05ProPro: 3.05 ± 0.055	1.853ProGln: 1.853 ± 0.035	3.227ProArg: 3.227 ± 0.048	2.986ProSer: 2.986 ± 0.047	2.736ProThr: 2.736 ± 0.044	4.823ProVal: 4.823 ± 0.057	0.815ProTrp: 0.815 ± 0.02	1.052ProTyr: 1.052 ± 0.026	0.003ProXaa: 0.003 ± 0.001
Gln	5.315GlnAla: 5.315 ± 0.064	0.262GlnCys: 0.262 ± 0.012	1.471GlnAsp: 1.471 ± 0.03	1.34GlnGlu: 1.34 ± 0.032	1.28GlnPhe: 1.28 ± 0.03	2.816GlnGly: 2.816 ± 0.033	0.946GlnHis: 0.946 ± 0.022	1.429GlnIle: 1.429 ± 0.036	0.939GlnLys: 0.939 ± 0.025	4.118GlnLeu: 4.118 ± 0.051	0.843GlnMet: 0.843 ± 0.02	0.761GlnAsn: 0.761 ± 0.023	2.104GlnPro: 2.104 ± 0.036	1.812GlnGln: 1.812 ± 0.034	3.308GlnArg: 3.308 ± 0.045	1.93GlnSer: 1.93 ± 0.033	1.7GlnThr: 1.7 ± 0.035	3.291GlnVal: 3.291 ± 0.046	0.609GlnTrp: 0.609 ± 0.018	0.714GlnTyr: 0.714 ± 0.022	0.003GlnXaa: 0.003 ± 0.001
Arg	8.304ArgAla: 8.304 ± 0.085	0.604ArgCys: 0.604 ± 0.019	4.055ArgAsp: 4.055 ± 0.054	3.986ArgGlu: 3.986 ± 0.055	2.918ArgPhe: 2.918 ± 0.039	4.92ArgGly: 4.92 ± 0.05	2.134ArgHis: 2.134 ± 0.036	3.239ArgIle: 3.239 ± 0.041	1.907ArgLys: 1.907 ± 0.03	8.443ArgLeu: 8.443 ± 0.085	1.862ArgMet: 1.862 ± 0.031	1.691ArgAsn: 1.691 ± 0.03	3.597ArgPro: 3.597 ± 0.052	3.018ArgGln: 3.018 ± 0.041	5.528ArgArg: 5.528 ± 0.068	3.741ArgSer: 3.741 ± 0.049	3.731ArgThr: 3.731 ± 0.05	5.596ArgVal: 5.596 ± 0.058	1.286ArgTrp: 1.286 ± 0.026	1.735ArgTyr: 1.735 ± 0.031	0.003ArgXaa: 0.003 ± 0.001
Ser	6.693SerAla: 6.693 ± 0.072	0.431SerCys: 0.431 ± 0.018	2.745SerAsp: 2.745 ± 0.045	2.385SerGlu: 2.385 ± 0.04	1.998SerPhe: 1.998 ± 0.033	5.362SerGly: 5.362 ± 0.069	1.177SerHis: 1.177 ± 0.031	2.186SerIle: 2.186 ± 0.035	1.444SerLys: 1.444 ± 0.029	5.807SerLeu: 5.807 ± 0.064	1.311SerMet: 1.311 ± 0.027	1.42SerAsn: 1.42 ± 0.032	3.188SerPro: 3.188 ± 0.042	1.719SerGln: 1.719 ± 0.033	3.735SerArg: 3.735 ± 0.046	3.14SerSer: 3.14 ± 0.053	3.161SerThr: 3.161 ± 0.054	4.294SerVal: 4.294 ± 0.056	0.78SerTrp: 0.78 ± 0.019	1.157SerTyr: 1.157 ± 0.026	0.004SerXaa: 0.004 ± 0.001
Thr	6.68ThrAla: 6.68 ± 0.076	0.451ThrCys: 0.451 ± 0.016	2.886ThrAsp: 2.886 ± 0.052	2.476ThrGlu: 2.476 ± 0.038	1.922ThrPhe: 1.922 ± 0.03	5.163ThrGly: 5.163 ± 0.075	1.253ThrHis: 1.253 ± 0.029	2.033ThrIle: 2.033 ± 0.038	1.251ThrLys: 1.251 ± 0.025	6.615ThrLeu: 6.615 ± 0.061	1.125ThrMet: 1.125 ± 0.024	1.368ThrAsn: 1.368 ± 0.038	3.651ThrPro: 3.651 ± 0.047	1.896ThrGln: 1.896 ± 0.039	3.674ThrArg: 3.674 ± 0.045	3.053ThrSer: 3.053 ± 0.057	3.328ThrThr: 3.328 ± 0.072	4.865ThrVal: 4.865 ± 0.073	0.824ThrTrp: 0.824 ± 0.023	1.21ThrTyr: 1.21 ± 0.039	0.004ThrXaa: 0.004 ± 0.001
Val	10.446ValAla: 10.446 ± 0.09	0.737ValCys: 0.737 ± 0.019	4.597ValAsp: 4.597 ± 0.055	3.963ValGlu: 3.963 ± 0.045	2.889ValPhe: 2.889 ± 0.038	6.003ValGly: 6.003 ± 0.067	1.75ValHis: 1.75 ± 0.032	3.283ValIle: 3.283 ± 0.043	2.424ValLys: 2.424 ± 0.04	8.867ValLeu: 8.867 ± 0.083	1.891ValMet: 1.891 ± 0.033	2.197ValAsn: 2.197 ± 0.037	4.584ValPro: 4.584 ± 0.055	2.888ValGln: 2.888 ± 0.04	5.793ValArg: 5.793 ± 0.058	4.677ValSer: 4.677 ± 0.05	4.853ValThr: 4.853 ± 0.081	7.13ValVal: 7.13 ± 0.069	1.116ValTrp: 1.116 ± 0.025	1.593ValTyr: 1.593 ± 0.029	0.005ValXaa: 0.005 ± 0.002
Trp	1.519TrpAla: 1.519 ± 0.03	0.164TrpCys: 0.164 ± 0.01	0.677TrpAsp: 0.677 ± 0.019	0.505TrpGlu: 0.505 ± 0.016	0.597TrpPhe: 0.597 ± 0.018	0.964TrpGly: 0.964 ± 0.023	0.413TrpHis: 0.413 ± 0.013	0.596TrpIle: 0.596 ± 0.019	0.421TrpLys: 0.421 ± 0.016	1.91TrpLeu: 1.91 ± 0.035	0.383TrpMet: 0.383 ± 0.014	0.442TrpAsn: 0.442 ± 0.017	0.781TrpPro: 0.781 ± 0.023	0.712TrpGln: 0.712 ± 0.02	1.295TrpArg: 1.295 ± 0.026	0.834TrpSer: 0.834 ± 0.022	0.838TrpThr: 0.838 ± 0.02	1.161TrpVal: 1.161 ± 0.022	0.313TrpTrp: 0.313 ± 0.015	0.281TrpTyr: 0.281 ± 0.013	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.407TyrAla: 2.407 ± 0.037	0.211TyrCys: 0.211 ± 0.01	1.267TyrAsp: 1.267 ± 0.077	1.007TyrGlu: 1.007 ± 0.022	0.823TyrPhe: 0.823 ± 0.019	1.848TyrGly: 1.848 ± 0.033	0.445TyrHis: 0.445 ± 0.016	0.68TyrIle: 0.68 ± 0.021	0.558TyrLys: 0.558 ± 0.019	2.103TyrLeu: 2.103 ± 0.036	0.369TyrMet: 0.369 ± 0.014	0.556TyrAsn: 0.556 ± 0.018	1.051TyrPro: 1.051 ± 0.023	0.747TyrGln: 0.747 ± 0.02	1.759TyrArg: 1.759 ± 0.027	1.059TyrSer: 1.059 ± 0.03	1.208TyrThr: 1.208 ± 0.031	1.635TyrVal: 1.635 ± 0.032	0.337TyrTrp: 0.337 ± 0.012	0.508TyrTyr: 0.508 ± 0.02	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.009XaaGly: 0.009 ± 0.003	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.006XaaArg: 0.006 ± 0.002	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5887 proteins (1990138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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