Amino acid dipepetide frequency for Corynebacterium sphenisci DSM 44792

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	32.283AlaAla: 32.283 ± 0.566	1.06AlaCys: 1.06 ± 0.046	10.275AlaAsp: 10.275 ± 0.157	12.492AlaGlu: 12.492 ± 0.21	3.399AlaPhe: 3.399 ± 0.07	18.808AlaGly: 18.808 ± 0.257	2.773AlaHis: 2.773 ± 0.067	4.918AlaIle: 4.918 ± 0.086	2.697AlaLys: 2.697 ± 0.093	14.425AlaLeu: 14.425 ± 0.203	3.156AlaMet: 3.156 ± 0.085	2.229AlaAsn: 2.229 ± 0.062	8.564AlaPro: 8.564 ± 0.189	3.082AlaGln: 3.082 ± 0.065	11.851AlaArg: 11.851 ± 0.172	4.281AlaSer: 4.281 ± 0.086	6.952AlaThr: 6.952 ± 0.096	12.437AlaVal: 12.437 ± 0.177	1.926AlaTrp: 1.926 ± 0.059	2.09AlaTyr: 2.09 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.111CysAla: 1.111 ± 0.047	0.076CysCys: 0.076 ± 0.012	0.423CysAsp: 0.423 ± 0.028	0.33CysGlu: 0.33 ± 0.025	0.233CysPhe: 0.233 ± 0.021	0.921CysGly: 0.921 ± 0.047	0.158CysHis: 0.158 ± 0.015	0.267CysIle: 0.267 ± 0.021	0.071CysLys: 0.071 ± 0.012	0.654CysLeu: 0.654 ± 0.032	0.121CysMet: 0.121 ± 0.015	0.144CysAsn: 0.144 ± 0.016	0.508CysPro: 0.508 ± 0.037	0.102CysGln: 0.102 ± 0.014	0.548CysArg: 0.548 ± 0.036	0.337CysSer: 0.337 ± 0.021	0.472CysThr: 0.472 ± 0.03	0.528CysVal: 0.528 ± 0.029	0.106CysTrp: 0.106 ± 0.013	0.135CysTyr: 0.135 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.114AspAla: 9.114 ± 0.163	0.537AspCys: 0.537 ± 0.031	3.391AspAsp: 3.391 ± 0.082	3.8AspGlu: 3.8 ± 0.09	1.748AspPhe: 1.748 ± 0.06	5.862AspGly: 5.862 ± 0.116	1.326AspHis: 1.326 ± 0.049	2.253AspIle: 2.253 ± 0.066	1.035AspLys: 1.035 ± 0.053	6.372AspLeu: 6.372 ± 0.113	1.025AspMet: 1.025 ± 0.044	0.972AspAsn: 0.972 ± 0.047	5.819AspPro: 5.819 ± 0.115	1.248AspGln: 1.248 ± 0.051	5.398AspArg: 5.398 ± 0.107	2.387AspSer: 2.387 ± 0.058	2.499AspThr: 2.499 ± 0.063	4.472AspVal: 4.472 ± 0.093	1.004AspTrp: 1.004 ± 0.039	1.461AspTyr: 1.461 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	8.67GluAla: 8.67 ± 0.161	0.352GluCys: 0.352 ± 0.024	3.483GluAsp: 3.483 ± 0.09	4.185GluGlu: 4.185 ± 0.096	1.771GluPhe: 1.771 ± 0.051	5.01GluGly: 5.01 ± 0.105	1.474GluHis: 1.474 ± 0.052	2.896GluIle: 2.896 ± 0.068	1.137GluLys: 1.137 ± 0.055	7.267GluLeu: 7.267 ± 0.143	1.113GluMet: 1.113 ± 0.045	0.951GluAsn: 0.951 ± 0.04	3.652GluPro: 3.652 ± 0.103	1.766GluGln: 1.766 ± 0.046	5.307GluArg: 5.307 ± 0.093	2.257GluSer: 2.257 ± 0.065	2.394GluThr: 2.394 ± 0.062	5.692GluVal: 5.692 ± 0.115	0.659GluTrp: 0.659 ± 0.038	1.096GluTyr: 1.096 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.917PheAla: 3.917 ± 0.087	0.21PheCys: 0.21 ± 0.02	1.964PheAsp: 1.964 ± 0.058	1.385PheGlu: 1.385 ± 0.042	0.857PhePhe: 0.857 ± 0.04	3.072PheGly: 3.072 ± 0.073	0.589PheHis: 0.589 ± 0.033	1.175PheIle: 1.175 ± 0.046	0.366PheLys: 0.366 ± 0.022	2.569PheLeu: 2.569 ± 0.079	0.461PheMet: 0.461 ± 0.03	0.553PheAsn: 0.553 ± 0.032	1.26PhePro: 1.26 ± 0.05	0.527PheGln: 0.527 ± 0.033	1.819PheArg: 1.819 ± 0.064	1.268PheSer: 1.268 ± 0.05	1.976PheThr: 1.976 ± 0.063	1.819PheVal: 1.819 ± 0.06	0.362PheTrp: 0.362 ± 0.023	0.517PheTyr: 0.517 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	14.842GlyAla: 14.842 ± 0.18	0.921GlyCys: 0.921 ± 0.043	5.771GlyAsp: 5.771 ± 0.11	6.498GlyGlu: 6.498 ± 0.119	3.12GlyPhe: 3.12 ± 0.085	9.482GlyGly: 9.482 ± 0.181	2.151GlyHis: 2.151 ± 0.067	4.289GlyIle: 4.289 ± 0.09	1.94GlyLys: 1.94 ± 0.066	9.687GlyLeu: 9.687 ± 0.146	2.547GlyMet: 2.547 ± 0.07	1.598GlyAsn: 1.598 ± 0.059	5.312GlyPro: 5.312 ± 0.121	2.168GlyGln: 2.168 ± 0.061	8.705GlyArg: 8.705 ± 0.138	4.289GlySer: 4.289 ± 0.098	5.013GlyThr: 5.013 ± 0.081	8.535GlyVal: 8.535 ± 0.143	1.714GlyTrp: 1.714 ± 0.062	2.225GlyTyr: 2.225 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.58HisAla: 2.58 ± 0.066	0.154HisCys: 0.154 ± 0.015	1.301HisAsp: 1.301 ± 0.056	1.032HisGlu: 1.032 ± 0.039	0.482HisPhe: 0.482 ± 0.028	2.098HisGly: 2.098 ± 0.061	0.546HisHis: 0.546 ± 0.032	0.74HisIle: 0.74 ± 0.035	0.276HisLys: 0.276 ± 0.022	2.187HisLeu: 2.187 ± 0.059	0.309HisMet: 0.309 ± 0.025	0.357HisAsn: 0.357 ± 0.026	1.77HisPro: 1.77 ± 0.056	0.517HisGln: 0.517 ± 0.033	2.022HisArg: 2.022 ± 0.055	0.787HisSer: 0.787 ± 0.03	0.829HisThr: 0.829 ± 0.036	1.586HisVal: 1.586 ± 0.053	0.256HisTrp: 0.256 ± 0.02	0.456HisTyr: 0.456 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.438IleAla: 6.438 ± 0.114	0.322IleCys: 0.322 ± 0.023	2.904IleAsp: 2.904 ± 0.073	2.265IleGlu: 2.265 ± 0.067	0.901IlePhe: 0.901 ± 0.045	4.337IleGly: 4.337 ± 0.093	0.753IleHis: 0.753 ± 0.034	1.847IleIle: 1.847 ± 0.067	0.636IleLys: 0.636 ± 0.037	3.455IleLeu: 3.455 ± 0.079	0.589IleMet: 0.589 ± 0.032	0.768IleAsn: 0.768 ± 0.04	2.204IlePro: 2.204 ± 0.063	0.716IleGln: 0.716 ± 0.038	3.09IleArg: 3.09 ± 0.065	1.669IleSer: 1.669 ± 0.054	2.29IleThr: 2.29 ± 0.06	3.11IleVal: 3.11 ± 0.088	0.401IleTrp: 0.401 ± 0.029	0.68IleTyr: 0.68 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.159LysAla: 2.159 ± 0.081	0.104LysCys: 0.104 ± 0.016	0.9LysAsp: 0.9 ± 0.049	0.995LysGlu: 0.995 ± 0.046	0.408LysPhe: 0.408 ± 0.032	1.369LysGly: 1.369 ± 0.06	0.317LysHis: 0.317 ± 0.02	0.799LysIle: 0.799 ± 0.039	0.758LysLys: 0.758 ± 0.059	1.717LysLeu: 1.717 ± 0.065	0.399LysMet: 0.399 ± 0.027	0.436LysAsn: 0.436 ± 0.03	1.038LysPro: 1.038 ± 0.049	0.416LysGln: 0.416 ± 0.024	1.311LysArg: 1.311 ± 0.055	0.931LysSer: 0.931 ± 0.042	1.05LysThr: 1.05 ± 0.049	1.558LysVal: 1.558 ± 0.062	0.253LysTrp: 0.253 ± 0.021	0.421LysTyr: 0.421 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	17.641LeuAla: 17.641 ± 0.256	0.637LeuCys: 0.637 ± 0.033	7.125LeuAsp: 7.125 ± 0.115	4.597LeuGlu: 4.597 ± 0.08	2.407LeuPhe: 2.407 ± 0.074	10.03LeuGly: 10.03 ± 0.141	2.017LeuHis: 2.017 ± 0.063	3.803LeuIle: 3.803 ± 0.095	1.39LeuLys: 1.39 ± 0.059	10.268LeuLeu: 10.268 ± 0.177	1.671LeuMet: 1.671 ± 0.057	1.507LeuAsn: 1.507 ± 0.054	6.085LeuPro: 6.085 ± 0.112	1.804LeuGln: 1.804 ± 0.06	8.18LeuArg: 8.18 ± 0.127	4.086LeuSer: 4.086 ± 0.077	5.621LeuThr: 5.621 ± 0.117	8.459LeuVal: 8.459 ± 0.12	1.057LeuTrp: 1.057 ± 0.041	1.402LeuTyr: 1.402 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.933MetAla: 2.933 ± 0.082	0.154MetCys: 0.154 ± 0.016	1.032MetAsp: 1.032 ± 0.047	0.847MetGlu: 0.847 ± 0.046	0.561MetPhe: 0.561 ± 0.031	1.639MetGly: 1.639 ± 0.058	0.461MetHis: 0.461 ± 0.026	0.855MetIle: 0.855 ± 0.04	0.381MetLys: 0.381 ± 0.027	2.125MetLeu: 2.125 ± 0.066	0.419MetMet: 0.419 ± 0.031	0.456MetAsn: 0.456 ± 0.029	1.17MetPro: 1.17 ± 0.043	0.426MetGln: 0.426 ± 0.028	1.506MetArg: 1.506 ± 0.046	1.428MetSer: 1.428 ± 0.048	1.501MetThr: 1.501 ± 0.052	1.514MetVal: 1.514 ± 0.052	0.193MetTrp: 0.193 ± 0.018	0.281MetTyr: 0.281 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.03AsnAla: 2.03 ± 0.062	0.147AsnCys: 0.147 ± 0.015	0.868AsnAsp: 0.868 ± 0.044	0.852AsnGlu: 0.852 ± 0.041	0.494AsnPhe: 0.494 ± 0.027	1.352AsnGly: 1.352 ± 0.047	0.383AsnHis: 0.383 ± 0.027	0.802AsnIle: 0.802 ± 0.038	0.355AsnLys: 0.355 ± 0.033	1.918AsnLeu: 1.918 ± 0.062	0.413AsnMet: 0.413 ± 0.023	0.362AsnAsn: 0.362 ± 0.029	1.512AsnPro: 1.512 ± 0.058	0.421AsnGln: 0.421 ± 0.031	1.411AsnArg: 1.411 ± 0.05	0.774AsnSer: 0.774 ± 0.042	0.863AsnThr: 0.863 ± 0.036	1.306AsnVal: 1.306 ± 0.051	0.276AsnTrp: 0.276 ± 0.022	0.447AsnTyr: 0.447 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	11.295ProAla: 11.295 ± 0.244	0.307ProCys: 0.307 ± 0.023	4.135ProAsp: 4.135 ± 0.09	5.017ProGlu: 5.017 ± 0.118	1.307ProPhe: 1.307 ± 0.048	7.693ProGly: 7.693 ± 0.157	1.047ProHis: 1.047 ± 0.036	1.626ProIle: 1.626 ± 0.053	1.0ProLys: 1.0 ± 0.049	4.81ProLeu: 4.81 ± 0.098	1.164ProMet: 1.164 ± 0.044	0.933ProAsn: 0.933 ± 0.041	3.039ProPro: 3.039 ± 0.126	1.132ProGln: 1.132 ± 0.044	4.269ProArg: 4.269 ± 0.082	1.76ProSer: 1.76 ± 0.053	2.661ProThr: 2.661 ± 0.062	5.355ProVal: 5.355 ± 0.111	0.825ProTrp: 0.825 ± 0.04	0.936ProTyr: 0.936 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.795GlnAla: 2.795 ± 0.076	0.127GlnCys: 0.127 ± 0.013	1.023GlnAsp: 1.023 ± 0.042	1.184GlnGlu: 1.184 ± 0.048	0.579GlnPhe: 0.579 ± 0.034	1.509GlnGly: 1.509 ± 0.057	0.416GlnHis: 0.416 ± 0.022	0.929GlnIle: 0.929 ± 0.04	0.466GlnLys: 0.466 ± 0.029	2.605GlnLeu: 2.605 ± 0.073	0.533GlnMet: 0.533 ± 0.034	0.421GlnAsn: 0.421 ± 0.026	1.177GlnPro: 1.177 ± 0.05	0.669GlnGln: 0.669 ± 0.034	1.798GlnArg: 1.798 ± 0.056	0.809GlnSer: 0.809 ± 0.038	0.919GlnThr: 0.919 ± 0.046	2.06GlnVal: 2.06 ± 0.054	0.403GlnTrp: 0.403 ± 0.028	0.434GlnTyr: 0.434 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	11.31ArgAla: 11.31 ± 0.197	0.512ArgCys: 0.512 ± 0.028	4.477ArgAsp: 4.477 ± 0.097	5.225ArgGlu: 5.225 ± 0.099	2.27ArgPhe: 2.27 ± 0.06	7.288ArgGly: 7.288 ± 0.123	1.773ArgHis: 1.773 ± 0.06	3.927ArgIle: 3.927 ± 0.086	1.311ArgLys: 1.311 ± 0.052	8.568ArgLeu: 8.568 ± 0.139	2.055ArgMet: 2.055 ± 0.052	1.354ArgAsn: 1.354 ± 0.055	4.914ArgPro: 4.914 ± 0.102	1.756ArgGln: 1.756 ± 0.062	9.017ArgArg: 9.017 ± 0.179	2.932ArgSer: 2.932 ± 0.076	4.193ArgThr: 4.193 ± 0.092	6.928ArgVal: 6.928 ± 0.123	1.235ArgTrp: 1.235 ± 0.049	1.636ArgTyr: 1.636 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.567SerAla: 5.567 ± 0.1	0.289SerCys: 0.289 ± 0.023	1.94SerAsp: 1.94 ± 0.064	1.661SerGlu: 1.661 ± 0.056	1.35SerPhe: 1.35 ± 0.045	4.634SerGly: 4.634 ± 0.085	0.708SerHis: 0.708 ± 0.035	1.562SerIle: 1.562 ± 0.055	0.749SerLys: 0.749 ± 0.033	3.554SerLeu: 3.554 ± 0.08	1.02SerMet: 1.02 ± 0.041	0.703SerAsn: 0.703 ± 0.035	2.42SerPro: 2.42 ± 0.069	0.794SerGln: 0.794 ± 0.037	3.118SerArg: 3.118 ± 0.073	1.821SerSer: 1.821 ± 0.056	2.389SerThr: 2.389 ± 0.065	3.013SerVal: 3.013 ± 0.077	0.705SerTrp: 0.705 ± 0.039	0.895SerTyr: 0.895 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.589ThrAla: 7.589 ± 0.124	0.395ThrCys: 0.395 ± 0.026	2.494ThrAsp: 2.494 ± 0.068	2.483ThrGlu: 2.483 ± 0.07	1.281ThrPhe: 1.281 ± 0.06	6.116ThrGly: 6.116 ± 0.089	0.893ThrHis: 0.893 ± 0.038	2.098ThrIle: 2.098 ± 0.062	0.844ThrLys: 0.844 ± 0.043	5.075ThrLeu: 5.075 ± 0.097	1.068ThrMet: 1.068 ± 0.046	0.809ThrAsn: 0.809 ± 0.04	3.538ThrPro: 3.538 ± 0.067	0.86ThrGln: 0.86 ± 0.035	4.046ThrArg: 4.046 ± 0.093	2.057ThrSer: 2.057 ± 0.063	2.843ThrThr: 2.843 ± 0.076	5.023ThrVal: 5.023 ± 0.097	0.844ThrTrp: 0.844 ± 0.033	0.9ThrTyr: 0.9 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	12.918ValAla: 12.918 ± 0.194	0.647ValCys: 0.647 ± 0.036	6.403ValAsp: 6.403 ± 0.124	4.733ValGlu: 4.733 ± 0.088	2.364ValPhe: 2.364 ± 0.065	6.782ValGly: 6.782 ± 0.119	1.917ValHis: 1.917 ± 0.064	3.498ValIle: 3.498 ± 0.089	1.428ValLys: 1.428 ± 0.059	8.949ValLeu: 8.949 ± 0.149	1.321ValMet: 1.321 ± 0.044	1.773ValAsn: 1.773 ± 0.063	4.527ValPro: 4.527 ± 0.089	1.662ValGln: 1.662 ± 0.059	6.126ValArg: 6.126 ± 0.128	3.422ValSer: 3.422 ± 0.067	5.127ValThr: 5.127 ± 0.091	7.551ValVal: 7.551 ± 0.156	0.88ValTrp: 0.88 ± 0.038	1.337ValTyr: 1.337 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	2.111TrpAla: 2.111 ± 0.058	0.13TrpCys: 0.13 ± 0.015	0.636TrpAsp: 0.636 ± 0.029	0.588TrpGlu: 0.588 ± 0.026	0.53TrpPhe: 0.53 ± 0.03	0.967TrpGly: 0.967 ± 0.049	0.234TrpHis: 0.234 ± 0.021	0.505TrpIle: 0.505 ± 0.034	0.187TrpLys: 0.187 ± 0.017	1.585TrpLeu: 1.585 ± 0.051	0.243TrpMet: 0.243 ± 0.023	0.287TrpAsn: 0.287 ± 0.021	0.776TrpPro: 0.776 ± 0.037	0.355TrpGln: 0.355 ± 0.027	1.352TrpArg: 1.352 ± 0.059	0.748TrpSer: 0.748 ± 0.038	0.804TrpThr: 0.804 ± 0.039	1.047TrpVal: 1.047 ± 0.046	0.333TrpTrp: 0.333 ± 0.028	0.272TrpTyr: 0.272 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.394TyrAla: 2.394 ± 0.071	0.167TyrCys: 0.167 ± 0.016	1.179TyrAsp: 1.179 ± 0.048	0.964TyrGlu: 0.964 ± 0.04	0.603TyrPhe: 0.603 ± 0.034	1.837TyrGly: 1.837 ± 0.064	0.347TyrHis: 0.347 ± 0.024	0.584TyrIle: 0.584 ± 0.034	0.312TyrLys: 0.312 ± 0.026	1.997TyrLeu: 1.997 ± 0.054	0.253TyrMet: 0.253 ± 0.022	0.376TyrAsn: 0.376 ± 0.027	1.027TyrPro: 1.027 ± 0.046	0.434TyrGln: 0.434 ± 0.023	1.808TyrArg: 1.808 ± 0.064	0.85TyrSer: 0.85 ± 0.036	0.858TyrThr: 0.858 ± 0.045	1.37TyrVal: 1.37 ± 0.05	0.261TyrTrp: 0.261 ± 0.018	0.411TyrTyr: 0.411 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1827 proteins (605766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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