Amino acid dipepetide frequency for Paramaledivibacter caminithermalis DSM 15212

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.914AlaAla: 3.914 ± 0.078	0.668AlaCys: 0.668 ± 0.026	2.536AlaAsp: 2.536 ± 0.047	3.303AlaGlu: 3.303 ± 0.061	2.58AlaPhe: 2.58 ± 0.051	3.884AlaGly: 3.884 ± 0.074	0.85AlaHis: 0.85 ± 0.026	5.849AlaIle: 5.849 ± 0.089	4.826AlaLys: 4.826 ± 0.071	5.774AlaLeu: 5.774 ± 0.09	1.585AlaMet: 1.585 ± 0.043	2.593AlaAsn: 2.593 ± 0.051	1.364AlaPro: 1.364 ± 0.035	1.439AlaGln: 1.439 ± 0.038	2.051AlaArg: 2.051 ± 0.047	3.228AlaSer: 3.228 ± 0.061	2.58AlaThr: 2.58 ± 0.053	4.111AlaVal: 4.111 ± 0.059	0.348AlaTrp: 0.348 ± 0.02	2.019AlaTyr: 2.019 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.499CysAla: 0.499 ± 0.023	0.15CysCys: 0.15 ± 0.011	0.593CysAsp: 0.593 ± 0.024	0.682CysGlu: 0.682 ± 0.028	0.453CysPhe: 0.453 ± 0.019	1.02CysGly: 1.02 ± 0.029	0.216CysHis: 0.216 ± 0.014	1.066CysIle: 1.066 ± 0.034	0.877CysLys: 0.877 ± 0.034	0.803CysLeu: 0.803 ± 0.028	0.255CysMet: 0.255 ± 0.015	0.628CysAsn: 0.628 ± 0.026	0.45CysPro: 0.45 ± 0.022	0.251CysGln: 0.251 ± 0.015	0.434CysArg: 0.434 ± 0.02	0.724CysSer: 0.724 ± 0.029	0.503CysThr: 0.503 ± 0.024	0.53CysVal: 0.53 ± 0.022	0.082CysTrp: 0.082 ± 0.009	0.371CysTyr: 0.371 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.517AspAla: 2.517 ± 0.048	0.538AspCys: 0.538 ± 0.021	2.86AspAsp: 2.86 ± 0.067	4.774AspGlu: 4.774 ± 0.078	2.736AspPhe: 2.736 ± 0.055	3.317AspGly: 3.317 ± 0.065	0.606AspHis: 0.606 ± 0.021	7.232AspIle: 7.232 ± 0.091	5.445AspLys: 5.445 ± 0.079	4.822AspLeu: 4.822 ± 0.073	1.557AspMet: 1.557 ± 0.033	3.313AspAsn: 3.313 ± 0.058	1.366AspPro: 1.366 ± 0.033	0.825AspGln: 0.825 ± 0.026	2.111AspArg: 2.111 ± 0.049	3.052AspSer: 3.052 ± 0.053	2.39AspThr: 2.39 ± 0.054	3.325AspVal: 3.325 ± 0.056	0.419AspTrp: 0.419 ± 0.021	2.715AspTyr: 2.715 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.439GluAla: 4.439 ± 0.078	0.608GluCys: 0.608 ± 0.024	4.319GluAsp: 4.319 ± 0.067	6.739GluGlu: 6.739 ± 0.088	2.94GluPhe: 2.94 ± 0.057	4.192GluGly: 4.192 ± 0.069	0.939GluHis: 0.939 ± 0.033	8.277GluIle: 8.277 ± 0.096	8.126GluLys: 8.126 ± 0.106	6.703GluLeu: 6.703 ± 0.095	1.955GluMet: 1.955 ± 0.042	4.862GluAsn: 4.862 ± 0.074	1.437GluPro: 1.437 ± 0.038	1.63GluGln: 1.63 ± 0.037	2.819GluArg: 2.819 ± 0.05	3.113GluSer: 3.113 ± 0.052	2.924GluThr: 2.924 ± 0.061	4.747GluVal: 4.747 ± 0.068	0.464GluTrp: 0.464 ± 0.023	3.102GluTyr: 3.102 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.314PheAla: 2.314 ± 0.051	0.485PheCys: 0.485 ± 0.022	2.56PheAsp: 2.56 ± 0.053	2.877PheGlu: 2.877 ± 0.054	2.017PhePhe: 2.017 ± 0.051	2.887PheGly: 2.887 ± 0.054	0.615PheHis: 0.615 ± 0.024	4.771PheIle: 4.771 ± 0.088	3.749PheLys: 3.749 ± 0.068	3.981PheLeu: 3.981 ± 0.065	1.115PheMet: 1.115 ± 0.034	2.751PheAsn: 2.751 ± 0.058	1.212PhePro: 1.212 ± 0.034	1.003PheGln: 1.003 ± 0.036	1.463PheArg: 1.463 ± 0.037	2.934PheSer: 2.934 ± 0.06	2.228PheThr: 2.228 ± 0.052	2.526PheVal: 2.526 ± 0.048	0.33PheTrp: 0.33 ± 0.016	1.708PheTyr: 1.708 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.006GlyAla: 4.006 ± 0.083	0.861GlyCys: 0.861 ± 0.03	3.21GlyAsp: 3.21 ± 0.063	4.247GlyGlu: 4.247 ± 0.064	3.062GlyPhe: 3.062 ± 0.052	4.268GlyGly: 4.268 ± 0.088	1.071GlyHis: 1.071 ± 0.037	7.209GlyIle: 7.209 ± 0.097	5.781GlyLys: 5.781 ± 0.085	5.892GlyLeu: 5.892 ± 0.085	1.744GlyMet: 1.744 ± 0.043	3.028GlyAsn: 3.028 ± 0.06	1.312GlyPro: 1.312 ± 0.037	1.457GlyGln: 1.457 ± 0.034	2.436GlyArg: 2.436 ± 0.052	3.291GlySer: 3.291 ± 0.058	3.36GlyThr: 3.36 ± 0.057	4.357GlyVal: 4.357 ± 0.066	0.566GlyTrp: 0.566 ± 0.029	3.042GlyTyr: 3.042 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.736HisAla: 0.736 ± 0.029	0.174HisCys: 0.174 ± 0.013	0.787HisAsp: 0.787 ± 0.028	0.929HisGlu: 0.929 ± 0.029	0.626HisPhe: 0.626 ± 0.024	0.998HisGly: 0.998 ± 0.033	0.304HisHis: 0.304 ± 0.017	1.563HisIle: 1.563 ± 0.037	1.155HisLys: 1.155 ± 0.03	1.307HisLeu: 1.307 ± 0.034	0.409HisMet: 0.409 ± 0.02	0.817HisAsn: 0.817 ± 0.027	0.711HisPro: 0.711 ± 0.027	0.339HisGln: 0.339 ± 0.018	0.627HisArg: 0.627 ± 0.026	0.875HisSer: 0.875 ± 0.031	0.711HisThr: 0.711 ± 0.027	0.818HisVal: 0.818 ± 0.025	0.11HisTrp: 0.11 ± 0.01	0.592HisTyr: 0.592 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.237IleAla: 6.237 ± 0.079	1.175IleCys: 1.175 ± 0.037	6.771IleAsp: 6.771 ± 0.088	7.995IleGlu: 7.995 ± 0.095	4.519IlePhe: 4.519 ± 0.073	6.674IleGly: 6.674 ± 0.093	1.466IleHis: 1.466 ± 0.044	10.66IleIle: 10.66 ± 0.133	9.622IleLys: 9.622 ± 0.104	9.694IleLeu: 9.694 ± 0.121	2.426IleMet: 2.426 ± 0.054	6.478IleAsn: 6.478 ± 0.075	3.789IlePro: 3.789 ± 0.059	2.277IleGln: 2.277 ± 0.039	3.691IleArg: 3.691 ± 0.058	6.884IleSer: 6.884 ± 0.094	5.07IleThr: 5.07 ± 0.07	6.466IleVal: 6.466 ± 0.093	0.635IleTrp: 0.635 ± 0.024	3.976IleTyr: 3.976 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.165LysAla: 5.165 ± 0.072	0.795LysCys: 0.795 ± 0.032	5.786LysAsp: 5.786 ± 0.072	9.192LysGlu: 9.192 ± 0.116	3.066LysPhe: 3.066 ± 0.052	5.51LysGly: 5.51 ± 0.076	1.298LysHis: 1.298 ± 0.036	9.312LysIle: 9.312 ± 0.095	9.201LysLys: 9.201 ± 0.107	7.898LysLeu: 7.898 ± 0.089	2.364LysMet: 2.364 ± 0.045	6.306LysAsn: 6.306 ± 0.087	2.4LysPro: 2.4 ± 0.041	2.215LysGln: 2.215 ± 0.043	3.64LysArg: 3.64 ± 0.061	4.787LysSer: 4.787 ± 0.075	4.033LysThr: 4.033 ± 0.056	5.526LysVal: 5.526 ± 0.076	0.666LysTrp: 0.666 ± 0.026	4.244LysTyr: 4.244 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	5.107LeuAla: 5.107 ± 0.074	1.015LeuCys: 1.015 ± 0.031	5.256LeuAsp: 5.256 ± 0.068	6.616LeuGlu: 6.616 ± 0.095	3.86LeuPhe: 3.86 ± 0.072	6.206LeuGly: 6.206 ± 0.088	1.157LeuHis: 1.157 ± 0.032	8.811LeuIle: 8.811 ± 0.107	8.767LeuLys: 8.767 ± 0.099	8.122LeuLeu: 8.122 ± 0.1	2.405LeuMet: 2.405 ± 0.042	5.529LeuAsn: 5.529 ± 0.078	2.843LeuPro: 2.843 ± 0.056	2.121LeuGln: 2.121 ± 0.045	3.506LeuArg: 3.506 ± 0.054	6.273LeuSer: 6.273 ± 0.092	4.357LeuThr: 4.357 ± 0.063	5.274LeuVal: 5.274 ± 0.076	0.572LeuTrp: 0.572 ± 0.024	3.307LeuTyr: 3.307 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.042	0.231MetCys: 0.231 ± 0.014	1.474MetAsp: 1.474 ± 0.04	1.949MetGlu: 1.949 ± 0.044	0.972MetPhe: 0.972 ± 0.03	1.726MetGly: 1.726 ± 0.042	0.317MetHis: 0.317 ± 0.017	2.605MetIle: 2.605 ± 0.051	2.637MetLys: 2.637 ± 0.05	2.205MetLeu: 2.205 ± 0.048	0.713MetMet: 0.713 ± 0.027	1.689MetAsn: 1.689 ± 0.038	0.842MetPro: 0.842 ± 0.033	0.591MetGln: 0.591 ± 0.022	0.931MetArg: 0.931 ± 0.03	1.477MetSer: 1.477 ± 0.043	1.316MetThr: 1.316 ± 0.039	1.536MetVal: 1.536 ± 0.042	0.138MetTrp: 0.138 ± 0.01	0.85MetTyr: 0.85 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.549AsnAla: 2.549 ± 0.053	0.594AsnCys: 0.594 ± 0.023	3.025AsnAsp: 3.025 ± 0.055	4.086AsnGlu: 4.086 ± 0.055	2.329AsnPhe: 2.329 ± 0.044	3.342AsnGly: 3.342 ± 0.064	0.864AsnHis: 0.864 ± 0.029	7.392AsnIle: 7.392 ± 0.087	5.947AsnLys: 5.947 ± 0.081	5.328AsnLeu: 5.328 ± 0.088	1.531AsnMet: 1.531 ± 0.036	4.172AsnAsn: 4.172 ± 0.085	2.211AsnPro: 2.211 ± 0.05	1.44AsnGln: 1.44 ± 0.04	2.372AsnArg: 2.372 ± 0.045	3.461AsnSer: 3.461 ± 0.061	2.776AsnThr: 2.776 ± 0.053	3.211AsnVal: 3.211 ± 0.052	0.441AsnTrp: 0.441 ± 0.02	2.569AsnTyr: 2.569 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	1.521ProAla: 1.521 ± 0.04	0.304ProCys: 0.304 ± 0.017	1.57ProAsp: 1.57 ± 0.038	2.257ProGlu: 2.257 ± 0.053	1.431ProPhe: 1.431 ± 0.04	1.732ProGly: 1.732 ± 0.037	0.583ProHis: 0.583 ± 0.026	2.952ProIle: 2.952 ± 0.054	2.4ProLys: 2.4 ± 0.041	2.684ProLeu: 2.684 ± 0.052	0.745ProMet: 0.745 ± 0.028	1.605ProAsn: 1.605 ± 0.04	0.74ProPro: 0.74 ± 0.027	0.853ProGln: 0.853 ± 0.028	0.991ProArg: 0.991 ± 0.028	1.705ProSer: 1.705 ± 0.039	1.439ProThr: 1.439 ± 0.039	2.143ProVal: 2.143 ± 0.05	0.254ProTrp: 0.254 ± 0.016	1.33ProTyr: 1.33 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.267GlnAla: 1.267 ± 0.038	0.205GlnCys: 0.205 ± 0.014	1.153GlnAsp: 1.153 ± 0.034	1.703GlnGlu: 1.703 ± 0.041	0.966GlnPhe: 0.966 ± 0.03	1.472GlnGly: 1.472 ± 0.036	0.343GlnHis: 0.343 ± 0.018	2.398GlnIle: 2.398 ± 0.048	2.153GlnLys: 2.153 ± 0.055	2.172GlnLeu: 2.172 ± 0.043	0.672GlnMet: 0.672 ± 0.024	1.447GlnAsn: 1.447 ± 0.04	0.594GlnPro: 0.594 ± 0.023	0.719GlnGln: 0.719 ± 0.025	1.093GlnArg: 1.093 ± 0.033	1.271GlnSer: 1.271 ± 0.036	0.944GlnThr: 0.944 ± 0.03	1.367GlnVal: 1.367 ± 0.037	0.205GlnTrp: 0.205 ± 0.014	0.996GlnTyr: 0.996 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.035ArgAla: 2.035 ± 0.046	0.392ArgCys: 0.392 ± 0.02	2.027ArgAsp: 2.027 ± 0.049	2.944ArgGlu: 2.944 ± 0.06	1.667ArgPhe: 1.667 ± 0.042	2.236ArgGly: 2.236 ± 0.047	0.581ArgHis: 0.581 ± 0.024	3.897ArgIle: 3.897 ± 0.064	3.668ArgLys: 3.668 ± 0.056	3.535ArgLeu: 3.535 ± 0.056	0.981ArgMet: 0.981 ± 0.031	2.223ArgAsn: 2.223 ± 0.05	1.033ArgPro: 1.033 ± 0.033	1.006ArgGln: 1.006 ± 0.032	1.709ArgArg: 1.709 ± 0.046	1.694ArgSer: 1.694 ± 0.043	1.684ArgThr: 1.684 ± 0.035	2.459ArgVal: 2.459 ± 0.041	0.27ArgTrp: 0.27 ± 0.015	1.678ArgTyr: 1.678 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	2.794SerAla: 2.794 ± 0.051	0.623SerCys: 0.623 ± 0.024	2.891SerAsp: 2.891 ± 0.053	3.536SerGlu: 3.536 ± 0.059	3.015SerPhe: 3.015 ± 0.065	3.795SerGly: 3.795 ± 0.072	0.942SerHis: 0.942 ± 0.028	6.398SerIle: 6.398 ± 0.078	5.436SerLys: 5.436 ± 0.075	5.668SerLeu: 5.668 ± 0.081	1.601SerMet: 1.601 ± 0.042	3.4SerAsn: 3.4 ± 0.069	1.684SerPro: 1.684 ± 0.038	1.607SerGln: 1.607 ± 0.039	2.198SerArg: 2.198 ± 0.049	3.759SerSer: 3.759 ± 0.063	2.767SerThr: 2.767 ± 0.051	3.237SerVal: 3.237 ± 0.057	0.437SerTrp: 0.437 ± 0.02	2.346SerTyr: 2.346 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	2.855ThrAla: 2.855 ± 0.065	0.467ThrCys: 0.467 ± 0.018	2.356ThrAsp: 2.356 ± 0.047	2.801ThrGlu: 2.801 ± 0.055	2.024ThrPhe: 2.024 ± 0.045	3.599ThrGly: 3.599 ± 0.06	0.77ThrHis: 0.77 ± 0.028	5.02ThrIle: 5.02 ± 0.067	3.823ThrLys: 3.823 ± 0.058	4.478ThrLeu: 4.478 ± 0.063	1.132ThrMet: 1.132 ± 0.034	2.459ThrAsn: 2.459 ± 0.054	1.805ThrPro: 1.805 ± 0.04	1.073ThrGln: 1.073 ± 0.033	1.564ThrArg: 1.564 ± 0.042	2.818ThrSer: 2.818 ± 0.05	2.391ThrThr: 2.391 ± 0.054	3.051ThrVal: 3.051 ± 0.065	0.33ThrTrp: 0.33 ± 0.019	1.829ThrTyr: 1.829 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.626ValAla: 3.626 ± 0.059	0.697ValCys: 0.697 ± 0.025	3.665ValAsp: 3.665 ± 0.059	4.329ValGlu: 4.329 ± 0.06	2.905ValPhe: 2.905 ± 0.057	4.034ValGly: 4.034 ± 0.067	0.873ValHis: 0.873 ± 0.028	6.211ValIle: 6.211 ± 0.077	5.525ValLys: 5.525 ± 0.062	5.793ValLeu: 5.793 ± 0.08	1.559ValMet: 1.559 ± 0.036	3.283ValAsn: 3.283 ± 0.06	1.955ValPro: 1.955 ± 0.047	1.229ValGln: 1.229 ± 0.032	2.146ValArg: 2.146 ± 0.051	3.783ValSer: 3.783 ± 0.057	2.909ValThr: 2.909 ± 0.058	4.285ValVal: 4.285 ± 0.072	0.393ValTrp: 0.393 ± 0.018	2.325ValTyr: 2.325 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.392TrpAla: 0.392 ± 0.02	0.076TrpCys: 0.076 ± 0.008	0.404TrpAsp: 0.404 ± 0.021	0.493TrpGlu: 0.493 ± 0.021	0.324TrpPhe: 0.324 ± 0.019	0.569TrpGly: 0.569 ± 0.027	0.132TrpHis: 0.132 ± 0.01	0.661TrpIle: 0.661 ± 0.024	0.565TrpLys: 0.565 ± 0.027	0.575TrpLeu: 0.575 ± 0.023	0.218TrpMet: 0.218 ± 0.015	0.476TrpAsn: 0.476 ± 0.02	0.156TrpPro: 0.156 ± 0.012	0.201TrpGln: 0.201 ± 0.014	0.271TrpArg: 0.271 ± 0.016	0.406TrpSer: 0.406 ± 0.022	0.346TrpThr: 0.346 ± 0.019	0.398TrpVal: 0.398 ± 0.02	0.095TrpTrp: 0.095 ± 0.01	0.32TrpTyr: 0.32 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.771TyrAla: 1.771 ± 0.041	0.531TyrCys: 0.531 ± 0.022	2.676TyrAsp: 2.676 ± 0.06	2.884TyrGlu: 2.884 ± 0.055	2.034TyrPhe: 2.034 ± 0.045	2.74TyrGly: 2.74 ± 0.054	0.658TyrHis: 0.658 ± 0.026	4.22TyrIle: 4.22 ± 0.067	3.702TyrLys: 3.702 ± 0.064	3.668TyrLeu: 3.668 ± 0.062	0.993TyrMet: 0.993 ± 0.031	2.583TyrAsn: 2.583 ± 0.057	1.336TyrPro: 1.336 ± 0.036	0.861TyrGln: 0.861 ± 0.028	1.666TyrArg: 1.666 ± 0.037	2.602TyrSer: 2.602 ± 0.047	1.917TyrThr: 1.917 ± 0.04	2.154TyrVal: 2.154 ± 0.047	0.323TyrTrp: 0.323 ± 0.016	1.928TyrTyr: 1.928 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3784 proteins (1112298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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