Amino acid dipepetide frequency for Stomatobaculum longum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.866AlaAla: 12.866 ± 0.227
1.218AlaCys: 1.218 ± 0.046
5.441AlaAsp: 5.441 ± 0.09
9.183AlaGlu: 9.183 ± 0.174
3.674AlaPhe: 3.674 ± 0.069
7.51AlaGly: 7.51 ± 0.117
1.462AlaHis: 1.462 ± 0.046
4.666AlaIle: 4.666 ± 0.107
5.073AlaLys: 5.073 ± 0.099
10.95AlaLeu: 10.95 ± 0.175
2.572AlaMet: 2.572 ± 0.063
2.572AlaAsn: 2.572 ± 0.074
3.092AlaPro: 3.092 ± 0.095
2.455AlaGln: 2.455 ± 0.06
4.957AlaArg: 4.957 ± 0.093
4.62AlaSer: 4.62 ± 0.094
3.897AlaThr: 3.897 ± 0.111
7.776AlaVal: 7.776 ± 0.125
0.702AlaTrp: 0.702 ± 0.034
3.037AlaTyr: 3.037 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.14CysAla: 1.14 ± 0.039
0.264CysCys: 0.264 ± 0.024
0.723CysAsp: 0.723 ± 0.032
0.795CysGlu: 0.795 ± 0.036
0.69CysPhe: 0.69 ± 0.033
1.41CysGly: 1.41 ± 0.057
0.259CysHis: 0.259 ± 0.02
0.862CysIle: 0.862 ± 0.035
0.592CysLys: 0.592 ± 0.027
1.205CysLeu: 1.205 ± 0.046
0.345CysMet: 0.345 ± 0.023
0.386CysAsn: 0.386 ± 0.025
0.614CysPro: 0.614 ± 0.029
0.254CysGln: 0.254 ± 0.018
0.815CysArg: 0.815 ± 0.039
0.696CysSer: 0.696 ± 0.036
0.685CysThr: 0.685 ± 0.035
0.843CysVal: 0.843 ± 0.038
0.103CysTrp: 0.103 ± 0.013
0.533CysTyr: 0.533 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
5.228AspAla: 5.228 ± 0.101
0.815AspCys: 0.815 ± 0.033
2.346AspAsp: 2.346 ± 0.067
4.031AspGlu: 4.031 ± 0.093
2.552AspPhe: 2.552 ± 0.064
4.485AspGly: 4.485 ± 0.109
0.82AspHis: 0.82 ± 0.04
3.244AspIle: 3.244 ± 0.083
2.674AspLys: 2.674 ± 0.076
4.547AspLeu: 4.547 ± 0.08
1.346AspMet: 1.346 ± 0.049
1.822AspAsn: 1.822 ± 0.06
1.944AspPro: 1.944 ± 0.063
1.183AspGln: 1.183 ± 0.041
2.866AspArg: 2.866 ± 0.064
3.062AspSer: 3.062 ± 0.075
2.732AspThr: 2.732 ± 0.071
3.148AspVal: 3.148 ± 0.067
0.608AspTrp: 0.608 ± 0.03
2.312AspTyr: 2.312 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
7.752GluAla: 7.752 ± 0.123
0.614GluCys: 0.614 ± 0.03
3.83GluAsp: 3.83 ± 0.073
7.558GluGlu: 7.558 ± 0.152
2.133GluPhe: 2.133 ± 0.063
4.529GluGly: 4.529 ± 0.088
1.368GluHis: 1.368 ± 0.049
4.639GluIle: 4.639 ± 0.09
5.985GluLys: 5.985 ± 0.117
7.915GluLeu: 7.915 ± 0.135
1.924GluMet: 1.924 ± 0.058
3.316GluAsn: 3.316 ± 0.07
2.146GluPro: 2.146 ± 0.062
2.978GluGln: 2.978 ± 0.083
4.958GluArg: 4.958 ± 0.116
4.132GluSer: 4.132 ± 0.08
4.415GluThr: 4.415 ± 0.087
4.792GluVal: 4.792 ± 0.099
0.46GluTrp: 0.46 ± 0.028
2.052GluTyr: 2.052 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.82PheAla: 3.82 ± 0.065
0.645PheCys: 0.645 ± 0.031
2.334PheAsp: 2.334 ± 0.055
2.43PheGlu: 2.43 ± 0.065
1.952PhePhe: 1.952 ± 0.064
3.241PheGly: 3.241 ± 0.07
0.823PheHis: 0.823 ± 0.032
1.948PheIle: 1.948 ± 0.062
1.315PheLys: 1.315 ± 0.043
4.557PheLeu: 4.557 ± 0.109
0.928PheMet: 0.928 ± 0.035
1.163PheAsn: 1.163 ± 0.044
1.651PhePro: 1.651 ± 0.046
1.346PheGln: 1.346 ± 0.044
2.712PheArg: 2.712 ± 0.069
3.101PheSer: 3.101 ± 0.077
2.226PheThr: 2.226 ± 0.067
2.747PheVal: 2.747 ± 0.069
0.455PheTrp: 0.455 ± 0.029
1.578PheTyr: 1.578 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.402GlyAla: 6.402 ± 0.106
1.021GlyCys: 1.021 ± 0.041
3.783GlyAsp: 3.783 ± 0.078
5.66GlyGlu: 5.66 ± 0.104
3.214GlyPhe: 3.214 ± 0.068
5.719GlyGly: 5.719 ± 0.133
1.322GlyHis: 1.322 ± 0.043
5.347GlyIle: 5.347 ± 0.09
5.48GlyLys: 5.48 ± 0.106
6.379GlyLeu: 6.379 ± 0.124
2.208GlyMet: 2.208 ± 0.066
2.85GlyAsn: 2.85 ± 0.076
1.46GlyPro: 1.46 ± 0.051
2.345GlyGln: 2.345 ± 0.066
3.796GlyArg: 3.796 ± 0.086
4.654GlySer: 4.654 ± 0.113
4.406GlyThr: 4.406 ± 0.108
5.233GlyVal: 5.233 ± 0.102
0.804GlyTrp: 0.804 ± 0.053
3.001GlyTyr: 3.001 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.518HisAla: 1.518 ± 0.044
0.372HisCys: 0.372 ± 0.027
0.829HisAsp: 0.829 ± 0.038
1.053HisGlu: 1.053 ± 0.047
0.912HisPhe: 0.912 ± 0.043
1.3HisGly: 1.3 ± 0.042
0.391HisHis: 0.391 ± 0.041
1.266HisIle: 1.266 ± 0.043
0.711HisLys: 0.711 ± 0.033
1.551HisLeu: 1.551 ± 0.045
0.498HisMet: 0.498 ± 0.026
0.548HisAsn: 0.548 ± 0.027
0.977HisPro: 0.977 ± 0.041
0.445HisGln: 0.445 ± 0.026
1.089HisArg: 1.089 ± 0.039
0.924HisSer: 0.924 ± 0.042
0.95HisThr: 0.95 ± 0.042
1.018HisVal: 1.018 ± 0.033
0.232HisTrp: 0.232 ± 0.018
0.868HisTyr: 0.868 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.732IleAla: 5.732 ± 0.098
0.867IleCys: 0.867 ± 0.034
3.225IleAsp: 3.225 ± 0.084
3.582IleGlu: 3.582 ± 0.074
2.317IlePhe: 2.317 ± 0.061
4.409IleGly: 4.409 ± 0.102
1.083IleHis: 1.083 ± 0.039
2.876IleIle: 2.876 ± 0.084
2.22IleLys: 2.22 ± 0.065
5.906IleLeu: 5.906 ± 0.12
1.256IleMet: 1.256 ± 0.051
1.828IleAsn: 1.828 ± 0.054
2.815IlePro: 2.815 ± 0.065
1.885IleGln: 1.885 ± 0.048
3.806IleArg: 3.806 ± 0.093
3.652IleSer: 3.652 ± 0.068
3.07IleThr: 3.07 ± 0.072
3.827IleVal: 3.827 ± 0.085
0.485IleTrp: 0.485 ± 0.025
1.983IleTyr: 1.983 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.018LysAla: 5.018 ± 0.106
0.466LysCys: 0.466 ± 0.025
2.765LysAsp: 2.765 ± 0.071
4.794LysGlu: 4.794 ± 0.099
1.476LysPhe: 1.476 ± 0.047
3.351LysGly: 3.351 ± 0.077
0.873LysHis: 0.873 ± 0.04
3.166LysIle: 3.166 ± 0.074
4.582LysLys: 4.582 ± 0.108
5.394LysLeu: 5.394 ± 0.101
1.5LysMet: 1.5 ± 0.048
2.49LysAsn: 2.49 ± 0.056
1.98LysPro: 1.98 ± 0.055
2.12LysGln: 2.12 ± 0.057
3.607LysArg: 3.607 ± 0.075
2.932LysSer: 2.932 ± 0.067
3.468LysThr: 3.468 ± 0.079
3.294LysVal: 3.294 ± 0.074
0.488LysTrp: 0.488 ± 0.032
1.797LysTyr: 1.797 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
9.207LeuAla: 9.207 ± 0.148
1.719LeuCys: 1.719 ± 0.056
4.949LeuAsp: 4.949 ± 0.079
6.127LeuGlu: 6.127 ± 0.122
4.61LeuPhe: 4.61 ± 0.115
7.17LeuGly: 7.17 ± 0.11
1.811LeuHis: 1.811 ± 0.058
5.278LeuIle: 5.278 ± 0.124
5.203LeuLys: 5.203 ± 0.088
11.716LeuLeu: 11.716 ± 0.258
2.437LeuMet: 2.437 ± 0.072
3.324LeuAsn: 3.324 ± 0.069
4.888LeuPro: 4.888 ± 0.112
3.213LeuGln: 3.213 ± 0.082
6.988LeuArg: 6.988 ± 0.138
7.373LeuSer: 7.373 ± 0.127
5.678LeuThr: 5.678 ± 0.104
5.845LeuVal: 5.845 ± 0.106
0.799LeuTrp: 0.799 ± 0.04
3.347LeuTyr: 3.347 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.209MetAla: 2.209 ± 0.068
0.253MetCys: 0.253 ± 0.02
1.378MetAsp: 1.378 ± 0.046
1.863MetGlu: 1.863 ± 0.055
0.715MetPhe: 0.715 ± 0.033
1.742MetGly: 1.742 ± 0.058
0.425MetHis: 0.425 ± 0.023
1.547MetIle: 1.547 ± 0.054
1.797MetLys: 1.797 ± 0.056
2.539MetLeu: 2.539 ± 0.067
0.715MetMet: 0.715 ± 0.032
1.282MetAsn: 1.282 ± 0.041
1.093MetPro: 1.093 ± 0.04
1.199MetGln: 1.199 ± 0.038
1.714MetArg: 1.714 ± 0.053
1.471MetSer: 1.471 ± 0.048
1.55MetThr: 1.55 ± 0.048
1.419MetVal: 1.419 ± 0.047
0.147MetTrp: 0.147 ± 0.015
0.618MetTyr: 0.618 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.429AsnAla: 3.429 ± 0.086
0.454AsnCys: 0.454 ± 0.024
1.566AsnAsp: 1.566 ± 0.06
2.171AsnGlu: 2.171 ± 0.056
1.491AsnPhe: 1.491 ± 0.047
3.269AsnGly: 3.269 ± 0.103
0.707AsnHis: 0.707 ± 0.035
2.12AsnIle: 2.12 ± 0.056
1.567AsnLys: 1.567 ± 0.053
3.445AsnLeu: 3.445 ± 0.071
0.975AsnMet: 0.975 ± 0.045
1.19AsnAsn: 1.19 ± 0.054
2.132AsnPro: 2.132 ± 0.079
1.211AsnGln: 1.211 ± 0.039
2.189AsnArg: 2.189 ± 0.061
1.78AsnSer: 1.78 ± 0.049
1.819AsnThr: 1.819 ± 0.065
2.239AsnVal: 2.239 ± 0.059
0.397AsnTrp: 0.397 ± 0.025
1.381AsnTyr: 1.381 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.702ProAla: 3.702 ± 0.12
0.422ProCys: 0.422 ± 0.03
2.381ProAsp: 2.381 ± 0.071
3.987ProGlu: 3.987 ± 0.093
1.648ProPhe: 1.648 ± 0.053
2.92ProGly: 2.92 ± 0.083
0.683ProHis: 0.683 ± 0.033
1.872ProIle: 1.872 ± 0.056
1.951ProLys: 1.951 ± 0.055
3.662ProLeu: 3.662 ± 0.085
0.829ProMet: 0.829 ± 0.033
1.297ProAsn: 1.297 ± 0.059
0.98ProPro: 0.98 ± 0.045
1.046ProGln: 1.046 ± 0.039
1.598ProArg: 1.598 ± 0.058
1.889ProSer: 1.889 ± 0.062
1.785ProThr: 1.785 ± 0.069
3.017ProVal: 3.017 ± 0.075
0.344ProTrp: 0.344 ± 0.025
1.428ProTyr: 1.428 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.966GlnAla: 2.966 ± 0.075
0.344GlnCys: 0.344 ± 0.025
1.451GlnAsp: 1.451 ± 0.048
2.296GlnGlu: 2.296 ± 0.063
1.162GlnPhe: 1.162 ± 0.04
2.209GlnGly: 2.209 ± 0.068
0.564GlnHis: 0.564 ± 0.032
1.845GlnIle: 1.845 ± 0.057
2.198GlnLys: 2.198 ± 0.059
3.131GlnLeu: 3.131 ± 0.071
0.846GlnMet: 0.846 ± 0.041
1.419GlnAsn: 1.419 ± 0.053
1.037GlnPro: 1.037 ± 0.045
1.224GlnGln: 1.224 ± 0.05
2.258GlnArg: 2.258 ± 0.051
1.808GlnSer: 1.808 ± 0.059
1.613GlnThr: 1.613 ± 0.051
1.822GlnVal: 1.822 ± 0.054
0.306GlnTrp: 0.306 ± 0.023
1.184GlnTyr: 1.184 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.665ArgAla: 5.665 ± 0.126
0.786ArgCys: 0.786 ± 0.042
3.069ArgAsp: 3.069 ± 0.084
6.226ArgGlu: 6.226 ± 0.122
2.775ArgPhe: 2.775 ± 0.07
3.708ArgGly: 3.708 ± 0.072
1.14ArgHis: 1.14 ± 0.044
3.818ArgIle: 3.818 ± 0.097
3.56ArgLys: 3.56 ± 0.07
5.56ArgLeu: 5.56 ± 0.104
1.808ArgMet: 1.808 ± 0.051
2.22ArgAsn: 2.22 ± 0.057
1.791ArgPro: 1.791 ± 0.058
2.152ArgGln: 2.152 ± 0.065
4.081ArgArg: 4.081 ± 0.098
2.691ArgSer: 2.691 ± 0.06
2.785ArgThr: 2.785 ± 0.064
3.593ArgVal: 3.593 ± 0.074
0.502ArgTrp: 0.502 ± 0.03
2.59ArgTyr: 2.59 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
5.901SerAla: 5.901 ± 0.118
0.774SerCys: 0.774 ± 0.036
2.966SerAsp: 2.966 ± 0.065
4.093SerGlu: 4.093 ± 0.087
2.95SerPhe: 2.95 ± 0.07
5.665SerGly: 5.665 ± 0.108
0.921SerHis: 0.921 ± 0.036
3.047SerIle: 3.047 ± 0.066
2.65SerLys: 2.65 ± 0.066
5.775SerLeu: 5.775 ± 0.105
1.403SerMet: 1.403 ± 0.049
1.782SerAsn: 1.782 ± 0.052
1.92SerPro: 1.92 ± 0.061
1.476SerGln: 1.476 ± 0.05
3.156SerArg: 3.156 ± 0.082
3.029SerSer: 3.029 ± 0.092
2.577SerThr: 2.577 ± 0.072
3.981SerVal: 3.981 ± 0.076
0.564SerTrp: 0.564 ± 0.032
2.506SerTyr: 2.506 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
6.173ThrAla: 6.173 ± 0.131
0.486ThrCys: 0.486 ± 0.031
2.882ThrAsp: 2.882 ± 0.071
4.526ThrGlu: 4.526 ± 0.092
1.783ThrPhe: 1.783 ± 0.061
4.647ThrGly: 4.647 ± 0.111
0.78ThrHis: 0.78 ± 0.032
2.777ThrIle: 2.777 ± 0.08
2.356ThrLys: 2.356 ± 0.068
5.359ThrLeu: 5.359 ± 0.092
1.197ThrMet: 1.197 ± 0.04
1.686ThrAsn: 1.686 ± 0.066
2.569ThrPro: 2.569 ± 0.083
1.258ThrGln: 1.258 ± 0.048
2.421ThrArg: 2.421 ± 0.062
2.449ThrSer: 2.449 ± 0.082
2.624ThrThr: 2.624 ± 0.106
4.91ThrVal: 4.91 ± 0.127
0.383ThrTrp: 0.383 ± 0.026
1.495ThrTyr: 1.495 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.237ValAla: 5.237 ± 0.094
0.992ValCys: 0.992 ± 0.043
3.301ValAsp: 3.301 ± 0.073
4.049ValGlu: 4.049 ± 0.08
2.863ValPhe: 2.863 ± 0.07
4.318ValGly: 4.318 ± 0.093
1.018ValHis: 1.018 ± 0.037
4.109ValIle: 4.109 ± 0.069
3.758ValLys: 3.758 ± 0.084
7.36ValLeu: 7.36 ± 0.126
1.789ValMet: 1.789 ± 0.05
2.682ValAsn: 2.682 ± 0.07
2.749ValPro: 2.749 ± 0.068
2.151ValGln: 2.151 ± 0.05
4.235ValArg: 4.235 ± 0.09
4.579ValSer: 4.579 ± 0.08
4.119ValThr: 4.119 ± 0.103
4.224ValVal: 4.224 ± 0.087
0.57ValTrp: 0.57 ± 0.028
2.352ValTyr: 2.352 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.027
0.131TrpCys: 0.131 ± 0.012
0.461TrpAsp: 0.461 ± 0.025
0.558TrpGlu: 0.558 ± 0.032
0.419TrpPhe: 0.419 ± 0.028
0.599TrpGly: 0.599 ± 0.03
0.187TrpHis: 0.187 ± 0.015
0.585TrpIle: 0.585 ± 0.031
0.595TrpLys: 0.595 ± 0.03
0.893TrpLeu: 0.893 ± 0.043
0.303TrpMet: 0.303 ± 0.021
0.447TrpAsn: 0.447 ± 0.03
0.216TrpPro: 0.216 ± 0.018
0.444TrpGln: 0.444 ± 0.027
0.486TrpArg: 0.486 ± 0.028
0.466TrpSer: 0.466 ± 0.031
0.397TrpThr: 0.397 ± 0.032
0.504TrpVal: 0.504 ± 0.028
0.107TrpTrp: 0.107 ± 0.013
0.473TrpTyr: 0.473 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.238TyrAla: 3.238 ± 0.07
0.574TyrCys: 0.574 ± 0.03
2.083TyrAsp: 2.083 ± 0.067
2.515TyrGlu: 2.515 ± 0.066
1.634TyrPhe: 1.634 ± 0.054
2.882TyrGly: 2.882 ± 0.061
0.818TyrHis: 0.818 ± 0.035
1.81TyrIle: 1.81 ± 0.05
1.294TyrLys: 1.294 ± 0.043
3.842TyrLeu: 3.842 ± 0.076
0.793TyrMet: 0.793 ± 0.036
1.225TyrAsn: 1.225 ± 0.039
1.388TyrPro: 1.388 ± 0.045
1.302TyrGln: 1.302 ± 0.05
2.788TyrArg: 2.788 ± 0.071
1.826TyrSer: 1.826 ± 0.052
1.967TyrThr: 1.967 ± 0.077
2.223TyrVal: 2.223 ± 0.059
0.333TyrTrp: 0.333 ± 0.026
1.698TyrTyr: 1.698 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2070 proteins (680711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski