Amino acid dipepetide frequency for Reichenbachiella sp. 5M10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.084AlaAla: 5.084 ± 0.09	0.644AlaCys: 0.644 ± 0.022	3.997AlaAsp: 3.997 ± 0.06	4.356AlaGlu: 4.356 ± 0.063	3.187AlaPhe: 3.187 ± 0.048	4.897AlaGly: 4.897 ± 0.083	1.431AlaHis: 1.431 ± 0.034	4.85AlaIle: 4.85 ± 0.072	4.141AlaLys: 4.141 ± 0.078	6.896AlaLeu: 6.896 ± 0.079	1.852AlaMet: 1.852 ± 0.042	3.133AlaAsn: 3.133 ± 0.053	2.259AlaPro: 2.259 ± 0.047	3.177AlaGln: 3.177 ± 0.051	2.339AlaArg: 2.339 ± 0.048	4.759AlaSer: 4.759 ± 0.078	4.018AlaThr: 4.018 ± 0.096	4.564AlaVal: 4.564 ± 0.079	0.854AlaTrp: 0.854 ± 0.029	2.905AlaTyr: 2.905 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.502CysAla: 0.502 ± 0.024	0.093CysCys: 0.093 ± 0.009	0.447CysAsp: 0.447 ± 0.017	0.458CysGlu: 0.458 ± 0.023	0.374CysPhe: 0.374 ± 0.017	0.598CysGly: 0.598 ± 0.023	0.198CysHis: 0.198 ± 0.012	0.514CysIle: 0.514 ± 0.022	0.346CysLys: 0.346 ± 0.017	0.72CysLeu: 0.72 ± 0.024	0.17CysMet: 0.17 ± 0.011	0.305CysAsn: 0.305 ± 0.017	0.295CysPro: 0.295 ± 0.018	0.333CysGln: 0.333 ± 0.017	0.263CysArg: 0.263 ± 0.013	0.507CysSer: 0.507 ± 0.023	0.468CysThr: 0.468 ± 0.022	0.447CysVal: 0.447 ± 0.019	0.089CysTrp: 0.089 ± 0.007	0.296CysTyr: 0.296 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.94AspAla: 3.94 ± 0.065	0.406AspCys: 0.406 ± 0.021	3.218AspAsp: 3.218 ± 0.069	4.449AspGlu: 4.449 ± 0.058	3.376AspPhe: 3.376 ± 0.053	4.553AspGly: 4.553 ± 0.101	1.299AspHis: 1.299 ± 0.032	4.138AspIle: 4.138 ± 0.061	3.438AspLys: 3.438 ± 0.058	5.773AspLeu: 5.773 ± 0.074	1.456AspMet: 1.456 ± 0.031	2.8AspAsn: 2.8 ± 0.064	2.381AspPro: 2.381 ± 0.053	2.792AspGln: 2.792 ± 0.057	2.526AspArg: 2.526 ± 0.048	3.565AspSer: 3.565 ± 0.061	3.012AspThr: 3.012 ± 0.05	3.886AspVal: 3.886 ± 0.056	0.88AspTrp: 0.88 ± 0.032	2.907AspTyr: 2.907 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.72GluAla: 4.72 ± 0.063	0.331GluCys: 0.331 ± 0.017	3.968GluAsp: 3.968 ± 0.06	5.503GluGlu: 5.503 ± 0.1	2.664GluPhe: 2.664 ± 0.044	4.584GluGly: 4.584 ± 0.064	1.315GluHis: 1.315 ± 0.032	5.009GluIle: 5.009 ± 0.067	4.521GluLys: 4.521 ± 0.078	6.454GluLeu: 6.454 ± 0.1	1.808GluMet: 1.808 ± 0.045	3.293GluAsn: 3.293 ± 0.059	1.765GluPro: 1.765 ± 0.041	2.644GluGln: 2.644 ± 0.051	2.678GluArg: 2.678 ± 0.05	4.158GluSer: 4.158 ± 0.068	3.476GluThr: 3.476 ± 0.058	4.932GluVal: 4.932 ± 0.064	0.776GluTrp: 0.776 ± 0.026	2.598GluTyr: 2.598 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.168PheAla: 3.168 ± 0.052	0.367PheCys: 0.367 ± 0.015	3.491PheAsp: 3.491 ± 0.055	3.27PheGlu: 3.27 ± 0.053	2.203PhePhe: 2.203 ± 0.05	3.489PheGly: 3.489 ± 0.064	0.891PheHis: 0.891 ± 0.026	2.821PheIle: 2.821 ± 0.047	2.441PheLys: 2.441 ± 0.053	3.855PheLeu: 3.855 ± 0.059	1.091PheMet: 1.091 ± 0.032	2.282PheAsn: 2.282 ± 0.048	1.552PhePro: 1.552 ± 0.035	1.58PheGln: 1.58 ± 0.034	1.813PheArg: 1.813 ± 0.036	3.347PheSer: 3.347 ± 0.053	2.596PheThr: 2.596 ± 0.051	3.26PheVal: 3.26 ± 0.052	0.575PheTrp: 0.575 ± 0.021	1.932PheTyr: 1.932 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.693GlyAla: 4.693 ± 0.083	0.605GlyCys: 0.605 ± 0.025	4.039GlyAsp: 4.039 ± 0.077	4.399GlyGlu: 4.399 ± 0.061	3.447GlyPhe: 3.447 ± 0.06	5.104GlyGly: 5.104 ± 0.098	1.388GlyHis: 1.388 ± 0.036	4.871GlyIle: 4.871 ± 0.069	4.174GlyLys: 4.174 ± 0.063	6.557GlyLeu: 6.557 ± 0.073	1.969GlyMet: 1.969 ± 0.038	3.176GlyAsn: 3.176 ± 0.062	1.528GlyPro: 1.528 ± 0.034	2.849GlyGln: 2.849 ± 0.048	2.596GlyArg: 2.596 ± 0.05	4.604GlySer: 4.604 ± 0.09	4.345GlyThr: 4.345 ± 0.092	5.216GlyVal: 5.216 ± 0.078	0.915GlyTrp: 0.915 ± 0.029	3.144GlyTyr: 3.144 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.339HisAla: 1.339 ± 0.033	0.194HisCys: 0.194 ± 0.014	1.097HisAsp: 1.097 ± 0.027	1.252HisGlu: 1.252 ± 0.031	1.1HisPhe: 1.1 ± 0.029	1.403HisGly: 1.403 ± 0.033	0.647HisHis: 0.647 ± 0.026	1.389HisIle: 1.389 ± 0.034	0.991HisLys: 0.991 ± 0.028	2.018HisLeu: 2.018 ± 0.04	0.476HisMet: 0.476 ± 0.019	0.864HisAsn: 0.864 ± 0.023	1.0HisPro: 1.0 ± 0.031	0.921HisGln: 0.921 ± 0.027	0.871HisArg: 0.871 ± 0.028	1.296HisSer: 1.296 ± 0.029	1.149HisThr: 1.149 ± 0.029	1.27HisVal: 1.27 ± 0.035	0.279HisTrp: 0.279 ± 0.014	1.001HisTyr: 1.001 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.099IleAla: 5.099 ± 0.075	0.564IleCys: 0.564 ± 0.025	4.794IleAsp: 4.794 ± 0.062	4.874IleGlu: 4.874 ± 0.063	2.662IlePhe: 2.662 ± 0.058	4.901IleGly: 4.901 ± 0.067	1.55IleHis: 1.55 ± 0.036	4.119IleIle: 4.119 ± 0.076	4.299IleLys: 4.299 ± 0.065	6.118IleLeu: 6.118 ± 0.085	1.339IleMet: 1.339 ± 0.029	3.647IleAsn: 3.647 ± 0.062	2.795IlePro: 2.795 ± 0.042	2.761IleGln: 2.761 ± 0.051	2.784IleArg: 2.784 ± 0.045	4.845IleSer: 4.845 ± 0.066	3.906IleThr: 3.906 ± 0.079	4.297IleVal: 4.297 ± 0.067	0.701IleTrp: 0.701 ± 0.025	2.599IleTyr: 2.599 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.1LysAla: 4.1 ± 0.07	0.315LysCys: 0.315 ± 0.015	3.37LysAsp: 3.37 ± 0.062	4.573LysGlu: 4.573 ± 0.075	2.176LysPhe: 2.176 ± 0.039	3.909LysGly: 3.909 ± 0.058	1.166LysHis: 1.166 ± 0.036	4.425LysIle: 4.425 ± 0.063	4.74LysLys: 4.74 ± 0.086	5.122LysLeu: 5.122 ± 0.073	1.624LysMet: 1.624 ± 0.035	3.171LysAsn: 3.171 ± 0.061	2.0LysPro: 2.0 ± 0.041	2.17LysGln: 2.17 ± 0.048	2.567LysArg: 2.567 ± 0.057	3.845LysSer: 3.845 ± 0.067	3.352LysThr: 3.352 ± 0.059	4.093LysVal: 4.093 ± 0.073	0.652LysTrp: 0.652 ± 0.023	2.502LysTyr: 2.502 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.683LeuAla: 6.683 ± 0.073	0.728LeuCys: 0.728 ± 0.025	5.964LeuAsp: 5.964 ± 0.069	5.911LeuGlu: 5.911 ± 0.083	4.208LeuPhe: 4.208 ± 0.07	6.229LeuGly: 6.229 ± 0.08	1.838LeuHis: 1.838 ± 0.04	6.363LeuIle: 6.363 ± 0.089	5.784LeuLys: 5.784 ± 0.081	8.868LeuLeu: 8.868 ± 0.101	2.369LeuMet: 2.369 ± 0.045	4.671LeuAsn: 4.671 ± 0.074	3.552LeuPro: 3.552 ± 0.048	3.427LeuGln: 3.427 ± 0.061	3.671LeuArg: 3.671 ± 0.063	7.711LeuSer: 7.711 ± 0.076	5.681LeuThr: 5.681 ± 0.075	5.953LeuVal: 5.953 ± 0.07	1.032LeuTrp: 1.032 ± 0.034	3.433LeuTyr: 3.433 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.821MetAla: 1.821 ± 0.039	0.171MetCys: 0.171 ± 0.011	1.559MetAsp: 1.559 ± 0.035	1.607MetGlu: 1.607 ± 0.035	0.865MetPhe: 0.865 ± 0.03	1.706MetGly: 1.706 ± 0.038	0.459MetHis: 0.459 ± 0.019	1.806MetIle: 1.806 ± 0.042	1.943MetLys: 1.943 ± 0.041	2.159MetLeu: 2.159 ± 0.04	0.711MetMet: 0.711 ± 0.025	1.262MetAsn: 1.262 ± 0.03	0.935MetPro: 0.935 ± 0.024	0.876MetGln: 0.876 ± 0.026	1.013MetArg: 1.013 ± 0.032	1.76MetSer: 1.76 ± 0.041	1.593MetThr: 1.593 ± 0.031	1.614MetVal: 1.614 ± 0.036	0.203MetTrp: 0.203 ± 0.012	0.784MetTyr: 0.784 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.052	0.38AsnCys: 0.38 ± 0.018	2.66AsnAsp: 2.66 ± 0.056	3.053AsnGlu: 3.053 ± 0.047	2.195AsnPhe: 2.195 ± 0.047	3.447AsnGly: 3.447 ± 0.079	1.089AsnHis: 1.089 ± 0.03	3.503AsnIle: 3.503 ± 0.062	2.722AsnLys: 2.722 ± 0.045	4.653AsnLeu: 4.653 ± 0.059	1.102AsnMet: 1.102 ± 0.028	2.437AsnAsn: 2.437 ± 0.066	2.408AsnPro: 2.408 ± 0.046	2.248AsnGln: 2.248 ± 0.039	1.955AsnArg: 1.955 ± 0.041	2.996AsnSer: 2.996 ± 0.059	2.808AsnThr: 2.808 ± 0.06	2.993AsnVal: 2.993 ± 0.062	0.651AsnTrp: 0.651 ± 0.023	2.365AsnTyr: 2.365 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.338ProAla: 2.338 ± 0.05	0.198ProCys: 0.198 ± 0.013	2.434ProAsp: 2.434 ± 0.042	2.819ProGlu: 2.819 ± 0.043	1.658ProPhe: 1.658 ± 0.036	2.253ProGly: 2.253 ± 0.046	0.701ProHis: 0.701 ± 0.023	2.367ProIle: 2.367 ± 0.043	2.02ProLys: 2.02 ± 0.045	2.999ProLeu: 2.999 ± 0.049	0.863ProMet: 0.863 ± 0.025	1.954ProAsn: 1.954 ± 0.04	0.874ProPro: 0.874 ± 0.027	1.288ProGln: 1.288 ± 0.031	1.067ProArg: 1.067 ± 0.034	2.514ProSer: 2.514 ± 0.051	2.137ProThr: 2.137 ± 0.053	2.657ProVal: 2.657 ± 0.048	0.441ProTrp: 0.441 ± 0.017	1.53ProTyr: 1.53 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.813GlnAla: 2.813 ± 0.047	0.215GlnCys: 0.215 ± 0.013	2.107GlnAsp: 2.107 ± 0.042	2.65GlnGlu: 2.65 ± 0.045	1.69GlnPhe: 1.69 ± 0.032	2.453GlnGly: 2.453 ± 0.044	0.76GlnHis: 0.76 ± 0.024	2.708GlnIle: 2.708 ± 0.039	2.57GlnLys: 2.57 ± 0.055	4.121GlnLeu: 4.121 ± 0.058	1.06GlnMet: 1.06 ± 0.027	2.123GlnAsn: 2.123 ± 0.042	1.262GlnPro: 1.262 ± 0.029	1.683GlnGln: 1.683 ± 0.04	1.623GlnArg: 1.623 ± 0.038	2.8GlnSer: 2.8 ± 0.044	2.138GlnThr: 2.138 ± 0.045	2.779GlnVal: 2.779 ± 0.042	0.548GlnTrp: 0.548 ± 0.024	1.699GlnTyr: 1.699 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.554ArgAla: 2.554 ± 0.054	0.242ArgCys: 0.242 ± 0.012	2.107ArgAsp: 2.107 ± 0.047	2.582ArgGlu: 2.582 ± 0.048	2.012ArgPhe: 2.012 ± 0.042	2.275ArgGly: 2.275 ± 0.043	0.763ArgHis: 0.763 ± 0.023	2.984ArgIle: 2.984 ± 0.049	2.454ArgLys: 2.454 ± 0.051	3.816ArgLeu: 3.816 ± 0.054	1.137ArgMet: 1.137 ± 0.03	1.85ArgAsn: 1.85 ± 0.044	1.307ArgPro: 1.307 ± 0.034	1.502ArgGln: 1.502 ± 0.038	1.618ArgArg: 1.618 ± 0.039	2.418ArgSer: 2.418 ± 0.049	2.024ArgThr: 2.024 ± 0.041	2.805ArgVal: 2.805 ± 0.047	0.494ArgTrp: 0.494 ± 0.021	1.833ArgTyr: 1.833 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.621SerAla: 4.621 ± 0.067	0.572SerCys: 0.572 ± 0.023	4.031SerAsp: 4.031 ± 0.063	4.168SerGlu: 4.168 ± 0.06	3.543SerPhe: 3.543 ± 0.058	5.218SerGly: 5.218 ± 0.102	1.387SerHis: 1.387 ± 0.031	4.96SerIle: 4.96 ± 0.06	3.811SerLys: 3.811 ± 0.06	6.535SerLeu: 6.535 ± 0.081	1.701SerMet: 1.701 ± 0.036	3.365SerAsn: 3.365 ± 0.058	2.471SerPro: 2.471 ± 0.044	2.565SerGln: 2.565 ± 0.049	2.507SerArg: 2.507 ± 0.049	4.929SerSer: 4.929 ± 0.076	4.169SerThr: 4.169 ± 0.085	4.45SerVal: 4.45 ± 0.065	0.791SerTrp: 0.791 ± 0.023	3.072SerTyr: 3.072 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.212ThrAla: 4.212 ± 0.091	0.371ThrCys: 0.371 ± 0.023	3.708ThrAsp: 3.708 ± 0.087	3.583ThrGlu: 3.583 ± 0.05	2.614ThrPhe: 2.614 ± 0.05	4.451ThrGly: 4.451 ± 0.087	1.178ThrHis: 1.178 ± 0.031	4.008ThrIle: 4.008 ± 0.077	2.907ThrLys: 2.907 ± 0.045	5.581ThrLeu: 5.581 ± 0.075	1.13ThrMet: 1.13 ± 0.029	2.707ThrAsn: 2.707 ± 0.06	2.488ThrPro: 2.488 ± 0.06	2.185ThrGln: 2.185 ± 0.054	1.95ThrArg: 1.95 ± 0.043	3.728ThrSer: 3.728 ± 0.078	3.617ThrThr: 3.617 ± 0.102	4.208ThrVal: 4.208 ± 0.094	0.768ThrTrp: 0.768 ± 0.028	2.433ThrTyr: 2.433 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.736ValAla: 4.736 ± 0.068	0.563ValCys: 0.563 ± 0.023	4.247ValAsp: 4.247 ± 0.062	4.394ValGlu: 4.394 ± 0.06	3.201ValPhe: 3.201 ± 0.055	4.387ValGly: 4.387 ± 0.065	1.216ValHis: 1.216 ± 0.031	4.657ValIle: 4.657 ± 0.068	3.759ValLys: 3.759 ± 0.064	6.654ValLeu: 6.654 ± 0.083	1.696ValMet: 1.696 ± 0.041	3.192ValAsn: 3.192 ± 0.059	2.362ValPro: 2.362 ± 0.045	2.344ValGln: 2.344 ± 0.044	2.538ValArg: 2.538 ± 0.044	5.279ValSer: 5.279 ± 0.071	4.155ValThr: 4.155 ± 0.101	4.88ValVal: 4.88 ± 0.07	0.805ValTrp: 0.805 ± 0.025	2.673ValTyr: 2.673 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.78TrpAla: 0.78 ± 0.026	0.111TrpCys: 0.111 ± 0.009	0.735TrpAsp: 0.735 ± 0.029	0.731TrpGlu: 0.731 ± 0.025	0.554TrpPhe: 0.554 ± 0.022	0.882TrpGly: 0.882 ± 0.03	0.271TrpHis: 0.271 ± 0.014	0.822TrpIle: 0.822 ± 0.027	0.712TrpLys: 0.712 ± 0.025	1.055TrpLeu: 1.055 ± 0.032	0.394TrpMet: 0.394 ± 0.017	0.591TrpAsn: 0.591 ± 0.021	0.329TrpPro: 0.329 ± 0.018	0.525TrpGln: 0.525 ± 0.019	0.474TrpArg: 0.474 ± 0.021	0.89TrpSer: 0.89 ± 0.028	0.701TrpThr: 0.701 ± 0.028	0.938TrpVal: 0.938 ± 0.03	0.194TrpTrp: 0.194 ± 0.012	0.514TrpTyr: 0.514 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.886TyrAla: 2.886 ± 0.046	0.354TyrCys: 0.354 ± 0.017	2.818TyrAsp: 2.818 ± 0.049	2.567TyrGlu: 2.567 ± 0.051	2.294TyrPhe: 2.294 ± 0.039	2.878TyrGly: 2.878 ± 0.054	1.011TyrHis: 1.011 ± 0.03	2.341TyrIle: 2.341 ± 0.043	2.1TyrLys: 2.1 ± 0.041	4.122TyrLeu: 4.122 ± 0.068	0.903TyrMet: 0.903 ± 0.025	2.098TyrAsn: 2.098 ± 0.049	1.548TyrPro: 1.548 ± 0.036	1.93TyrGln: 1.93 ± 0.039	1.926TyrArg: 1.926 ± 0.041	2.915TyrSer: 2.915 ± 0.052	2.48TyrThr: 2.48 ± 0.057	2.494TyrVal: 2.494 ± 0.044	0.556TyrTrp: 0.556 ± 0.02	2.138TyrTyr: 2.138 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3696 proteins (1385859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---