Amino acid dipepetide frequency for Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.755AlaAla: 16.755 ± 0.143	1.003AlaCys: 1.003 ± 0.025	7.023AlaAsp: 7.023 ± 0.062	7.205AlaGlu: 7.205 ± 0.075	4.713AlaPhe: 4.713 ± 0.063	11.133AlaGly: 11.133 ± 0.088	2.088AlaHis: 2.088 ± 0.034	6.811AlaIle: 6.811 ± 0.063	4.574AlaLys: 4.574 ± 0.06	12.718AlaLeu: 12.718 ± 0.091	3.501AlaMet: 3.501 ± 0.05	3.185AlaAsn: 3.185 ± 0.051	5.1AlaPro: 5.1 ± 0.062	3.53AlaGln: 3.53 ± 0.04	7.925AlaArg: 7.925 ± 0.084	6.832AlaSer: 6.832 ± 0.066	6.117AlaThr: 6.117 ± 0.072	8.889AlaVal: 8.889 ± 0.074	1.446AlaTrp: 1.446 ± 0.03	2.64AlaTyr: 2.64 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.026	0.112CysCys: 0.112 ± 0.008	0.519CysAsp: 0.519 ± 0.016	0.407CysGlu: 0.407 ± 0.014	0.349CysPhe: 0.349 ± 0.014	0.904CysGly: 0.904 ± 0.021	0.22CysHis: 0.22 ± 0.01	0.374CysIle: 0.374 ± 0.014	0.194CysLys: 0.194 ± 0.01	0.774CysLeu: 0.774 ± 0.022	0.162CysMet: 0.162 ± 0.009	0.212CysAsn: 0.212 ± 0.01	0.399CysPro: 0.399 ± 0.018	0.234CysGln: 0.234 ± 0.011	0.593CysArg: 0.593 ± 0.015	0.483CysSer: 0.483 ± 0.019	0.421CysThr: 0.421 ± 0.016	0.61CysVal: 0.61 ± 0.019	0.121CysTrp: 0.121 ± 0.008	0.218CysTyr: 0.218 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.726AspAla: 6.726 ± 0.065	0.471AspCys: 0.471 ± 0.017	3.107AspAsp: 3.107 ± 0.044	3.278AspGlu: 3.278 ± 0.045	2.362AspPhe: 2.362 ± 0.034	5.299AspGly: 5.299 ± 0.061	1.263AspHis: 1.263 ± 0.028	3.383AspIle: 3.383 ± 0.049	2.034AspLys: 2.034 ± 0.033	5.638AspLeu: 5.638 ± 0.055	1.42AspMet: 1.42 ± 0.027	1.46AspAsn: 1.46 ± 0.029	3.339AspPro: 3.339 ± 0.048	1.776AspGln: 1.776 ± 0.03	4.212AspArg: 4.212 ± 0.048	2.179AspSer: 2.179 ± 0.035	2.568AspThr: 2.568 ± 0.038	4.112AspVal: 4.112 ± 0.049	0.963AspTrp: 0.963 ± 0.023	1.496AspTyr: 1.496 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.157GluAla: 7.157 ± 0.075	0.363GluCys: 0.363 ± 0.015	2.513GluAsp: 2.513 ± 0.043	2.847GluGlu: 2.847 ± 0.048	1.872GluPhe: 1.872 ± 0.03	3.916GluGly: 3.916 ± 0.051	1.17GluHis: 1.17 ± 0.026	3.602GluIle: 3.602 ± 0.05	2.56GluLys: 2.56 ± 0.046	5.083GluLeu: 5.083 ± 0.059	1.503GluMet: 1.503 ± 0.026	1.64GluAsn: 1.64 ± 0.029	2.726GluPro: 2.726 ± 0.045	2.009GluGln: 2.009 ± 0.04	4.454GluArg: 4.454 ± 0.057	2.147GluSer: 2.147 ± 0.034	3.346GluThr: 3.346 ± 0.043	3.541GluVal: 3.541 ± 0.048	0.679GluTrp: 0.679 ± 0.021	0.917GluTyr: 0.917 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.837PheAla: 4.837 ± 0.053	0.397PheCys: 0.397 ± 0.014	2.757PheAsp: 2.757 ± 0.039	2.214PheGlu: 2.214 ± 0.038	1.594PhePhe: 1.594 ± 0.033	3.903PheGly: 3.903 ± 0.05	0.799PheHis: 0.799 ± 0.022	1.869PheIle: 1.869 ± 0.032	1.131PheLys: 1.131 ± 0.029	3.488PheLeu: 3.488 ± 0.054	0.834PheMet: 0.834 ± 0.022	1.106PheAsn: 1.106 ± 0.024	1.637PhePro: 1.637 ± 0.033	1.081PheGln: 1.081 ± 0.021	2.315PheArg: 2.315 ± 0.034	2.485PheSer: 2.485 ± 0.039	1.964PheThr: 1.964 ± 0.036	3.108PheVal: 3.108 ± 0.045	0.585PheTrp: 0.585 ± 0.021	0.958PheTyr: 0.958 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.091GlyAla: 9.091 ± 0.09	0.837GlyCys: 0.837 ± 0.021	4.503GlyAsp: 4.503 ± 0.057	4.583GlyGlu: 4.583 ± 0.055	3.81GlyPhe: 3.81 ± 0.044	7.628GlyGly: 7.628 ± 0.156	1.906GlyHis: 1.906 ± 0.034	5.115GlyIle: 5.115 ± 0.061	3.948GlyLys: 3.948 ± 0.053	8.866GlyLeu: 8.866 ± 0.072	2.424GlyMet: 2.424 ± 0.042	2.466GlyAsn: 2.466 ± 0.051	3.516GlyPro: 3.516 ± 0.044	2.805GlyGln: 2.805 ± 0.042	5.722GlyArg: 5.722 ± 0.062	5.064GlySer: 5.064 ± 0.069	4.894GlyThr: 4.894 ± 0.088	6.172GlyVal: 6.172 ± 0.066	1.388GlyTrp: 1.388 ± 0.028	2.326GlyTyr: 2.326 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.261HisAla: 2.261 ± 0.035	0.227HisCys: 0.227 ± 0.011	1.237HisAsp: 1.237 ± 0.028	1.062HisGlu: 1.062 ± 0.025	0.912HisPhe: 0.912 ± 0.02	1.999HisGly: 1.999 ± 0.031	0.574HisHis: 0.574 ± 0.022	0.999HisIle: 0.999 ± 0.024	0.572HisLys: 0.572 ± 0.016	1.969HisLeu: 1.969 ± 0.034	0.533HisMet: 0.533 ± 0.017	0.487HisAsn: 0.487 ± 0.016	1.241HisPro: 1.241 ± 0.025	0.63HisGln: 0.63 ± 0.018	1.343HisArg: 1.343 ± 0.031	0.946HisSer: 0.946 ± 0.023	0.802HisThr: 0.802 ± 0.021	1.505HisVal: 1.505 ± 0.028	0.314HisTrp: 0.314 ± 0.013	0.56HisTyr: 0.56 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.685IleAla: 7.685 ± 0.068	0.521IleCys: 0.521 ± 0.014	3.805IleAsp: 3.805 ± 0.045	3.513IleGlu: 3.513 ± 0.049	1.936IlePhe: 1.936 ± 0.032	5.376IleGly: 5.376 ± 0.056	0.997IleHis: 0.997 ± 0.022	2.585IleIle: 2.585 ± 0.043	1.661IleLys: 1.661 ± 0.032	4.583IleLeu: 4.583 ± 0.057	1.1IleMet: 1.1 ± 0.024	1.523IleAsn: 1.523 ± 0.027	2.382IlePro: 2.382 ± 0.033	1.221IleGln: 1.221 ± 0.022	3.338IleArg: 3.338 ± 0.039	3.333IleSer: 3.333 ± 0.049	2.731IleThr: 2.731 ± 0.047	4.746IleVal: 4.746 ± 0.052	0.641IleTrp: 0.641 ± 0.019	1.185IleTyr: 1.185 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.883LysAla: 4.883 ± 0.052	0.177LysCys: 0.177 ± 0.01	1.912LysAsp: 1.912 ± 0.036	1.646LysGlu: 1.646 ± 0.034	1.049LysPhe: 1.049 ± 0.022	2.906LysGly: 2.906 ± 0.041	0.656LysHis: 0.656 ± 0.016	1.996LysIle: 1.996 ± 0.032	1.644LysLys: 1.644 ± 0.032	3.694LysLeu: 3.694 ± 0.049	0.94LysMet: 0.94 ± 0.026	1.022LysAsn: 1.022 ± 0.026	2.459LysPro: 2.459 ± 0.042	1.197LysGln: 1.197 ± 0.026	2.503LysArg: 2.503 ± 0.036	2.148LysSer: 2.148 ± 0.035	2.308LysThr: 2.308 ± 0.035	2.754LysVal: 2.754 ± 0.046	0.44LysTrp: 0.44 ± 0.016	0.695LysTyr: 0.695 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.155LeuAla: 13.155 ± 0.105	0.876LeuCys: 0.876 ± 0.021	5.881LeuAsp: 5.881 ± 0.056	4.929LeuGlu: 4.929 ± 0.058	3.722LeuPhe: 3.722 ± 0.048	8.291LeuGly: 8.291 ± 0.07	1.831LeuHis: 1.831 ± 0.031	5.128LeuIle: 5.128 ± 0.059	3.94LeuLys: 3.94 ± 0.046	9.233LeuLeu: 9.233 ± 0.086	2.285LeuMet: 2.285 ± 0.032	2.551LeuAsn: 2.551 ± 0.037	5.237LeuPro: 5.237 ± 0.057	2.709LeuGln: 2.709 ± 0.034	6.143LeuArg: 6.143 ± 0.064	6.56LeuSer: 6.56 ± 0.063	5.367LeuThr: 5.367 ± 0.058	7.552LeuVal: 7.552 ± 0.076	1.137LeuTrp: 1.137 ± 0.022	2.067LeuTyr: 2.067 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.295MetAla: 3.295 ± 0.046	0.152MetCys: 0.152 ± 0.009	1.125MetAsp: 1.125 ± 0.023	1.076MetGlu: 1.076 ± 0.022	0.747MetPhe: 0.747 ± 0.02	1.726MetGly: 1.726 ± 0.034	0.473MetHis: 0.473 ± 0.017	1.392MetIle: 1.392 ± 0.029	1.075MetLys: 1.075 ± 0.023	2.611MetLeu: 2.611 ± 0.039	0.683MetMet: 0.683 ± 0.018	0.837MetAsn: 0.837 ± 0.019	1.519MetPro: 1.519 ± 0.029	0.858MetGln: 0.858 ± 0.019	1.824MetArg: 1.824 ± 0.033	1.697MetSer: 1.697 ± 0.028	1.899MetThr: 1.899 ± 0.033	1.788MetVal: 1.788 ± 0.027	0.216MetTrp: 0.216 ± 0.011	0.304MetTyr: 0.304 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.332AsnAla: 3.332 ± 0.047	0.278AsnCys: 0.278 ± 0.013	1.46AsnAsp: 1.46 ± 0.026	1.315AsnGlu: 1.315 ± 0.029	1.102AsnPhe: 1.102 ± 0.026	2.639AsnGly: 2.639 ± 0.06	0.534AsnHis: 0.534 ± 0.014	1.47AsnIle: 1.47 ± 0.031	0.778AsnLys: 0.778 ± 0.022	2.636AsnLeu: 2.636 ± 0.04	0.653AsnMet: 0.653 ± 0.018	0.79AsnAsn: 0.79 ± 0.027	1.888AsnPro: 1.888 ± 0.031	0.801AsnGln: 0.801 ± 0.023	1.786AsnArg: 1.786 ± 0.031	1.417AsnSer: 1.417 ± 0.031	1.384AsnThr: 1.384 ± 0.032	2.054AsnVal: 2.054 ± 0.038	0.459AsnTrp: 0.459 ± 0.016	0.736AsnTyr: 0.736 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.192ProAla: 6.192 ± 0.075	0.289ProCys: 0.289 ± 0.013	3.61ProAsp: 3.61 ± 0.046	3.267ProGlu: 3.267 ± 0.045	2.065ProPhe: 2.065 ± 0.037	4.324ProGly: 4.324 ± 0.06	1.02ProHis: 1.02 ± 0.024	2.346ProIle: 2.346 ± 0.034	1.879ProLys: 1.879 ± 0.034	4.666ProLeu: 4.666 ± 0.055	1.173ProMet: 1.173 ± 0.026	1.394ProAsn: 1.394 ± 0.028	2.272ProPro: 2.272 ± 0.043	1.634ProGln: 1.634 ± 0.026	2.728ProArg: 2.728 ± 0.042	2.781ProSer: 2.781 ± 0.037	2.458ProThr: 2.458 ± 0.038	4.127ProVal: 4.127 ± 0.045	0.696ProTrp: 0.696 ± 0.021	1.232ProTyr: 1.232 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.013GlnAla: 4.013 ± 0.052	0.218GlnCys: 0.218 ± 0.011	1.408GlnAsp: 1.408 ± 0.028	1.435GlnGlu: 1.435 ± 0.027	1.023GlnPhe: 1.023 ± 0.024	2.36GlnGly: 2.36 ± 0.036	0.629GlnHis: 0.629 ± 0.019	1.794GlnIle: 1.794 ± 0.029	1.219GlnLys: 1.219 ± 0.025	2.761GlnLeu: 2.761 ± 0.038	0.904GlnMet: 0.904 ± 0.023	0.876GlnAsn: 0.876 ± 0.021	1.731GlnPro: 1.731 ± 0.037	1.228GlnGln: 1.228 ± 0.038	2.301GlnArg: 2.301 ± 0.039	1.826GlnSer: 1.826 ± 0.033	1.762GlnThr: 1.762 ± 0.031	2.065GlnVal: 2.065 ± 0.032	0.424GlnTrp: 0.424 ± 0.018	0.605GlnTyr: 0.605 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.032ArgAla: 7.032 ± 0.068	0.478ArgCys: 0.478 ± 0.018	3.927ArgAsp: 3.927 ± 0.046	3.778ArgGlu: 3.778 ± 0.055	2.853ArgPhe: 2.853 ± 0.042	4.485ArgGly: 4.485 ± 0.051	1.668ArgHis: 1.668 ± 0.032	4.022ArgIle: 4.022 ± 0.048	2.525ArgLys: 2.525 ± 0.039	7.345ArgLeu: 7.345 ± 0.082	1.802ArgMet: 1.802 ± 0.032	1.899ArgAsn: 1.899 ± 0.034	3.291ArgPro: 3.291 ± 0.049	2.584ArgGln: 2.584 ± 0.042	5.106ArgArg: 5.106 ± 0.065	3.607ArgSer: 3.607 ± 0.048	3.327ArgThr: 3.327 ± 0.042	4.269ArgVal: 4.269 ± 0.049	0.927ArgTrp: 0.927 ± 0.022	1.654ArgTyr: 1.654 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.488SerAla: 6.488 ± 0.071	0.423SerCys: 0.423 ± 0.018	3.129SerAsp: 3.129 ± 0.039	2.801SerGlu: 2.801 ± 0.042	2.414SerPhe: 2.414 ± 0.035	6.083SerGly: 6.083 ± 0.077	1.151SerHis: 1.151 ± 0.026	3.109SerIle: 3.109 ± 0.048	1.824SerLys: 1.824 ± 0.031	5.548SerLeu: 5.548 ± 0.053	1.419SerMet: 1.419 ± 0.027	1.53SerAsn: 1.53 ± 0.027	2.785SerPro: 2.785 ± 0.04	1.674SerGln: 1.674 ± 0.028	3.673SerArg: 3.673 ± 0.046	3.186SerSer: 3.186 ± 0.049	2.867SerThr: 2.867 ± 0.048	4.35SerVal: 4.35 ± 0.052	0.799SerTrp: 0.799 ± 0.024	1.325SerTyr: 1.325 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.217ThrAla: 6.217 ± 0.072	0.416ThrCys: 0.416 ± 0.015	2.804ThrAsp: 2.804 ± 0.039	2.582ThrGlu: 2.582 ± 0.039	2.086ThrPhe: 2.086 ± 0.032	5.283ThrGly: 5.283 ± 0.081	0.983ThrHis: 0.983 ± 0.022	3.21ThrIle: 3.21 ± 0.043	1.681ThrLys: 1.681 ± 0.033	5.607ThrLeu: 5.607 ± 0.063	1.288ThrMet: 1.288 ± 0.026	1.432ThrAsn: 1.432 ± 0.033	3.017ThrPro: 3.017 ± 0.044	1.374ThrGln: 1.374 ± 0.028	3.107ThrArg: 3.107 ± 0.043	3.167ThrSer: 3.167 ± 0.048	2.872ThrThr: 2.872 ± 0.055	4.49ThrVal: 4.49 ± 0.064	0.644ThrTrp: 0.644 ± 0.02	1.235ThrTyr: 1.235 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.409ValAla: 9.409 ± 0.071	0.627ValCys: 0.627 ± 0.019	4.246ValAsp: 4.246 ± 0.05	4.361ValGlu: 4.361 ± 0.055	2.929ValPhe: 2.929 ± 0.045	5.812ValGly: 5.812 ± 0.062	1.388ValHis: 1.388 ± 0.028	4.054ValIle: 4.054 ± 0.049	2.586ValLys: 2.586 ± 0.043	7.434ValLeu: 7.434 ± 0.062	1.88ValMet: 1.88 ± 0.036	1.988ValAsn: 1.988 ± 0.038	3.787ValPro: 3.787 ± 0.052	1.977ValGln: 1.977 ± 0.033	4.736ValArg: 4.736 ± 0.051	4.617ValSer: 4.617 ± 0.055	4.468ValThr: 4.468 ± 0.058	5.979ValVal: 5.979 ± 0.07	0.9ValTrp: 0.9 ± 0.021	1.452ValTyr: 1.452 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.265TrpAla: 1.265 ± 0.026	0.125TrpCys: 0.125 ± 0.007	0.632TrpAsp: 0.632 ± 0.02	0.524TrpGlu: 0.524 ± 0.019	0.572TrpPhe: 0.572 ± 0.017	0.88TrpGly: 0.88 ± 0.021	0.341TrpHis: 0.341 ± 0.013	0.667TrpIle: 0.667 ± 0.021	0.518TrpLys: 0.518 ± 0.015	1.681TrpLeu: 1.681 ± 0.037	0.359TrpMet: 0.359 ± 0.014	0.499TrpAsn: 0.499 ± 0.017	0.709TrpPro: 0.709 ± 0.018	0.554TrpGln: 0.554 ± 0.017	1.07TrpArg: 1.07 ± 0.024	0.858TrpSer: 0.858 ± 0.024	0.787TrpThr: 0.787 ± 0.022	0.819TrpVal: 0.819 ± 0.02	0.236TrpTrp: 0.236 ± 0.012	0.277TrpTyr: 0.277 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.036	0.242TyrCys: 0.242 ± 0.012	1.487TyrAsp: 1.487 ± 0.028	1.223TyrGlu: 1.223 ± 0.028	0.955TyrPhe: 0.955 ± 0.024	2.119TyrGly: 2.119 ± 0.037	0.485TyrHis: 0.485 ± 0.016	0.933TyrIle: 0.933 ± 0.024	0.685TyrLys: 0.685 ± 0.021	2.26TyrLeu: 2.26 ± 0.035	0.434TyrMet: 0.434 ± 0.014	0.615TyrAsn: 0.615 ± 0.02	1.119TyrPro: 1.119 ± 0.025	0.705TyrGln: 0.705 ± 0.019	1.699TyrArg: 1.699 ± 0.037	1.244TyrSer: 1.244 ± 0.027	1.153TyrThr: 1.153 ± 0.031	1.697TyrVal: 1.697 ± 0.025	0.359TyrTrp: 0.359 ± 0.016	0.576TyrTyr: 0.576 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6260 proteins (1921430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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