Amino acid dipepetide frequency for Bos taurus papillomavirus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.563AlaAla: 6.563 ± 2.282
2.871AlaCys: 2.871 ± 1.245
3.692AlaAsp: 3.692 ± 0.818
4.922AlaGlu: 4.922 ± 1.402
0.82AlaPhe: 0.82 ± 0.404
3.692AlaGly: 3.692 ± 1.171
0.82AlaHis: 0.82 ± 0.403
2.871AlaIle: 2.871 ± 0.462
3.281AlaLys: 3.281 ± 1.147
6.153AlaLeu: 6.153 ± 1.731
0.41AlaMet: 0.41 ± 0.373
2.461AlaAsn: 2.461 ± 0.942
3.281AlaPro: 3.281 ± 1.21
2.461AlaGln: 2.461 ± 0.807
2.871AlaArg: 2.871 ± 0.973
4.512AlaSer: 4.512 ± 2.326
3.692AlaThr: 3.692 ± 1.012
4.102AlaVal: 4.102 ± 0.823
0.41AlaTrp: 0.41 ± 0.373
2.051AlaTyr: 2.051 ± 0.904
0.0AlaXaa: 0.0 ± 0.0
Cys
2.461CysAla: 2.461 ± 0.814
1.231CysCys: 1.231 ± 0.884
1.641CysAsp: 1.641 ± 0.943
0.0CysGlu: 0.0 ± 0.0
2.051CysPhe: 2.051 ± 0.772
1.231CysGly: 1.231 ± 1.014
0.41CysHis: 0.41 ± 0.348
2.051CysIle: 2.051 ± 1.126
1.641CysLys: 1.641 ± 1.181
2.461CysLeu: 2.461 ± 1.646
0.41CysMet: 0.41 ± 0.373
0.41CysAsn: 0.41 ± 0.697
4.512CysPro: 4.512 ± 1.529
0.82CysGln: 0.82 ± 0.57
0.82CysArg: 0.82 ± 0.434
1.231CysSer: 1.231 ± 0.434
3.692CysThr: 3.692 ± 1.516
1.641CysVal: 1.641 ± 1.007
0.41CysTrp: 0.41 ± 0.338
1.231CysTyr: 1.231 ± 1.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.512AspAla: 4.512 ± 1.308
1.231AspCys: 1.231 ± 1.074
2.051AspAsp: 2.051 ± 0.908
2.051AspGlu: 2.051 ± 0.922
4.512AspPhe: 4.512 ± 1.678
6.153AspGly: 6.153 ± 1.642
1.231AspHis: 1.231 ± 0.693
2.051AspIle: 2.051 ± 0.904
1.641AspLys: 1.641 ± 0.84
5.742AspLeu: 5.742 ± 1.097
1.231AspMet: 1.231 ± 0.455
2.461AspAsn: 2.461 ± 0.646
2.051AspPro: 2.051 ± 0.996
3.281AspGln: 3.281 ± 0.743
3.692AspArg: 3.692 ± 1.137
4.512AspSer: 4.512 ± 1.275
3.281AspThr: 3.281 ± 0.753
4.102AspVal: 4.102 ± 1.812
1.231AspTrp: 1.231 ± 0.7
0.41AspTyr: 0.41 ± 0.338
0.0AspXaa: 0.0 ± 0.0
Glu
2.461GluAla: 2.461 ± 0.897
1.641GluCys: 1.641 ± 0.943
4.102GluAsp: 4.102 ± 0.935
6.973GluGlu: 6.973 ± 2.791
0.41GluPhe: 0.41 ± 0.366
4.922GluGly: 4.922 ± 0.769
1.231GluHis: 1.231 ± 0.672
1.641GluIle: 1.641 ± 0.681
3.281GluLys: 3.281 ± 1.406
4.102GluLeu: 4.102 ± 0.985
0.41GluMet: 0.41 ± 0.348
4.102GluAsn: 4.102 ± 1.002
3.692GluPro: 3.692 ± 1.318
2.461GluGln: 2.461 ± 0.528
3.281GluArg: 3.281 ± 1.322
0.82GluSer: 0.82 ± 0.654
4.102GluThr: 4.102 ± 1.179
2.871GluVal: 2.871 ± 1.732
0.0GluTrp: 0.0 ± 0.0
2.051GluTyr: 2.051 ± 0.964
0.0GluXaa: 0.0 ± 0.0
Phe
2.461PheAla: 2.461 ± 0.875
1.231PheCys: 1.231 ± 0.838
4.512PheAsp: 4.512 ± 1.377
1.231PheGlu: 1.231 ± 0.672
1.231PhePhe: 1.231 ± 0.564
1.641PheGly: 1.641 ± 0.557
2.051PheHis: 2.051 ± 0.742
1.641PheIle: 1.641 ± 0.737
2.461PheLys: 2.461 ± 1.42
5.332PheLeu: 5.332 ± 1.597
0.82PheMet: 0.82 ± 0.698
2.871PheAsn: 2.871 ± 1.134
2.461PhePro: 2.461 ± 1.116
1.641PheGln: 1.641 ± 0.514
2.051PheArg: 2.051 ± 0.922
2.461PheSer: 2.461 ± 0.928
1.231PheThr: 1.231 ± 0.685
1.641PheVal: 1.641 ± 0.732
1.641PheTrp: 1.641 ± 0.665
1.641PheTyr: 1.641 ± 0.807
0.0PheXaa: 0.0 ± 0.0
Gly
2.871GlyAla: 2.871 ± 1.041
2.461GlyCys: 2.461 ± 1.276
4.512GlyAsp: 4.512 ± 0.681
4.512GlyGlu: 4.512 ± 0.642
1.641GlyPhe: 1.641 ± 0.737
9.434GlyGly: 9.434 ± 2.971
2.461GlyHis: 2.461 ± 0.877
4.512GlyIle: 4.512 ± 0.988
3.281GlyLys: 3.281 ± 1.632
4.512GlyLeu: 4.512 ± 1.42
0.41GlyMet: 0.41 ± 0.513
3.692GlyAsn: 3.692 ± 0.837
3.281GlyPro: 3.281 ± 1.597
4.102GlyGln: 4.102 ± 1.005
6.973GlyArg: 6.973 ± 2.358
6.563GlySer: 6.563 ± 0.834
6.153GlyThr: 6.153 ± 1.794
4.512GlyVal: 4.512 ± 1.313
0.41GlyTrp: 0.41 ± 0.348
1.231GlyTyr: 1.231 ± 0.766
0.0GlyXaa: 0.0 ± 0.0
His
1.641HisAla: 1.641 ± 0.973
0.82HisCys: 0.82 ± 0.762
1.641HisAsp: 1.641 ± 1.191
1.231HisGlu: 1.231 ± 0.602
2.051HisPhe: 2.051 ± 0.823
0.82HisGly: 0.82 ± 0.42
2.461HisHis: 2.461 ± 1.767
2.051HisIle: 2.051 ± 1.187
0.82HisLys: 0.82 ± 0.403
0.41HisLeu: 0.41 ± 0.366
0.82HisMet: 0.82 ± 0.747
2.051HisAsn: 2.051 ± 1.109
3.281HisPro: 3.281 ± 1.88
0.41HisGln: 0.41 ± 0.348
2.051HisArg: 2.051 ± 0.948
0.82HisSer: 0.82 ± 0.403
0.82HisThr: 0.82 ± 0.434
2.871HisVal: 2.871 ± 1.099
0.0HisTrp: 0.0 ± 0.0
0.82HisTyr: 0.82 ± 0.57
0.0HisXaa: 0.0 ± 0.0
Ile
1.231IleAla: 1.231 ± 0.685
0.41IleCys: 0.41 ± 0.348
2.461IleAsp: 2.461 ± 0.901
3.281IleGlu: 3.281 ± 1.382
2.461IlePhe: 2.461 ± 0.795
4.512IleGly: 4.512 ± 2.633
0.82IleHis: 0.82 ± 0.403
1.641IleIle: 1.641 ± 1.005
1.641IleLys: 1.641 ± 0.542
3.692IleLeu: 3.692 ± 1.046
0.82IleMet: 0.82 ± 0.404
0.41IleAsn: 0.41 ± 0.338
4.102IlePro: 4.102 ± 0.635
0.82IleGln: 0.82 ± 0.403
1.231IleArg: 1.231 ± 0.793
1.641IleSer: 1.641 ± 1.007
3.281IleThr: 3.281 ± 0.832
2.461IleVal: 2.461 ± 0.86
0.0IleTrp: 0.0 ± 0.0
0.82IleTyr: 0.82 ± 0.461
0.0IleXaa: 0.0 ± 0.0
Lys
2.461LysAla: 2.461 ± 1.038
1.641LysCys: 1.641 ± 0.557
3.692LysAsp: 3.692 ± 0.759
2.461LysGlu: 2.461 ± 1.012
2.051LysPhe: 2.051 ± 0.845
1.641LysGly: 1.641 ± 1.076
1.231LysHis: 1.231 ± 0.692
2.461LysIle: 2.461 ± 0.486
2.461LysLys: 2.461 ± 0.538
3.281LysLeu: 3.281 ± 0.902
2.051LysMet: 2.051 ± 1.021
2.051LysAsn: 2.051 ± 1.012
2.871LysPro: 2.871 ± 1.109
1.641LysGln: 1.641 ± 1.113
4.512LysArg: 4.512 ± 1.402
2.461LysSer: 2.461 ± 1.4
2.461LysThr: 2.461 ± 1.059
2.871LysVal: 2.871 ± 1.29
0.41LysTrp: 0.41 ± 0.366
1.231LysTyr: 1.231 ± 0.7
0.0LysXaa: 0.0 ± 0.0
Leu
4.922LeuAla: 4.922 ± 1.299
2.461LeuCys: 2.461 ± 1.641
4.102LeuAsp: 4.102 ± 0.673
4.922LeuGlu: 4.922 ± 1.06
5.742LeuPhe: 5.742 ± 1.33
6.563LeuGly: 6.563 ± 1.352
1.231LeuHis: 1.231 ± 0.585
1.641LeuIle: 1.641 ± 0.602
5.332LeuLys: 5.332 ± 1.432
13.536LeuLeu: 13.536 ± 4.835
0.0LeuMet: 0.0 ± 0.0
2.461LeuAsn: 2.461 ± 0.492
4.102LeuPro: 4.102 ± 1.382
5.332LeuGln: 5.332 ± 1.631
3.281LeuArg: 3.281 ± 0.608
6.153LeuSer: 6.153 ± 2.104
5.742LeuThr: 5.742 ± 0.862
6.563LeuVal: 6.563 ± 1.415
1.641LeuTrp: 1.641 ± 0.7
4.102LeuTyr: 4.102 ± 1.922
0.0LeuXaa: 0.0 ± 0.0
Met
2.051MetAla: 2.051 ± 0.461
0.82MetCys: 0.82 ± 0.566
0.41MetAsp: 0.41 ± 0.338
0.0MetGlu: 0.0 ± 0.0
0.41MetPhe: 0.41 ± 0.348
0.82MetGly: 0.82 ± 0.677
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.41MetLys: 0.41 ± 0.373
0.41MetLeu: 0.41 ± 0.373
0.82MetMet: 0.82 ± 0.404
0.82MetAsn: 0.82 ± 0.42
0.82MetPro: 0.82 ± 0.617
2.461MetGln: 2.461 ± 0.751
1.231MetArg: 1.231 ± 0.702
1.641MetSer: 1.641 ± 0.764
0.82MetThr: 0.82 ± 0.434
1.231MetVal: 1.231 ± 0.793
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.641AsnAla: 1.641 ± 0.867
1.231AsnCys: 1.231 ± 1.12
1.641AsnAsp: 1.641 ± 0.904
1.641AsnGlu: 1.641 ± 1.047
1.231AsnPhe: 1.231 ± 0.81
3.281AsnGly: 3.281 ± 1.411
0.41AsnHis: 0.41 ± 0.462
1.641AsnIle: 1.641 ± 0.542
2.461AsnLys: 2.461 ± 0.852
2.461AsnLeu: 2.461 ± 1.024
1.231AsnMet: 1.231 ± 0.677
2.051AsnAsn: 2.051 ± 1.08
4.512AsnPro: 4.512 ± 1.326
2.051AsnGln: 2.051 ± 1.08
1.641AsnArg: 1.641 ± 0.263
4.512AsnSer: 4.512 ± 1.27
2.871AsnThr: 2.871 ± 1.449
1.641AsnVal: 1.641 ± 0.807
0.82AsnTrp: 0.82 ± 0.42
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.922ProAla: 4.922 ± 1.061
1.641ProCys: 1.641 ± 1.202
5.742ProAsp: 5.742 ± 2.003
2.871ProGlu: 2.871 ± 1.026
1.641ProPhe: 1.641 ± 0.557
4.512ProGly: 4.512 ± 1.166
2.871ProHis: 2.871 ± 1.272
2.051ProIle: 2.051 ± 0.664
2.871ProLys: 2.871 ± 1.015
7.793ProLeu: 7.793 ± 1.025
0.41ProMet: 0.41 ± 0.434
1.641ProAsn: 1.641 ± 0.947
5.332ProPro: 5.332 ± 1.797
1.231ProGln: 1.231 ± 0.452
4.512ProArg: 4.512 ± 1.278
8.614ProSer: 8.614 ± 2.81
2.051ProThr: 2.051 ± 1.082
4.922ProVal: 4.922 ± 0.809
0.41ProTrp: 0.41 ± 0.513
1.641ProTyr: 1.641 ± 0.673
0.0ProXaa: 0.0 ± 0.0
Gln
2.051GlnAla: 2.051 ± 0.988
0.82GlnCys: 0.82 ± 0.57
1.641GlnAsp: 1.641 ± 0.601
1.641GlnGlu: 1.641 ± 0.802
2.051GlnPhe: 2.051 ± 0.936
5.742GlnGly: 5.742 ± 1.137
0.41GlnHis: 0.41 ± 0.366
2.051GlnIle: 2.051 ± 1.012
1.231GlnLys: 1.231 ± 0.644
2.871GlnLeu: 2.871 ± 0.617
1.231GlnMet: 1.231 ± 0.376
3.281GlnAsn: 3.281 ± 0.89
2.871GlnPro: 2.871 ± 0.705
1.641GlnGln: 1.641 ± 0.947
1.641GlnArg: 1.641 ± 0.577
3.281GlnSer: 3.281 ± 0.8
1.641GlnThr: 1.641 ± 0.575
2.871GlnVal: 2.871 ± 0.894
0.82GlnTrp: 0.82 ± 0.747
0.82GlnTyr: 0.82 ± 0.404
0.0GlnXaa: 0.0 ± 0.0
Arg
3.281ArgAla: 3.281 ± 0.685
2.051ArgCys: 2.051 ± 1.316
2.051ArgAsp: 2.051 ± 1.009
2.871ArgGlu: 2.871 ± 0.51
2.051ArgPhe: 2.051 ± 1.187
5.332ArgGly: 5.332 ± 1.435
4.102ArgHis: 4.102 ± 1.463
1.641ArgIle: 1.641 ± 0.892
3.692ArgLys: 3.692 ± 1.116
4.922ArgLeu: 4.922 ± 1.27
0.0ArgMet: 0.0 ± 0.324
2.051ArgAsn: 2.051 ± 1.44
6.973ArgPro: 6.973 ± 1.669
1.231ArgGln: 1.231 ± 0.846
5.742ArgArg: 5.742 ± 1.224
1.641ArgSer: 1.641 ± 1.056
2.871ArgThr: 2.871 ± 0.608
6.563ArgVal: 6.563 ± 1.424
0.82ArgTrp: 0.82 ± 0.434
1.641ArgTyr: 1.641 ± 0.861
0.0ArgXaa: 0.0 ± 0.0
Ser
4.922SerAla: 4.922 ± 1.341
1.231SerCys: 1.231 ± 0.686
3.281SerAsp: 3.281 ± 1.114
3.692SerGlu: 3.692 ± 1.209
3.281SerPhe: 3.281 ± 1.135
3.692SerGly: 3.692 ± 1.164
0.82SerHis: 0.82 ± 0.434
1.641SerIle: 1.641 ± 0.681
2.871SerLys: 2.871 ± 1.584
6.563SerLeu: 6.563 ± 1.407
0.82SerMet: 0.82 ± 0.679
0.82SerAsn: 0.82 ± 0.403
5.742SerPro: 5.742 ± 1.799
4.102SerGln: 4.102 ± 1.467
5.742SerArg: 5.742 ± 1.125
8.614SerSer: 8.614 ± 1.497
8.203SerThr: 8.203 ± 1.774
6.563SerVal: 6.563 ± 1.813
0.82SerTrp: 0.82 ± 0.434
2.871SerTyr: 2.871 ± 0.887
0.0SerXaa: 0.0 ± 0.0
Thr
2.871ThrAla: 2.871 ± 0.841
2.461ThrCys: 2.461 ± 1.264
4.922ThrAsp: 4.922 ± 0.959
4.512ThrGlu: 4.512 ± 0.797
2.051ThrPhe: 2.051 ± 0.768
6.153ThrGly: 6.153 ± 1.686
1.231ThrHis: 1.231 ± 0.672
4.102ThrIle: 4.102 ± 1.03
2.051ThrLys: 2.051 ± 0.807
6.973ThrLeu: 6.973 ± 2.527
1.231ThrMet: 1.231 ± 0.685
2.051ThrAsn: 2.051 ± 1.471
3.692ThrPro: 3.692 ± 1.603
2.051ThrGln: 2.051 ± 0.457
4.102ThrArg: 4.102 ± 1.021
4.922ThrSer: 4.922 ± 0.988
2.051ThrThr: 2.051 ± 0.91
4.102ThrVal: 4.102 ± 1.796
0.82ThrTrp: 0.82 ± 0.697
3.281ThrTyr: 3.281 ± 1.271
0.0ThrXaa: 0.0 ± 0.0
Val
4.922ValAla: 4.922 ± 1.215
2.051ValCys: 2.051 ± 1.063
3.692ValAsp: 3.692 ± 0.818
4.102ValGlu: 4.102 ± 2.23
3.692ValPhe: 3.692 ± 0.827
3.692ValGly: 3.692 ± 1.01
2.871ValHis: 2.871 ± 1.018
0.82ValIle: 0.82 ± 0.404
2.461ValLys: 2.461 ± 0.594
4.102ValLeu: 4.102 ± 0.561
0.82ValMet: 0.82 ± 0.697
2.461ValAsn: 2.461 ± 0.907
3.692ValPro: 3.692 ± 1.478
0.82ValGln: 0.82 ± 0.747
4.922ValArg: 4.922 ± 1.86
7.793ValSer: 7.793 ± 1.377
7.793ValThr: 7.793 ± 1.274
2.051ValVal: 2.051 ± 1.408
1.231ValTrp: 1.231 ± 1.015
1.641ValTyr: 1.641 ± 0.715
0.0ValXaa: 0.0 ± 0.0
Trp
0.82TrpAla: 0.82 ± 0.434
0.41TrpCys: 0.41 ± 0.697
0.82TrpAsp: 0.82 ± 0.461
0.82TrpGlu: 0.82 ± 0.404
0.41TrpPhe: 0.41 ± 0.366
1.641TrpGly: 1.641 ± 0.69
0.82TrpHis: 0.82 ± 0.461
0.41TrpIle: 0.41 ± 0.366
0.82TrpLys: 0.82 ± 0.404
2.051TrpLeu: 2.051 ± 1.407
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.41TrpGln: 0.41 ± 0.338
0.0TrpArg: 0.0 ± 0.0
1.641TrpSer: 1.641 ± 0.841
0.82TrpThr: 0.82 ± 0.461
0.82TrpVal: 0.82 ± 0.747
0.0TrpTrp: 0.0 ± 0.0
0.41TrpTyr: 0.41 ± 0.373
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.871TyrAla: 2.871 ± 0.66
1.641TyrCys: 1.641 ± 0.785
0.82TyrAsp: 0.82 ± 0.617
0.82TyrGlu: 0.82 ± 0.816
2.461TyrPhe: 2.461 ± 0.993
2.051TyrGly: 2.051 ± 0.809
0.41TyrHis: 0.41 ± 0.338
0.82TyrIle: 0.82 ± 0.404
1.231TyrLys: 1.231 ± 0.434
2.461TyrLeu: 2.461 ± 1.048
0.82TyrMet: 0.82 ± 0.6
0.82TyrAsn: 0.82 ± 0.579
0.41TyrPro: 0.41 ± 0.338
1.641TyrGln: 1.641 ± 0.665
1.641TyrArg: 1.641 ± 0.673
2.461TyrSer: 2.461 ± 1.208
2.051TyrThr: 2.051 ± 0.664
1.231TyrVal: 1.231 ± 0.452
1.231TyrTrp: 1.231 ± 0.787
2.051TyrTyr: 2.051 ± 0.703
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2439 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski