Amino acid dipepetide frequency for Desulfovibrio litoralis DSM 11393

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.287AlaAla: 5.287 ± 0.113	1.166AlaCys: 1.166 ± 0.043	3.839AlaAsp: 3.839 ± 0.076	5.141AlaGlu: 5.141 ± 0.098	3.587AlaPhe: 3.587 ± 0.068	5.287AlaGly: 5.287 ± 0.108	1.383AlaHis: 1.383 ± 0.041	5.114AlaIle: 5.114 ± 0.084	5.825AlaLys: 5.825 ± 0.099	9.288AlaLeu: 9.288 ± 0.129	1.874AlaMet: 1.874 ± 0.049	3.31AlaAsn: 3.31 ± 0.068	2.311AlaPro: 2.311 ± 0.065	2.988AlaGln: 2.988 ± 0.066	2.949AlaArg: 2.949 ± 0.065	4.684AlaSer: 4.684 ± 0.092	4.0AlaThr: 4.0 ± 0.08	5.117AlaVal: 5.117 ± 0.095	0.848AlaTrp: 0.848 ± 0.034	2.458AlaTyr: 2.458 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.805CysAla: 0.805 ± 0.035	0.263CysCys: 0.263 ± 0.018	0.589CysAsp: 0.589 ± 0.029	0.626CysGlu: 0.626 ± 0.03	0.651CysPhe: 0.651 ± 0.03	0.972CysGly: 0.972 ± 0.042	0.287CysHis: 0.287 ± 0.026	0.913CysIle: 0.913 ± 0.034	0.706CysLys: 0.706 ± 0.031	1.434CysLeu: 1.434 ± 0.042	0.276CysMet: 0.276 ± 0.019	0.542CysAsn: 0.542 ± 0.031	0.689CysPro: 0.689 ± 0.033	0.427CysGln: 0.427 ± 0.029	0.486CysArg: 0.486 ± 0.026	0.907CysSer: 0.907 ± 0.034	0.656CysThr: 0.656 ± 0.029	0.79CysVal: 0.79 ± 0.033	0.118CysTrp: 0.118 ± 0.012	0.396CysTyr: 0.396 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.661AspAla: 3.661 ± 0.071	0.661AspCys: 0.661 ± 0.03	2.265AspAsp: 2.265 ± 0.06	3.18AspGlu: 3.18 ± 0.075	2.65AspPhe: 2.65 ± 0.068	3.104AspGly: 3.104 ± 0.102	0.774AspHis: 0.774 ± 0.032	4.088AspIle: 4.088 ± 0.088	3.802AspLys: 3.802 ± 0.069	5.329AspLeu: 5.329 ± 0.071	1.137AspMet: 1.137 ± 0.036	2.759AspAsn: 2.759 ± 0.074	2.078AspPro: 2.078 ± 0.053	1.491AspGln: 1.491 ± 0.044	1.717AspArg: 1.717 ± 0.054	3.142AspSer: 3.142 ± 0.068	2.376AspThr: 2.376 ± 0.064	2.954AspVal: 2.954 ± 0.078	0.64AspTrp: 0.64 ± 0.033	1.789AspTyr: 1.789 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.446GluAla: 5.446 ± 0.092	0.555GluCys: 0.555 ± 0.027	2.834GluAsp: 2.834 ± 0.07	4.49GluGlu: 4.49 ± 0.089	2.607GluPhe: 2.607 ± 0.057	3.224GluGly: 3.224 ± 0.079	1.325GluHis: 1.325 ± 0.044	4.552GluIle: 4.552 ± 0.079	5.535GluLys: 5.535 ± 0.094	8.134GluLeu: 8.134 ± 0.127	1.469GluMet: 1.469 ± 0.042	3.874GluAsn: 3.874 ± 0.08	1.96GluPro: 1.96 ± 0.056	3.272GluGln: 3.272 ± 0.075	3.187GluArg: 3.187 ± 0.071	3.393GluSer: 3.393 ± 0.066	3.505GluThr: 3.505 ± 0.074	3.716GluVal: 3.716 ± 0.078	0.594GluTrp: 0.594 ± 0.028	2.046GluTyr: 2.046 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.295PheAla: 3.295 ± 0.066	0.727PheCys: 0.727 ± 0.034	2.492PheAsp: 2.492 ± 0.057	2.712PheGlu: 2.712 ± 0.059	2.63PhePhe: 2.63 ± 0.077	3.078PheGly: 3.078 ± 0.071	0.698PheHis: 0.698 ± 0.029	3.647PheIle: 3.647 ± 0.081	2.779PheLys: 2.779 ± 0.066	4.758PheLeu: 4.758 ± 0.097	1.122PheMet: 1.122 ± 0.038	2.518PheAsn: 2.518 ± 0.056	1.691PhePro: 1.691 ± 0.045	1.203PheGln: 1.203 ± 0.036	1.515PheArg: 1.515 ± 0.045	4.006PheSer: 4.006 ± 0.084	2.392PheThr: 2.392 ± 0.061	2.889PheVal: 2.889 ± 0.06	0.583PheTrp: 0.583 ± 0.028	1.659PheTyr: 1.659 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.885GlyAla: 4.885 ± 0.101	0.888GlyCys: 0.888 ± 0.035	2.994GlyAsp: 2.994 ± 0.081	3.742GlyGlu: 3.742 ± 0.069	3.323GlyPhe: 3.323 ± 0.075	4.758GlyGly: 4.758 ± 0.128	1.262GlyHis: 1.262 ± 0.041	4.926GlyIle: 4.926 ± 0.087	4.432GlyLys: 4.432 ± 0.077	6.778GlyLeu: 6.778 ± 0.103	1.707GlyMet: 1.707 ± 0.048	2.695GlyAsn: 2.695 ± 0.075	1.406GlyPro: 1.406 ± 0.046	2.155GlyGln: 2.155 ± 0.056	2.816GlyArg: 2.816 ± 0.068	4.086GlySer: 4.086 ± 0.092	3.653GlyThr: 3.653 ± 0.107	4.708GlyVal: 4.708 ± 0.083	0.631GlyTrp: 0.631 ± 0.031	2.188GlyTyr: 2.188 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.302HisAla: 1.302 ± 0.041	0.286HisCys: 0.286 ± 0.017	0.884HisAsp: 0.884 ± 0.036	1.037HisGlu: 1.037 ± 0.037	0.888HisPhe: 0.888 ± 0.035	1.218HisGly: 1.218 ± 0.045	0.41HisHis: 0.41 ± 0.024	1.445HisIle: 1.445 ± 0.043	1.24HisLys: 1.24 ± 0.043	1.99HisLeu: 1.99 ± 0.056	0.329HisMet: 0.329 ± 0.021	1.027HisAsn: 1.027 ± 0.036	0.938HisPro: 0.938 ± 0.039	0.626HisGln: 0.626 ± 0.025	0.639HisArg: 0.639 ± 0.032	1.304HisSer: 1.304 ± 0.039	0.889HisThr: 0.889 ± 0.036	0.88HisVal: 0.88 ± 0.03	0.216HisTrp: 0.216 ± 0.016	0.669HisTyr: 0.669 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.492IleAla: 5.492 ± 0.083	0.904IleCys: 0.904 ± 0.037	3.754IleAsp: 3.754 ± 0.069	4.646IleGlu: 4.646 ± 0.084	3.291IlePhe: 3.291 ± 0.086	4.399IleGly: 4.399 ± 0.084	1.238IleHis: 1.238 ± 0.04	5.417IleIle: 5.417 ± 0.101	5.45IleLys: 5.45 ± 0.092	7.555IleLeu: 7.555 ± 0.108	1.522IleMet: 1.522 ± 0.055	3.976IleAsn: 3.976 ± 0.084	3.205IlePro: 3.205 ± 0.067	2.443IleGln: 2.443 ± 0.063	2.548IleArg: 2.548 ± 0.059	5.107IleSer: 5.107 ± 0.093	3.871IleThr: 3.871 ± 0.096	4.44IleVal: 4.44 ± 0.081	0.663IleTrp: 0.663 ± 0.028	2.126IleTyr: 2.126 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.807LysAla: 5.807 ± 0.105	0.568LysCys: 0.568 ± 0.031	4.289LysAsp: 4.289 ± 0.092	5.915LysGlu: 5.915 ± 0.114	2.022LysPhe: 2.022 ± 0.07	3.912LysGly: 3.912 ± 0.068	1.337LysHis: 1.337 ± 0.044	5.288LysIle: 5.288 ± 0.093	5.834LysLys: 5.834 ± 0.113	6.693LysLeu: 6.693 ± 0.089	1.823LysMet: 1.823 ± 0.049	4.821LysAsn: 4.821 ± 0.085	2.514LysPro: 2.514 ± 0.05	3.106LysGln: 3.106 ± 0.074	3.088LysArg: 3.088 ± 0.063	3.61LysSer: 3.61 ± 0.067	4.327LysThr: 4.327 ± 0.075	4.13LysVal: 4.13 ± 0.086	0.559LysTrp: 0.559 ± 0.026	2.007LysTyr: 2.007 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	9.016LeuAla: 9.016 ± 0.142	1.562LeuCys: 1.562 ± 0.044	5.27LeuAsp: 5.27 ± 0.078	7.277LeuGlu: 7.277 ± 0.105	5.054LeuPhe: 5.054 ± 0.091	7.2LeuGly: 7.2 ± 0.115	1.826LeuHis: 1.826 ± 0.043	6.994LeuIle: 6.994 ± 0.113	7.878LeuLys: 7.878 ± 0.105	11.023LeuLeu: 11.023 ± 0.182	2.392LeuMet: 2.392 ± 0.062	5.984LeuAsn: 5.984 ± 0.095	4.916LeuPro: 4.916 ± 0.088	3.374LeuGln: 3.374 ± 0.072	4.389LeuArg: 4.389 ± 0.074	8.408LeuSer: 8.408 ± 0.116	5.514LeuThr: 5.514 ± 0.095	6.11LeuVal: 6.11 ± 0.098	1.02LeuTrp: 1.02 ± 0.041	2.886LeuTyr: 2.886 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.832MetAla: 1.832 ± 0.051	0.2MetCys: 0.2 ± 0.018	1.009MetAsp: 1.009 ± 0.038	1.206MetGlu: 1.206 ± 0.039	0.996MetPhe: 0.996 ± 0.036	1.539MetGly: 1.539 ± 0.046	0.432MetHis: 0.432 ± 0.025	1.363MetIle: 1.363 ± 0.045	1.46MetLys: 1.46 ± 0.05	2.567MetLeu: 2.567 ± 0.072	0.479MetMet: 0.479 ± 0.025	1.194MetAsn: 1.194 ± 0.039	1.283MetPro: 1.283 ± 0.043	1.129MetGln: 1.129 ± 0.04	1.124MetArg: 1.124 ± 0.037	1.761MetSer: 1.761 ± 0.043	1.168MetThr: 1.168 ± 0.037	1.197MetVal: 1.197 ± 0.038	0.188MetTrp: 0.188 ± 0.015	0.554MetTyr: 0.554 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.091AsnAla: 4.091 ± 0.089	0.617AsnCys: 0.617 ± 0.031	2.454AsnAsp: 2.454 ± 0.073	2.921AsnGlu: 2.921 ± 0.063	2.384AsnPhe: 2.384 ± 0.057	2.963AsnGly: 2.963 ± 0.087	0.845AsnHis: 0.845 ± 0.033	5.036AsnIle: 5.036 ± 0.095	4.132AsnLys: 4.132 ± 0.091	5.293AsnLeu: 5.293 ± 0.09	1.216AsnMet: 1.216 ± 0.037	3.613AsnAsn: 3.613 ± 0.082	2.556AsnPro: 2.556 ± 0.059	2.103AsnGln: 2.103 ± 0.062	1.649AsnArg: 1.649 ± 0.051	3.855AsnSer: 3.855 ± 0.078	3.284AsnThr: 3.284 ± 0.084	2.733AsnVal: 2.733 ± 0.069	0.535AsnTrp: 0.535 ± 0.026	1.568AsnTyr: 1.568 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.569ProAla: 2.569 ± 0.056	0.484ProCys: 0.484 ± 0.025	2.32ProAsp: 2.32 ± 0.053	3.303ProGlu: 3.303 ± 0.072	2.002ProPhe: 2.002 ± 0.052	2.06ProGly: 2.06 ± 0.056	0.744ProHis: 0.744 ± 0.035	2.538ProIle: 2.538 ± 0.063	2.72ProLys: 2.72 ± 0.058	4.303ProLeu: 4.303 ± 0.086	0.812ProMet: 0.812 ± 0.03	2.239ProAsn: 2.239 ± 0.055	1.42ProPro: 1.42 ± 0.051	1.66ProGln: 1.66 ± 0.058	1.296ProArg: 1.296 ± 0.044	2.468ProSer: 2.468 ± 0.058	1.959ProThr: 1.959 ± 0.062	2.706ProVal: 2.706 ± 0.062	0.444ProTrp: 0.444 ± 0.023	1.348ProTyr: 1.348 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.508GlnAla: 3.508 ± 0.068	0.343GlnCys: 0.343 ± 0.023	1.887GlnAsp: 1.887 ± 0.046	2.826GlnGlu: 2.826 ± 0.062	1.079GlnPhe: 1.079 ± 0.034	2.365GlnGly: 2.365 ± 0.064	0.769GlnHis: 0.769 ± 0.031	2.447GlnIle: 2.447 ± 0.053	3.06GlnLys: 3.06 ± 0.07	3.313GlnLeu: 3.313 ± 0.074	0.885GlnMet: 0.885 ± 0.036	2.496GlnAsn: 2.496 ± 0.068	1.304GlnPro: 1.304 ± 0.048	1.612GlnGln: 1.612 ± 0.063	1.608GlnArg: 1.608 ± 0.04	2.272GlnSer: 2.272 ± 0.051	2.282GlnThr: 2.282 ± 0.061	2.16GlnVal: 2.16 ± 0.058	0.297GlnTrp: 0.297 ± 0.019	1.018GlnTyr: 1.018 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.597ArgAla: 2.597 ± 0.066	0.502ArgCys: 0.502 ± 0.029	1.784ArgAsp: 1.784 ± 0.048	2.658ArgGlu: 2.658 ± 0.06	2.088ArgPhe: 2.088 ± 0.059	2.191ArgGly: 2.191 ± 0.06	0.775ArgHis: 0.775 ± 0.032	3.127ArgIle: 3.127 ± 0.063	2.668ArgLys: 2.668 ± 0.065	4.78ArgLeu: 4.78 ± 0.091	1.061ArgMet: 1.061 ± 0.04	1.885ArgAsn: 1.885 ± 0.043	1.533ArgPro: 1.533 ± 0.062	1.559ArgGln: 1.559 ± 0.043	1.777ArgArg: 1.777 ± 0.046	2.562ArgSer: 2.562 ± 0.063	1.849ArgThr: 1.849 ± 0.05	2.306ArgVal: 2.306 ± 0.051	0.424ArgTrp: 0.424 ± 0.024	1.447ArgTyr: 1.447 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.619SerAla: 4.619 ± 0.087	0.872SerCys: 0.872 ± 0.037	3.149SerAsp: 3.149 ± 0.074	4.428SerGlu: 4.428 ± 0.083	3.585SerPhe: 3.585 ± 0.078	5.334SerGly: 5.334 ± 0.117	1.205SerHis: 1.205 ± 0.045	4.437SerIle: 4.437 ± 0.084	4.01SerLys: 4.01 ± 0.072	7.878SerLeu: 7.878 ± 0.11	1.414SerMet: 1.414 ± 0.043	2.917SerAsn: 2.917 ± 0.061	2.553SerPro: 2.553 ± 0.059	2.463SerGln: 2.463 ± 0.055	2.481SerArg: 2.481 ± 0.056	4.886SerSer: 4.886 ± 0.094	3.324SerThr: 3.324 ± 0.066	4.44SerVal: 4.44 ± 0.087	0.722SerTrp: 0.722 ± 0.035	2.043SerTyr: 2.043 ± 0.055	0.001SerXaa: 0.001 ± 0.002
Thr	4.308ThrAla: 4.308 ± 0.072	0.532ThrCys: 0.532 ± 0.03	2.472ThrAsp: 2.472 ± 0.068	3.314ThrGlu: 3.314 ± 0.075	2.284ThrPhe: 2.284 ± 0.062	3.611ThrGly: 3.611 ± 0.086	1.033ThrHis: 1.033 ± 0.037	3.834ThrIle: 3.834 ± 0.087	3.48ThrLys: 3.48 ± 0.07	5.874ThrLeu: 5.874 ± 0.092	1.025ThrMet: 1.025 ± 0.036	2.542ThrAsn: 2.542 ± 0.08	3.102ThrPro: 3.102 ± 0.069	2.319ThrGln: 2.319 ± 0.053	1.923ThrArg: 1.923 ± 0.052	2.932ThrSer: 2.932 ± 0.066	3.104ThrThr: 3.104 ± 0.083	3.485ThrVal: 3.485 ± 0.078	0.531ThrTrp: 0.531 ± 0.025	1.43ThrTyr: 1.43 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.909ValAla: 4.909 ± 0.075	0.848ValCys: 0.848 ± 0.034	3.238ValAsp: 3.238 ± 0.066	3.977ValGlu: 3.977 ± 0.075	3.109ValPhe: 3.109 ± 0.079	3.998ValGly: 3.998 ± 0.078	1.031ValHis: 1.031 ± 0.035	4.164ValIle: 4.164 ± 0.079	4.069ValLys: 4.069 ± 0.077	6.671ValLeu: 6.671 ± 0.093	1.362ValMet: 1.362 ± 0.04	3.147ValAsn: 3.147 ± 0.082	2.394ValPro: 2.394 ± 0.06	1.895ValGln: 1.895 ± 0.052	2.478ValArg: 2.478 ± 0.061	4.404ValSer: 4.404 ± 0.085	2.797ValThr: 2.797 ± 0.063	4.113ValVal: 4.113 ± 0.087	0.579ValTrp: 0.579 ± 0.027	1.928ValTyr: 1.928 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.034	0.109TrpCys: 0.109 ± 0.011	0.445TrpAsp: 0.445 ± 0.025	0.664TrpGlu: 0.664 ± 0.029	0.448TrpPhe: 0.448 ± 0.024	0.684TrpGly: 0.684 ± 0.032	0.244TrpHis: 0.244 ± 0.018	0.634TrpIle: 0.634 ± 0.027	0.592TrpLys: 0.592 ± 0.029	1.275TrpLeu: 1.275 ± 0.047	0.185TrpMet: 0.185 ± 0.015	0.579TrpAsn: 0.579 ± 0.026	0.193TrpPro: 0.193 ± 0.016	0.526TrpGln: 0.526 ± 0.028	0.604TrpArg: 0.604 ± 0.027	0.652TrpSer: 0.652 ± 0.031	0.484TrpThr: 0.484 ± 0.024	0.611TrpVal: 0.611 ± 0.032	0.171TrpTrp: 0.171 ± 0.018	0.293TrpTyr: 0.293 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.311TyrAla: 2.311 ± 0.059	0.446TyrCys: 0.446 ± 0.027	1.627TyrAsp: 1.627 ± 0.048	1.656TyrGlu: 1.656 ± 0.057	1.716TyrPhe: 1.716 ± 0.055	2.133TyrGly: 2.133 ± 0.066	0.599TyrHis: 0.599 ± 0.029	2.083TyrIle: 2.083 ± 0.059	1.976TyrLys: 1.976 ± 0.053	3.157TyrLeu: 3.157 ± 0.065	0.593TyrMet: 0.593 ± 0.027	1.729TyrAsn: 1.729 ± 0.045	1.349TyrPro: 1.349 ± 0.047	1.179TyrGln: 1.179 ± 0.037	1.299TyrArg: 1.299 ± 0.046	2.322TyrSer: 2.322 ± 0.058	1.701TyrThr: 1.701 ± 0.048	1.629TyrVal: 1.629 ± 0.041	0.346TyrTrp: 0.346 ± 0.025	1.257TyrTyr: 1.257 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 2355 proteins (790836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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