Amino acid dipepetide frequency for Wenling tombus-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.309AlaAla: 15.309 ± 3.758
3.062AlaCys: 3.062 ± 1.355
4.899AlaAsp: 4.899 ± 1.519
1.837AlaGlu: 1.837 ± 1.133
1.837AlaPhe: 1.837 ± 1.133
4.899AlaGly: 4.899 ± 2.266
1.225AlaHis: 1.225 ± 0.563
2.449AlaIle: 2.449 ± 1.534
4.287AlaLys: 4.287 ± 3.179
6.124AlaLeu: 6.124 ± 0.532
0.612AlaMet: 0.612 ± 0.727
4.899AlaAsn: 4.899 ± 1.945
5.511AlaPro: 5.511 ± 2.825
7.961AlaGln: 7.961 ± 1.34
6.736AlaArg: 6.736 ± 3.064
7.961AlaSer: 7.961 ± 1.543
6.124AlaThr: 6.124 ± 0.737
6.736AlaVal: 6.736 ± 1.931
3.062AlaTrp: 3.062 ± 0.369
2.449AlaTyr: 2.449 ± 0.9
0.0AlaXaa: 0.0 ± 0.0
Cys
1.837CysAla: 1.837 ± 0.728
1.225CysCys: 1.225 ± 0.563
0.612CysAsp: 0.612 ± 0.631
1.225CysGlu: 1.225 ± 0.767
1.225CysPhe: 1.225 ± 0.767
2.449CysGly: 2.449 ± 1.126
0.0CysHis: 0.0 ± 0.0
0.612CysIle: 0.612 ± 0.383
0.0CysLys: 0.0 ± 0.0
3.062CysLeu: 3.062 ± 1.674
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.837CysPro: 1.837 ± 0.728
1.225CysGln: 1.225 ± 0.552
1.225CysArg: 1.225 ± 0.782
0.0CysSer: 0.0 ± 0.0
1.225CysThr: 1.225 ± 0.767
1.837CysVal: 1.837 ± 0.728
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.062AspAla: 3.062 ± 0.65
1.225AspCys: 1.225 ± 0.563
4.287AspAsp: 4.287 ± 2.182
2.449AspGlu: 2.449 ± 1.018
3.062AspPhe: 3.062 ± 0.65
4.899AspGly: 4.899 ± 0.041
0.612AspHis: 0.612 ± 0.383
1.837AspIle: 1.837 ± 0.399
2.449AspLys: 2.449 ± 0.02
1.837AspLeu: 1.837 ± 1.233
1.837AspMet: 1.837 ± 0.891
2.449AspAsn: 2.449 ± 0.859
6.124AspPro: 6.124 ± 1.455
3.062AspGln: 3.062 ± 0.727
1.837AspArg: 1.837 ± 1.15
1.837AspSer: 1.837 ± 0.399
1.225AspThr: 1.225 ± 1.455
3.062AspVal: 3.062 ± 0.369
0.612AspTrp: 0.612 ± 0.727
1.225AspTyr: 1.225 ± 0.782
0.0AspXaa: 0.0 ± 0.0
Glu
1.225GluAla: 1.225 ± 0.563
0.612GluCys: 0.612 ± 0.631
0.612GluAsp: 0.612 ± 0.727
1.225GluGlu: 1.225 ± 1.455
0.612GluPhe: 0.612 ± 0.727
4.287GluGly: 4.287 ± 2.226
1.225GluHis: 1.225 ± 0.782
0.0GluIle: 0.0 ± 0.0
3.674GluLys: 3.674 ± 0.574
3.062GluLeu: 3.062 ± 1.101
0.0GluMet: 0.0 ± 0.0
1.837GluAsn: 1.837 ± 1.233
0.0GluPro: 0.0 ± 0.0
0.0GluGln: 0.0 ± 0.0
4.287GluArg: 4.287 ± 2.874
2.449GluSer: 2.449 ± 0.859
3.674GluThr: 3.674 ± 1.589
3.062GluVal: 3.062 ± 1.737
0.612GluTrp: 0.612 ± 0.383
0.612GluTyr: 0.612 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
1.225PheAla: 1.225 ± 0.563
0.612PheCys: 0.612 ± 0.631
1.837PheAsp: 1.837 ± 1.893
0.0PheGlu: 0.0 ± 0.0
0.0PhePhe: 0.0 ± 0.0
1.225PheGly: 1.225 ± 0.767
2.449PheHis: 2.449 ± 1.126
3.062PheIle: 3.062 ± 1.181
1.225PheLys: 1.225 ± 1.455
1.225PheLeu: 1.225 ± 0.563
0.0PheMet: 0.0 ± 0.0
0.612PheAsn: 0.612 ± 0.631
3.062PhePro: 3.062 ± 0.369
0.612PheGln: 0.612 ± 0.383
2.449PheArg: 2.449 ± 1.745
1.225PheSer: 1.225 ± 1.262
3.062PheThr: 3.062 ± 1.355
1.225PheVal: 1.225 ± 0.563
1.225PheTrp: 1.225 ± 0.552
0.612PheTyr: 0.612 ± 0.727
0.0PheXaa: 0.0 ± 0.0
Gly
11.023GlyAla: 11.023 ± 3.804
1.225GlyCys: 1.225 ± 1.455
6.124GlyAsp: 6.124 ± 0.737
1.225GlyGlu: 1.225 ± 1.455
3.062GlyPhe: 3.062 ± 1.737
5.511GlyGly: 5.511 ± 1.836
2.449GlyHis: 2.449 ± 0.02
1.837GlyIle: 1.837 ± 1.893
3.674GlyLys: 3.674 ± 1.532
5.511GlyLeu: 5.511 ± 2.341
0.0GlyMet: 0.0 ± 0.0
1.837GlyAsn: 1.837 ± 0.612
3.674GlyPro: 3.674 ± 1.281
4.287GlyGln: 4.287 ± 1.442
2.449GlyArg: 2.449 ± 1.126
9.798GlySer: 9.798 ± 2.23
8.573GlyThr: 8.573 ± 0.523
4.899GlyVal: 4.899 ± 0.041
0.0GlyTrp: 0.0 ± 0.0
1.837GlyTyr: 1.837 ± 0.612
0.0GlyXaa: 0.0 ± 0.0
His
1.837HisAla: 1.837 ± 0.728
0.612HisCys: 0.612 ± 0.631
0.612HisAsp: 0.612 ± 0.383
0.612HisGlu: 0.612 ± 0.631
0.0HisPhe: 0.0 ± 0.0
1.837HisGly: 1.837 ± 1.15
1.837HisHis: 1.837 ± 0.728
0.612HisIle: 0.612 ± 0.631
0.612HisLys: 0.612 ± 0.727
5.511HisLeu: 5.511 ± 1.689
0.612HisMet: 0.612 ± 0.383
0.0HisAsn: 0.0 ± 0.0
1.225HisPro: 1.225 ± 0.552
1.837HisGln: 1.837 ± 0.612
2.449HisArg: 2.449 ± 1.029
1.837HisSer: 1.837 ± 1.15
2.449HisThr: 2.449 ± 1.745
5.511HisVal: 5.511 ± 1.162
0.612HisTrp: 0.612 ± 0.383
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.225IleAla: 1.225 ± 0.563
0.0IleCys: 0.0 ± 0.0
1.837IleAsp: 1.837 ± 1.133
1.225IleGlu: 1.225 ± 0.782
0.612IlePhe: 0.612 ± 0.631
3.674IleGly: 3.674 ± 0.798
0.612IleHis: 0.612 ± 0.631
1.225IleIle: 1.225 ± 1.262
1.225IleLys: 1.225 ± 0.563
1.225IleLeu: 1.225 ± 0.767
1.225IleMet: 1.225 ± 0.552
1.225IleAsn: 1.225 ± 0.782
3.674IlePro: 3.674 ± 1.656
0.612IleGln: 0.612 ± 0.631
1.837IleArg: 1.837 ± 1.133
1.225IleSer: 1.225 ± 1.262
2.449IleThr: 2.449 ± 1.029
4.287IleVal: 4.287 ± 1.135
1.225IleTrp: 1.225 ± 0.782
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.674LysAla: 3.674 ± 0.574
0.612LysCys: 0.612 ± 0.631
1.225LysAsp: 1.225 ± 0.552
0.612LysGlu: 0.612 ± 0.727
1.225LysPhe: 1.225 ± 0.563
7.961LysGly: 7.961 ± 0.341
0.612LysHis: 0.612 ± 0.727
0.0LysIle: 0.0 ± 0.0
1.225LysLys: 1.225 ± 0.767
2.449LysLeu: 2.449 ± 1.029
0.0LysMet: 0.0 ± 0.0
0.612LysAsn: 0.612 ± 0.727
3.062LysPro: 3.062 ± 0.727
1.225LysGln: 1.225 ± 0.563
1.837LysArg: 1.837 ± 1.15
3.062LysSer: 3.062 ± 1.182
1.837LysThr: 1.837 ± 0.399
0.612LysVal: 0.612 ± 0.631
1.225LysTrp: 1.225 ± 0.552
2.449LysTyr: 2.449 ± 1.948
0.0LysXaa: 0.0 ± 0.0
Leu
9.798LeuAla: 9.798 ± 1.073
0.612LeuCys: 0.612 ± 0.631
2.449LeuAsp: 2.449 ± 1.564
3.674LeuGlu: 3.674 ± 0.574
2.449LeuPhe: 2.449 ± 1.126
6.736LeuGly: 6.736 ± 0.431
4.899LeuHis: 4.899 ± 1.519
3.062LeuIle: 3.062 ± 0.65
1.837LeuLys: 1.837 ± 0.399
5.511LeuLeu: 5.511 ± 1.085
0.612LeuMet: 0.612 ± 0.727
1.837LeuAsn: 1.837 ± 0.399
10.41LeuPro: 10.41 ± 4.136
3.062LeuGln: 3.062 ± 1.951
5.511LeuArg: 5.511 ± 1.249
6.124LeuSer: 6.124 ± 1.455
7.961LeuThr: 7.961 ± 2.359
8.573LeuVal: 8.573 ± 1.32
1.225LeuTrp: 1.225 ± 0.767
1.837LeuTyr: 1.837 ± 2.182
0.0LeuXaa: 0.0 ± 0.0
Met
1.837MetAla: 1.837 ± 0.399
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.612MetGlu: 0.612 ± 0.727
0.0MetPhe: 0.0 ± 0.0
1.225MetGly: 1.225 ± 0.563
0.0MetHis: 0.0 ± 0.0
0.612MetIle: 0.612 ± 0.383
0.612MetLys: 0.612 ± 0.631
1.225MetLeu: 1.225 ± 0.767
0.0MetMet: 0.0 ± 0.0
0.612MetAsn: 0.612 ± 0.727
2.449MetPro: 2.449 ± 1.029
0.612MetGln: 0.612 ± 0.727
0.0MetArg: 0.0 ± 0.0
0.612MetSer: 0.612 ± 0.727
3.062MetThr: 3.062 ± 0.369
0.612MetVal: 0.612 ± 0.631
1.225MetTrp: 1.225 ± 1.455
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.674AsnAla: 3.674 ± 1.656
0.0AsnCys: 0.0 ± 0.0
1.225AsnAsp: 1.225 ± 0.552
1.837AsnGlu: 1.837 ± 0.612
0.0AsnPhe: 0.0 ± 0.0
3.062AsnGly: 3.062 ± 0.727
2.449AsnHis: 2.449 ± 1.029
1.837AsnIle: 1.837 ± 1.221
0.612AsnLys: 0.612 ± 0.727
3.674AsnLeu: 3.674 ± 1.224
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
3.674AsnPro: 3.674 ± 1.743
0.0AsnGln: 0.0 ± 0.0
2.449AsnArg: 2.449 ± 1.018
2.449AsnSer: 2.449 ± 1.104
1.837AsnThr: 1.837 ± 0.612
0.612AsnVal: 0.612 ± 0.383
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
7.961ProAla: 7.961 ± 2.885
2.449ProCys: 2.449 ± 1.126
0.612ProAsp: 0.612 ± 0.727
2.449ProGlu: 2.449 ± 0.859
3.062ProPhe: 3.062 ± 0.65
5.511ProGly: 5.511 ± 1.085
4.287ProHis: 4.287 ± 1.728
3.062ProIle: 3.062 ± 1.737
4.287ProLys: 4.287 ± 0.415
10.41ProLeu: 10.41 ± 1.748
1.225ProMet: 1.225 ± 0.563
1.225ProAsn: 1.225 ± 0.782
4.287ProPro: 4.287 ± 1.442
3.674ProGln: 3.674 ± 0.798
4.899ProArg: 4.899 ± 1.035
8.573ProSer: 8.573 ± 2.271
2.449ProThr: 2.449 ± 0.02
7.961ProVal: 7.961 ± 2.01
0.612ProTrp: 0.612 ± 0.631
1.225ProTyr: 1.225 ± 0.563
0.0ProXaa: 0.0 ± 0.0
Gln
5.511GlnAla: 5.511 ± 1.523
0.0GlnCys: 0.0 ± 0.0
4.287GlnAsp: 4.287 ± 1.442
0.612GlnGlu: 0.612 ± 0.727
1.225GlnPhe: 1.225 ± 1.262
1.225GlnGly: 1.225 ± 0.782
0.612GlnHis: 0.612 ± 0.383
0.612GlnIle: 0.612 ± 0.383
0.0GlnLys: 0.0 ± 0.0
5.511GlnLeu: 5.511 ± 0.728
2.449GlnMet: 2.449 ± 1.104
0.0GlnAsn: 0.0 ± 0.0
5.511GlnPro: 5.511 ± 0.354
1.837GlnGln: 1.837 ± 1.233
3.062GlnArg: 3.062 ± 0.727
2.449GlnSer: 2.449 ± 0.02
1.225GlnThr: 1.225 ± 0.563
3.062GlnVal: 3.062 ± 0.369
0.612GlnTrp: 0.612 ± 0.631
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.899ArgAla: 4.899 ± 1.8
0.612ArgCys: 0.612 ± 0.383
4.287ArgAsp: 4.287 ± 2.684
4.287ArgGlu: 4.287 ± 1.912
2.449ArgPhe: 2.449 ± 1.745
3.062ArgGly: 3.062 ± 1.243
1.225ArgHis: 1.225 ± 0.563
0.0ArgIle: 0.0 ± 0.0
2.449ArgLys: 2.449 ± 0.02
7.961ArgLeu: 7.961 ± 1.142
1.837ArgMet: 1.837 ± 0.359
4.287ArgAsn: 4.287 ± 0.593
3.674ArgPro: 3.674 ± 0.752
3.674ArgGln: 3.674 ± 2.122
7.961ArgArg: 7.961 ± 0.341
1.837ArgSer: 1.837 ± 0.399
4.899ArgThr: 4.899 ± 1.013
4.899ArgVal: 4.899 ± 2.208
1.225ArgTrp: 1.225 ± 0.767
3.674ArgTyr: 3.674 ± 0.542
0.0ArgXaa: 0.0 ± 0.0
Ser
6.124SerAla: 6.124 ± 1.7
0.612SerCys: 0.612 ± 0.383
1.837SerAsp: 1.837 ± 1.372
2.449SerGlu: 2.449 ± 1.948
1.837SerPhe: 1.837 ± 0.728
7.348SerGly: 7.348 ± 1.698
1.837SerHis: 1.837 ± 1.133
3.062SerIle: 3.062 ± 0.65
1.837SerLys: 1.837 ± 1.15
4.287SerLeu: 4.287 ± 1.728
1.837SerMet: 1.837 ± 1.372
2.449SerAsn: 2.449 ± 0.859
7.961SerPro: 7.961 ± 2.403
0.612SerGln: 0.612 ± 0.383
4.899SerArg: 4.899 ± 1.958
7.348SerSer: 7.348 ± 2.726
6.124SerThr: 6.124 ± 1.205
5.511SerVal: 5.511 ± 0.728
3.062SerTrp: 3.062 ± 0.727
2.449SerTyr: 2.449 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
6.736ThrAla: 6.736 ± 1.878
1.837ThrCys: 1.837 ± 0.728
6.124ThrAsp: 6.124 ± 2.362
1.225ThrGlu: 1.225 ± 1.262
1.225ThrPhe: 1.225 ± 0.563
6.124ThrGly: 6.124 ± 2.201
3.062ThrHis: 3.062 ± 1.101
0.612ThrIle: 0.612 ± 0.383
1.837ThrLys: 1.837 ± 0.728
7.961ThrLeu: 7.961 ± 0.689
1.837ThrMet: 1.837 ± 0.612
2.449ThrAsn: 2.449 ± 0.859
6.736ThrPro: 6.736 ± 1.224
1.837ThrGln: 1.837 ± 0.399
4.899ThrArg: 4.899 ± 1.945
3.062ThrSer: 3.062 ± 1.502
4.899ThrThr: 4.899 ± 1.519
8.573ThrVal: 8.573 ± 0.599
0.612ThrTrp: 0.612 ± 0.383
3.674ThrTyr: 3.674 ± 1.712
0.0ThrXaa: 0.0 ± 0.0
Val
7.348ValAla: 7.348 ± 0.819
3.674ValCys: 3.674 ± 2.301
4.899ValAsp: 4.899 ± 2.909
3.062ValGlu: 3.062 ± 2.367
1.837ValPhe: 1.837 ± 0.728
7.348ValGly: 7.348 ± 0.819
0.0ValHis: 0.0 ± 0.0
3.674ValIle: 3.674 ± 2.265
3.674ValLys: 3.674 ± 0.542
6.124ValLeu: 6.124 ± 1.3
0.612ValMet: 0.612 ± 0.631
2.449ValAsn: 2.449 ± 0.02
6.736ValPro: 6.736 ± 1.616
3.062ValGln: 3.062 ± 1.101
7.348ValArg: 7.348 ± 2.448
7.961ValSer: 7.961 ± 2.349
6.124ValThr: 6.124 ± 2.461
4.899ValVal: 4.899 ± 0.92
0.0ValTrp: 0.0 ± 0.0
1.837ValTyr: 1.837 ± 0.399
0.0ValXaa: 0.0 ± 0.0
Trp
2.449TrpAla: 2.449 ± 1.018
0.612TrpCys: 0.612 ± 0.383
0.612TrpAsp: 0.612 ± 0.383
0.0TrpGlu: 0.0 ± 0.0
1.225TrpPhe: 1.225 ± 0.552
0.612TrpGly: 0.612 ± 0.383
0.612TrpHis: 0.612 ± 0.383
1.225TrpIle: 1.225 ± 1.455
0.0TrpLys: 0.0 ± 0.0
1.837TrpLeu: 1.837 ± 1.15
0.0TrpMet: 0.0 ± 0.0
0.612TrpAsn: 0.612 ± 0.727
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.225TrpArg: 1.225 ± 0.782
1.225TrpSer: 1.225 ± 0.552
1.225TrpThr: 1.225 ± 1.455
2.449TrpVal: 2.449 ± 0.02
0.0TrpTrp: 0.0 ± 0.0
1.837TrpTyr: 1.837 ± 1.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.225TyrAla: 1.225 ± 0.563
0.0TyrCys: 0.0 ± 0.0
1.225TyrAsp: 1.225 ± 0.563
2.449TyrGlu: 2.449 ± 0.02
0.0TyrPhe: 0.0 ± 0.0
0.0TyrGly: 0.0 ± 0.0
0.612TyrHis: 0.612 ± 0.383
1.225TyrIle: 1.225 ± 0.552
0.0TyrLys: 0.0 ± 0.0
3.674TyrLeu: 3.674 ± 1.743
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.612TyrPro: 0.612 ± 0.631
0.612TyrGln: 0.612 ± 0.383
1.837TyrArg: 1.837 ± 1.233
2.449TyrSer: 2.449 ± 0.9
4.899TyrThr: 4.899 ± 0.041
4.287TyrVal: 4.287 ± 2.309
0.612TyrTrp: 0.612 ± 0.727
0.612TyrTyr: 0.612 ± 0.727
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski