Amino acid dipepetide frequency for Staphylococcus auricularis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.71AlaAla: 4.71 ± 0.102
0.539AlaCys: 0.539 ± 0.029
3.642AlaAsp: 3.642 ± 0.117
4.174AlaGlu: 4.174 ± 0.096
3.061AlaPhe: 3.061 ± 0.071
4.259AlaGly: 4.259 ± 0.098
1.571AlaHis: 1.571 ± 0.048
5.839AlaIle: 5.839 ± 0.108
4.562AlaLys: 4.562 ± 0.155
7.153AlaLeu: 7.153 ± 0.119
1.916AlaMet: 1.916 ± 0.059
2.88AlaAsn: 2.88 ± 0.074
2.029AlaPro: 2.029 ± 0.064
3.321AlaGln: 3.321 ± 0.097
2.543AlaArg: 2.543 ± 0.073
4.118AlaSer: 4.118 ± 0.16
4.062AlaThr: 4.062 ± 0.108
4.914AlaVal: 4.914 ± 0.102
0.492AlaTrp: 0.492 ± 0.031
2.354AlaTyr: 2.354 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.355CysAla: 0.355 ± 0.026
0.08CysCys: 0.08 ± 0.012
0.38CysAsp: 0.38 ± 0.026
0.348CysGlu: 0.348 ± 0.027
0.24CysPhe: 0.24 ± 0.021
0.579CysGly: 0.579 ± 0.036
0.217CysHis: 0.217 ± 0.02
0.505CysIle: 0.505 ± 0.035
0.262CysLys: 0.262 ± 0.022
0.539CysLeu: 0.539 ± 0.031
0.143CysMet: 0.143 ± 0.016
0.247CysAsn: 0.247 ± 0.02
0.277CysPro: 0.277 ± 0.025
0.188CysGln: 0.188 ± 0.02
0.208CysArg: 0.208 ± 0.018
0.372CysSer: 0.372 ± 0.029
0.35CysThr: 0.35 ± 0.025
0.4CysVal: 0.4 ± 0.026
0.047CysTrp: 0.047 ± 0.009
0.248CysTyr: 0.248 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.409AspAla: 4.409 ± 0.191
0.343AspCys: 0.343 ± 0.027
4.35AspAsp: 4.35 ± 0.125
5.829AspGlu: 5.829 ± 0.122
2.666AspPhe: 2.666 ± 0.073
3.548AspGly: 3.548 ± 0.1
1.671AspHis: 1.671 ± 0.052
5.254AspIle: 5.254 ± 0.113
4.4AspLys: 4.4 ± 0.112
5.297AspLeu: 5.297 ± 0.104
1.707AspMet: 1.707 ± 0.047
2.813AspAsn: 2.813 ± 0.11
1.913AspPro: 1.913 ± 0.079
3.066AspGln: 3.066 ± 0.092
2.279AspArg: 2.279 ± 0.07
2.99AspSer: 2.99 ± 0.094
3.418AspThr: 3.418 ± 0.078
4.537AspVal: 4.537 ± 0.09
0.509AspTrp: 0.509 ± 0.031
2.883AspTyr: 2.883 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
5.693GluAla: 5.693 ± 0.11
0.232GluCys: 0.232 ± 0.02
4.936GluAsp: 4.936 ± 0.12
5.376GluGlu: 5.376 ± 0.148
2.038GluPhe: 2.038 ± 0.068
4.134GluGly: 4.134 ± 0.096
1.871GluHis: 1.871 ± 0.064
4.897GluIle: 4.897 ± 0.093
4.59GluLys: 4.59 ± 0.108
5.946GluLeu: 5.946 ± 0.119
2.088GluMet: 2.088 ± 0.068
3.4GluAsn: 3.4 ± 0.079
2.143GluPro: 2.143 ± 0.064
3.892GluGln: 3.892 ± 0.097
3.246GluArg: 3.246 ± 0.095
3.862GluSer: 3.862 ± 0.162
4.482GluThr: 4.482 ± 0.107
5.022GluVal: 5.022 ± 0.108
0.552GluTrp: 0.552 ± 0.033
