Amino acid dipepetide frequency for Roseateles aquatilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.19AlaAla: 19.19 ± 0.165	1.208AlaCys: 1.208 ± 0.027	6.976AlaAsp: 6.976 ± 0.063	6.567AlaGlu: 6.567 ± 0.07	3.83AlaPhe: 3.83 ± 0.044	11.02AlaGly: 11.02 ± 0.085	2.61AlaHis: 2.61 ± 0.041	5.023AlaIle: 5.023 ± 0.067	3.587AlaLys: 3.587 ± 0.057	16.177AlaLeu: 16.177 ± 0.169	3.666AlaMet: 3.666 ± 0.052	2.627AlaAsn: 2.627 ± 0.046	7.059AlaPro: 7.059 ± 0.086	5.908AlaGln: 5.908 ± 0.08	10.078AlaArg: 10.078 ± 0.088	7.468AlaSer: 7.468 ± 0.074	6.56AlaThr: 6.56 ± 0.064	9.173AlaVal: 9.173 ± 0.083	2.043AlaTrp: 2.043 ± 0.038	2.324AlaTyr: 2.324 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.105CysAla: 1.105 ± 0.028	0.112CysCys: 0.112 ± 0.009	0.493CysAsp: 0.493 ± 0.019	0.467CysGlu: 0.467 ± 0.017	0.263CysPhe: 0.263 ± 0.011	0.882CysGly: 0.882 ± 0.024	0.23CysHis: 0.23 ± 0.012	0.312CysIle: 0.312 ± 0.014	0.194CysLys: 0.194 ± 0.01	0.809CysLeu: 0.809 ± 0.021	0.169CysMet: 0.169 ± 0.01	0.182CysAsn: 0.182 ± 0.01	0.455CysPro: 0.455 ± 0.017	0.245CysGln: 0.245 ± 0.011	0.576CysArg: 0.576 ± 0.019	0.448CysSer: 0.448 ± 0.017	0.392CysThr: 0.392 ± 0.018	0.65CysVal: 0.65 ± 0.019	0.128CysTrp: 0.128 ± 0.009	0.165CysTyr: 0.165 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.942AspAla: 7.942 ± 0.075	0.439AspCys: 0.439 ± 0.017	3.155AspAsp: 3.155 ± 0.051	3.49AspGlu: 3.49 ± 0.044	1.992AspPhe: 1.992 ± 0.035	5.506AspGly: 5.506 ± 0.062	1.168AspHis: 1.168 ± 0.027	2.129AspIle: 2.129 ± 0.037	1.604AspLys: 1.604 ± 0.033	5.866AspLeu: 5.866 ± 0.057	1.111AspMet: 1.111 ± 0.025	1.123AspAsn: 1.123 ± 0.025	3.248AspPro: 3.248 ± 0.043	1.983AspGln: 1.983 ± 0.047	4.172AspArg: 4.172 ± 0.058	2.306AspSer: 2.306 ± 0.035	2.514AspThr: 2.514 ± 0.036	4.037AspVal: 4.037 ± 0.049	1.113AspTrp: 1.113 ± 0.025	1.237AspTyr: 1.237 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.001GluAla: 7.001 ± 0.069	0.335GluCys: 0.335 ± 0.015	2.428GluAsp: 2.428 ± 0.04	2.356GluGlu: 2.356 ± 0.049	1.597GluPhe: 1.597 ± 0.029	3.57GluGly: 3.57 ± 0.047	1.277GluHis: 1.277 ± 0.027	2.434GluIle: 2.434 ± 0.047	1.434GluLys: 1.434 ± 0.03	6.063GluLeu: 6.063 ± 0.07	1.108GluMet: 1.108 ± 0.025	1.043GluAsn: 1.043 ± 0.023	2.598GluPro: 2.598 ± 0.043	2.632GluGln: 2.632 ± 0.043	4.946GluArg: 4.946 ± 0.059	2.487GluSer: 2.487 ± 0.041	2.462GluThr: 2.462 ± 0.038	3.869GluVal: 3.869 ± 0.045	0.704GluTrp: 0.704 ± 0.02	0.92GluTyr: 0.92 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.809PheAla: 3.809 ± 0.049	0.331PheCys: 0.331 ± 0.014	2.465PheAsp: 2.465 ± 0.038	1.898PheGlu: 1.898 ± 0.033	1.193PhePhe: 1.193 ± 0.033	3.088PheGly: 3.088 ± 0.047	0.669PheHis: 0.669 ± 0.021	1.299PheIle: 1.299 ± 0.029	1.066PheLys: 1.066 ± 0.028	2.711PheLeu: 2.711 ± 0.04	0.695PheMet: 0.695 ± 0.019	1.05PheAsn: 1.05 ± 0.027	1.331PhePro: 1.331 ± 0.03	1.076PheGln: 1.076 ± 0.025	1.825PheArg: 1.825 ± 0.033	2.014PheSer: 2.014 ± 0.033	1.689PheThr: 1.689 ± 0.036	2.461PheVal: 2.461 ± 0.035	0.473PheTrp: 0.473 ± 0.016	0.746PheTyr: 0.746 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.185GlyAla: 10.185 ± 0.089	0.797GlyCys: 0.797 ± 0.022	4.509GlyAsp: 4.509 ± 0.054	4.427GlyGlu: 4.427 ± 0.058	2.991GlyPhe: 2.991 ± 0.043	7.336GlyGly: 7.336 ± 0.094	2.009GlyHis: 2.009 ± 0.041	3.48GlyIle: 3.48 ± 0.046	2.865GlyLys: 2.865 ± 0.05	9.522GlyLeu: 9.522 ± 0.086	2.108GlyMet: 2.108 ± 0.041	2.044GlyAsn: 2.044 ± 0.044	3.512GlyPro: 3.512 ± 0.05	3.637GlyGln: 3.637 ± 0.056	6.259GlyArg: 6.259 ± 0.057	4.481GlySer: 4.481 ± 0.063	4.394GlyThr: 4.394 ± 0.061	6.346GlyVal: 6.346 ± 0.068	1.553GlyTrp: 1.553 ± 0.029	2.063GlyTyr: 2.063 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.901HisAla: 2.901 ± 0.039	0.253HisCys: 0.253 ± 0.012	1.218HisAsp: 1.218 ± 0.029	1.229HisGlu: 1.229 ± 0.03	0.787HisPhe: 0.787 ± 0.022	2.152HisGly: 2.152 ± 0.035	0.635HisHis: 0.635 ± 0.019	0.697HisIle: 0.697 ± 0.021	0.435HisLys: 0.435 ± 0.014	2.302HisLeu: 2.302 ± 0.042	0.395HisMet: 0.395 ± 0.015	0.39HisAsn: 0.39 ± 0.015	1.446HisPro: 1.446 ± 0.032	0.786HisGln: 0.786 ± 0.023	1.686HisArg: 1.686 ± 0.032	0.898HisSer: 0.898 ± 0.025	0.851HisThr: 0.851 ± 0.022	1.544HisVal: 1.544 ± 0.03	0.419HisTrp: 0.419 ± 0.015	0.545HisTyr: 0.545 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.973IleAla: 5.973 ± 0.063	0.34IleCys: 0.34 ± 0.012	2.998IleAsp: 2.998 ± 0.043	2.825IleGlu: 2.825 ± 0.045	1.003IlePhe: 1.003 ± 0.026	3.914IleGly: 3.914 ± 0.052	0.762IleHis: 0.762 ± 0.022	1.09IleIle: 1.09 ± 0.027	1.282IleLys: 1.282 ± 0.03	2.866IleLeu: 2.866 ± 0.047	0.555IleMet: 0.555 ± 0.02	1.203IleAsn: 1.203 ± 0.03	1.85IlePro: 1.85 ± 0.036	1.261IleGln: 1.261 ± 0.027	2.49IleArg: 2.49 ± 0.037	2.106IleSer: 2.106 ± 0.036	2.147IleThr: 2.147 ± 0.037	3.271IleVal: 3.271 ± 0.048	0.432IleTrp: 0.432 ± 0.015	0.765IleTyr: 0.765 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.819LysAla: 3.819 ± 0.063	0.127LysCys: 0.127 ± 0.009	1.62LysAsp: 1.62 ± 0.043	1.255LysGlu: 1.255 ± 0.029	0.742LysPhe: 0.742 ± 0.021	2.215LysGly: 2.215 ± 0.036	0.555LysHis: 0.555 ± 0.018	1.125LysIle: 1.125 ± 0.028	1.042LysLys: 1.042 ± 0.038	3.185LysLeu: 3.185 ± 0.054	0.578LysMet: 0.578 ± 0.017	0.765LysAsn: 0.765 ± 0.022	1.946LysPro: 1.946 ± 0.042	1.169LysGln: 1.169 ± 0.028	2.175LysArg: 2.175 ± 0.032	1.585LysSer: 1.585 ± 0.028	1.741LysThr: 1.741 ± 0.035	2.144LysVal: 2.144 ± 0.037	0.298LysTrp: 0.298 ± 0.013	0.517LysTyr: 0.517 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.127LeuAla: 15.127 ± 0.128	0.913LeuCys: 0.913 ± 0.024	6.507LeuAsp: 6.507 ± 0.066	4.978LeuGlu: 4.978 ± 0.055	3.197LeuPhe: 3.197 ± 0.045	8.897LeuGly: 8.897 ± 0.09	2.267LeuHis: 2.267 ± 0.04	4.382LeuIle: 4.382 ± 0.048	3.546LeuLys: 3.546 ± 0.046	11.891LeuLeu: 11.891 ± 0.139	2.645LeuMet: 2.645 ± 0.043	2.717LeuAsn: 2.717 ± 0.044	6.488LeuPro: 6.488 ± 0.07	4.164LeuGln: 4.164 ± 0.053	9.108LeuArg: 9.108 ± 0.089	6.872LeuSer: 6.872 ± 0.096	5.887LeuThr: 5.887 ± 0.091	7.754LeuVal: 7.754 ± 0.076	1.405LeuTrp: 1.405 ± 0.03	1.889LeuTyr: 1.889 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.927MetAla: 2.927 ± 0.045	0.141MetCys: 0.141 ± 0.008	1.181MetAsp: 1.181 ± 0.025	0.962MetGlu: 0.962 ± 0.023	0.612MetPhe: 0.612 ± 0.019	1.724MetGly: 1.724 ± 0.028	0.497MetHis: 0.497 ± 0.017	0.845MetIle: 0.845 ± 0.022	0.872MetLys: 0.872 ± 0.021	2.545MetLeu: 2.545 ± 0.041	0.482MetMet: 0.482 ± 0.017	0.741MetAsn: 0.741 ± 0.021	1.518MetPro: 1.518 ± 0.029	0.949MetGln: 0.949 ± 0.021	1.826MetArg: 1.826 ± 0.033	1.707MetSer: 1.707 ± 0.03	1.652MetThr: 1.652 ± 0.031	1.536MetVal: 1.536 ± 0.033	0.207MetTrp: 0.207 ± 0.012	0.336MetTyr: 0.336 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.122AsnAla: 3.122 ± 0.05	0.222AsnCys: 0.222 ± 0.013	1.286AsnAsp: 1.286 ± 0.027	1.141AsnGlu: 1.141 ± 0.022	0.829AsnPhe: 0.829 ± 0.027	2.269AsnGly: 2.269 ± 0.046	0.424AsnHis: 0.424 ± 0.015	0.963AsnIle: 0.963 ± 0.026	0.658AsnLys: 0.658 ± 0.019	2.338AsnLeu: 2.338 ± 0.038	0.462AsnMet: 0.462 ± 0.019	0.654AsnAsn: 0.654 ± 0.022	1.531AsnPro: 1.531 ± 0.038	0.842AsnGln: 0.842 ± 0.022	1.537AsnArg: 1.537 ± 0.027	1.073AsnSer: 1.073 ± 0.029	1.257AsnThr: 1.257 ± 0.035	1.73AsnVal: 1.73 ± 0.034	0.371AsnTrp: 0.371 ± 0.014	0.614AsnTyr: 0.614 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.78ProAla: 7.78 ± 0.095	0.361ProCys: 0.361 ± 0.016	3.496ProAsp: 3.496 ± 0.048	3.233ProGlu: 3.233 ± 0.045	1.614ProPhe: 1.614 ± 0.033	4.926ProGly: 4.926 ± 0.046	1.096ProHis: 1.096 ± 0.028	1.815ProIle: 1.815 ± 0.033	1.436ProLys: 1.436 ± 0.03	5.587ProLeu: 5.587 ± 0.066	1.391ProMet: 1.391 ± 0.023	1.128ProAsn: 1.128 ± 0.028	3.222ProPro: 3.222 ± 0.066	2.053ProGln: 2.053 ± 0.035	3.721ProArg: 3.721 ± 0.056	3.211ProSer: 3.211 ± 0.045	2.926ProThr: 2.926 ± 0.048	4.282ProVal: 4.282 ± 0.055	0.859ProTrp: 0.859 ± 0.023	0.998ProTyr: 0.998 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.881GlnAla: 5.881 ± 0.069	0.242GlnCys: 0.242 ± 0.012	1.799GlnAsp: 1.799 ± 0.035	1.585GlnGlu: 1.585 ± 0.034	1.169GlnPhe: 1.169 ± 0.022	3.21GlnGly: 3.21 ± 0.041	0.844GlnHis: 0.844 ± 0.022	1.661GlnIle: 1.661 ± 0.049	0.869GlnLys: 0.869 ± 0.022	4.631GlnLeu: 4.631 ± 0.058	0.901GlnMet: 0.901 ± 0.021	0.738GlnAsn: 0.738 ± 0.022	2.366GlnPro: 2.366 ± 0.038	1.976GlnGln: 1.976 ± 0.044	3.79GlnArg: 3.79 ± 0.057	2.034GlnSer: 2.034 ± 0.037	1.922GlnThr: 1.922 ± 0.035	3.248GlnVal: 3.248 ± 0.081	0.658GlnTrp: 0.658 ± 0.02	0.737GlnTyr: 0.737 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.079ArgAla: 9.079 ± 0.09	0.659ArgCys: 0.659 ± 0.022	4.327ArgAsp: 4.327 ± 0.047	4.546ArgGlu: 4.546 ± 0.062	2.88ArgPhe: 2.88 ± 0.038	5.378ArgGly: 5.378 ± 0.059	2.139ArgHis: 2.139 ± 0.041	3.324ArgIle: 3.324 ± 0.041	1.903ArgLys: 1.903 ± 0.035	9.071ArgLeu: 9.071 ± 0.101	1.988ArgMet: 1.988 ± 0.036	1.679ArgAsn: 1.679 ± 0.027	3.919ArgPro: 3.919 ± 0.057	3.475ArgGln: 3.475 ± 0.043	6.614ArgArg: 6.614 ± 0.087	3.747ArgSer: 3.747 ± 0.047	3.216ArgThr: 3.216 ± 0.045	5.596ArgVal: 5.596 ± 0.064	1.478ArgTrp: 1.478 ± 0.029	1.774ArgTyr: 1.774 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.138SerAla: 7.138 ± 0.075	0.44SerCys: 0.44 ± 0.018	2.751SerAsp: 2.751 ± 0.047	2.403SerGlu: 2.403 ± 0.037	1.986SerPhe: 1.986 ± 0.034	5.318SerGly: 5.318 ± 0.062	1.125SerHis: 1.125 ± 0.023	2.202SerIle: 2.202 ± 0.04	1.409SerLys: 1.409 ± 0.03	5.969SerLeu: 5.969 ± 0.064	1.285SerMet: 1.285 ± 0.029	1.305SerAsn: 1.305 ± 0.032	3.245SerPro: 3.245 ± 0.053	1.964SerGln: 1.964 ± 0.037	3.915SerArg: 3.915 ± 0.056	3.387SerSer: 3.387 ± 0.067	3.227SerThr: 3.227 ± 0.057	3.832SerVal: 3.832 ± 0.052	0.769SerTrp: 0.769 ± 0.019	1.168SerTyr: 1.168 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.576ThrAla: 6.576 ± 0.072	0.39ThrCys: 0.39 ± 0.015	2.656ThrAsp: 2.656 ± 0.052	2.24ThrGlu: 2.24 ± 0.034	1.487ThrPhe: 1.487 ± 0.031	4.635ThrGly: 4.635 ± 0.07	1.044ThrHis: 1.044 ± 0.027	1.917ThrIle: 1.917 ± 0.037	1.188ThrLys: 1.188 ± 0.03	6.418ThrLeu: 6.418 ± 0.077	1.127ThrMet: 1.127 ± 0.022	1.147ThrAsn: 1.147 ± 0.034	3.657ThrPro: 3.657 ± 0.051	1.924ThrGln: 1.924 ± 0.036	3.62ThrArg: 3.62 ± 0.05	2.898ThrSer: 2.898 ± 0.056	3.039ThrThr: 3.039 ± 0.072	4.159ThrVal: 4.159 ± 0.057	0.721ThrTrp: 0.721 ± 0.022	0.993ThrTyr: 0.993 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.558ValAla: 9.558 ± 0.086	0.633ValCys: 0.633 ± 0.02	4.432ValAsp: 4.432 ± 0.054	4.085ValGlu: 4.085 ± 0.05	2.436ValPhe: 2.436 ± 0.039	5.642ValGly: 5.642 ± 0.059	1.458ValHis: 1.458 ± 0.029	3.087ValIle: 3.087 ± 0.046	2.231ValLys: 2.231 ± 0.042	8.351ValLeu: 8.351 ± 0.088	1.795ValMet: 1.795 ± 0.034	1.886ValAsn: 1.886 ± 0.035	3.983ValPro: 3.983 ± 0.048	2.689ValGln: 2.689 ± 0.044	5.251ValArg: 5.251 ± 0.058	4.17ValSer: 4.17 ± 0.049	4.008ValThr: 4.008 ± 0.057	6.008ValVal: 6.008 ± 0.071	0.97ValTrp: 0.97 ± 0.025	1.446ValTyr: 1.446 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.554TrpAla: 1.554 ± 0.03	0.149TrpCys: 0.149 ± 0.009	0.658TrpAsp: 0.658 ± 0.021	0.554TrpGlu: 0.554 ± 0.015	0.518TrpPhe: 0.518 ± 0.017	0.99TrpGly: 0.99 ± 0.022	0.385TrpHis: 0.385 ± 0.014	0.722TrpIle: 0.722 ± 0.022	0.42TrpLys: 0.42 ± 0.014	2.154TrpLeu: 2.154 ± 0.041	0.432TrpMet: 0.432 ± 0.018	0.386TrpAsn: 0.386 ± 0.017	0.787TrpPro: 0.787 ± 0.023	0.725TrpGln: 0.725 ± 0.022	1.482TrpArg: 1.482 ± 0.032	0.91TrpSer: 0.91 ± 0.025	0.868TrpThr: 0.868 ± 0.026	0.994TrpVal: 0.994 ± 0.025	0.324TrpTrp: 0.324 ± 0.015	0.279TrpTyr: 0.279 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.038	0.184TyrCys: 0.184 ± 0.009	1.178TyrAsp: 1.178 ± 0.029	1.021TyrGlu: 1.021 ± 0.023	0.767TyrPhe: 0.767 ± 0.019	1.843TyrGly: 1.843 ± 0.036	0.373TyrHis: 0.373 ± 0.014	0.626TyrIle: 0.626 ± 0.02	0.563TyrLys: 0.563 ± 0.016	2.179TyrLeu: 2.179 ± 0.035	0.368TyrMet: 0.368 ± 0.015	0.516TyrAsn: 0.516 ± 0.018	0.974TyrPro: 0.974 ± 0.023	0.806TyrGln: 0.806 ± 0.021	1.72TyrArg: 1.72 ± 0.031	1.038TyrSer: 1.038 ± 0.03	1.084TyrThr: 1.084 ± 0.027	1.482TyrVal: 1.482 ± 0.03	0.367TyrTrp: 0.367 ± 0.015	0.506TyrTyr: 0.506 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5438 proteins (1868886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---