Amino acid dipepetide frequency for Taibaiella sp. KBW10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.569AlaAla: 7.569 ± 0.115
0.806AlaCys: 0.806 ± 0.032
3.989AlaAsp: 3.989 ± 0.057
3.988AlaGlu: 3.988 ± 0.077
3.532AlaPhe: 3.532 ± 0.065
5.73AlaGly: 5.73 ± 0.094
1.566AlaHis: 1.566 ± 0.04
5.716AlaIle: 5.716 ± 0.088
4.724AlaLys: 4.724 ± 0.085
7.939AlaLeu: 7.939 ± 0.109
1.824AlaMet: 1.824 ± 0.049
4.002AlaAsn: 4.002 ± 0.085
2.889AlaPro: 2.889 ± 0.062
4.012AlaGln: 4.012 ± 0.067
2.414AlaArg: 2.414 ± 0.057
4.565AlaSer: 4.565 ± 0.084
5.531AlaThr: 5.531 ± 0.122
4.934AlaVal: 4.934 ± 0.079
0.732AlaTrp: 0.732 ± 0.027
3.417AlaTyr: 3.417 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.036
0.137CysCys: 0.137 ± 0.014
0.505CysAsp: 0.505 ± 0.025
0.39CysGlu: 0.39 ± 0.02
0.475CysPhe: 0.475 ± 0.022
0.812CysGly: 0.812 ± 0.031
0.185CysHis: 0.185 ± 0.015
0.715CysIle: 0.715 ± 0.033
0.539CysLys: 0.539 ± 0.026
0.815CysLeu: 0.815 ± 0.03
0.22CysMet: 0.22 ± 0.014
0.501CysAsn: 0.501 ± 0.027
0.412CysPro: 0.412 ± 0.024
0.233CysGln: 0.233 ± 0.016
0.326CysArg: 0.326 ± 0.019
0.727CysSer: 0.727 ± 0.03
0.674CysThr: 0.674 ± 0.029
0.532CysVal: 0.532 ± 0.026
0.094CysTrp: 0.094 ± 0.01
0.362CysTyr: 0.362 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.095AspAla: 4.095 ± 0.065
0.457AspCys: 0.457 ± 0.021
2.054AspAsp: 2.054 ± 0.053
2.627AspGlu: 2.627 ± 0.057
2.751AspPhe: 2.751 ± 0.055
3.515AspGly: 3.515 ± 0.068
0.968AspHis: 0.968 ± 0.032
3.959AspIle: 3.959 ± 0.065
3.715AspLys: 3.715 ± 0.07
4.35AspLeu: 4.35 ± 0.081
1.237AspMet: 1.237 ± 0.036
2.646AspAsn: 2.646 ± 0.056
1.854AspPro: 1.854 ± 0.054
1.718AspGln: 1.718 ± 0.041
2.011AspArg: 2.011 ± 0.064
2.725AspSer: 2.725 ± 0.057
3.139AspThr: 3.139 ± 0.058
2.965AspVal: 2.965 ± 0.056
0.721AspTrp: 0.721 ± 0.021
2.452AspTyr: 2.452 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.607GluAla: 4.607 ± 0.09
0.318GluCys: 0.318 ± 0.018
2.654GluAsp: 2.654 ± 0.057
3.751GluGlu: 3.751 ± 0.081
1.785GluPhe: 1.785 ± 0.045
3.497GluGly: 3.497 ± 0.055
1.237GluHis: 1.237 ± 0.035
3.723GluIle: 3.723 ± 0.067
4.024GluLys: 4.024 ± 0.078
4.965GluLeu: 4.965 ± 0.09
1.509GluMet: 1.509 ± 0.039
2.812GluAsn: 2.812 ± 0.054
1.473GluPro: 1.473 ± 0.04
3.07GluGln: 3.07 ± 0.068
2.356GluArg: 2.356 ± 0.053
2.627GluSer: 2.627 ± 0.051
3.001GluThr: 3.001 ± 0.067
3.571GluVal: 3.571 ± 0.071
0.659GluTrp: 0.659 ± 0.028
2.001GluTyr: 2.001 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.404PheAla: 3.404 ± 0.061
0.496PheCys: 0.496 ± 0.024
2.619PheAsp: 2.619 ± 0.05
2.689PheGlu: 2.689 ± 0.056
2.222PhePhe: 2.222 ± 0.055
3.238PheGly: 3.238 ± 0.06
0.784PheHis: 0.784 ± 0.028
3.277PheIle: 3.277 ± 0.06
2.967PheLys: 2.967 ± 0.047
4.163PheLeu: 4.163 ± 0.085
1.082PheMet: 1.082 ± 0.033
2.799PheAsn: 2.799 ± 0.063
1.714PhePro: 1.714 ± 0.044
1.411PheGln: 1.411 ± 0.039
1.66PheArg: 1.66 ± 0.04
3.489PheSer: 3.489 ± 0.062
3.09PheThr: 3.09 ± 0.06
2.827PheVal: 2.827 ± 0.063
0.55PheTrp: 0.55 ± 0.027
2.054PheTyr: 2.054 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.225GlyAla: 5.225 ± 0.089
0.779GlyCys: 0.779 ± 0.032
3.011GlyAsp: 3.011 ± 0.062
2.763GlyGlu: 2.763 ± 0.064
3.432GlyPhe: 3.432 ± 0.07
4.954GlyGly: 4.954 ± 0.095
1.216GlyHis: 1.216 ± 0.035
5.601GlyIle: 5.601 ± 0.079
4.789GlyLys: 4.789 ± 0.08
6.378GlyLeu: 6.378 ± 0.085
1.898GlyMet: 1.898 ± 0.044
4.105GlyAsn: 4.105 ± 0.084
1.46GlyPro: 1.46 ± 0.045
2.489GlyGln: 2.489 ± 0.055
2.313GlyArg: 2.313 ± 0.046
4.555GlySer: 4.555 ± 0.09
5.291GlyThr: 5.291 ± 0.126
4.216GlyVal: 4.216 ± 0.085
0.829GlyTrp: 0.829 ± 0.028
3.004GlyTyr: 3.004 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.184HisAla: 1.184 ± 0.033
0.251HisCys: 0.251 ± 0.016
0.731HisAsp: 0.731 ± 0.029
0.834HisGlu: 0.834 ± 0.031
1.201HisPhe: 1.201 ± 0.034
0.955HisGly: 0.955 ± 0.03
0.596HisHis: 0.596 ± 0.025
1.608HisIle: 1.608 ± 0.041
1.32HisLys: 1.32 ± 0.04
1.875HisLeu: 1.875 ± 0.046
0.358HisMet: 0.358 ± 0.019
1.109HisAsn: 1.109 ± 0.033
1.003HisPro: 1.003 ± 0.033
0.855HisGln: 0.855 ± 0.03
0.741HisArg: 0.741 ± 0.025
1.106HisSer: 1.106 ± 0.034
1.261HisThr: 1.261 ± 0.035
0.858HisVal: 0.858 ± 0.033
0.284HisTrp: 0.284 ± 0.019
1.021HisTyr: 1.021 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.304IleAla: 6.304 ± 0.092
0.828IleCys: 0.828 ± 0.034
4.267IleAsp: 4.267 ± 0.069
4.114IleGlu: 4.114 ± 0.074
3.084IlePhe: 3.084 ± 0.063
5.004IleGly: 5.004 ± 0.08
1.416IleHis: 1.416 ± 0.035
5.075IleIle: 5.075 ± 0.076
4.691IleLys: 4.691 ± 0.076
6.252IleLeu: 6.252 ± 0.096
1.475IleMet: 1.475 ± 0.039
4.123IleAsn: 4.123 ± 0.081
3.346IlePro: 3.346 ± 0.057
2.623IleGln: 2.623 ± 0.052
2.787IleArg: 2.787 ± 0.052
4.855IleSer: 4.855 ± 0.071
4.717IleThr: 4.717 ± 0.078
4.487IleVal: 4.487 ± 0.068
0.686IleTrp: 0.686 ± 0.022
2.693IleTyr: 2.693 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.218LysAla: 5.218 ± 0.087
0.36LysCys: 0.36 ± 0.024
4.005LysAsp: 4.005 ± 0.075
4.885LysGlu: 4.885 ± 0.09
2.193LysPhe: 2.193 ± 0.053
4.554LysGly: 4.554 ± 0.084
1.205LysHis: 1.205 ± 0.033
4.976LysIle: 4.976 ± 0.081
5.154LysLys: 5.154 ± 0.092
5.063LysLeu: 5.063 ± 0.071
2.097LysMet: 2.097 ± 0.047
3.804LysAsn: 3.804 ± 0.068
2.485LysPro: 2.485 ± 0.061
2.907LysGln: 2.907 ± 0.06
2.502LysArg: 2.502 ± 0.057
3.643LysSer: 3.643 ± 0.061
3.914LysThr: 3.914 ± 0.07
4.363LysVal: 4.363 ± 0.065
0.745LysTrp: 0.745 ± 0.024
2.589LysTyr: 2.589 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
6.817LeuAla: 6.817 ± 0.1
1.04LeuCys: 1.04 ± 0.034
4.408LeuAsp: 4.408 ± 0.063
4.699LeuGlu: 4.699 ± 0.09
4.342LeuPhe: 4.342 ± 0.078
5.897LeuGly: 5.897 ± 0.076
1.813LeuHis: 1.813 ± 0.046
6.09LeuIle: 6.09 ± 0.096
6.478LeuLys: 6.478 ± 0.097
9.585LeuLeu: 9.585 ± 0.145
2.286LeuMet: 2.286 ± 0.054
5.185LeuAsn: 5.185 ± 0.082
4.133LeuPro: 4.133 ± 0.068
4.301LeuGln: 4.301 ± 0.08
3.383LeuArg: 3.383 ± 0.063
7.582LeuSer: 7.582 ± 0.091
4.902LeuThr: 4.902 ± 0.076
5.087LeuVal: 5.087 ± 0.075
0.94LeuTrp: 0.94 ± 0.036
3.513LeuTyr: 3.513 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.986MetAla: 1.986 ± 0.044
0.155MetCys: 0.155 ± 0.013
1.25MetAsp: 1.25 ± 0.033
1.394MetGlu: 1.394 ± 0.036
0.847MetPhe: 0.847 ± 0.032
1.612MetGly: 1.612 ± 0.034
0.518MetHis: 0.518 ± 0.022
1.673MetIle: 1.673 ± 0.04
1.992MetLys: 1.992 ± 0.04
2.236MetLeu: 2.236 ± 0.05
0.755MetMet: 0.755 ± 0.03
1.385MetAsn: 1.385 ± 0.035
1.199MetPro: 1.199 ± 0.033
1.142MetGln: 1.142 ± 0.036
1.0MetArg: 1.0 ± 0.029
1.529MetSer: 1.529 ± 0.038
1.302MetThr: 1.302 ± 0.038
1.527MetVal: 1.527 ± 0.037
0.177MetTrp: 0.177 ± 0.012
0.811MetTyr: 0.811 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.582AsnAla: 4.582 ± 0.078
0.485AsnCys: 0.485 ± 0.022
2.705AsnAsp: 2.705 ± 0.055
2.848AsnGlu: 2.848 ± 0.053
2.441AsnPhe: 2.441 ± 0.054
4.246AsnGly: 4.246 ± 0.089
0.914AsnHis: 0.914 ± 0.03
4.497AsnIle: 4.497 ± 0.074
3.531AsnLys: 3.531 ± 0.062
4.521AsnLeu: 4.521 ± 0.071
1.3AsnMet: 1.3 ± 0.035
3.877AsnAsn: 3.877 ± 0.099
2.941AsnPro: 2.941 ± 0.07
1.949AsnGln: 1.949 ± 0.047
2.129AsnArg: 2.129 ± 0.047
3.184AsnSer: 3.184 ± 0.073
4.138AsnThr: 4.138 ± 0.097
3.415AsnVal: 3.415 ± 0.064
0.697AsnTrp: 0.697 ± 0.027
2.573AsnTyr: 2.573 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
3.31ProAla: 3.31 ± 0.075
0.316ProCys: 0.316 ± 0.016
2.127ProAsp: 2.127 ± 0.049
2.976ProGlu: 2.976 ± 0.053
1.917ProPhe: 1.917 ± 0.052
2.576ProGly: 2.576 ± 0.068
0.671ProHis: 0.671 ± 0.028
2.413ProIle: 2.413 ± 0.051
2.374ProLys: 2.374 ± 0.057
3.382ProLeu: 3.382 ± 0.061
0.915ProMet: 0.915 ± 0.029
2.347ProAsn: 2.347 ± 0.059
1.053ProPro: 1.053 ± 0.038
1.517ProGln: 1.517 ± 0.036
0.96ProArg: 0.96 ± 0.027
2.205ProSer: 2.205 ± 0.052
2.302ProThr: 2.302 ± 0.076
3.122ProVal: 3.122 ± 0.065
0.353ProTrp: 0.353 ± 0.021
1.673ProTyr: 1.673 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.077GlnAla: 3.077 ± 0.054
0.302GlnCys: 0.302 ± 0.018
1.71GlnAsp: 1.71 ± 0.04
2.377GlnGlu: 2.377 ± 0.057
1.78GlnPhe: 1.78 ± 0.042
2.239GlnGly: 2.239 ± 0.047
0.963GlnHis: 0.963 ± 0.037
2.703GlnIle: 2.703 ± 0.053
3.21GlnLys: 3.21 ± 0.074
4.062GlnLeu: 4.062 ± 0.075
1.058GlnMet: 1.058 ± 0.029
2.259GlnAsn: 2.259 ± 0.048
1.363GlnPro: 1.363 ± 0.038
2.598GlnGln: 2.598 ± 0.067
1.462GlnArg: 1.462 ± 0.047
2.57GlnSer: 2.57 ± 0.052
2.442GlnThr: 2.442 ± 0.053
2.496GlnVal: 2.496 ± 0.048
0.542GlnTrp: 0.542 ± 0.024
2.144GlnTyr: 2.144 ± 0.047
0.001GlnXaa: 0.001 ± 0.001
Arg
2.255ArgAla: 2.255 ± 0.053
0.268ArgCys: 0.268 ± 0.017
1.585ArgAsp: 1.585 ± 0.039
1.752ArgGlu: 1.752 ± 0.048
2.017ArgPhe: 2.017 ± 0.043
1.797ArgGly: 1.797 ± 0.049
0.699ArgHis: 0.699 ± 0.027
3.107ArgIle: 3.107 ± 0.058
2.77ArgLys: 2.77 ± 0.064
3.564ArgLeu: 3.564 ± 0.062
1.172ArgMet: 1.172 ± 0.034
2.207ArgAsn: 2.207 ± 0.045
1.328ArgPro: 1.328 ± 0.038
1.505ArgGln: 1.505 ± 0.035
1.35ArgArg: 1.35 ± 0.043
2.152ArgSer: 2.152 ± 0.051
2.003ArgThr: 2.003 ± 0.041
2.144ArgVal: 2.144 ± 0.048
0.43ArgTrp: 0.43 ± 0.018
1.837ArgTyr: 1.837 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.734SerAla: 4.734 ± 0.077
0.699SerCys: 0.699 ± 0.028
2.907SerAsp: 2.907 ± 0.055
2.873SerGlu: 2.873 ± 0.061
3.6SerPhe: 3.6 ± 0.061
5.48SerGly: 5.48 ± 0.097
1.003SerHis: 1.003 ± 0.037
4.898SerIle: 4.898 ± 0.07
3.545SerLys: 3.545 ± 0.064
6.236SerLeu: 6.236 ± 0.085
1.474SerMet: 1.474 ± 0.037
3.345SerAsn: 3.345 ± 0.069
2.311SerPro: 2.311 ± 0.056
1.837SerGln: 1.837 ± 0.042
2.158SerArg: 2.158 ± 0.049
3.953SerSer: 3.953 ± 0.086
3.981SerThr: 3.981 ± 0.096
4.21SerVal: 4.21 ± 0.06
0.773SerTrp: 0.773 ± 0.027
2.744SerTyr: 2.744 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
5.778ThrAla: 5.778 ± 0.118
0.515ThrCys: 0.515 ± 0.029
3.336ThrAsp: 3.336 ± 0.063
3.141ThrGlu: 3.141 ± 0.053
3.106ThrPhe: 3.106 ± 0.065
5.066ThrGly: 5.066 ± 0.116
1.023ThrHis: 1.023 ± 0.033
5.017ThrIle: 5.017 ± 0.078
3.312ThrLys: 3.312 ± 0.057
5.978ThrLeu: 5.978 ± 0.088
1.191ThrMet: 1.191 ± 0.038
3.392ThrAsn: 3.392 ± 0.084
3.017ThrPro: 3.017 ± 0.074
2.377ThrGln: 2.377 ± 0.045
1.827ThrArg: 1.827 ± 0.038
3.51ThrSer: 3.51 ± 0.085
4.536ThrThr: 4.536 ± 0.141
4.566ThrVal: 4.566 ± 0.093
0.614ThrTrp: 0.614 ± 0.028
2.858ThrTyr: 2.858 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
5.074ValAla: 5.074 ± 0.078
0.655ValCys: 0.655 ± 0.028
3.141ValAsp: 3.141 ± 0.059
2.772ValGlu: 2.772 ± 0.058
2.964ValPhe: 2.964 ± 0.057
3.71ValGly: 3.71 ± 0.067
1.231ValHis: 1.231 ± 0.036
4.224ValIle: 4.224 ± 0.073
3.98ValLys: 3.98 ± 0.061
6.156ValLeu: 6.156 ± 0.081
1.497ValMet: 1.497 ± 0.039
3.538ValAsn: 3.538 ± 0.071
2.618ValPro: 2.618 ± 0.055
2.476ValGln: 2.476 ± 0.045
2.174ValArg: 2.174 ± 0.045
4.514ValSer: 4.514 ± 0.08
4.038ValThr: 4.038 ± 0.089
4.199ValVal: 4.199 ± 0.081
0.722ValTrp: 0.722 ± 0.026
2.838ValTyr: 2.838 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.8TrpAla: 0.8 ± 0.031
0.11TrpCys: 0.11 ± 0.011
0.633TrpAsp: 0.633 ± 0.023
0.603TrpGlu: 0.603 ± 0.022
0.514TrpPhe: 0.514 ± 0.025
0.741TrpGly: 0.741 ± 0.024
0.267TrpHis: 0.267 ± 0.016
0.736TrpIle: 0.736 ± 0.029
0.799TrpLys: 0.799 ± 0.026
1.086TrpLeu: 1.086 ± 0.035
0.327TrpMet: 0.327 ± 0.017
0.696TrpAsn: 0.696 ± 0.031
0.238TrpPro: 0.238 ± 0.018
0.534TrpGln: 0.534 ± 0.023
0.458TrpArg: 0.458 ± 0.021
0.695TrpSer: 0.695 ± 0.026
0.674TrpThr: 0.674 ± 0.029
0.689TrpVal: 0.689 ± 0.029
0.15TrpTrp: 0.15 ± 0.013
0.496TrpTyr: 0.496 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.111TyrAla: 3.111 ± 0.061
0.426TyrCys: 0.426 ± 0.016
2.324TyrAsp: 2.324 ± 0.06
2.165TyrGlu: 2.165 ± 0.051
2.331TyrPhe: 2.331 ± 0.055
2.682TyrGly: 2.682 ± 0.053
0.877TyrHis: 0.877 ± 0.03
2.818TyrIle: 2.818 ± 0.052
2.747TyrLys: 2.747 ± 0.048
3.874TyrLeu: 3.874 ± 0.077
0.814TyrMet: 0.814 ± 0.027
2.842TyrAsn: 2.842 ± 0.068
1.67TyrPro: 1.67 ± 0.043
1.802TyrGln: 1.802 ± 0.046
1.93TyrArg: 1.93 ± 0.045
2.576TyrSer: 2.576 ± 0.058
3.224TyrThr: 3.224 ± 0.073
2.316TyrVal: 2.316 ± 0.041
0.55TyrTrp: 0.55 ± 0.027
2.122TyrTyr: 2.122 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3074 proteins (1064520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski