Amino acid dipepetide frequency for Sedimentitalea nanhaiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.077AlaAla: 16.077 ± 0.152	1.143AlaCys: 1.143 ± 0.03	7.044AlaAsp: 7.044 ± 0.071	7.356AlaGlu: 7.356 ± 0.081	4.236AlaPhe: 4.236 ± 0.057	10.111AlaGly: 10.111 ± 0.094	2.283AlaHis: 2.283 ± 0.043	6.028AlaIle: 6.028 ± 0.064	3.575AlaLys: 3.575 ± 0.055	13.12AlaLeu: 13.12 ± 0.114	3.822AlaMet: 3.822 ± 0.051	2.802AlaAsn: 2.802 ± 0.049	5.564AlaPro: 5.564 ± 0.085	4.777AlaGln: 4.777 ± 0.068	8.84AlaArg: 8.84 ± 0.089	5.608AlaSer: 5.608 ± 0.067	5.922AlaThr: 5.922 ± 0.066	8.458AlaVal: 8.458 ± 0.084	1.409AlaTrp: 1.409 ± 0.032	2.471AlaTyr: 2.471 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.133CysAla: 1.133 ± 0.029	0.136CysCys: 0.136 ± 0.011	0.669CysAsp: 0.669 ± 0.021	0.464CysGlu: 0.464 ± 0.018	0.347CysPhe: 0.347 ± 0.014	0.996CysGly: 0.996 ± 0.032	0.286CysHis: 0.286 ± 0.017	0.434CysIle: 0.434 ± 0.017	0.251CysLys: 0.251 ± 0.015	0.895CysLeu: 0.895 ± 0.025	0.202CysMet: 0.202 ± 0.012	0.239CysAsn: 0.239 ± 0.014	0.524CysPro: 0.524 ± 0.021	0.277CysGln: 0.277 ± 0.015	0.62CysArg: 0.62 ± 0.023	0.48CysSer: 0.48 ± 0.018	0.468CysThr: 0.468 ± 0.019	0.605CysVal: 0.605 ± 0.018	0.13CysTrp: 0.13 ± 0.01	0.223CysTyr: 0.223 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.094AspAla: 7.094 ± 0.074	0.592AspCys: 0.592 ± 0.022	3.402AspAsp: 3.402 ± 0.064	3.319AspGlu: 3.319 ± 0.051	2.318AspPhe: 2.318 ± 0.047	5.594AspGly: 5.594 ± 0.074	1.402AspHis: 1.402 ± 0.032	3.274AspIle: 3.274 ± 0.051	1.704AspLys: 1.704 ± 0.038	6.71AspLeu: 6.71 ± 0.078	1.713AspMet: 1.713 ± 0.034	1.407AspAsn: 1.407 ± 0.036	3.768AspPro: 3.768 ± 0.058	2.003AspGln: 2.003 ± 0.038	4.539AspArg: 4.539 ± 0.052	2.471AspSer: 2.471 ± 0.037	3.191AspThr: 3.191 ± 0.045	4.353AspVal: 4.353 ± 0.057	1.138AspTrp: 1.138 ± 0.031	1.553AspTyr: 1.553 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.674GluAla: 6.674 ± 0.082	0.384GluCys: 0.384 ± 0.017	3.087GluAsp: 3.087 ± 0.051	2.86GluGlu: 2.86 ± 0.069	1.862GluPhe: 1.862 ± 0.039	3.977GluGly: 3.977 ± 0.059	1.062GluHis: 1.062 ± 0.026	3.71GluIle: 3.71 ± 0.053	2.034GluLys: 2.034 ± 0.052	5.175GluLeu: 5.175 ± 0.062	1.768GluMet: 1.768 ± 0.039	1.773GluAsn: 1.773 ± 0.035	2.407GluPro: 2.407 ± 0.045	2.16GluGln: 2.16 ± 0.042	4.056GluArg: 4.056 ± 0.06	2.129GluSer: 2.129 ± 0.042	3.811GluThr: 3.811 ± 0.051	3.803GluVal: 3.803 ± 0.053	0.675GluTrp: 0.675 ± 0.022	1.072GluTyr: 1.072 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.38PheAla: 4.38 ± 0.055	0.44PheCys: 0.44 ± 0.018	2.876PheAsp: 2.876 ± 0.049	2.154PheGlu: 2.154 ± 0.04	1.44PhePhe: 1.44 ± 0.034	3.704PheGly: 3.704 ± 0.05	0.752PheHis: 0.752 ± 0.025	1.629PheIle: 1.629 ± 0.033	0.934PheLys: 0.934 ± 0.03	3.475PheLeu: 3.475 ± 0.056	0.882PheMet: 0.882 ± 0.026	1.061PheAsn: 1.061 ± 0.029	1.538PhePro: 1.538 ± 0.03	1.174PheGln: 1.174 ± 0.029	2.205PheArg: 2.205 ± 0.039	2.261PheSer: 2.261 ± 0.042	1.979PheThr: 1.979 ± 0.041	2.714PheVal: 2.714 ± 0.047	0.59PheTrp: 0.59 ± 0.021	0.945PheTyr: 0.945 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.558GlyAla: 9.558 ± 0.089	0.918GlyCys: 0.918 ± 0.028	4.637GlyAsp: 4.637 ± 0.071	4.337GlyGlu: 4.337 ± 0.06	3.729GlyPhe: 3.729 ± 0.048	7.558GlyGly: 7.558 ± 0.148	1.978GlyHis: 1.978 ± 0.034	4.437GlyIle: 4.437 ± 0.055	3.148GlyLys: 3.148 ± 0.061	9.236GlyLeu: 9.236 ± 0.091	2.666GlyMet: 2.666 ± 0.042	2.22GlyAsn: 2.22 ± 0.054	3.629GlyPro: 3.629 ± 0.053	3.35GlyGln: 3.35 ± 0.05	5.644GlyArg: 5.644 ± 0.062	4.365GlySer: 4.365 ± 0.052	4.653GlyThr: 4.653 ± 0.056	6.411GlyVal: 6.411 ± 0.063	1.528GlyTrp: 1.528 ± 0.032	2.34GlyTyr: 2.34 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.268HisAla: 2.268 ± 0.046	0.24HisCys: 0.24 ± 0.013	1.283HisAsp: 1.283 ± 0.034	1.018HisGlu: 1.018 ± 0.029	0.81HisPhe: 0.81 ± 0.025	1.91HisGly: 1.91 ± 0.041	0.571HisHis: 0.571 ± 0.021	1.008HisIle: 1.008 ± 0.027	0.556HisLys: 0.556 ± 0.021	2.142HisLeu: 2.142 ± 0.044	0.556HisMet: 0.556 ± 0.019	0.466HisAsn: 0.466 ± 0.018	1.41HisPro: 1.41 ± 0.034	0.634HisGln: 0.634 ± 0.022	1.441HisArg: 1.441 ± 0.036	1.016HisSer: 1.016 ± 0.03	0.886HisThr: 0.886 ± 0.027	1.558HisVal: 1.558 ± 0.033	0.347HisTrp: 0.347 ± 0.016	0.536HisTyr: 0.536 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.257IleAla: 7.257 ± 0.082	0.648IleCys: 0.648 ± 0.023	3.604IleAsp: 3.604 ± 0.043	3.514IleGlu: 3.514 ± 0.05	1.686IlePhe: 1.686 ± 0.04	4.927IleGly: 4.927 ± 0.059	0.929IleHis: 0.929 ± 0.026	2.112IleIle: 2.112 ± 0.038	1.514IleLys: 1.514 ± 0.033	4.998IleLeu: 4.998 ± 0.075	1.089IleMet: 1.089 ± 0.032	1.406IleAsn: 1.406 ± 0.033	2.394IlePro: 2.394 ± 0.047	1.39IleGln: 1.39 ± 0.03	3.347IleArg: 3.347 ± 0.049	3.061IleSer: 3.061 ± 0.042	2.838IleThr: 2.838 ± 0.047	3.936IleVal: 3.936 ± 0.059	0.745IleTrp: 0.745 ± 0.025	1.201IleTyr: 1.201 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.65LysAla: 3.65 ± 0.058	0.209LysCys: 0.209 ± 0.011	1.725LysAsp: 1.725 ± 0.038	1.388LysGlu: 1.388 ± 0.038	0.944LysPhe: 0.944 ± 0.024	2.589LysGly: 2.589 ± 0.045	0.632LysHis: 0.632 ± 0.019	1.659LysIle: 1.659 ± 0.033	1.204LysLys: 1.204 ± 0.034	2.909LysLeu: 2.909 ± 0.051	0.883LysMet: 0.883 ± 0.028	0.859LysAsn: 0.859 ± 0.027	1.861LysPro: 1.861 ± 0.044	1.032LysGln: 1.032 ± 0.025	2.267LysArg: 2.267 ± 0.048	1.961LysSer: 1.961 ± 0.039	2.002LysThr: 2.002 ± 0.038	2.188LysVal: 2.188 ± 0.044	0.393LysTrp: 0.393 ± 0.018	0.672LysTyr: 0.672 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.686LeuAla: 12.686 ± 0.121	0.99LeuCys: 0.99 ± 0.026	6.254LeuAsp: 6.254 ± 0.081	4.837LeuGlu: 4.837 ± 0.066	3.582LeuPhe: 3.582 ± 0.056	8.44LeuGly: 8.44 ± 0.079	1.878LeuHis: 1.878 ± 0.039	5.444LeuIle: 5.444 ± 0.074	3.193LeuLys: 3.193 ± 0.053	8.939LeuLeu: 8.939 ± 0.098	2.776LeuMet: 2.776 ± 0.047	3.001LeuAsn: 3.001 ± 0.051	5.47LeuPro: 5.47 ± 0.079	3.046LeuGln: 3.046 ± 0.043	7.028LeuArg: 7.028 ± 0.077	6.487LeuSer: 6.487 ± 0.063	6.147LeuThr: 6.147 ± 0.074	6.832LeuVal: 6.832 ± 0.079	1.248LeuTrp: 1.248 ± 0.031	2.021LeuTyr: 2.021 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.523MetAla: 3.523 ± 0.054	0.203MetCys: 0.203 ± 0.013	1.445MetAsp: 1.445 ± 0.034	1.244MetGlu: 1.244 ± 0.028	0.874MetPhe: 0.874 ± 0.026	2.317MetGly: 2.317 ± 0.036	0.488MetHis: 0.488 ± 0.021	1.635MetIle: 1.635 ± 0.031	1.082MetLys: 1.082 ± 0.025	2.702MetLeu: 2.702 ± 0.042	0.861MetMet: 0.861 ± 0.028	0.918MetAsn: 0.918 ± 0.024	1.54MetPro: 1.54 ± 0.034	1.125MetGln: 1.125 ± 0.03	1.987MetArg: 1.987 ± 0.037	1.82MetSer: 1.82 ± 0.033	2.131MetThr: 2.131 ± 0.043	1.867MetVal: 1.867 ± 0.034	0.219MetTrp: 0.219 ± 0.013	0.406MetTyr: 0.406 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.311AsnAla: 3.311 ± 0.053	0.279AsnCys: 0.279 ± 0.015	1.574AsnAsp: 1.574 ± 0.04	1.248AsnGlu: 1.248 ± 0.027	0.956AsnPhe: 0.956 ± 0.024	2.424AsnGly: 2.424 ± 0.043	0.534AsnHis: 0.534 ± 0.019	1.398AsnIle: 1.398 ± 0.031	0.706AsnLys: 0.706 ± 0.025	2.609AsnLeu: 2.609 ± 0.045	0.741AsnMet: 0.741 ± 0.023	0.726AsnAsn: 0.726 ± 0.026	1.92AsnPro: 1.92 ± 0.035	0.818AsnGln: 0.818 ± 0.022	2.027AsnArg: 2.027 ± 0.037	1.285AsnSer: 1.285 ± 0.03	1.454AsnThr: 1.454 ± 0.03	1.824AsnVal: 1.824 ± 0.037	0.449AsnTrp: 0.449 ± 0.02	0.649AsnTyr: 0.649 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.528ProAla: 5.528 ± 0.083	0.392ProCys: 0.392 ± 0.019	4.18ProAsp: 4.18 ± 0.057	3.85ProGlu: 3.85 ± 0.061	1.923ProPhe: 1.923 ± 0.035	4.586ProGly: 4.586 ± 0.062	1.041ProHis: 1.041 ± 0.029	2.327ProIle: 2.327 ± 0.035	1.625ProLys: 1.625 ± 0.035	4.614ProLeu: 4.614 ± 0.061	1.366ProMet: 1.366 ± 0.034	1.389ProAsn: 1.389 ± 0.03	2.436ProPro: 2.436 ± 0.058	1.837ProGln: 1.837 ± 0.034	2.826ProArg: 2.826 ± 0.043	2.461ProSer: 2.461 ± 0.038	2.488ProThr: 2.488 ± 0.041	4.335ProVal: 4.335 ± 0.06	0.654ProTrp: 0.654 ± 0.022	1.178ProTyr: 1.178 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.556GlnAla: 4.556 ± 0.073	0.241GlnCys: 0.241 ± 0.012	1.983GlnAsp: 1.983 ± 0.038	1.596GlnGlu: 1.596 ± 0.034	1.132GlnPhe: 1.132 ± 0.027	2.867GlnGly: 2.867 ± 0.043	0.658GlnHis: 0.658 ± 0.02	2.277GlnIle: 2.277 ± 0.042	1.189GlnLys: 1.189 ± 0.033	2.905GlnLeu: 2.905 ± 0.05	1.162GlnMet: 1.162 ± 0.029	1.018GlnAsn: 1.018 ± 0.026	1.78GlnPro: 1.78 ± 0.037	1.301GlnGln: 1.301 ± 0.036	2.351GlnArg: 2.351 ± 0.039	1.987GlnSer: 1.987 ± 0.039	2.123GlnThr: 2.123 ± 0.046	2.553GlnVal: 2.553 ± 0.045	0.44GlnTrp: 0.44 ± 0.019	0.631GlnTyr: 0.631 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.141ArgAla: 8.141 ± 0.087	0.537ArgCys: 0.537 ± 0.02	4.481ArgAsp: 4.481 ± 0.051	3.642ArgGlu: 3.642 ± 0.056	2.794ArgPhe: 2.794 ± 0.047	4.642ArgGly: 4.642 ± 0.056	1.64ArgHis: 1.64 ± 0.033	4.079ArgIle: 4.079 ± 0.051	2.348ArgLys: 2.348 ± 0.042	7.321ArgLeu: 7.321 ± 0.07	2.049ArgMet: 2.049 ± 0.039	1.918ArgAsn: 1.918 ± 0.039	3.311ArgPro: 3.311 ± 0.05	2.497ArgGln: 2.497 ± 0.047	5.079ArgArg: 5.079 ± 0.072	3.449ArgSer: 3.449 ± 0.052	3.142ArgThr: 3.142 ± 0.05	4.773ArgVal: 4.773 ± 0.058	0.913ArgTrp: 0.913 ± 0.028	1.589ArgTyr: 1.589 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.964SerAla: 5.964 ± 0.071	0.45SerCys: 0.45 ± 0.021	3.475SerAsp: 3.475 ± 0.048	2.907SerGlu: 2.907 ± 0.05	2.147SerPhe: 2.147 ± 0.042	5.536SerGly: 5.536 ± 0.066	1.125SerHis: 1.125 ± 0.025	2.613SerIle: 2.613 ± 0.049	1.52SerLys: 1.52 ± 0.039	4.998SerLeu: 4.998 ± 0.066	1.438SerMet: 1.438 ± 0.029	1.385SerAsn: 1.385 ± 0.028	2.606SerPro: 2.606 ± 0.037	1.692SerGln: 1.692 ± 0.04	3.353SerArg: 3.353 ± 0.048	2.618SerSer: 2.618 ± 0.055	2.635SerThr: 2.635 ± 0.04	3.949SerVal: 3.949 ± 0.061	0.758SerTrp: 0.758 ± 0.021	1.321SerTyr: 1.321 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.437ThrAla: 6.437 ± 0.07	0.503ThrCys: 0.503 ± 0.018	3.289ThrAsp: 3.289 ± 0.048	2.934ThrGlu: 2.934 ± 0.043	1.894ThrPhe: 1.894 ± 0.038	5.595ThrGly: 5.595 ± 0.064	1.174ThrHis: 1.174 ± 0.032	2.752ThrIle: 2.752 ± 0.05	1.407ThrLys: 1.407 ± 0.033	5.926ThrLeu: 5.926 ± 0.063	1.376ThrMet: 1.376 ± 0.03	1.329ThrAsn: 1.329 ± 0.035	3.415ThrPro: 3.415 ± 0.053	1.76ThrGln: 1.76 ± 0.033	3.533ThrArg: 3.533 ± 0.053	2.679ThrSer: 2.679 ± 0.047	2.887ThrThr: 2.887 ± 0.054	4.313ThrVal: 4.313 ± 0.054	0.665ThrTrp: 0.665 ± 0.02	1.284ThrTyr: 1.284 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.616ValAla: 8.616 ± 0.087	0.678ValCys: 0.678 ± 0.019	4.109ValAsp: 4.109 ± 0.053	4.0ValGlu: 4.0 ± 0.062	2.946ValPhe: 2.946 ± 0.048	5.379ValGly: 5.379 ± 0.064	1.384ValHis: 1.384 ± 0.034	4.185ValIle: 4.185 ± 0.055	1.978ValLys: 1.978 ± 0.043	7.645ValLeu: 7.645 ± 0.082	2.102ValMet: 2.102 ± 0.038	1.947ValAsn: 1.947 ± 0.039	3.671ValPro: 3.671 ± 0.045	2.54ValGln: 2.54 ± 0.04	4.46ValArg: 4.46 ± 0.051	4.334ValSer: 4.334 ± 0.054	4.537ValThr: 4.537 ± 0.058	5.526ValVal: 5.526 ± 0.074	0.97ValTrp: 0.97 ± 0.026	1.475ValTyr: 1.475 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.363TrpAla: 1.363 ± 0.029	0.145TrpCys: 0.145 ± 0.011	0.764TrpAsp: 0.764 ± 0.022	0.583TrpGlu: 0.583 ± 0.02	0.589TrpPhe: 0.589 ± 0.02	1.02TrpGly: 1.02 ± 0.026	0.33TrpHis: 0.33 ± 0.014	0.708TrpIle: 0.708 ± 0.022	0.454TrpLys: 0.454 ± 0.017	1.612TrpLeu: 1.612 ± 0.04	0.417TrpMet: 0.417 ± 0.016	0.452TrpAsn: 0.452 ± 0.018	0.716TrpPro: 0.716 ± 0.024	0.61TrpGln: 0.61 ± 0.023	1.095TrpArg: 1.095 ± 0.029	0.812TrpSer: 0.812 ± 0.023	0.775TrpThr: 0.775 ± 0.024	0.879TrpVal: 0.879 ± 0.024	0.226TrpTrp: 0.226 ± 0.014	0.301TrpTyr: 0.301 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.429TyrAla: 2.429 ± 0.042	0.254TyrCys: 0.254 ± 0.015	1.662TyrAsp: 1.662 ± 0.031	1.228TyrGlu: 1.228 ± 0.031	0.924TyrPhe: 0.924 ± 0.023	2.17TyrGly: 2.17 ± 0.038	0.51TyrHis: 0.51 ± 0.019	0.888TyrIle: 0.888 ± 0.025	0.603TyrLys: 0.603 ± 0.022	2.371TyrLeu: 2.371 ± 0.042	0.516TyrMet: 0.516 ± 0.021	0.618TyrAsn: 0.618 ± 0.019	1.074TyrPro: 1.074 ± 0.027	0.73TyrGln: 0.73 ± 0.022	1.647TyrArg: 1.647 ± 0.034	1.204TyrSer: 1.204 ± 0.028	1.082TyrThr: 1.082 ± 0.03	1.604TyrVal: 1.604 ± 0.034	0.354TyrTrp: 0.354 ± 0.017	0.61TyrTyr: 0.61 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4762 proteins (1450164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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