2.071GluTyr: 2.071 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.7PheAla: 2.7 ± 0.073
0.298PheCys: 0.298 ± 0.024
3.008PheAsp: 3.008 ± 0.074
2.993PheGlu: 2.993 ± 0.083
1.951PhePhe: 1.951 ± 0.078
3.018PheGly: 3.018 ± 0.088
0.829PheHis: 0.829 ± 0.04
4.037PheIle: 4.037 ± 0.114
3.01PheLys: 3.01 ± 0.071
3.79PheLeu: 3.79 ± 0.091
1.114PheMet: 1.114 ± 0.045
2.604PheAsn: 2.604 ± 0.072
1.217PhePro: 1.217 ± 0.051
1.292PheGln: 1.292 ± 0.049
1.241PheArg: 1.241 ± 0.053
2.731PheSer: 2.731 ± 0.075
2.459PheThr: 2.459 ± 0.064
3.203PheVal: 3.203 ± 0.082
0.343PheTrp: 0.343 ± 0.028
1.637PheTyr: 1.637 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.369GlyAla: 4.369 ± 0.095
0.445GlyCys: 0.445 ± 0.029
3.442GlyAsp: 3.442 ± 0.103
4.032GlyGlu: 4.032 ± 0.092
3.133GlyPhe: 3.133 ± 0.08
4.305GlyGly: 4.305 ± 0.116
1.572GlyHis: 1.572 ± 0.051
5.291GlyIle: 5.291 ± 0.109
4.08GlyLys: 4.08 ± 0.103
6.056GlyLeu: 6.056 ± 0.116
1.747GlyMet: 1.747 ± 0.06
2.418GlyAsn: 2.418 ± 0.078
1.677GlyPro: 1.677 ± 0.048
2.591GlyGln: 2.591 ± 0.073
2.306GlyArg: 2.306 ± 0.075
3.575GlySer: 3.575 ± 0.091
3.84GlyThr: 3.84 ± 0.113
4.64GlyVal: 4.64 ± 0.106
0.537GlyTrp: 0.537 ± 0.032
2.806GlyTyr: 2.806 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.516HisAla: 1.516 ± 0.049
0.178HisCys: 0.178 ± 0.018
1.552HisAsp: 1.552 ± 0.053
1.499HisGlu: 1.499 ± 0.058
1.276HisPhe: 1.276 ± 0.049
1.477HisGly: 1.477 ± 0.055
0.884HisHis: 0.884 ± 0.041
1.989HisIle: 1.989 ± 0.06
1.221HisLys: 1.221 ± 0.048
2.328HisLeu: 2.328 ± 0.07
0.662HisMet: 0.662 ± 0.034
0.989HisAsn: 0.989 ± 0.041
1.182HisPro: 1.182 ± 0.044
1.206HisGln: 1.206 ± 0.044
0.952HisArg: 0.952 ± 0.044
1.211HisSer: 1.211 ± 0.046
1.329HisThr: 1.329 ± 0.048
1.702HisVal: 1.702 ± 0.06
0.197HisTrp: 0.197 ± 0.017
1.202HisTyr: 1.202 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.036IleAla: 6.036 ± 0.112
0.614IleCys: 0.614 ± 0.031
5.421IleAsp: 5.421 ± 0.118
5.776IleGlu: 5.776 ± 0.114
3.492IlePhe: 3.492 ± 0.095
5.729IleGly: 5.729 ± 0.136
1.701IleHis: 1.701 ± 0.056
6.615IleIle: 6.615 ± 0.17
4.684IleLys: 4.684 ± 0.11
7.178IleLeu: 7.178 ± 0.155
1.741IleMet: 1.741 ± 0.056
3.812IleAsn: 3.812 ± 0.099
2.988IlePro: 2.988 ± 0.097
3.056IleGln: 3.056 ± 0.078
2.584IleArg: 2.584 ± 0.071
4.752IleSer: 4.752 ± 0.087
4.312IleThr: 4.312 ± 0.089
6.103IleVal: 6.103 ± 0.124
0.454IleTrp: 0.454 ± 0.029
2.653IleTyr: 2.653 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.847LysAla: 4.847 ± 0.148
0.257LysCys: 0.257 ± 0.021
5.034LysAsp: 5.034 ± 0.152
5.264LysGlu: 5.264 ± 0.123
1.804LysPhe: 1.804 ± 0.062
3.762LysGly: 3.762 ± 0.102
1.682LysHis: 1.682 ± 0.067
3.862LysIle: 3.862 ± 0.084
4.455LysLys: 4.455 ± 0.143
5.267LysLeu: 5.267 ± 0.098
1.923LysMet: 1.923 ± 0.057
2.921LysAsn: 2.921 ± 0.081
2.299LysPro: 2.299 ± 0.097
3.732LysGln: 3.732 ± 0.102
3.001LysArg: 3.001 ± 0.079
3.615LysSer: 3.615 ± 0.082
3.253LysThr: 3.253 ± 0.082
4.319LysVal: 4.319 ± 0.098
0.514LysTrp: 0.514 ± 0.028
2.323LysTyr: 2.323 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.328LeuAla: 6.328 ± 0.114
0.62LeuCys: 0.62 ± 0.033
5.643LeuAsp: 5.643 ± 0.108
5.784LeuGlu: 5.784 ± 0.119
4.482LeuPhe: 4.482 ± 0.138
5.928LeuGly: 5.928 ± 0.121
1.771LeuHis: 1.771 ± 0.052
7.682LeuIle: 7.682 ± 0.168
6.083LeuLys: 6.083 ± 0.111
8.882LeuLeu: 8.882 ± 0.179
2.446LeuMet: 2.446 ± 0.07
5.216LeuAsn: 5.216 ± 0.102
3.628LeuPro: 3.628 ± 0.084
3.291LeuGln: 3.291 ± 0.072
3.118LeuArg: 3.118 ± 0.07
6.63LeuSer: 6.63 ± 0.136
5.813LeuThr: 5.813 ± 0.111
5.858LeuVal: 5.858 ± 0.117
0.585LeuTrp: 0.585 ± 0.036
3.068LeuTyr: 3.068 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.802MetAla: 1.802 ± 0.053
0.135MetCys: 0.135 ± 0.014
1.534MetAsp: 1.534 ± 0.05
1.366MetGlu: 1.366 ± 0.055
1.065MetPhe: 1.065 ± 0.038
1.537MetGly: 1.537 ± 0.05
0.552MetHis: 0.552 ± 0.034
2.288MetIle: 2.288 ± 0.073
2.219MetLys: 2.219 ± 0.062
2.431MetLeu: 2.431 ± 0.068
0.834MetMet: 0.834 ± 0.041
1.532MetAsn: 1.532 ± 0.049
1.002MetPro: 1.002 ± 0.045
0.934MetGln: 0.934 ± 0.037
1.039MetArg: 1.039 ± 0.049
1.876MetSer: 1.876 ± 0.07
1.822MetThr: 1.822 ± 0.056
1.572MetVal: 1.572 ± 0.052
0.162MetTrp: 0.162 ± 0.018
0.827MetTyr: 0.827 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.085AsnAla: 3.085 ± 0.08
0.228AsnCys: 0.228 ± 0.021
3.522AsnAsp: 3.522 ± 0.091
3.933AsnGlu: 3.933 ± 0.087
1.721AsnPhe: 1.721 ± 0.05
3.02AsnGly: 3.02 ± 0.079
1.424AsnHis: 1.424 ± 0.048
3.74AsnIle: 3.74 ± 0.073
3.31AsnLys: 3.31 ± 0.098
3.75AsnLeu: 3.75 ± 0.105
1.292AsnMet: 1.292 ± 0.057
2.468AsnAsn: 2.468 ± 0.079
1.807AsnPro: 1.807 ± 0.051
2.631AsnGln: 2.631 ± 0.089
1.829AsnArg: 1.829 ± 0.062
2.171AsnSer: 2.171 ± 0.078
2.443AsnThr: 2.443 ± 0.065
3.146AsnVal: 3.146 ± 0.076
0.384AsnTrp: 0.384 ± 0.027
2.003AsnTyr: 2.003 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
1.869ProAla: 1.869 ± 0.08
0.16ProCys: 0.16 ± 0.018
2.101ProAsp: 2.101 ± 0.113
2.976ProGlu: 2.976 ± 0.083
1.796ProPhe: 1.796 ± 0.058
2.153ProGly: 2.153 ± 0.123
0.892ProHis: 0.892 ± 0.046
2.676ProIle: 2.676 ± 0.065
2.013ProLys: 2.013 ± 0.064
3.075ProLeu: 3.075 ± 0.08
0.832ProMet: 0.832 ± 0.036
1.754ProAsn: 1.754 ± 0.077
0.829ProPro: 0.829 ± 0.055
1.431ProGln: 1.431 ± 0.055
1.049ProArg: 1.049 ± 0.043
2.163ProSer: 2.163 ± 0.067
2.071ProThr: 2.071 ± 0.058
2.606ProVal: 2.606 ± 0.081
0.295ProTrp: 0.295 ± 0.023
1.419ProTyr: 1.419 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.251GlnAla: 3.251 ± 0.091
0.225GlnCys: 0.225 ± 0.018
2.464GlnAsp: 2.464 ± 0.094
2.229GlnGlu: 2.229 ± 0.058
2.239GlnPhe: 2.239 ± 0.055
2.353GlnGly: 2.353 ± 0.064
1.382GlnHis: 1.382 ± 0.047
3.031GlnIle: 3.031 ± 0.079
2.509GlnLys: 2.509 ± 0.087
4.977GlnLeu: 4.977 ± 0.112
1.212GlnMet: 1.212 ± 0.055
2.074GlnAsn: 2.074 ± 0.069
1.519GlnPro: 1.519 ± 0.049
3.413GlnGln: 3.413 ± 0.144
2.089GlnArg: 2.089 ± 0.066
2.926GlnSer: 2.926 ± 0.077
2.668GlnThr: 2.668 ± 0.068
2.568GlnVal: 2.568 ± 0.067
0.407GlnTrp: 0.407 ± 0.028
2.043GlnTyr: 2.043 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
2.288ArgAla: 2.288 ± 0.063
0.177ArgCys: 0.177 ± 0.021
2.219ArgAsp: 2.219 ± 0.071
2.619ArgGlu: 2.619 ± 0.072
1.772ArgPhe: 1.772 ± 0.059
2.061ArgGly: 2.061 ± 0.062
0.952ArgHis: 0.952 ± 0.039
3.098ArgIle: 3.098 ± 0.071
2.611ArgLys: 2.611 ± 0.075
3.527ArgLeu: 3.527 ± 0.091
1.077ArgMet: 1.077 ± 0.045
1.786ArgAsn: 1.786 ± 0.053
1.184ArgPro: 1.184 ± 0.043
1.806ArgGln: 1.806 ± 0.063
1.704ArgArg: 1.704 ± 0.057
1.901ArgSer: 1.901 ± 0.066
1.986ArgThr: 1.986 ± 0.062
2.548ArgVal: 2.548 ± 0.071
0.272ArgTrp: 0.272 ± 0.022
1.796ArgTyr: 1.796 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.543SerAla: 3.543 ± 0.14
0.305SerCys: 0.305 ± 0.023
3.722SerAsp: 3.722 ± 0.109
4.425SerGlu: 4.425 ± 0.184
2.796SerPhe: 2.796 ± 0.063
3.89SerGly: 3.89 ± 0.095
1.501SerHis: 1.501 ± 0.054
4.597SerIle: 4.597 ± 0.099
3.643SerLys: 3.643 ± 0.088
5.486SerLeu: 5.486 ± 0.139
1.579SerMet: 1.579 ± 0.055
2.886SerAsn: 2.886 ± 0.095
1.782SerPro: 1.782 ± 0.055
2.665SerGln: 2.665 ± 0.064
2.101SerArg: 2.101 ± 0.056
3.578SerSer: 3.578 ± 0.165
3.725SerThr: 3.725 ± 0.263
3.787SerVal: 3.787 ± 0.091
0.397SerTrp: 0.397 ± 0.029
2.306SerTyr: 2.306 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
3.84ThrAla: 3.84 ± 0.09
0.343ThrCys: 0.343 ± 0.025
3.427ThrAsp: 3.427 ± 0.094
3.972ThrGlu: 3.972 ± 0.096
2.771ThrPhe: 2.771 ± 0.075
3.775ThrGly: 3.775 ± 0.087
1.464ThrHis: 1.464 ± 0.044
4.697ThrIle: 4.697 ± 0.105
3.265ThrLys: 3.265 ± 0.089
5.888ThrLeu: 5.888 ± 0.109
1.366ThrMet: 1.366 ± 0.054
2.501ThrAsn: 2.501 ± 0.083
2.548ThrPro: 2.548 ± 0.096
2.416ThrGln: 2.416 ± 0.075
1.923ThrArg: 1.923 ± 0.054
3.677ThrSer: 3.677 ± 0.277
3.578ThrThr: 3.578 ± 0.094
4.464ThrVal: 4.464 ± 0.12
0.422ThrTrp: 0.422 ± 0.031
2.288ThrTyr: 2.288 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
4.799ValAla: 4.799 ± 0.105
0.482ValCys: 0.482 ± 0.03
4.277ValAsp: 4.277 ± 0.109
4.819ValGlu: 4.819 ± 0.103
2.768ValPhe: 2.768 ± 0.077
4.515ValGly: 4.515 ± 0.092
1.312ValHis: 1.312 ± 0.05
6.023ValIle: 6.023 ± 0.116
4.677ValLys: 4.677 ± 0.095
6.518ValLeu: 6.518 ± 0.118
1.794ValMet: 1.794 ± 0.059
3.443ValAsn: 3.443 ± 0.071
2.636ValPro: 2.636 ± 0.079
2.311ValGln: 2.311 ± 0.064
2.308ValArg: 2.308 ± 0.07
4.222ValSer: 4.222 ± 0.089
4.62ValThr: 4.62 ± 0.116
5.169ValVal: 5.169 ± 0.107
0.475ValTrp: 0.475 ± 0.026
2.301ValTyr: 2.301 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.394TrpAla: 0.394 ± 0.023
0.058TrpCys: 0.058 ± 0.01
0.417TrpAsp: 0.417 ± 0.03
0.367TrpGlu: 0.367 ± 0.028
0.482TrpPhe: 0.482 ± 0.029
0.427TrpGly: 0.427 ± 0.025
0.168TrpHis: 0.168 ± 0.017
0.632TrpIle: 0.632 ± 0.034
0.379TrpLys: 0.379 ± 0.026
1.037TrpLeu: 1.037 ± 0.044
0.275TrpMet: 0.275 ± 0.022
0.399TrpAsn: 0.399 ± 0.028
0.2TrpPro: 0.2 ± 0.02
0.328TrpGln: 0.328 ± 0.023
0.272TrpArg: 0.272 ± 0.022
0.445TrpSer: 0.445 ± 0.03
0.317TrpThr: 0.317 ± 0.023
0.474TrpVal: 0.474 ± 0.031
0.082TrpTrp: 0.082 ± 0.013
0.3TrpTyr: 0.3 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.306TyrAla: 2.306 ± 0.059
0.265TyrCys: 0.265 ± 0.023
2.795TyrAsp: 2.795 ± 0.082
2.688TyrGlu: 2.688 ± 0.061
1.923TyrPhe: 1.923 ± 0.065
2.394TyrGly: 2.394 ± 0.066
1.136TyrHis: 1.136 ± 0.049
2.946TyrIle: 2.946 ± 0.082
2.161TyrLys: 2.161 ± 0.061
3.73TyrLeu: 3.73 ± 0.086
0.78TyrMet: 0.78 ± 0.035
1.764TyrAsn: 1.764 ± 0.059
1.297TyrPro: 1.297 ± 0.047
2.011TyrGln: 2.011 ± 0.064
1.591TyrArg: 1.591 ± 0.061
1.901TyrSer: 1.901 ± 0.056
2.074TyrThr: 2.074 ± 0.062
2.438TyrVal: 2.438 ± 0.07
0.328TyrTrp: 0.328 ± 0.025
1.601TyrTyr: 1.601 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2003 proteins (599734 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski