Amino acid dipepetide frequency for Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 26808 / PB)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.734AlaAla: 10.734 ± 0.157	1.186AlaCys: 1.186 ± 0.039	3.976AlaAsp: 3.976 ± 0.065	6.551AlaGlu: 6.551 ± 0.103	3.056AlaPhe: 3.056 ± 0.057	8.878AlaGly: 8.878 ± 0.113	1.263AlaHis: 1.263 ± 0.04	4.586AlaIle: 4.586 ± 0.084	3.367AlaLys: 3.367 ± 0.063	10.164AlaLeu: 10.164 ± 0.118	1.799AlaMet: 1.799 ± 0.055	2.029AlaAsn: 2.029 ± 0.051	3.055AlaPro: 3.055 ± 0.064	2.406AlaGln: 2.406 ± 0.053	6.429AlaArg: 6.429 ± 0.088	4.097AlaSer: 4.097 ± 0.086	3.43AlaThr: 3.43 ± 0.079	8.255AlaVal: 8.255 ± 0.124	0.89AlaTrp: 0.89 ± 0.032	2.292AlaTyr: 2.292 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.032	0.309CysCys: 0.309 ± 0.022	0.631CysAsp: 0.631 ± 0.029	0.791CysGlu: 0.791 ± 0.031	0.55CysPhe: 0.55 ± 0.027	1.543CysGly: 1.543 ± 0.051	0.321CysHis: 0.321 ± 0.02	0.669CysIle: 0.669 ± 0.03	0.5CysLys: 0.5 ± 0.023	1.513CysLeu: 1.513 ± 0.043	0.281CysMet: 0.281 ± 0.02	0.42CysAsn: 0.42 ± 0.022	0.889CysPro: 0.889 ± 0.04	0.394CysGln: 0.394 ± 0.025	1.248CysArg: 1.248 ± 0.045	0.907CysSer: 0.907 ± 0.03	0.618CysThr: 0.618 ± 0.029	0.759CysVal: 0.759 ± 0.033	0.21CysTrp: 0.21 ± 0.018	0.518CysTyr: 0.518 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	3.81AspAla: 3.81 ± 0.075	0.731AspCys: 0.731 ± 0.029	2.18AspAsp: 2.18 ± 0.054	3.664AspGlu: 3.664 ± 0.068	2.16AspPhe: 2.16 ± 0.054	3.825AspGly: 3.825 ± 0.077	0.777AspHis: 0.777 ± 0.033	3.055AspIle: 3.055 ± 0.063	1.997AspLys: 1.997 ± 0.053	5.726AspLeu: 5.726 ± 0.091	0.93AspMet: 0.93 ± 0.036	1.285AspAsn: 1.285 ± 0.041	2.839AspPro: 2.839 ± 0.06	1.185AspGln: 1.185 ± 0.035	3.29AspArg: 3.29 ± 0.062	2.072AspSer: 2.072 ± 0.05	1.944AspThr: 1.944 ± 0.046	3.872AspVal: 3.872 ± 0.076	0.566AspTrp: 0.566 ± 0.025	1.933AspTyr: 1.933 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.857GluAla: 6.857 ± 0.109	0.731GluCys: 0.731 ± 0.034	3.266GluAsp: 3.266 ± 0.077	7.394GluGlu: 7.394 ± 0.125	2.326GluPhe: 2.326 ± 0.057	5.539GluGly: 5.539 ± 0.086	1.193GluHis: 1.193 ± 0.036	5.832GluIle: 5.832 ± 0.091	5.673GluLys: 5.673 ± 0.098	7.74GluLeu: 7.74 ± 0.108	2.124GluMet: 2.124 ± 0.054	2.566GluAsn: 2.566 ± 0.059	2.501GluPro: 2.501 ± 0.055	2.69GluGln: 2.69 ± 0.055	5.833GluArg: 5.833 ± 0.101	2.871GluSer: 2.871 ± 0.062	2.964GluThr: 2.964 ± 0.057	5.865GluVal: 5.865 ± 0.101	0.695GluTrp: 0.695 ± 0.029	2.024GluTyr: 2.024 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.042PheAla: 3.042 ± 0.059	0.705PheCys: 0.705 ± 0.029	1.947PheAsp: 1.947 ± 0.047	2.113PheGlu: 2.113 ± 0.049	1.748PhePhe: 1.748 ± 0.057	3.036PheGly: 3.036 ± 0.062	0.71PheHis: 0.71 ± 0.031	2.336PheIle: 2.336 ± 0.057	1.524PheLys: 1.524 ± 0.041	4.608PheLeu: 4.608 ± 0.098	0.748PheMet: 0.748 ± 0.027	1.188PheAsn: 1.188 ± 0.043	1.81PhePro: 1.81 ± 0.051	1.257PheGln: 1.257 ± 0.044	2.484PheArg: 2.484 ± 0.052	2.42PheSer: 2.42 ± 0.052	1.937PheThr: 1.937 ± 0.047	2.445PheVal: 2.445 ± 0.048	0.47PheTrp: 0.47 ± 0.026	1.334PheTyr: 1.334 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.542GlyAla: 6.542 ± 0.099	1.442GlyCys: 1.442 ± 0.048	3.811GlyAsp: 3.811 ± 0.08	6.269GlyGlu: 6.269 ± 0.1	3.216GlyPhe: 3.216 ± 0.072	6.576GlyGly: 6.576 ± 0.114	1.361GlyHis: 1.361 ± 0.041	6.001GlyIle: 6.001 ± 0.082	5.104GlyLys: 5.104 ± 0.064	7.979GlyLeu: 7.979 ± 0.11	2.358GlyMet: 2.358 ± 0.052	2.496GlyAsn: 2.496 ± 0.056	2.49GlyPro: 2.49 ± 0.056	2.168GlyGln: 2.168 ± 0.051	5.893GlyArg: 5.893 ± 0.101	4.328GlySer: 4.328 ± 0.083	4.107GlyThr: 4.107 ± 0.074	6.656GlyVal: 6.656 ± 0.102	0.961GlyTrp: 0.961 ± 0.034	2.879GlyTyr: 2.879 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.122HisAla: 1.122 ± 0.037	0.279HisCys: 0.279 ± 0.02	0.802HisAsp: 0.802 ± 0.034	0.855HisGlu: 0.855 ± 0.031	0.795HisPhe: 0.795 ± 0.028	1.268HisGly: 1.268 ± 0.043	0.48HisHis: 0.48 ± 0.028	0.962HisIle: 0.962 ± 0.039	0.596HisLys: 0.596 ± 0.03	2.266HisLeu: 2.266 ± 0.051	0.288HisMet: 0.288 ± 0.017	0.57HisAsn: 0.57 ± 0.028	1.286HisPro: 1.286 ± 0.042	0.61HisGln: 0.61 ± 0.027	1.209HisArg: 1.209 ± 0.04	0.794HisSer: 0.794 ± 0.033	0.757HisThr: 0.757 ± 0.032	1.034HisVal: 1.034 ± 0.036	0.217HisTrp: 0.217 ± 0.019	0.681HisTyr: 0.681 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.926IleAla: 5.926 ± 0.092	0.954IleCys: 0.954 ± 0.035	3.286IleAsp: 3.286 ± 0.071	4.145IleGlu: 4.145 ± 0.084	2.413IlePhe: 2.413 ± 0.058	4.718IleGly: 4.718 ± 0.088	0.95IleHis: 0.95 ± 0.034	3.944IleIle: 3.944 ± 0.075	3.299IleLys: 3.299 ± 0.072	6.103IleLeu: 6.103 ± 0.087	1.239IleMet: 1.239 ± 0.042	2.145IleAsn: 2.145 ± 0.053	3.32IlePro: 3.32 ± 0.066	1.611IleGln: 1.611 ± 0.047	3.974IleArg: 3.974 ± 0.07	3.473IleSer: 3.473 ± 0.067	3.421IleThr: 3.421 ± 0.076	4.373IleVal: 4.373 ± 0.073	0.62IleTrp: 0.62 ± 0.028	1.931IleTyr: 1.931 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.354LysAla: 4.354 ± 0.082	0.491LysCys: 0.491 ± 0.03	2.538LysAsp: 2.538 ± 0.062	5.015LysGlu: 5.015 ± 0.092	1.371LysPhe: 1.371 ± 0.046	4.188LysGly: 4.188 ± 0.068	0.801LysHis: 0.801 ± 0.028	3.415LysIle: 3.415 ± 0.075	3.719LysLys: 3.719 ± 0.083	4.454LysLeu: 4.454 ± 0.086	1.338LysMet: 1.338 ± 0.043	2.013LysAsn: 2.013 ± 0.059	2.096LysPro: 2.096 ± 0.055	1.538LysGln: 1.538 ± 0.047	3.596LysArg: 3.596 ± 0.067	2.428LysSer: 2.428 ± 0.052	2.496LysThr: 2.496 ± 0.055	3.749LysVal: 3.749 ± 0.072	0.492LysTrp: 0.492 ± 0.026	1.533LysTyr: 1.533 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.626LeuAla: 10.626 ± 0.138	1.402LeuCys: 1.402 ± 0.045	5.17LeuAsp: 5.17 ± 0.083	8.3LeuGlu: 8.3 ± 0.1	4.117LeuPhe: 4.117 ± 0.093	8.139LeuGly: 8.139 ± 0.124	1.717LeuHis: 1.717 ± 0.05	6.114LeuIle: 6.114 ± 0.101	6.153LeuLys: 6.153 ± 0.108	12.104LeuLeu: 12.104 ± 0.17	2.176LeuMet: 2.176 ± 0.058	3.37LeuAsn: 3.37 ± 0.064	5.329LeuPro: 5.329 ± 0.096	3.739LeuGln: 3.739 ± 0.073	7.062LeuArg: 7.062 ± 0.1	6.128LeuSer: 6.128 ± 0.113	5.18LeuThr: 5.18 ± 0.076	8.143LeuVal: 8.143 ± 0.097	0.957LeuTrp: 0.957 ± 0.036	2.767LeuTyr: 2.767 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.255MetAla: 2.255 ± 0.05	0.234MetCys: 0.234 ± 0.016	1.052MetAsp: 1.052 ± 0.037	1.716MetGlu: 1.716 ± 0.047	0.569MetPhe: 0.569 ± 0.029	1.88MetGly: 1.88 ± 0.048	0.329MetHis: 0.329 ± 0.022	1.332MetIle: 1.332 ± 0.043	1.389MetLys: 1.389 ± 0.046	2.321MetLeu: 2.321 ± 0.058	0.542MetMet: 0.542 ± 0.028	0.772MetAsn: 0.772 ± 0.029	1.117MetPro: 1.117 ± 0.036	0.765MetGln: 0.765 ± 0.033	1.468MetArg: 1.468 ± 0.048	1.223MetSer: 1.223 ± 0.039	1.023MetThr: 1.023 ± 0.037	1.705MetVal: 1.705 ± 0.047	0.16MetTrp: 0.16 ± 0.013	0.42MetTyr: 0.42 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.312AsnAla: 2.312 ± 0.053	0.471AsnCys: 0.471 ± 0.022	1.168AsnAsp: 1.168 ± 0.037	1.706AsnGlu: 1.706 ± 0.043	1.17AsnPhe: 1.17 ± 0.042	2.363AsnGly: 2.363 ± 0.058	0.526AsnHis: 0.526 ± 0.028	2.177AsnIle: 2.177 ± 0.05	1.504AsnLys: 1.504 ± 0.048	3.487AsnLeu: 3.487 ± 0.065	0.649AsnMet: 0.649 ± 0.027	1.078AsnAsn: 1.078 ± 0.046	2.048AsnPro: 2.048 ± 0.052	0.858AsnGln: 0.858 ± 0.036	2.278AsnArg: 2.278 ± 0.062	1.524AsnSer: 1.524 ± 0.045	1.482AsnThr: 1.482 ± 0.044	2.072AsnVal: 2.072 ± 0.047	0.398AsnTrp: 0.398 ± 0.021	1.14AsnTyr: 1.14 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.925ProAla: 3.925 ± 0.079	0.566ProCys: 0.566 ± 0.026	2.776ProAsp: 2.776 ± 0.061	4.656ProGlu: 4.656 ± 0.079	1.932ProPhe: 1.932 ± 0.054	4.663ProGly: 4.663 ± 0.088	0.924ProHis: 0.924 ± 0.035	1.814ProIle: 1.814 ± 0.053	1.533ProLys: 1.533 ± 0.049	4.795ProLeu: 4.795 ± 0.078	0.699ProMet: 0.699 ± 0.031	1.13ProAsn: 1.13 ± 0.045	2.304ProPro: 2.304 ± 0.058	1.625ProGln: 1.625 ± 0.048	2.522ProArg: 2.522 ± 0.056	2.039ProSer: 2.039 ± 0.047	1.713ProThr: 1.713 ± 0.052	4.365ProVal: 4.365 ± 0.079	0.523ProTrp: 0.523 ± 0.027	1.408ProTyr: 1.408 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.748GlnAla: 2.748 ± 0.059	0.298GlnCys: 0.298 ± 0.023	1.407GlnAsp: 1.407 ± 0.041	3.007GlnGlu: 3.007 ± 0.063	0.898GlnPhe: 0.898 ± 0.042	2.485GlnGly: 2.485 ± 0.055	0.5GlnHis: 0.5 ± 0.024	1.948GlnIle: 1.948 ± 0.058	2.02GlnLys: 2.02 ± 0.05	3.056GlnLeu: 3.056 ± 0.066	0.806GlnMet: 0.806 ± 0.034	1.012GlnAsn: 1.012 ± 0.036	1.233GlnPro: 1.233 ± 0.043	1.324GlnGln: 1.324 ± 0.044	2.018GlnArg: 2.018 ± 0.05	1.252GlnSer: 1.252 ± 0.04	1.248GlnThr: 1.248 ± 0.04	2.68GlnVal: 2.68 ± 0.054	0.26GlnTrp: 0.26 ± 0.018	0.789GlnTyr: 0.789 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.136ArgAla: 5.136 ± 0.092	1.05ArgCys: 1.05 ± 0.044	3.324ArgAsp: 3.324 ± 0.065	6.492ArgGlu: 6.492 ± 0.12	2.609ArgPhe: 2.609 ± 0.056	4.861ArgGly: 4.861 ± 0.077	1.179ArgHis: 1.179 ± 0.041	4.391ArgIle: 4.391 ± 0.07	3.698ArgLys: 3.698 ± 0.078	7.712ArgLeu: 7.712 ± 0.117	1.809ArgMet: 1.809 ± 0.042	1.978ArgAsn: 1.978 ± 0.051	2.817ArgPro: 2.817 ± 0.063	2.562ArgGln: 2.562 ± 0.064	5.493ArgArg: 5.493 ± 0.092	3.317ArgSer: 3.317 ± 0.069	2.704ArgThr: 2.704 ± 0.057	5.233ArgVal: 5.233 ± 0.081	0.754ArgTrp: 0.754 ± 0.035	2.29ArgTyr: 2.29 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.674SerAla: 3.674 ± 0.08	0.865SerCys: 0.865 ± 0.035	2.263SerAsp: 2.263 ± 0.057	3.058SerGlu: 3.058 ± 0.067	2.461SerPhe: 2.461 ± 0.058	4.851SerGly: 4.851 ± 0.085	0.939SerHis: 0.939 ± 0.03	2.885SerIle: 2.885 ± 0.061	1.947SerLys: 1.947 ± 0.052	6.313SerLeu: 6.313 ± 0.11	1.01SerMet: 1.01 ± 0.036	1.371SerAsn: 1.371 ± 0.043	2.496SerPro: 2.496 ± 0.057	1.462SerGln: 1.462 ± 0.046	3.762SerArg: 3.762 ± 0.072	2.811SerSer: 2.811 ± 0.073	2.191SerThr: 2.191 ± 0.052	3.378SerVal: 3.378 ± 0.068	0.694SerTrp: 0.694 ± 0.03	1.712SerTyr: 1.712 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.408ThrAla: 4.408 ± 0.085	0.641ThrCys: 0.641 ± 0.029	2.103ThrAsp: 2.103 ± 0.055	2.678ThrGlu: 2.678 ± 0.068	1.708ThrPhe: 1.708 ± 0.052	5.035ThrGly: 5.035 ± 0.08	0.78ThrHis: 0.78 ± 0.03	2.682ThrIle: 2.682 ± 0.065	1.86ThrLys: 1.86 ± 0.057	4.586ThrLeu: 4.586 ± 0.077	0.912ThrMet: 0.912 ± 0.036	1.215ThrAsn: 1.215 ± 0.042	2.639ThrPro: 2.639 ± 0.067	1.049ThrGln: 1.049 ± 0.04	2.546ThrArg: 2.546 ± 0.052	2.266ThrSer: 2.266 ± 0.052	2.301ThrThr: 2.301 ± 0.059	4.048ThrVal: 4.048 ± 0.08	0.458ThrTrp: 0.458 ± 0.026	1.241ThrTyr: 1.241 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.915ValAla: 6.915 ± 0.102	1.051ValCys: 1.051 ± 0.04	4.08ValAsp: 4.08 ± 0.077	5.478ValGlu: 5.478 ± 0.091	3.082ValPhe: 3.082 ± 0.072	5.361ValGly: 5.361 ± 0.103	1.227ValHis: 1.227 ± 0.041	5.502ValIle: 5.502 ± 0.087	4.074ValLys: 4.074 ± 0.084	8.584ValLeu: 8.584 ± 0.126	1.836ValMet: 1.836 ± 0.051	2.404ValAsn: 2.404 ± 0.055	3.581ValPro: 3.581 ± 0.068	2.154ValGln: 2.154 ± 0.054	4.981ValArg: 4.981 ± 0.089	4.109ValSer: 4.109 ± 0.075	3.792ValThr: 3.792 ± 0.064	6.656ValVal: 6.656 ± 0.107	0.715ValTrp: 0.715 ± 0.028	2.2ValTyr: 2.2 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.727TrpAla: 0.727 ± 0.03	0.143TrpCys: 0.143 ± 0.012	0.594TrpAsp: 0.594 ± 0.027	0.955TrpGlu: 0.955 ± 0.037	0.398TrpPhe: 0.398 ± 0.023	0.848TrpGly: 0.848 ± 0.037	0.224TrpHis: 0.224 ± 0.016	0.56TrpIle: 0.56 ± 0.029	0.544TrpLys: 0.544 ± 0.026	1.229TrpLeu: 1.229 ± 0.044	0.272TrpMet: 0.272 ± 0.018	0.379TrpAsn: 0.379 ± 0.022	0.433TrpPro: 0.433 ± 0.021	0.438TrpGln: 0.438 ± 0.025	0.751TrpArg: 0.751 ± 0.033	0.506TrpSer: 0.506 ± 0.025	0.396TrpThr: 0.396 ± 0.022	0.669TrpVal: 0.669 ± 0.033	0.164TrpTrp: 0.164 ± 0.016	0.348TrpTyr: 0.348 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.05	0.553TyrCys: 0.553 ± 0.025	1.466TyrAsp: 1.466 ± 0.048	1.845TyrGlu: 1.845 ± 0.047	1.282TyrPhe: 1.282 ± 0.04	2.578TyrGly: 2.578 ± 0.062	0.671TyrHis: 0.671 ± 0.027	1.642TyrIle: 1.642 ± 0.049	1.125TyrLys: 1.125 ± 0.039	3.953TyrLeu: 3.953 ± 0.072	0.453TyrMet: 0.453 ± 0.026	0.991TyrAsn: 0.991 ± 0.038	1.629TyrPro: 1.629 ± 0.049	1.152TyrGln: 1.152 ± 0.038	2.575TyrArg: 2.575 ± 0.06	1.58TyrSer: 1.58 ± 0.049	1.451TyrThr: 1.451 ± 0.048	1.823TyrVal: 1.823 ± 0.045	0.374TyrTrp: 0.374 ± 0.024	1.308TyrTyr: 1.308 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2803 proteins (812553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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