Amino acid dipepetide frequency for Streptococcus phage Javan84

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.092AlaAla: 4.092 ± 1.501
0.379AlaCys: 0.379 ± 0.174
4.47AlaAsp: 4.47 ± 0.398
6.44AlaGlu: 6.44 ± 0.954
2.273AlaPhe: 2.273 ± 0.595
5.683AlaGly: 5.683 ± 1.112
1.364AlaHis: 1.364 ± 0.337
7.047AlaIle: 7.047 ± 1.014
6.365AlaLys: 6.365 ± 0.683
7.047AlaLeu: 7.047 ± 1.149
2.803AlaMet: 2.803 ± 1.013
3.94AlaAsn: 3.94 ± 0.591
2.576AlaPro: 2.576 ± 0.415
2.879AlaGln: 2.879 ± 0.61
2.879AlaArg: 2.879 ± 0.5
5.001AlaSer: 5.001 ± 0.869
5.152AlaThr: 5.152 ± 0.792
6.062AlaVal: 6.062 ± 1.122
0.985AlaTrp: 0.985 ± 0.314
2.273AlaTyr: 2.273 ± 0.394
0.0AlaXaa: 0.0 ± 0.0
Cys
0.379CysAla: 0.379 ± 0.148
0.076CysCys: 0.076 ± 0.069
0.53CysAsp: 0.53 ± 0.172
0.379CysGlu: 0.379 ± 0.194
0.303CysPhe: 0.303 ± 0.147
0.606CysGly: 0.606 ± 0.213
0.076CysHis: 0.076 ± 0.076
0.152CysIle: 0.152 ± 0.139
0.152CysLys: 0.152 ± 0.099
0.303CysLeu: 0.303 ± 0.167
0.227CysMet: 0.227 ± 0.126
0.303CysAsn: 0.303 ± 0.154
0.455CysPro: 0.455 ± 0.212
0.227CysGln: 0.227 ± 0.127
0.303CysArg: 0.303 ± 0.126
0.455CysSer: 0.455 ± 0.147
0.303CysThr: 0.303 ± 0.145
0.152CysVal: 0.152 ± 0.107
0.076CysTrp: 0.076 ± 0.069
0.227CysTyr: 0.227 ± 0.163
0.0CysXaa: 0.0 ± 0.0
Asp
3.637AspAla: 3.637 ± 0.713
0.455AspCys: 0.455 ± 0.198
3.182AspAsp: 3.182 ± 0.469
4.167AspGlu: 4.167 ± 0.666
3.41AspPhe: 3.41 ± 0.528
4.546AspGly: 4.546 ± 0.579
0.227AspHis: 0.227 ± 0.122
4.773AspIle: 4.773 ± 0.676
5.531AspLys: 5.531 ± 0.746
4.773AspLeu: 4.773 ± 0.602
1.667AspMet: 1.667 ± 0.45
3.031AspAsn: 3.031 ± 0.46
1.743AspPro: 1.743 ± 0.409
1.364AspGln: 1.364 ± 0.352
2.728AspArg: 2.728 ± 0.487
3.788AspSer: 3.788 ± 0.522
4.773AspThr: 4.773 ± 0.6
2.728AspVal: 2.728 ± 0.457
1.212AspTrp: 1.212 ± 0.325
3.031AspTyr: 3.031 ± 0.625
0.0AspXaa: 0.0 ± 0.0
Glu
5.455GluAla: 5.455 ± 0.75
0.833GluCys: 0.833 ± 0.322
2.728GluAsp: 2.728 ± 0.561
5.607GluGlu: 5.607 ± 0.909
2.425GluPhe: 2.425 ± 0.375
3.031GluGly: 3.031 ± 0.557
1.364GluHis: 1.364 ± 0.375
6.062GluIle: 6.062 ± 0.805
5.91GluLys: 5.91 ± 1.049
9.017GluLeu: 9.017 ± 1.406
2.122GluMet: 2.122 ± 0.47
3.637GluAsn: 3.637 ± 0.483
1.44GluPro: 1.44 ± 0.378
3.713GluGln: 3.713 ± 0.475
3.864GluArg: 3.864 ± 0.548
2.955GluSer: 2.955 ± 0.479
2.652GluThr: 2.652 ± 0.481
4.622GluVal: 4.622 ± 0.748
0.606GluTrp: 0.606 ± 0.16
3.561GluTyr: 3.561 ± 0.509
0.0GluXaa: 0.0 ± 0.0
Phe
2.652PheAla: 2.652 ± 0.553
0.152PheCys: 0.152 ± 0.091
3.788PheAsp: 3.788 ± 0.586
2.652PheGlu: 2.652 ± 0.43
1.061PhePhe: 1.061 ± 0.352
3.107PheGly: 3.107 ± 0.384
0.909PheHis: 0.909 ± 0.268
2.122PheIle: 2.122 ± 0.343
3.713PheLys: 3.713 ± 0.514
2.803PheLeu: 2.803 ± 0.487
1.212PheMet: 1.212 ± 0.321
1.818PheAsn: 1.818 ± 0.318
1.137PhePro: 1.137 ± 0.242
0.682PheGln: 0.682 ± 0.194
1.818PheArg: 1.818 ± 0.44
2.425PheSer: 2.425 ± 0.54
2.273PheThr: 2.273 ± 0.486
2.122PheVal: 2.122 ± 0.432
0.455PheTrp: 0.455 ± 0.211
0.909PheTyr: 0.909 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
4.622GlyAla: 4.622 ± 0.788
0.455GlyCys: 0.455 ± 0.165
3.561GlyAsp: 3.561 ± 0.582
3.182GlyGlu: 3.182 ± 0.476
2.803GlyPhe: 2.803 ± 0.532
3.258GlyGly: 3.258 ± 0.53
0.682GlyHis: 0.682 ± 0.208
5.228GlyIle: 5.228 ± 1.024
5.304GlyLys: 5.304 ± 0.749
4.773GlyLeu: 4.773 ± 0.582
2.122GlyMet: 2.122 ± 0.343
3.182GlyAsn: 3.182 ± 0.643
0.985GlyPro: 0.985 ± 0.273
3.637GlyGln: 3.637 ± 0.555
2.5GlyArg: 2.5 ± 0.409
4.622GlySer: 4.622 ± 0.996
4.016GlyThr: 4.016 ± 0.63
5.91GlyVal: 5.91 ± 1.107
0.985GlyTrp: 0.985 ± 0.313
2.652GlyTyr: 2.652 ± 0.488
0.0GlyXaa: 0.0 ± 0.0
His
1.364HisAla: 1.364 ± 0.31
0.152HisCys: 0.152 ± 0.082
0.985HisAsp: 0.985 ± 0.298
0.758HisGlu: 0.758 ± 0.261
0.682HisPhe: 0.682 ± 0.215
1.061HisGly: 1.061 ± 0.335
0.682HisHis: 0.682 ± 0.239
0.909HisIle: 0.909 ± 0.334
0.985HisLys: 0.985 ± 0.403
0.985HisLeu: 0.985 ± 0.274
0.303HisMet: 0.303 ± 0.172
0.682HisAsn: 0.682 ± 0.214
0.455HisPro: 0.455 ± 0.159
0.606HisGln: 0.606 ± 0.227
1.061HisArg: 1.061 ± 0.254
1.364HisSer: 1.364 ± 0.209
0.758HisThr: 0.758 ± 0.248
1.061HisVal: 1.061 ± 0.321
0.455HisTrp: 0.455 ± 0.161
0.833HisTyr: 0.833 ± 0.241
0.0HisXaa: 0.0 ± 0.0
Ile
5.758IleAla: 5.758 ± 0.758
0.455IleCys: 0.455 ± 0.227
6.213IleAsp: 6.213 ± 0.85
5.758IleGlu: 5.758 ± 0.68
2.046IlePhe: 2.046 ± 0.332
5.152IleGly: 5.152 ± 0.772
1.44IleHis: 1.44 ± 0.406
4.016IleIle: 4.016 ± 0.566
4.773IleLys: 4.773 ± 0.682
4.092IleLeu: 4.092 ± 0.509
0.833IleMet: 0.833 ± 0.24
3.41IleAsn: 3.41 ± 0.585
2.652IlePro: 2.652 ± 0.761
2.349IleGln: 2.349 ± 0.415
3.41IleArg: 3.41 ± 0.551
4.849IleSer: 4.849 ± 0.507
4.319IleThr: 4.319 ± 0.664
4.925IleVal: 4.925 ± 0.882
0.606IleTrp: 0.606 ± 0.184
2.803IleTyr: 2.803 ± 0.543
0.0IleXaa: 0.0 ± 0.0
Lys
5.91LysAla: 5.91 ± 0.796
0.303LysCys: 0.303 ± 0.129
4.092LysAsp: 4.092 ± 0.677
6.516LysGlu: 6.516 ± 1.06
2.728LysPhe: 2.728 ± 0.355
3.561LysGly: 3.561 ± 0.524
1.515LysHis: 1.515 ± 0.41
4.47LysIle: 4.47 ± 0.728
5.986LysLys: 5.986 ± 0.971
5.834LysLeu: 5.834 ± 0.76
2.197LysMet: 2.197 ± 0.408
3.864LysAsn: 3.864 ± 0.522
2.349LysPro: 2.349 ± 0.461
4.092LysGln: 4.092 ± 0.756
4.47LysArg: 4.47 ± 0.645
4.016LysSer: 4.016 ± 0.419
4.546LysThr: 4.546 ± 0.686
4.773LysVal: 4.773 ± 0.747
1.061LysTrp: 1.061 ± 0.313
2.122LysTyr: 2.122 ± 0.386
0.0LysXaa: 0.0 ± 0.0
Leu
6.895LeuAla: 6.895 ± 0.779
0.303LeuCys: 0.303 ± 0.18
5.38LeuAsp: 5.38 ± 0.814
7.047LeuGlu: 7.047 ± 0.925
2.5LeuPhe: 2.5 ± 0.34
5.152LeuGly: 5.152 ± 0.582
1.137LeuHis: 1.137 ± 0.303
4.773LeuIle: 4.773 ± 0.685
6.213LeuLys: 6.213 ± 0.749
6.289LeuLeu: 6.289 ± 0.872
1.894LeuMet: 1.894 ± 0.325
4.698LeuAsn: 4.698 ± 0.465
2.5LeuPro: 2.5 ± 0.411
3.713LeuGln: 3.713 ± 0.591
4.167LeuArg: 4.167 ± 0.629
5.607LeuSer: 5.607 ± 0.549
4.546LeuThr: 4.546 ± 0.636
5.91LeuVal: 5.91 ± 0.749
0.227LeuTrp: 0.227 ± 0.123
2.349LeuTyr: 2.349 ± 0.542
0.0LeuXaa: 0.0 ± 0.0
Met
3.031MetAla: 3.031 ± 0.623
0.0MetCys: 0.0 ± 0.0
1.364MetAsp: 1.364 ± 0.334
1.288MetGlu: 1.288 ± 0.296
1.137MetPhe: 1.137 ± 0.263
1.515MetGly: 1.515 ± 0.345
0.227MetHis: 0.227 ± 0.141
1.515MetIle: 1.515 ± 0.326
2.122MetLys: 2.122 ± 0.493
2.652MetLeu: 2.652 ± 0.478
0.909MetMet: 0.909 ± 0.346
1.44MetAsn: 1.44 ± 0.378
0.682MetPro: 0.682 ± 0.225
1.288MetGln: 1.288 ± 0.316
1.515MetArg: 1.515 ± 0.327
1.44MetSer: 1.44 ± 0.345
2.349MetThr: 2.349 ± 0.416
1.364MetVal: 1.364 ± 0.522
0.303MetTrp: 0.303 ± 0.179
0.909MetTyr: 0.909 ± 0.278
0.0MetXaa: 0.0 ± 0.0
Asn
3.334AsnAla: 3.334 ± 0.494
0.227AsnCys: 0.227 ± 0.119
3.334AsnAsp: 3.334 ± 0.595
2.955AsnGlu: 2.955 ± 0.687
1.743AsnPhe: 1.743 ± 0.342
4.47AsnGly: 4.47 ± 0.692
1.364AsnHis: 1.364 ± 0.295
3.713AsnIle: 3.713 ± 0.514
3.713AsnLys: 3.713 ± 0.606
3.637AsnLeu: 3.637 ± 0.45
1.44AsnMet: 1.44 ± 0.333
2.273AsnAsn: 2.273 ± 0.451
2.5AsnPro: 2.5 ± 0.379
1.667AsnGln: 1.667 ± 0.387
1.818AsnArg: 1.818 ± 0.357
2.803AsnSer: 2.803 ± 0.446
2.046AsnThr: 2.046 ± 0.37
3.031AsnVal: 3.031 ± 0.468
0.682AsnTrp: 0.682 ± 0.22
2.349AsnTyr: 2.349 ± 0.402
0.0AsnXaa: 0.0 ± 0.0
Pro
2.349ProAla: 2.349 ± 0.37
0.0ProCys: 0.0 ± 0.0
2.5ProAsp: 2.5 ± 0.426
2.5ProGlu: 2.5 ± 0.43
2.046ProPhe: 2.046 ± 0.612
1.364ProGly: 1.364 ± 0.302
0.53ProHis: 0.53 ± 0.186
1.591ProIle: 1.591 ± 0.351
1.591ProLys: 1.591 ± 0.375
2.046ProLeu: 2.046 ± 0.337
0.758ProMet: 0.758 ± 0.237
1.97ProAsn: 1.97 ± 0.382
1.288ProPro: 1.288 ± 0.282
1.137ProGln: 1.137 ± 0.44
1.061ProArg: 1.061 ± 0.294
2.349ProSer: 2.349 ± 0.407
2.349ProThr: 2.349 ± 0.608
2.046ProVal: 2.046 ± 0.427
0.379ProTrp: 0.379 ± 0.167
0.833ProTyr: 0.833 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
3.94GlnAla: 3.94 ± 0.849
0.152GlnCys: 0.152 ± 0.101
1.212GlnAsp: 1.212 ± 0.249
3.031GlnGlu: 3.031 ± 0.614
1.818GlnPhe: 1.818 ± 0.376
2.955GlnGly: 2.955 ± 0.731
0.227GlnHis: 0.227 ± 0.125
3.334GlnIle: 3.334 ± 0.414
2.879GlnLys: 2.879 ± 0.456
3.031GlnLeu: 3.031 ± 0.517
1.44GlnMet: 1.44 ± 0.354
1.743GlnAsn: 1.743 ± 0.303
1.591GlnPro: 1.591 ± 0.519
2.652GlnGln: 2.652 ± 1.099
1.818GlnArg: 1.818 ± 0.465
2.879GlnSer: 2.879 ± 0.467
2.728GlnThr: 2.728 ± 0.587
2.803GlnVal: 2.803 ± 0.531
0.379GlnTrp: 0.379 ± 0.141
1.894GlnTyr: 1.894 ± 0.395
0.0GlnXaa: 0.0 ± 0.0
Arg
4.167ArgAla: 4.167 ± 0.477
0.53ArgCys: 0.53 ± 0.167
1.97ArgAsp: 1.97 ± 0.344
3.94ArgGlu: 3.94 ± 0.55
1.515ArgPhe: 1.515 ± 0.284
2.652ArgGly: 2.652 ± 0.328
0.833ArgHis: 0.833 ± 0.288
2.5ArgIle: 2.5 ± 0.468
3.561ArgLys: 3.561 ± 0.76
4.773ArgLeu: 4.773 ± 0.516
1.137ArgMet: 1.137 ± 0.286
1.894ArgAsn: 1.894 ± 0.416
0.909ArgPro: 0.909 ± 0.275
2.349ArgGln: 2.349 ± 0.479
2.273ArgArg: 2.273 ± 0.503
2.046ArgSer: 2.046 ± 0.387
2.122ArgThr: 2.122 ± 0.456
2.879ArgVal: 2.879 ± 0.516
0.53ArgTrp: 0.53 ± 0.18
2.349ArgTyr: 2.349 ± 0.386
0.0ArgXaa: 0.0 ± 0.0
Ser
6.895SerAla: 6.895 ± 1.795
0.227SerCys: 0.227 ± 0.13
4.47SerAsp: 4.47 ± 0.607
3.637SerGlu: 3.637 ± 0.466
2.803SerPhe: 2.803 ± 0.783
5.38SerGly: 5.38 ± 1.015
0.455SerHis: 0.455 ± 0.194
3.637SerIle: 3.637 ± 0.777
4.016SerLys: 4.016 ± 0.676
4.243SerLeu: 4.243 ± 0.562
2.197SerMet: 2.197 ± 0.494
2.5SerAsn: 2.5 ± 0.533
2.349SerPro: 2.349 ± 0.46
2.425SerGln: 2.425 ± 0.456
2.273SerArg: 2.273 ± 0.424
4.243SerSer: 4.243 ± 0.929
3.94SerThr: 3.94 ± 0.579
4.092SerVal: 4.092 ± 0.577
1.212SerTrp: 1.212 ± 0.268
2.728SerTyr: 2.728 ± 0.538
0.0SerXaa: 0.0 ± 0.0
Thr
6.062ThrAla: 6.062 ± 1.326
0.076ThrCys: 0.076 ± 0.083
3.107ThrAsp: 3.107 ± 0.581
3.637ThrGlu: 3.637 ± 0.505
2.576ThrPhe: 2.576 ± 0.652
4.167ThrGly: 4.167 ± 0.426
1.137ThrHis: 1.137 ± 0.318
5.91ThrIle: 5.91 ± 0.813
4.167ThrLys: 4.167 ± 0.775
5.38ThrLeu: 5.38 ± 0.658
1.061ThrMet: 1.061 ± 0.286
2.652ThrAsn: 2.652 ± 0.387
2.122ThrPro: 2.122 ± 0.413
2.5ThrGln: 2.5 ± 0.496
1.667ThrArg: 1.667 ± 0.38
3.864ThrSer: 3.864 ± 0.659
4.092ThrThr: 4.092 ± 0.733
4.773ThrVal: 4.773 ± 0.738
0.682ThrTrp: 0.682 ± 0.288
2.5ThrTyr: 2.5 ± 0.402
0.0ThrXaa: 0.0 ± 0.0
Val
5.531ValAla: 5.531 ± 0.978
0.227ValCys: 0.227 ± 0.131
4.622ValAsp: 4.622 ± 0.568
4.773ValGlu: 4.773 ± 0.547
2.046ValPhe: 2.046 ± 0.307
3.788ValGly: 3.788 ± 0.907
1.061ValHis: 1.061 ± 0.338
4.395ValIle: 4.395 ± 0.63
4.773ValLys: 4.773 ± 0.537
5.38ValLeu: 5.38 ± 0.705
1.515ValMet: 1.515 ± 0.367
3.107ValAsn: 3.107 ± 0.38
1.44ValPro: 1.44 ± 0.255
2.728ValGln: 2.728 ± 0.605
2.425ValArg: 2.425 ± 0.488
5.986ValSer: 5.986 ± 0.809
6.44ValThr: 6.44 ± 0.75
5.304ValVal: 5.304 ± 0.728
0.455ValTrp: 0.455 ± 0.175
1.894ValTyr: 1.894 ± 0.44
0.0ValXaa: 0.0 ± 0.0
Trp
0.758TrpAla: 0.758 ± 0.289
0.227TrpCys: 0.227 ± 0.132
0.833TrpAsp: 0.833 ± 0.22
0.985TrpGlu: 0.985 ± 0.273
0.379TrpPhe: 0.379 ± 0.146
0.53TrpGly: 0.53 ± 0.193
0.227TrpHis: 0.227 ± 0.129
1.061TrpIle: 1.061 ± 0.383
0.758TrpLys: 0.758 ± 0.216
0.985TrpLeu: 0.985 ± 0.227
0.152TrpMet: 0.152 ± 0.109
0.833TrpAsn: 0.833 ± 0.294
0.076TrpPro: 0.076 ± 0.086
0.455TrpGln: 0.455 ± 0.193
0.53TrpArg: 0.53 ± 0.187
1.212TrpSer: 1.212 ± 0.377
0.606TrpThr: 0.606 ± 0.225
0.985TrpVal: 0.985 ± 0.257
0.152TrpTrp: 0.152 ± 0.153
0.227TrpTyr: 0.227 ± 0.108
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.879TyrAla: 2.879 ± 0.491
0.455TyrCys: 0.455 ± 0.174
2.425TyrAsp: 2.425 ± 0.596
2.349TyrGlu: 2.349 ± 0.415
1.515TyrPhe: 1.515 ± 0.368
2.5TyrGly: 2.5 ± 0.481
0.682TyrHis: 0.682 ± 0.201
2.652TyrIle: 2.652 ± 0.574
1.97TyrLys: 1.97 ± 0.441
3.258TyrLeu: 3.258 ± 0.547
0.985TyrMet: 0.985 ± 0.21
2.122TyrAsn: 2.122 ± 0.449
1.44TyrPro: 1.44 ± 0.336
2.046TyrGln: 2.046 ± 0.475
2.349TyrArg: 2.349 ± 0.43
1.818TyrSer: 1.818 ± 0.338
2.122TyrThr: 2.122 ± 0.449
2.349TyrVal: 2.349 ± 0.491
0.53TyrTrp: 0.53 ± 0.18
1.818TyrTyr: 1.818 ± 0.416
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (13199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski