Amino acid dipepetide frequency for Filibacter tadaridae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.16AlaAla: 6.16 ± 0.109
0.573AlaCys: 0.573 ± 0.026
4.011AlaAsp: 4.011 ± 0.068
5.175AlaGlu: 5.175 ± 0.081
3.625AlaPhe: 3.625 ± 0.075
5.702AlaGly: 5.702 ± 0.102
1.359AlaHis: 1.359 ± 0.04
6.473AlaIle: 6.473 ± 0.099
4.623AlaLys: 4.623 ± 0.084
7.581AlaLeu: 7.581 ± 0.093
2.335AlaMet: 2.335 ± 0.054
2.683AlaAsn: 2.683 ± 0.053
2.137AlaPro: 2.137 ± 0.055
2.293AlaGln: 2.293 ± 0.058
2.925AlaArg: 2.925 ± 0.072
4.228AlaSer: 4.228 ± 0.068
4.047AlaThr: 4.047 ± 0.088
5.829AlaVal: 5.829 ± 0.103
0.564AlaTrp: 0.564 ± 0.027
2.394AlaTyr: 2.394 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.44CysAla: 0.44 ± 0.027
0.083CysCys: 0.083 ± 0.012
0.34CysAsp: 0.34 ± 0.02
0.402CysGlu: 0.402 ± 0.02
0.246CysPhe: 0.246 ± 0.015
0.609CysGly: 0.609 ± 0.03
0.171CysHis: 0.171 ± 0.014
0.503CysIle: 0.503 ± 0.026
0.31CysLys: 0.31 ± 0.017
0.528CysLeu: 0.528 ± 0.025
0.159CysMet: 0.159 ± 0.016
0.253CysAsn: 0.253 ± 0.017
0.301CysPro: 0.301 ± 0.021
0.151CysGln: 0.151 ± 0.014
0.266CysArg: 0.266 ± 0.017
0.447CysSer: 0.447 ± 0.021
0.396CysThr: 0.396 ± 0.019
0.371CysVal: 0.371 ± 0.02
0.058CysTrp: 0.058 ± 0.008
0.18CysTyr: 0.18 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.931AspAla: 3.931 ± 0.08
0.358AspCys: 0.358 ± 0.021
2.851AspAsp: 2.851 ± 0.069
4.963AspGlu: 4.963 ± 0.08
2.604AspPhe: 2.604 ± 0.058
3.928AspGly: 3.928 ± 0.075
1.013AspHis: 1.013 ± 0.032
4.161AspIle: 4.161 ± 0.074
3.269AspLys: 3.269 ± 0.063
4.771AspLeu: 4.771 ± 0.076
1.496AspMet: 1.496 ± 0.04
1.972AspAsn: 1.972 ± 0.059
2.011AspPro: 2.011 ± 0.054
1.541AspGln: 1.541 ± 0.045
2.363AspArg: 2.363 ± 0.054
2.905AspSer: 2.905 ± 0.06
2.698AspThr: 2.698 ± 0.062
4.16AspVal: 4.16 ± 0.069
0.641AspTrp: 0.641 ± 0.031
2.052AspTyr: 2.052 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.415GluAla: 5.415 ± 0.085
0.314GluCys: 0.314 ± 0.018
3.911GluAsp: 3.911 ± 0.071
6.64GluGlu: 6.64 ± 0.128
2.582GluPhe: 2.582 ± 0.061
4.61GluGly: 4.61 ± 0.075
1.422GluHis: 1.422 ± 0.04
5.303GluIle: 5.303 ± 0.09
6.24GluLys: 6.24 ± 0.085
7.324GluLeu: 7.324 ± 0.113
2.612GluMet: 2.612 ± 0.067
3.253GluAsn: 3.253 ± 0.064
2.011GluPro: 2.011 ± 0.047
3.148GluGln: 3.148 ± 0.063
3.733GluArg: 3.733 ± 0.088
3.847GluSer: 3.847 ± 0.065
4.18GluThr: 4.18 ± 0.072
5.204GluVal: 5.204 ± 0.082
0.851GluTrp: 0.851 ± 0.032
1.897GluTyr: 1.897 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.32PheAla: 3.32 ± 0.065
0.304PheCys: 0.304 ± 0.019
2.594PheAsp: 2.594 ± 0.058
2.933PheGlu: 2.933 ± 0.072
2.349PhePhe: 2.349 ± 0.07
3.53PheGly: 3.53 ± 0.075
1.025PheHis: 1.025 ± 0.037
4.06PheIle: 4.06 ± 0.086
2.399PheLys: 2.399 ± 0.054
4.382PheLeu: 4.382 ± 0.088
1.309PheMet: 1.309 ± 0.048
1.883PheAsn: 1.883 ± 0.05
1.655PhePro: 1.655 ± 0.047
1.345PheGln: 1.345 ± 0.038
1.707PheArg: 1.707 ± 0.044
3.185PheSer: 3.185 ± 0.07
2.819PheThr: 2.819 ± 0.052
3.259PheVal: 3.259 ± 0.071
0.455PheTrp: 0.455 ± 0.026
1.541PheTyr: 1.541 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.123GlyAla: 5.123 ± 0.095
0.553GlyCys: 0.553 ± 0.029
3.431GlyAsp: 3.431 ± 0.07
4.706GlyGlu: 4.706 ± 0.07
3.5GlyPhe: 3.5 ± 0.07
4.994GlyGly: 4.994 ± 0.093
1.481GlyHis: 1.481 ± 0.043
6.114GlyIle: 6.114 ± 0.095
5.37GlyLys: 5.37 ± 0.076
6.805GlyLeu: 6.805 ± 0.11
2.343GlyMet: 2.343 ± 0.063
2.8GlyAsn: 2.8 ± 0.056
1.826GlyPro: 1.826 ± 0.051
2.233GlyGln: 2.233 ± 0.05
2.912GlyArg: 2.912 ± 0.058
4.145GlySer: 4.145 ± 0.069
4.416GlyThr: 4.416 ± 0.076
5.128GlyVal: 5.128 ± 0.084
0.793GlyTrp: 0.793 ± 0.032
2.56GlyTyr: 2.56 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.529HisAla: 1.529 ± 0.044
0.168HisCys: 0.168 ± 0.015
1.033HisAsp: 1.033 ± 0.033
1.465HisGlu: 1.465 ± 0.04
1.012HisPhe: 1.012 ± 0.041
1.434HisGly: 1.434 ± 0.045
0.519HisHis: 0.519 ± 0.027
1.46HisIle: 1.46 ± 0.04
0.916HisLys: 0.916 ± 0.034
2.006HisLeu: 2.006 ± 0.052
0.539HisMet: 0.539 ± 0.025
0.696HisAsn: 0.696 ± 0.029
1.109HisPro: 1.109 ± 0.04
0.682HisGln: 0.682 ± 0.029
0.857HisArg: 0.857 ± 0.03
1.15HisSer: 1.15 ± 0.039
1.111HisThr: 1.111 ± 0.035
1.476HisVal: 1.476 ± 0.033
0.187HisTrp: 0.187 ± 0.017
0.787HisTyr: 0.787 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.743IleAla: 6.743 ± 0.1
0.502IleCys: 0.502 ± 0.025
4.61IleAsp: 4.61 ± 0.082
5.731IleGlu: 5.731 ± 0.094
3.109IlePhe: 3.109 ± 0.078
6.436IleGly: 6.436 ± 0.114
1.778IleHis: 1.778 ± 0.046
6.003IleIle: 6.003 ± 0.104
3.769IleLys: 3.769 ± 0.064
6.792IleLeu: 6.792 ± 0.106
1.884IleMet: 1.884 ± 0.05
2.713IleAsn: 2.713 ± 0.064
3.394IlePro: 3.394 ± 0.063
2.685IleGln: 2.685 ± 0.058
3.396IleArg: 3.396 ± 0.063
4.78IleSer: 4.78 ± 0.073
4.266IleThr: 4.266 ± 0.076
6.056IleVal: 6.056 ± 0.103
0.639IleTrp: 0.639 ± 0.031
2.236IleTyr: 2.236 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.544LysAla: 4.544 ± 0.078
0.291LysCys: 0.291 ± 0.018
3.641LysAsp: 3.641 ± 0.071
6.194LysGlu: 6.194 ± 0.094
1.987LysPhe: 1.987 ± 0.046
4.335LysGly: 4.335 ± 0.077
1.1LysHis: 1.1 ± 0.038
4.13LysIle: 4.13 ± 0.07
5.682LysLys: 5.682 ± 0.09
5.661LysLeu: 5.661 ± 0.076
2.46LysMet: 2.46 ± 0.06
3.017LysAsn: 3.017 ± 0.061
2.222LysPro: 2.222 ± 0.055
2.394LysGln: 2.394 ± 0.052
3.395LysArg: 3.395 ± 0.071
3.761LysSer: 3.761 ± 0.071
3.841LysThr: 3.841 ± 0.066
4.668LysVal: 4.668 ± 0.074
0.824LysTrp: 0.824 ± 0.034
1.913LysTyr: 1.913 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
7.519LeuAla: 7.519 ± 0.104
0.556LeuCys: 0.556 ± 0.025
4.938LeuAsp: 4.938 ± 0.086
6.222LeuGlu: 6.222 ± 0.1
5.07LeuPhe: 5.07 ± 0.106
6.296LeuGly: 6.296 ± 0.09
1.988LeuHis: 1.988 ± 0.052
7.182LeuIle: 7.182 ± 0.105
6.163LeuLys: 6.163 ± 0.084
10.34LeuLeu: 10.34 ± 0.148
2.546LeuMet: 2.546 ± 0.063
3.811LeuAsn: 3.811 ± 0.061
3.862LeuPro: 3.862 ± 0.067
3.299LeuGln: 3.299 ± 0.06
3.754LeuArg: 3.754 ± 0.073
6.46LeuSer: 6.46 ± 0.084
5.951LeuThr: 5.951 ± 0.083
6.378LeuVal: 6.378 ± 0.087
0.774LeuTrp: 0.774 ± 0.035
3.05LeuTyr: 3.05 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.181MetAla: 2.181 ± 0.053
0.14MetCys: 0.14 ± 0.013
1.814MetAsp: 1.814 ± 0.042
2.229MetGlu: 2.229 ± 0.048
1.133MetPhe: 1.133 ± 0.042
1.891MetGly: 1.891 ± 0.056
0.547MetHis: 0.547 ± 0.023
2.129MetIle: 2.129 ± 0.056
2.782MetLys: 2.782 ± 0.049
2.562MetLeu: 2.562 ± 0.066
0.999MetMet: 0.999 ± 0.036
1.587MetAsn: 1.587 ± 0.043
1.123MetPro: 1.123 ± 0.036
1.024MetGln: 1.024 ± 0.035
1.238MetArg: 1.238 ± 0.039
1.679MetSer: 1.679 ± 0.046
2.12MetThr: 2.12 ± 0.049
1.68MetVal: 1.68 ± 0.05
0.208MetTrp: 0.208 ± 0.016
0.818MetTyr: 0.818 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.004AsnAla: 3.004 ± 0.057
0.275AsnCys: 0.275 ± 0.017
2.162AsnAsp: 2.162 ± 0.057
3.314AsnGlu: 3.314 ± 0.064
1.659AsnPhe: 1.659 ± 0.044
3.244AsnGly: 3.244 ± 0.064
0.891AsnHis: 0.891 ± 0.035
2.667AsnIle: 2.667 ± 0.058
2.434AsnLys: 2.434 ± 0.049
3.459AsnLeu: 3.459 ± 0.066
1.179AsnMet: 1.179 ± 0.034
1.617AsnAsn: 1.617 ± 0.058
2.127AsnPro: 2.127 ± 0.052
1.391AsnGln: 1.391 ± 0.047
2.048AsnArg: 2.048 ± 0.049
2.028AsnSer: 2.028 ± 0.049
2.024AsnThr: 2.024 ± 0.055
2.949AsnVal: 2.949 ± 0.059
0.46AsnTrp: 0.46 ± 0.026
1.449AsnTyr: 1.449 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.516ProAla: 2.516 ± 0.055
0.186ProCys: 0.186 ± 0.018
2.079ProAsp: 2.079 ± 0.053
2.99ProGlu: 2.99 ± 0.059
2.08ProPhe: 2.08 ± 0.059
2.475ProGly: 2.475 ± 0.063
0.797ProHis: 0.797 ± 0.035
2.919ProIle: 2.919 ± 0.052
2.031ProLys: 2.031 ± 0.048
3.505ProLeu: 3.505 ± 0.073
0.888ProMet: 0.888 ± 0.034
1.458ProAsn: 1.458 ± 0.037
1.097ProPro: 1.097 ± 0.044
0.985ProGln: 0.985 ± 0.036
1.142ProArg: 1.142 ± 0.036
2.307ProSer: 2.307 ± 0.057
2.115ProThr: 2.115 ± 0.053
3.014ProVal: 3.014 ± 0.068
0.336ProTrp: 0.336 ± 0.019
1.361ProTyr: 1.361 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.541GlnAla: 2.541 ± 0.054
0.167GlnCys: 0.167 ± 0.014
1.552GlnAsp: 1.552 ± 0.047
2.39GlnGlu: 2.39 ± 0.061
1.502GlnPhe: 1.502 ± 0.041
1.958GlnGly: 1.958 ± 0.049
0.678GlnHis: 0.678 ± 0.028
2.175GlnIle: 2.175 ± 0.051
2.299GlnLys: 2.299 ± 0.062
3.668GlnLeu: 3.668 ± 0.065
1.037GlnMet: 1.037 ± 0.036
1.316GlnAsn: 1.316 ± 0.039
1.089GlnPro: 1.089 ± 0.041
1.581GlnGln: 1.581 ± 0.048
1.473GlnArg: 1.473 ± 0.042
2.039GlnSer: 2.039 ± 0.045
1.915GlnThr: 1.915 ± 0.042
2.25GlnVal: 2.25 ± 0.052
0.364GlnTrp: 0.364 ± 0.02
1.08GlnTyr: 1.08 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.685ArgAla: 2.685 ± 0.063
0.252ArgCys: 0.252 ± 0.018
2.145ArgAsp: 2.145 ± 0.056
3.159ArgGlu: 3.159 ± 0.065
2.117ArgPhe: 2.117 ± 0.053
2.495ArgGly: 2.495 ± 0.055
0.889ArgHis: 0.889 ± 0.032
3.444ArgIle: 3.444 ± 0.068
3.342ArgLys: 3.342 ± 0.067
4.318ArgLeu: 4.318 ± 0.08
1.469ArgMet: 1.469 ± 0.042
1.8ArgAsn: 1.8 ± 0.046
1.43ArgPro: 1.43 ± 0.049
1.598ArgGln: 1.598 ± 0.045
1.849ArgArg: 1.849 ± 0.056
2.438ArgSer: 2.438 ± 0.046
2.29ArgThr: 2.29 ± 0.05
2.776ArgVal: 2.776 ± 0.057
0.402ArgTrp: 0.402 ± 0.023
1.468ArgTyr: 1.468 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.108SerAla: 4.108 ± 0.078
0.357SerCys: 0.357 ± 0.018
2.956SerAsp: 2.956 ± 0.061
3.931SerGlu: 3.931 ± 0.074
3.304SerPhe: 3.304 ± 0.071
4.67SerGly: 4.67 ± 0.074
1.072SerHis: 1.072 ± 0.032
5.022SerIle: 5.022 ± 0.076
3.657SerLys: 3.657 ± 0.069
5.886SerLeu: 5.886 ± 0.093
1.789SerMet: 1.789 ± 0.049
2.343SerAsn: 2.343 ± 0.058
2.137SerPro: 2.137 ± 0.049
1.717SerGln: 1.717 ± 0.041
2.468SerArg: 2.468 ± 0.057
3.719SerSer: 3.719 ± 0.071
3.452SerThr: 3.452 ± 0.073
4.435SerVal: 4.435 ± 0.071
0.579SerTrp: 0.579 ± 0.024
1.978SerTyr: 1.978 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.656ThrAla: 4.656 ± 0.083
0.33ThrCys: 0.33 ± 0.022
3.288ThrAsp: 3.288 ± 0.062
4.05ThrGlu: 4.05 ± 0.076
2.746ThrPhe: 2.746 ± 0.06
4.625ThrGly: 4.625 ± 0.078
1.165ThrHis: 1.165 ± 0.045
4.859ThrIle: 4.859 ± 0.087
3.295ThrLys: 3.295 ± 0.06
5.316ThrLeu: 5.316 ± 0.076
1.56ThrMet: 1.56 ± 0.039
2.295ThrAsn: 2.295 ± 0.054
2.39ThrPro: 2.39 ± 0.053
1.486ThrGln: 1.486 ± 0.044
2.003ThrArg: 2.003 ± 0.045
3.339ThrSer: 3.339 ± 0.062
3.234ThrThr: 3.234 ± 0.064
4.716ThrVal: 4.716 ± 0.079
0.462ThrTrp: 0.462 ± 0.024
2.004ThrTyr: 2.004 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.408ValAla: 5.408 ± 0.089
0.48ValCys: 0.48 ± 0.023
3.92ValAsp: 3.92 ± 0.068
5.029ValGlu: 5.029 ± 0.073
3.252ValPhe: 3.252 ± 0.073
4.877ValGly: 4.877 ± 0.078
1.412ValHis: 1.412 ± 0.037
5.767ValIle: 5.767 ± 0.093
4.732ValLys: 4.732 ± 0.078
7.227ValLeu: 7.227 ± 0.116
2.008ValMet: 2.008 ± 0.049
3.147ValAsn: 3.147 ± 0.065
2.811ValPro: 2.811 ± 0.06
2.247ValGln: 2.247 ± 0.042
2.943ValArg: 2.943 ± 0.067
4.517ValSer: 4.517 ± 0.081
4.51ValThr: 4.51 ± 0.071
5.319ValVal: 5.319 ± 0.089
0.575ValTrp: 0.575 ± 0.026
2.172ValTyr: 2.172 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.582TrpAla: 0.582 ± 0.026
0.064TrpCys: 0.064 ± 0.009
0.471TrpAsp: 0.471 ± 0.025
0.569TrpGlu: 0.569 ± 0.025
0.494TrpPhe: 0.494 ± 0.024
0.648TrpGly: 0.648 ± 0.03
0.187TrpHis: 0.187 ± 0.015
0.849TrpIle: 0.849 ± 0.033
0.725TrpLys: 0.725 ± 0.031
1.07TrpLeu: 1.07 ± 0.036
0.358TrpMet: 0.358 ± 0.021
0.471TrpAsn: 0.471 ± 0.023
0.245TrpPro: 0.245 ± 0.017
0.331TrpGln: 0.331 ± 0.019
0.401TrpArg: 0.401 ± 0.022
0.589TrpSer: 0.589 ± 0.026
0.575TrpThr: 0.575 ± 0.029
0.567TrpVal: 0.567 ± 0.027
0.107TrpTrp: 0.107 ± 0.012
0.289TrpTyr: 0.289 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.311TyrAla: 2.311 ± 0.055
0.264TyrCys: 0.264 ± 0.018
1.94TyrAsp: 1.94 ± 0.049
2.407TyrGlu: 2.407 ± 0.053
1.68TyrPhe: 1.68 ± 0.049
2.476TyrGly: 2.476 ± 0.055
0.645TyrHis: 0.645 ± 0.028
2.301TyrIle: 2.301 ± 0.056
2.021TyrLys: 2.021 ± 0.05
2.959TyrLeu: 2.959 ± 0.06
0.913TyrMet: 0.913 ± 0.033
1.266TyrAsn: 1.266 ± 0.041
1.305TyrPro: 1.305 ± 0.039
0.943TyrGln: 0.943 ± 0.031
1.49TyrArg: 1.49 ± 0.046
2.016TyrSer: 2.016 ± 0.055
1.857TyrThr: 1.857 ± 0.046
2.119TyrVal: 2.119 ± 0.048
0.315TyrTrp: 0.315 ± 0.02
1.158TyrTyr: 1.158 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3039 proteins (876302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski