Amino acid dipepetide frequency for Bifidobacterium samirii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.953AlaAla: 17.953 ± 0.308
1.246AlaCys: 1.246 ± 0.05
10.335AlaAsp: 10.335 ± 0.163
6.014AlaGlu: 6.014 ± 0.102
3.754AlaPhe: 3.754 ± 0.072
10.655AlaGly: 10.655 ± 0.149
2.309AlaHis: 2.309 ± 0.072
5.466AlaIle: 5.466 ± 0.1
3.939AlaLys: 3.939 ± 0.078
10.815AlaLeu: 10.815 ± 0.14
3.495AlaMet: 3.495 ± 0.076
2.936AlaAsn: 2.936 ± 0.063
4.615AlaPro: 4.615 ± 0.097
3.853AlaGln: 3.853 ± 0.095
7.526AlaArg: 7.526 ± 0.145
6.994AlaSer: 6.994 ± 0.107
6.752AlaThr: 6.752 ± 0.111
9.548AlaVal: 9.548 ± 0.136
1.695AlaTrp: 1.695 ± 0.053
2.93AlaTyr: 2.93 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.276CysAla: 1.276 ± 0.049
0.145CysCys: 0.145 ± 0.015
0.69CysAsp: 0.69 ± 0.034
0.483CysGlu: 0.483 ± 0.031
0.279CysPhe: 0.279 ± 0.022
1.037CysGly: 1.037 ± 0.041
0.225CysHis: 0.225 ± 0.018
0.405CysIle: 0.405 ± 0.028
0.169CysLys: 0.169 ± 0.014
0.756CysLeu: 0.756 ± 0.035
0.264CysMet: 0.264 ± 0.02
0.22CysAsn: 0.22 ± 0.017
0.492CysPro: 0.492 ± 0.026
0.184CysGln: 0.184 ± 0.018
0.67CysArg: 0.67 ± 0.034
0.446CysSer: 0.446 ± 0.024
0.534CysThr: 0.534 ± 0.024
0.794CysVal: 0.794 ± 0.032
0.141CysTrp: 0.141 ± 0.016
0.256CysTyr: 0.256 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
10.076AspAla: 10.076 ± 0.18
0.618AspCys: 0.618 ± 0.033
6.22AspAsp: 6.22 ± 0.122
5.264AspGlu: 5.264 ± 0.096
2.253AspPhe: 2.253 ± 0.06
8.155AspGly: 8.155 ± 0.148
1.461AspHis: 1.461 ± 0.047
3.106AspIle: 3.106 ± 0.067
1.952AspLys: 1.952 ± 0.067
5.741AspLeu: 5.741 ± 0.095
1.872AspMet: 1.872 ± 0.048
1.467AspAsn: 1.467 ± 0.054
4.269AspPro: 4.269 ± 0.083
1.799AspGln: 1.799 ± 0.052
4.605AspArg: 4.605 ± 0.085
3.034AspSer: 3.034 ± 0.083
3.657AspThr: 3.657 ± 0.09
5.843AspVal: 5.843 ± 0.098
1.188AspTrp: 1.188 ± 0.045
2.147AspTyr: 2.147 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
6.245GluAla: 6.245 ± 0.118
0.469GluCys: 0.469 ± 0.03
3.076GluAsp: 3.076 ± 0.081
2.991GluGlu: 2.991 ± 0.083
1.743GluPhe: 1.743 ± 0.056
3.771GluGly: 3.771 ± 0.079
1.606GluHis: 1.606 ± 0.05
2.528GluIle: 2.528 ± 0.065
1.623GluLys: 1.623 ± 0.059
4.956GluLeu: 4.956 ± 0.094
1.28GluMet: 1.28 ± 0.045
1.537GluAsn: 1.537 ± 0.049
2.877GluPro: 2.877 ± 0.071
2.127GluGln: 2.127 ± 0.057
5.147GluArg: 5.147 ± 0.107
3.305GluSer: 3.305 ± 0.077
3.689GluThr: 3.689 ± 0.07
3.031GluVal: 3.031 ± 0.068
0.697GluTrp: 0.697 ± 0.03
1.715GluTyr: 1.715 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
4.143PheAla: 4.143 ± 0.082
0.317PheCys: 0.317 ± 0.022
2.954PheAsp: 2.954 ± 0.064
1.655PheGlu: 1.655 ± 0.053
1.038PhePhe: 1.038 ± 0.042
3.115PheGly: 3.115 ± 0.079
0.687PheHis: 0.687 ± 0.031
1.448PheIle: 1.448 ± 0.059
0.857PheLys: 0.857 ± 0.037
2.547PheLeu: 2.547 ± 0.057
0.737PheMet: 0.737 ± 0.032
1.053PheAsn: 1.053 ± 0.043
1.388PhePro: 1.388 ± 0.049
0.809PheGln: 0.809 ± 0.036
1.848PheArg: 1.848 ± 0.059
1.933PheSer: 1.933 ± 0.06
2.142PheThr: 2.142 ± 0.055
2.681PheVal: 2.681 ± 0.075
0.408PheTrp: 0.408 ± 0.025
0.903PheTyr: 0.903 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
8.688GlyAla: 8.688 ± 0.135
0.862GlyCys: 0.862 ± 0.037
5.848GlyAsp: 5.848 ± 0.093
5.151GlyGlu: 5.151 ± 0.1
3.146GlyPhe: 3.146 ± 0.072
6.868GlyGly: 6.868 ± 0.125
1.743GlyHis: 1.743 ± 0.052
4.429GlyIle: 4.429 ± 0.084
3.094GlyLys: 3.094 ± 0.084
7.118GlyLeu: 7.118 ± 0.114
2.467GlyMet: 2.467 ± 0.062
2.355GlyAsn: 2.355 ± 0.079
2.869GlyPro: 2.869 ± 0.072
2.286GlyGln: 2.286 ± 0.067
6.094GlyArg: 6.094 ± 0.12
5.048GlySer: 5.048 ± 0.111
5.604GlyThr: 5.604 ± 0.106
6.889GlyVal: 6.889 ± 0.105
1.341GlyTrp: 1.341 ± 0.046
2.745GlyTyr: 2.745 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.435HisAla: 2.435 ± 0.064
0.225HisCys: 0.225 ± 0.018
1.761HisAsp: 1.761 ± 0.044
1.154HisGlu: 1.154 ± 0.042
0.541HisPhe: 0.541 ± 0.025
1.983HisGly: 1.983 ± 0.059
0.55HisHis: 0.55 ± 0.031
0.994HisIle: 0.994 ± 0.037
0.426HisLys: 0.426 ± 0.024
1.564HisLeu: 1.564 ± 0.042
0.498HisMet: 0.498 ± 0.026
0.515HisAsn: 0.515 ± 0.026
1.326HisPro: 1.326 ± 0.044
0.502HisGln: 0.502 ± 0.024
1.594HisArg: 1.594 ± 0.058
0.778HisSer: 0.778 ± 0.029
1.14HisThr: 1.14 ± 0.044
1.773HisVal: 1.773 ± 0.052
0.313HisTrp: 0.313 ± 0.02
0.599HisTyr: 0.599 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.659IleAla: 6.659 ± 0.111
0.502IleCys: 0.502 ± 0.033
4.251IleAsp: 4.251 ± 0.091
2.932IleGlu: 2.932 ± 0.066
1.12IlePhe: 1.12 ± 0.043
4.59IleGly: 4.59 ± 0.101
0.895IleHis: 0.895 ± 0.034
2.287IleIle: 2.287 ± 0.075
1.232IleLys: 1.232 ± 0.045
3.538IleLeu: 3.538 ± 0.078
1.144IleMet: 1.144 ± 0.047
1.39IleAsn: 1.39 ± 0.049
2.414IlePro: 2.414 ± 0.058
1.105IleGln: 1.105 ± 0.044
3.138IleArg: 3.138 ± 0.069
2.294IleSer: 2.294 ± 0.068
2.722IleThr: 2.722 ± 0.065
4.647IleVal: 4.647 ± 0.091
0.521IleTrp: 0.521 ± 0.029
1.014IleTyr: 1.014 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.006LysAla: 4.006 ± 0.102
0.146LysCys: 0.146 ± 0.017
2.014LysAsp: 2.014 ± 0.074
1.638LysGlu: 1.638 ± 0.055
0.746LysPhe: 0.746 ± 0.036
2.267LysGly: 2.267 ± 0.058
0.587LysHis: 0.587 ± 0.028
1.273LysIle: 1.273 ± 0.051
1.121LysLys: 1.121 ± 0.051
2.299LysLeu: 2.299 ± 0.06
0.625LysMet: 0.625 ± 0.03
1.006LysAsn: 1.006 ± 0.044
1.808LysPro: 1.808 ± 0.061
0.92LysGln: 0.92 ± 0.038
2.031LysArg: 2.031 ± 0.068
1.617LysSer: 1.617 ± 0.059
2.044LysThr: 2.044 ± 0.056
2.21LysVal: 2.21 ± 0.068
0.374LysTrp: 0.374 ± 0.021
0.826LysTyr: 0.826 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
11.08LeuAla: 11.08 ± 0.141
0.907LeuCys: 0.907 ± 0.035
6.664LeuAsp: 6.664 ± 0.101
4.099LeuGlu: 4.099 ± 0.092
2.912LeuPhe: 2.912 ± 0.066
6.887LeuGly: 6.887 ± 0.111
1.761LeuHis: 1.761 ± 0.047
4.281LeuIle: 4.281 ± 0.088
2.646LeuLys: 2.646 ± 0.074
7.535LeuLeu: 7.535 ± 0.121
2.151LeuMet: 2.151 ± 0.056
2.416LeuAsn: 2.416 ± 0.065
4.555LeuPro: 4.555 ± 0.094
2.105LeuGln: 2.105 ± 0.057
5.776LeuArg: 5.776 ± 0.099
4.852LeuSer: 4.852 ± 0.087
5.738LeuThr: 5.738 ± 0.105
6.339LeuVal: 6.339 ± 0.095
1.047LeuTrp: 1.047 ± 0.035
2.1LeuTyr: 2.1 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.972MetAla: 2.972 ± 0.067
0.241MetCys: 0.241 ± 0.019
1.533MetAsp: 1.533 ± 0.05
1.074MetGlu: 1.074 ± 0.039
0.874MetPhe: 0.874 ± 0.031
1.901MetGly: 1.901 ± 0.05
0.523MetHis: 0.523 ± 0.03
1.284MetIle: 1.284 ± 0.038
0.777MetLys: 0.777 ± 0.031
2.532MetLeu: 2.532 ± 0.063
0.807MetMet: 0.807 ± 0.039
0.869MetAsn: 0.869 ± 0.034
1.578MetPro: 1.578 ± 0.048
0.728MetGln: 0.728 ± 0.026
1.99MetArg: 1.99 ± 0.06
1.658MetSer: 1.658 ± 0.045
2.286MetThr: 2.286 ± 0.059
1.747MetVal: 1.747 ± 0.055
0.323MetTrp: 0.323 ± 0.02
0.53MetTyr: 0.53 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.174AsnAla: 3.174 ± 0.072
0.206AsnCys: 0.206 ± 0.017
1.799AsnAsp: 1.799 ± 0.057
1.52AsnGlu: 1.52 ± 0.047
0.761AsnPhe: 0.761 ± 0.032
2.845AsnGly: 2.845 ± 0.063
0.531AsnHis: 0.531 ± 0.03
1.258AsnIle: 1.258 ± 0.048
0.798AsnLys: 0.798 ± 0.044
2.313AsnLeu: 2.313 ± 0.059
0.647AsnMet: 0.647 ± 0.033
0.794AsnAsn: 0.794 ± 0.04
1.905AsnPro: 1.905 ± 0.064
0.805AsnGln: 0.805 ± 0.045
1.837AsnArg: 1.837 ± 0.055
1.197AsnSer: 1.197 ± 0.043
1.613AsnThr: 1.613 ± 0.053
1.981AsnVal: 1.981 ± 0.051
0.376AsnTrp: 0.376 ± 0.025
0.805AsnTyr: 0.805 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.287ProAla: 6.287 ± 0.11
0.331ProCys: 0.331 ± 0.024
4.2ProAsp: 4.2 ± 0.092
3.062ProGlu: 3.062 ± 0.08
1.663ProPhe: 1.663 ± 0.049
3.789ProGly: 3.789 ± 0.082
0.953ProHis: 0.953 ± 0.035
2.104ProIle: 2.104 ± 0.059
1.346ProLys: 1.346 ± 0.047
3.632ProLeu: 3.632 ± 0.073
1.152ProMet: 1.152 ± 0.036
1.216ProAsn: 1.216 ± 0.04
1.501ProPro: 1.501 ± 0.07
1.651ProGln: 1.651 ± 0.05
2.618ProArg: 2.618 ± 0.071
3.15ProSer: 3.15 ± 0.082
3.107ProThr: 3.107 ± 0.075
4.15ProVal: 4.15 ± 0.081
0.714ProTrp: 0.714 ± 0.032
1.474ProTyr: 1.474 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.489GlnAla: 3.489 ± 0.08
0.222GlnCys: 0.222 ± 0.018
1.552GlnAsp: 1.552 ± 0.049
1.41GlnGlu: 1.41 ± 0.05
0.877GlnPhe: 0.877 ± 0.036
2.117GlnGly: 2.117 ± 0.06
0.563GlnHis: 0.563 ± 0.028
1.582GlnIle: 1.582 ± 0.048
0.807GlnLys: 0.807 ± 0.039
2.767GlnLeu: 2.767 ± 0.071
0.813GlnMet: 0.813 ± 0.033
0.82GlnAsn: 0.82 ± 0.043
1.451GlnPro: 1.451 ± 0.067
1.232GlnGln: 1.232 ± 0.055
2.101GlnArg: 2.101 ± 0.062
1.68GlnSer: 1.68 ± 0.055
1.789GlnThr: 1.789 ± 0.058
2.157GlnVal: 2.157 ± 0.053
0.51GlnTrp: 0.51 ± 0.027
0.983GlnTyr: 0.983 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
6.556ArgAla: 6.556 ± 0.127
0.67ArgCys: 0.67 ± 0.034
4.521ArgAsp: 4.521 ± 0.096
3.948ArgGlu: 3.948 ± 0.088
2.679ArgPhe: 2.679 ± 0.062
4.373ArgGly: 4.373 ± 0.106
1.742ArgHis: 1.742 ± 0.054
4.141ArgIle: 4.141 ± 0.078
2.113ArgLys: 2.113 ± 0.068
6.461ArgLeu: 6.461 ± 0.141
2.229ArgMet: 2.229 ± 0.053
1.91ArgAsn: 1.91 ± 0.056
3.286ArgPro: 3.286 ± 0.086
2.216ArgGln: 2.216 ± 0.059
6.671ArgArg: 6.671 ± 0.165
3.492ArgSer: 3.492 ± 0.074
4.144ArgThr: 4.144 ± 0.086
4.733ArgVal: 4.733 ± 0.092
1.019ArgTrp: 1.019 ± 0.044
2.183ArgTyr: 2.183 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
6.422SerAla: 6.422 ± 0.119
0.453SerCys: 0.453 ± 0.025
4.0SerAsp: 4.0 ± 0.11
2.581SerGlu: 2.581 ± 0.065
1.93SerPhe: 1.93 ± 0.061
5.414SerGly: 5.414 ± 0.112
1.066SerHis: 1.066 ± 0.038
2.665SerIle: 2.665 ± 0.062
1.54SerLys: 1.54 ± 0.05
4.812SerLeu: 4.812 ± 0.092
1.49SerMet: 1.49 ± 0.041
1.446SerAsn: 1.446 ± 0.05
2.488SerPro: 2.488 ± 0.062
1.701SerGln: 1.701 ± 0.05
3.541SerArg: 3.541 ± 0.093
3.451SerSer: 3.451 ± 0.105
3.232SerThr: 3.232 ± 0.074
4.281SerVal: 4.281 ± 0.089
0.897SerTrp: 0.897 ± 0.043
1.594SerTyr: 1.594 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
7.396ThrAla: 7.396 ± 0.138
0.516ThrCys: 0.516 ± 0.031
4.31ThrAsp: 4.31 ± 0.089
2.592ThrGlu: 2.592 ± 0.056
2.08ThrPhe: 2.08 ± 0.061
5.581ThrGly: 5.581 ± 0.098
1.122ThrHis: 1.122 ± 0.04
3.415ThrIle: 3.415 ± 0.07
1.634ThrLys: 1.634 ± 0.05
5.989ThrLeu: 5.989 ± 0.107
1.578ThrMet: 1.578 ± 0.044
1.608ThrAsn: 1.608 ± 0.056
3.629ThrPro: 3.629 ± 0.078
1.667ThrGln: 1.667 ± 0.044
3.426ThrArg: 3.426 ± 0.08
3.183ThrSer: 3.183 ± 0.073
4.005ThrThr: 4.005 ± 0.102
6.043ThrVal: 6.043 ± 0.114
0.836ThrTrp: 0.836 ± 0.038
1.644ThrTyr: 1.644 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
9.46ValAla: 9.46 ± 0.148
0.897ValCys: 0.897 ± 0.039
5.84ValAsp: 5.84 ± 0.092
4.404ValGlu: 4.404 ± 0.081
2.774ValPhe: 2.774 ± 0.07
5.661ValGly: 5.661 ± 0.106
1.482ValHis: 1.482 ± 0.046
3.916ValIle: 3.916 ± 0.082
2.332ValLys: 2.332 ± 0.065
6.679ValLeu: 6.679 ± 0.103
1.918ValMet: 1.918 ± 0.052
2.286ValAsn: 2.286 ± 0.057
3.83ValPro: 3.83 ± 0.083
1.819ValGln: 1.819 ± 0.055
5.284ValArg: 5.284 ± 0.087
4.638ValSer: 4.638 ± 0.077
5.456ValThr: 5.456 ± 0.115
6.45ValVal: 6.45 ± 0.13
1.087ValTrp: 1.087 ± 0.04
1.911ValTyr: 1.911 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.277TrpAla: 1.277 ± 0.044
0.194TrpCys: 0.194 ± 0.019
0.935TrpAsp: 0.935 ± 0.039
0.624TrpGlu: 0.624 ± 0.031
0.576TrpPhe: 0.576 ± 0.029
0.994TrpGly: 0.994 ± 0.045
0.373TrpHis: 0.373 ± 0.025
0.728TrpIle: 0.728 ± 0.031
0.483TrpLys: 0.483 ± 0.025
1.421TrpLeu: 1.421 ± 0.046
0.453TrpMet: 0.453 ± 0.027
0.569TrpAsn: 0.569 ± 0.033
0.583TrpPro: 0.583 ± 0.027
0.561TrpGln: 0.561 ± 0.032
1.098TrpArg: 1.098 ± 0.042
0.892TrpSer: 0.892 ± 0.04
0.949TrpThr: 0.949 ± 0.039
0.779TrpVal: 0.779 ± 0.033
0.289TrpTrp: 0.289 ± 0.023
0.435TrpTyr: 0.435 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.236TyrAla: 3.236 ± 0.071
0.3TyrCys: 0.3 ± 0.021
2.223TyrAsp: 2.223 ± 0.069
1.821TyrGlu: 1.821 ± 0.051
0.919TyrPhe: 0.919 ± 0.042
2.641TyrGly: 2.641 ± 0.07
0.491TyrHis: 0.491 ± 0.026
1.085TyrIle: 1.085 ± 0.04
0.67TyrLys: 0.67 ± 0.037
2.374TyrLeu: 2.374 ± 0.056
0.605TyrMet: 0.605 ± 0.033
0.751TyrAsn: 0.751 ± 0.038
1.239TyrPro: 1.239 ± 0.039
0.85TyrGln: 0.85 ± 0.035
2.092TyrArg: 2.092 ± 0.056
1.364TyrSer: 1.364 ± 0.045
1.65TyrThr: 1.65 ± 0.066
2.048TyrVal: 2.048 ± 0.056
0.438TyrTrp: 0.438 ± 0.025
0.885TyrTyr: 0.885 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1965 proteins (737665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski