Amino acid dipepetide frequency for Circoviridae 1 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.671AlaAla: 15.671 ± 6.145
0.979AlaCys: 0.979 ± 0.935
3.918AlaAsp: 3.918 ± 1.627
5.877AlaGlu: 5.877 ± 2.513
1.959AlaPhe: 1.959 ± 0.813
7.835AlaGly: 7.835 ± 2.131
2.938AlaHis: 2.938 ± 1.443
2.938AlaIle: 2.938 ± 1.452
2.938AlaLys: 2.938 ± 1.443
3.918AlaLeu: 3.918 ± 2.176
0.979AlaMet: 0.979 ± 0.818
1.959AlaAsn: 1.959 ± 1.87
4.897AlaPro: 4.897 ± 1.715
4.897AlaGln: 4.897 ± 1.215
5.877AlaArg: 5.877 ± 2.108
6.856AlaSer: 6.856 ± 1.16
0.979AlaThr: 0.979 ± 1.238
5.877AlaVal: 5.877 ± 1.671
0.0AlaTrp: 0.0 ± 0.0
4.897AlaTyr: 4.897 ± 1.952
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.979CysCys: 0.979 ± 0.762
0.0CysAsp: 0.0 ± 0.0
0.979CysGlu: 0.979 ± 0.762
0.979CysPhe: 0.979 ± 0.762
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.959CysLeu: 1.959 ± 0.921
0.0CysMet: 0.0 ± 0.0
1.959CysAsn: 1.959 ± 1.87
1.959CysPro: 1.959 ± 1.525
0.0CysGln: 0.0 ± 0.0
0.979CysArg: 0.979 ± 0.762
0.979CysSer: 0.979 ± 0.762
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.979CysTyr: 0.979 ± 0.935
0.979CysXaa: 0.979 ± 0.762
Asp
4.897AspAla: 4.897 ± 1.329
0.0AspCys: 0.0 ± 0.0
1.959AspAsp: 1.959 ± 2.477
6.856AspGlu: 6.856 ± 2.568
0.0AspPhe: 0.0 ± 0.0
1.959AspGly: 1.959 ± 0.921
0.979AspHis: 0.979 ± 0.935
1.959AspIle: 1.959 ± 0.921
0.979AspLys: 0.979 ± 0.818
2.938AspLeu: 2.938 ± 1.348
2.938AspMet: 2.938 ± 1.391
3.918AspAsn: 3.918 ± 3.225
0.979AspPro: 0.979 ± 0.818
0.0AspGln: 0.0 ± 0.0
1.959AspArg: 1.959 ± 1.155
3.918AspSer: 3.918 ± 0.932
7.835AspThr: 7.835 ± 0.594
0.979AspVal: 0.979 ± 0.935
0.979AspTrp: 0.979 ± 1.238
3.918AspTyr: 3.918 ± 2.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.897GluAla: 4.897 ± 2.989
0.0GluCys: 0.0 ± 0.0
3.918GluAsp: 3.918 ± 2.093
2.938GluGlu: 2.938 ± 2.287
1.959GluPhe: 1.959 ± 1.525
2.938GluGly: 2.938 ± 1.348
1.959GluHis: 1.959 ± 1.636
1.959GluIle: 1.959 ± 1.155
3.918GluLys: 3.918 ± 0.932
6.856GluLeu: 6.856 ± 2.578
1.959GluMet: 1.959 ± 0.921
1.959GluAsn: 1.959 ± 1.525
1.959GluPro: 1.959 ± 0.907
1.959GluGln: 1.959 ± 1.155
4.897GluArg: 4.897 ± 1.068
2.938GluSer: 2.938 ± 1.65
2.938GluThr: 2.938 ± 1.391
3.918GluVal: 3.918 ± 2.033
0.0GluTrp: 0.0 ± 0.0
4.897GluTyr: 4.897 ± 2.144
0.0GluXaa: 0.0 ± 0.0
Phe
0.979PheAla: 0.979 ± 0.762
0.979PheCys: 0.979 ± 0.762
3.918PheAsp: 3.918 ± 0.951
1.959PheGlu: 1.959 ± 1.525
0.0PhePhe: 0.0 ± 0.0
3.918PheGly: 3.918 ± 2.033
1.959PheHis: 1.959 ± 0.813
0.0PheIle: 0.0 ± 0.0
1.959PheLys: 1.959 ± 0.907
2.938PheLeu: 2.938 ± 2.387
0.979PheMet: 0.979 ± 0.818
0.0PheAsn: 0.0 ± 0.0
1.959PhePro: 1.959 ± 1.525
0.979PheGln: 0.979 ± 0.935
0.979PheArg: 0.979 ± 0.935
0.979PheSer: 0.979 ± 0.818
5.877PheThr: 5.877 ± 2.818
1.959PheVal: 1.959 ± 0.921
0.979PheTrp: 0.979 ± 0.818
0.0PheTyr: 0.0 ± 0.0
0.979PheXaa: 0.979 ± 1.238
Gly
7.835GlyAla: 7.835 ± 2.45
0.979GlyCys: 0.979 ± 0.762
2.938GlyAsp: 2.938 ± 1.409
3.918GlyGlu: 3.918 ± 2.603
3.918GlyPhe: 3.918 ± 2.524
8.815GlyGly: 8.815 ± 2.651
0.979GlyHis: 0.979 ± 0.818
0.979GlyIle: 0.979 ± 0.935
5.877GlyLys: 5.877 ± 2.311
4.897GlyLeu: 4.897 ± 1.215
1.959GlyMet: 1.959 ± 1.636
0.0GlyAsn: 0.0 ± 0.0
1.959GlyPro: 1.959 ± 0.813
4.897GlyGln: 4.897 ± 2.092
6.856GlyArg: 6.856 ± 1.714
1.959GlySer: 1.959 ± 1.87
9.794GlyThr: 9.794 ± 2.196
4.897GlyVal: 4.897 ± 1.571
0.0GlyTrp: 0.0 ± 0.0
6.856GlyTyr: 6.856 ± 1.158
0.0GlyXaa: 0.0 ± 0.0
His
4.897HisAla: 4.897 ± 4.091
0.0HisCys: 0.0 ± 0.0
0.979HisAsp: 0.979 ± 1.238
1.959HisGlu: 1.959 ± 1.636
0.979HisPhe: 0.979 ± 0.818
2.938HisGly: 2.938 ± 1.505
1.959HisHis: 1.959 ± 1.333
1.959HisIle: 1.959 ± 0.813
0.979HisLys: 0.979 ± 0.935
4.897HisLeu: 4.897 ± 0.93
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.938HisPro: 2.938 ± 0.994
0.979HisGln: 0.979 ± 0.935
0.979HisArg: 0.979 ± 0.762
0.979HisSer: 0.979 ± 0.762
0.0HisThr: 0.0 ± 0.0
1.959HisVal: 1.959 ± 0.813
0.0HisTrp: 0.0 ± 0.0
0.979HisTyr: 0.979 ± 0.818
0.0HisXaa: 0.0 ± 0.0
Ile
1.959IleAla: 1.959 ± 0.813
0.979IleCys: 0.979 ± 0.762
2.938IleAsp: 2.938 ± 1.348
2.938IleGlu: 2.938 ± 1.692
1.959IlePhe: 1.959 ± 0.813
3.918IleGly: 3.918 ± 0.932
1.959IleHis: 1.959 ± 0.907
0.979IleIle: 0.979 ± 0.762
2.938IleLys: 2.938 ± 1.65
4.897IleLeu: 4.897 ± 1.201
0.979IleMet: 0.979 ± 0.935
2.938IleAsn: 2.938 ± 1.409
1.959IlePro: 1.959 ± 1.87
1.959IleGln: 1.959 ± 1.333
2.938IleArg: 2.938 ± 1.391
1.959IleSer: 1.959 ± 0.921
2.938IleThr: 2.938 ± 1.65
0.979IleVal: 0.979 ± 0.935
0.0IleTrp: 0.0 ± 0.0
1.959IleTyr: 1.959 ± 1.333
0.979IleXaa: 0.979 ± 0.762
Lys
2.938LysAla: 2.938 ± 1.443
0.979LysCys: 0.979 ± 0.935
1.959LysAsp: 1.959 ± 0.921
1.959LysGlu: 1.959 ± 0.921
1.959LysPhe: 1.959 ± 1.656
4.897LysGly: 4.897 ± 0.93
0.979LysHis: 0.979 ± 0.818
6.856LysIle: 6.856 ± 1.247
6.856LysLys: 6.856 ± 3.629
1.959LysLeu: 1.959 ± 1.525
1.959LysMet: 1.959 ± 1.23
4.897LysAsn: 4.897 ± 1.329
5.877LysPro: 5.877 ± 2.513
2.938LysGln: 2.938 ± 1.409
11.753LysArg: 11.753 ± 3.69
3.918LysSer: 3.918 ± 1.627
3.918LysThr: 3.918 ± 1.408
6.856LysVal: 6.856 ± 3.593
0.0LysTrp: 0.0 ± 0.0
0.979LysTyr: 0.979 ± 0.818
0.0LysXaa: 0.0 ± 0.0
Leu
8.815LeuAla: 8.815 ± 2.525
2.938LeuCys: 2.938 ± 1.692
3.918LeuAsp: 3.918 ± 0.932
2.938LeuGlu: 2.938 ± 2.287
0.979LeuPhe: 0.979 ± 0.818
2.938LeuGly: 2.938 ± 1.443
0.0LeuHis: 0.0 ± 0.0
2.938LeuIle: 2.938 ± 1.692
5.877LeuLys: 5.877 ± 0.911
5.877LeuLeu: 5.877 ± 2.696
0.979LeuMet: 0.979 ± 1.238
1.959LeuAsn: 1.959 ± 0.813
1.959LeuPro: 1.959 ± 0.813
1.959LeuGln: 1.959 ± 0.907
2.938LeuArg: 2.938 ± 2.287
3.918LeuSer: 3.918 ± 0.932
3.918LeuThr: 3.918 ± 0.932
6.856LeuVal: 6.856 ± 2.806
0.979LeuTrp: 0.979 ± 0.762
2.938LeuTyr: 2.938 ± 1.348
0.0LeuXaa: 0.0 ± 0.0
Met
0.979MetAla: 0.979 ± 0.762
0.0MetCys: 0.0 ± 0.0
1.959MetAsp: 1.959 ± 0.813
0.979MetGlu: 0.979 ± 1.238
0.979MetPhe: 0.979 ± 0.935
0.0MetGly: 0.0 ± 0.0
0.979MetHis: 0.979 ± 0.818
0.0MetIle: 0.0 ± 0.0
4.897MetLys: 4.897 ± 1.068
0.979MetLeu: 0.979 ± 0.762
0.0MetMet: 0.0 ± 0.0
0.979MetAsn: 0.979 ± 0.935
0.979MetPro: 0.979 ± 0.762
0.0MetGln: 0.0 ± 0.0
0.979MetArg: 0.979 ± 0.935
2.938MetSer: 2.938 ± 1.833
1.959MetThr: 1.959 ± 1.155
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.897AsnAla: 4.897 ± 2.895
0.979AsnCys: 0.979 ± 0.762
1.959AsnAsp: 1.959 ± 0.813
0.0AsnGlu: 0.0 ± 0.0
0.979AsnPhe: 0.979 ± 0.762
2.938AsnGly: 2.938 ± 0.456
0.979AsnHis: 0.979 ± 0.818
1.959AsnIle: 1.959 ± 1.87
1.959AsnLys: 1.959 ± 1.155
1.959AsnLeu: 1.959 ± 0.921
0.979AsnMet: 0.979 ± 0.953
2.938AsnAsn: 2.938 ± 1.391
2.938AsnPro: 2.938 ± 0.456
0.979AsnGln: 0.979 ± 0.935
3.918AsnArg: 3.918 ± 2.093
1.959AsnSer: 1.959 ± 1.656
2.938AsnThr: 2.938 ± 1.65
1.959AsnVal: 1.959 ± 0.907
0.0AsnTrp: 0.0 ± 0.0
0.979AsnTyr: 0.979 ± 0.935
0.0AsnXaa: 0.0 ± 0.0
Pro
4.897ProAla: 4.897 ± 2.989
0.0ProCys: 0.0 ± 0.0
3.918ProAsp: 3.918 ± 2.033
1.959ProGlu: 1.959 ± 0.907
0.979ProPhe: 0.979 ± 0.762
4.897ProGly: 4.897 ± 0.93
0.0ProHis: 0.0 ± 0.0
1.959ProIle: 1.959 ± 0.921
5.877ProLys: 5.877 ± 1.874
5.877ProLeu: 5.877 ± 1.409
1.959ProMet: 1.959 ± 1.525
0.979ProAsn: 0.979 ± 0.935
7.835ProPro: 7.835 ± 3.424
0.979ProGln: 0.979 ± 0.935
2.938ProArg: 2.938 ± 2.455
0.0ProSer: 0.0 ± 0.0
2.938ProThr: 2.938 ± 0.456
0.979ProVal: 0.979 ± 0.762
0.979ProTrp: 0.979 ± 0.762
1.959ProTyr: 1.959 ± 1.636
0.0ProXaa: 0.0 ± 0.0
Gln
3.918GlnAla: 3.918 ± 1.842
0.0GlnCys: 0.0 ± 0.0
1.959GlnAsp: 1.959 ± 1.87
3.918GlnGlu: 3.918 ± 1.167
0.979GlnPhe: 0.979 ± 0.762
3.918GlnGly: 3.918 ± 1.842
1.959GlnHis: 1.959 ± 0.907
2.938GlnIle: 2.938 ± 1.452
3.918GlnLys: 3.918 ± 1.627
0.979GlnLeu: 0.979 ± 0.818
0.0GlnMet: 0.0 ± 0.0
0.979GlnAsn: 0.979 ± 1.238
0.979GlnPro: 0.979 ± 0.762
0.0GlnGln: 0.0 ± 0.0
1.959GlnArg: 1.959 ± 0.907
0.0GlnSer: 0.0 ± 0.0
0.979GlnThr: 0.979 ± 0.935
0.979GlnVal: 0.979 ± 0.818
0.979GlnTrp: 0.979 ± 0.762
1.959GlnTyr: 1.959 ± 0.813
0.0GlnXaa: 0.0 ± 0.0
Arg
2.938ArgAla: 2.938 ± 0.456
0.979ArgCys: 0.979 ± 0.762
0.0ArgAsp: 0.0 ± 0.0
2.938ArgGlu: 2.938 ± 1.515
4.897ArgPhe: 4.897 ± 0.93
7.835ArgGly: 7.835 ± 0.959
2.938ArgHis: 2.938 ± 1.409
4.897ArgIle: 4.897 ± 1.215
4.897ArgLys: 4.897 ± 1.215
4.897ArgLeu: 4.897 ± 2.685
0.979ArgMet: 0.979 ± 0.762
3.918ArgAsn: 3.918 ± 0.932
2.938ArgPro: 2.938 ± 1.452
1.959ArgGln: 1.959 ± 0.813
10.774ArgArg: 10.774 ± 3.773
4.897ArgSer: 4.897 ± 2.092
2.938ArgThr: 2.938 ± 2.27
7.835ArgVal: 7.835 ± 3.178
3.918ArgTrp: 3.918 ± 1.514
5.877ArgTyr: 5.877 ± 2.311
0.0ArgXaa: 0.0 ± 0.0
Ser
3.918SerAla: 3.918 ± 0.951
0.0SerCys: 0.0 ± 0.0
2.938SerAsp: 2.938 ± 0.994
1.959SerGlu: 1.959 ± 1.155
1.959SerPhe: 1.959 ± 0.813
3.918SerGly: 3.918 ± 2.574
2.938SerHis: 2.938 ± 2.44
1.959SerIle: 1.959 ± 1.656
5.877SerLys: 5.877 ± 2.885
0.979SerLeu: 0.979 ± 0.935
0.0SerMet: 0.0 ± 0.0
3.918SerAsn: 3.918 ± 1.225
1.959SerPro: 1.959 ± 1.525
1.959SerGln: 1.959 ± 0.813
3.918SerArg: 3.918 ± 0.869
2.938SerSer: 2.938 ± 2.455
3.918SerThr: 3.918 ± 1.225
1.959SerVal: 1.959 ± 0.921
0.0SerTrp: 0.0 ± 0.0
2.938SerTyr: 2.938 ± 1.692
0.0SerXaa: 0.0 ± 0.0
Thr
2.938ThrAla: 2.938 ± 0.456
0.979ThrCys: 0.979 ± 0.762
3.918ThrAsp: 3.918 ± 3.312
3.918ThrGlu: 3.918 ± 0.869
3.918ThrPhe: 3.918 ± 2.103
6.856ThrGly: 6.856 ± 3.316
1.959ThrHis: 1.959 ± 0.813
2.938ThrIle: 2.938 ± 1.409
0.979ThrLys: 0.979 ± 0.935
5.877ThrLeu: 5.877 ± 1.287
0.0ThrMet: 0.0 ± 0.0
1.959ThrAsn: 1.959 ± 0.907
1.959ThrPro: 1.959 ± 0.813
4.897ThrGln: 4.897 ± 1.215
5.877ThrArg: 5.877 ± 1.647
4.897ThrSer: 4.897 ± 2.895
2.938ThrThr: 2.938 ± 1.348
0.979ThrVal: 0.979 ± 1.238
0.0ThrTrp: 0.0 ± 0.0
3.918ThrTyr: 3.918 ± 1.627
0.0ThrXaa: 0.0 ± 0.0
Val
5.877ValAla: 5.877 ± 1.659
0.0ValCys: 0.0 ± 0.0
3.918ValAsp: 3.918 ± 3.225
4.897ValGlu: 4.897 ± 2.584
1.959ValPhe: 1.959 ± 1.87
5.877ValGly: 5.877 ± 1.671
0.979ValHis: 0.979 ± 1.238
2.938ValIle: 2.938 ± 1.409
6.856ValLys: 6.856 ± 1.16
0.0ValLeu: 0.0 ± 0.0
0.979ValMet: 0.979 ± 0.818
2.938ValAsn: 2.938 ± 2.44
4.897ValPro: 4.897 ± 2.195
0.979ValGln: 0.979 ± 0.762
6.856ValArg: 6.856 ± 1.407
0.979ValSer: 0.979 ± 0.935
1.959ValThr: 1.959 ± 0.921
5.877ValVal: 5.877 ± 1.659
0.0ValTrp: 0.0 ± 0.0
1.959ValTyr: 1.959 ± 0.813
0.0ValXaa: 0.0 ± 0.0
Trp
0.979TrpAla: 0.979 ± 0.762
0.0TrpCys: 0.0 ± 0.0
0.979TrpAsp: 0.979 ± 0.935
0.979TrpGlu: 0.979 ± 1.238
0.979TrpPhe: 0.979 ± 0.762
0.0TrpGly: 0.0 ± 0.0
0.979TrpHis: 0.979 ± 0.762
0.979TrpIle: 0.979 ± 1.238
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.959TrpSer: 1.959 ± 0.813
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.979TrpTrp: 0.979 ± 0.818
0.979TrpTyr: 0.979 ± 0.762
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.959TyrAla: 1.959 ± 0.813
0.979TyrCys: 0.979 ± 0.762
1.959TyrAsp: 1.959 ± 0.813
4.897TyrGlu: 4.897 ± 1.068
1.959TyrPhe: 1.959 ± 0.921
3.918TyrGly: 3.918 ± 0.951
2.938TyrHis: 2.938 ± 1.443
3.918TyrIle: 3.918 ± 1.514
3.918TyrLys: 3.918 ± 1.627
2.938TyrLeu: 2.938 ± 1.515
0.979TyrMet: 0.979 ± 0.774
0.0TyrAsn: 0.0 ± 0.0
0.979TyrPro: 0.979 ± 0.762
0.979TyrGln: 0.979 ± 0.762
5.877TyrArg: 5.877 ± 1.287
0.979TyrSer: 0.979 ± 0.762
2.938TyrThr: 2.938 ± 0.456
5.877TyrVal: 5.877 ± 0.565
0.0TyrTrp: 0.0 ± 0.0
2.938TyrTyr: 2.938 ± 2.455
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
2.938XaaLys: 2.938 ± 1.515
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1022 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski