Amino acid dipepetide frequency for Methyloceanibacter superfactus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.923AlaAla: 16.923 ± 0.233	1.276AlaCys: 1.276 ± 0.048	6.844AlaAsp: 6.844 ± 0.116	8.115AlaGlu: 8.115 ± 0.129	4.265AlaPhe: 4.265 ± 0.084	10.147AlaGly: 10.147 ± 0.127	2.282AlaHis: 2.282 ± 0.059	6.006AlaIle: 6.006 ± 0.102	5.235AlaLys: 5.235 ± 0.097	13.628AlaLeu: 13.628 ± 0.171	3.334AlaMet: 3.334 ± 0.061	2.83AlaAsn: 2.83 ± 0.058	6.253AlaPro: 6.253 ± 0.129	3.758AlaGln: 3.758 ± 0.07	8.434AlaArg: 8.434 ± 0.125	6.376AlaSer: 6.376 ± 0.097	5.948AlaThr: 5.948 ± 0.095	8.804AlaVal: 8.804 ± 0.127	1.505AlaTrp: 1.505 ± 0.049	2.651AlaTyr: 2.651 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.042	0.144CysCys: 0.144 ± 0.014	0.585CysAsp: 0.585 ± 0.034	0.456CysGlu: 0.456 ± 0.025	0.342CysPhe: 0.342 ± 0.02	0.976CysGly: 0.976 ± 0.04	0.288CysHis: 0.288 ± 0.023	0.381CysIle: 0.381 ± 0.023	0.261CysLys: 0.261 ± 0.023	0.872CysLeu: 0.872 ± 0.035	0.202CysMet: 0.202 ± 0.016	0.276CysAsn: 0.276 ± 0.022	0.518CysPro: 0.518 ± 0.029	0.262CysGln: 0.262 ± 0.02	0.696CysArg: 0.696 ± 0.032	0.524CysSer: 0.524 ± 0.03	0.425CysThr: 0.425 ± 0.026	0.71CysVal: 0.71 ± 0.031	0.129CysTrp: 0.129 ± 0.014	0.215CysTyr: 0.215 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.976AspAla: 6.976 ± 0.099	0.521AspCys: 0.521 ± 0.032	3.487AspAsp: 3.487 ± 0.079	4.002AspGlu: 4.002 ± 0.073	2.169AspPhe: 2.169 ± 0.056	5.352AspGly: 5.352 ± 0.084	1.188AspHis: 1.188 ± 0.044	2.945AspIle: 2.945 ± 0.06	2.095AspLys: 2.095 ± 0.065	5.842AspLeu: 5.842 ± 0.101	1.328AspMet: 1.328 ± 0.045	1.353AspAsn: 1.353 ± 0.042	3.367AspPro: 3.367 ± 0.072	1.799AspGln: 1.799 ± 0.052	3.955AspArg: 3.955 ± 0.079	2.251AspSer: 2.251 ± 0.052	2.792AspThr: 2.792 ± 0.056	4.277AspVal: 4.277 ± 0.074	0.956AspTrp: 0.956 ± 0.041	1.592AspTyr: 1.592 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	8.255GluAla: 8.255 ± 0.135	0.394GluCys: 0.394 ± 0.024	3.216GluAsp: 3.216 ± 0.074	3.7GluGlu: 3.7 ± 0.093	1.678GluPhe: 1.678 ± 0.052	4.511GluGly: 4.511 ± 0.085	1.339GluHis: 1.339 ± 0.047	3.506GluIle: 3.506 ± 0.076	2.26GluLys: 2.26 ± 0.064	5.783GluLeu: 5.783 ± 0.1	1.456GluMet: 1.456 ± 0.045	1.42GluAsn: 1.42 ± 0.045	3.262GluPro: 3.262 ± 0.076	2.155GluGln: 2.155 ± 0.068	4.859GluArg: 4.859 ± 0.088	2.663GluSer: 2.663 ± 0.062	3.81GluThr: 3.81 ± 0.067	4.023GluVal: 4.023 ± 0.094	0.704GluTrp: 0.704 ± 0.035	1.012GluTyr: 1.012 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.649PheAla: 4.649 ± 0.094	0.398PheCys: 0.398 ± 0.025	2.565PheAsp: 2.565 ± 0.064	2.184PheGlu: 2.184 ± 0.057	1.398PhePhe: 1.398 ± 0.05	3.616PheGly: 3.616 ± 0.084	0.696PheHis: 0.696 ± 0.028	1.649PheIle: 1.649 ± 0.052	1.165PheLys: 1.165 ± 0.037	3.225PheLeu: 3.225 ± 0.073	0.801PheMet: 0.801 ± 0.034	0.928PheAsn: 0.928 ± 0.031	1.585PhePro: 1.585 ± 0.052	0.966PheGln: 0.966 ± 0.038	2.228PheArg: 2.228 ± 0.05	2.018PheSer: 2.018 ± 0.058	2.001PheThr: 2.001 ± 0.054	2.881PheVal: 2.881 ± 0.064	0.565PheTrp: 0.565 ± 0.027	0.98PheTyr: 0.98 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.375GlyAla: 9.375 ± 0.146	0.847GlyCys: 0.847 ± 0.034	4.961GlyAsp: 4.961 ± 0.089	5.036GlyGlu: 5.036 ± 0.091	3.567GlyPhe: 3.567 ± 0.074	7.36GlyGly: 7.36 ± 0.145	1.921GlyHis: 1.921 ± 0.053	4.15GlyIle: 4.15 ± 0.082	3.607GlyLys: 3.607 ± 0.089	8.985GlyLeu: 8.985 ± 0.129	2.127GlyMet: 2.127 ± 0.064	2.041GlyAsn: 2.041 ± 0.057	3.805GlyPro: 3.805 ± 0.073	2.765GlyGln: 2.765 ± 0.065	5.881GlyArg: 5.881 ± 0.115	4.462GlySer: 4.462 ± 0.086	4.468GlyThr: 4.468 ± 0.089	6.122GlyVal: 6.122 ± 0.102	1.322GlyTrp: 1.322 ± 0.049	2.325GlyTyr: 2.325 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.403HisAla: 2.403 ± 0.068	0.243HisCys: 0.243 ± 0.017	1.271HisAsp: 1.271 ± 0.042	1.246HisGlu: 1.246 ± 0.038	0.82HisPhe: 0.82 ± 0.032	1.997HisGly: 1.997 ± 0.051	0.557HisHis: 0.557 ± 0.031	0.894HisIle: 0.894 ± 0.035	0.59HisLys: 0.59 ± 0.029	2.038HisLeu: 2.038 ± 0.058	0.489HisMet: 0.489 ± 0.024	0.495HisAsn: 0.495 ± 0.027	1.278HisPro: 1.278 ± 0.048	0.531HisGln: 0.531 ± 0.025	1.343HisArg: 1.343 ± 0.043	0.866HisSer: 0.866 ± 0.04	0.84HisThr: 0.84 ± 0.037	1.552HisVal: 1.552 ± 0.048	0.294HisTrp: 0.294 ± 0.02	0.561HisTyr: 0.561 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.047IleAla: 7.047 ± 0.12	0.481IleCys: 0.481 ± 0.024	3.546IleAsp: 3.546 ± 0.062	3.537IleGlu: 3.537 ± 0.075	1.631IlePhe: 1.631 ± 0.049	4.897IleGly: 4.897 ± 0.082	0.847IleHis: 0.847 ± 0.039	2.065IleIle: 2.065 ± 0.067	1.86IleLys: 1.86 ± 0.05	4.225IleLeu: 4.225 ± 0.086	0.922IleMet: 0.922 ± 0.039	1.267IleAsn: 1.267 ± 0.043	2.214IlePro: 2.214 ± 0.058	1.045IleGln: 1.045 ± 0.04	2.681IleArg: 2.681 ± 0.066	2.526IleSer: 2.526 ± 0.062	2.547IleThr: 2.547 ± 0.058	4.29IleVal: 4.29 ± 0.084	0.549IleTrp: 0.549 ± 0.03	1.165IleTyr: 1.165 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.867LysAla: 4.867 ± 0.093	0.23LysCys: 0.23 ± 0.022	2.27LysAsp: 2.27 ± 0.059	2.076LysGlu: 2.076 ± 0.06	1.043LysPhe: 1.043 ± 0.04	3.061LysGly: 3.061 ± 0.076	0.703LysHis: 0.703 ± 0.032	1.894LysIle: 1.894 ± 0.06	1.693LysLys: 1.693 ± 0.06	3.819LysLeu: 3.819 ± 0.085	0.7LysMet: 0.7 ± 0.028	0.951LysAsn: 0.951 ± 0.034	2.532LysPro: 2.532 ± 0.067	1.211LysGln: 1.211 ± 0.041	3.018LysArg: 3.018 ± 0.074	2.127LysSer: 2.127 ± 0.071	2.259LysThr: 2.259 ± 0.052	2.713LysVal: 2.713 ± 0.069	0.391LysTrp: 0.391 ± 0.026	0.704LysTyr: 0.704 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.815LeuAla: 13.815 ± 0.187	0.888LeuCys: 0.888 ± 0.036	6.15LeuAsp: 6.15 ± 0.098	5.488LeuGlu: 5.488 ± 0.091	3.664LeuPhe: 3.664 ± 0.08	8.617LeuGly: 8.617 ± 0.11	1.887LeuHis: 1.887 ± 0.06	5.231LeuIle: 5.231 ± 0.092	4.435LeuLys: 4.435 ± 0.082	9.734LeuLeu: 9.734 ± 0.139	2.178LeuMet: 2.178 ± 0.055	2.59LeuAsn: 2.59 ± 0.056	5.46LeuPro: 5.46 ± 0.095	2.482LeuGln: 2.482 ± 0.057	6.621LeuArg: 6.621 ± 0.122	5.806LeuSer: 5.806 ± 0.087	5.532LeuThr: 5.532 ± 0.1	7.602LeuVal: 7.602 ± 0.106	1.206LeuTrp: 1.206 ± 0.044	2.159LeuTyr: 2.159 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.991MetAla: 2.991 ± 0.063	0.134MetCys: 0.134 ± 0.014	1.025MetAsp: 1.025 ± 0.038	1.088MetGlu: 1.088 ± 0.045	0.69MetPhe: 0.69 ± 0.03	1.703MetGly: 1.703 ± 0.049	0.509MetHis: 0.509 ± 0.028	1.206MetIle: 1.206 ± 0.046	0.916MetLys: 0.916 ± 0.033	2.622MetLeu: 2.622 ± 0.065	0.565MetMet: 0.565 ± 0.027	0.614MetAsn: 0.614 ± 0.029	1.524MetPro: 1.524 ± 0.048	0.725MetGln: 0.725 ± 0.031	1.874MetArg: 1.874 ± 0.047	1.56MetSer: 1.56 ± 0.045	1.653MetThr: 1.653 ± 0.049	1.673MetVal: 1.673 ± 0.047	0.243MetTrp: 0.243 ± 0.018	0.279MetTyr: 0.279 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.895AsnAla: 2.895 ± 0.067	0.281AsnCys: 0.281 ± 0.023	1.35AsnAsp: 1.35 ± 0.045	1.307AsnGlu: 1.307 ± 0.045	0.92AsnPhe: 0.92 ± 0.038	2.169AsnGly: 2.169 ± 0.073	0.416AsnHis: 0.416 ± 0.024	1.251AsnIle: 1.251 ± 0.044	0.793AsnLys: 0.793 ± 0.036	2.366AsnLeu: 2.366 ± 0.062	0.607AsnMet: 0.607 ± 0.031	0.613AsnAsn: 0.613 ± 0.034	1.76AsnPro: 1.76 ± 0.057	0.665AsnGln: 0.665 ± 0.027	1.642AsnArg: 1.642 ± 0.048	1.122AsnSer: 1.122 ± 0.04	1.207AsnThr: 1.207 ± 0.04	1.994AsnVal: 1.994 ± 0.059	0.407AsnTrp: 0.407 ± 0.025	0.629AsnTyr: 0.629 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.201ProAla: 6.201 ± 0.121	0.452ProCys: 0.452 ± 0.028	3.722ProAsp: 3.722 ± 0.073	4.035ProGlu: 4.035 ± 0.089	2.019ProPhe: 2.019 ± 0.051	4.695ProGly: 4.695 ± 0.079	1.109ProHis: 1.109 ± 0.036	2.374ProIle: 2.374 ± 0.055	2.28ProLys: 2.28 ± 0.067	4.821ProLeu: 4.821 ± 0.086	1.274ProMet: 1.274 ± 0.041	1.407ProAsn: 1.407 ± 0.05	3.058ProPro: 3.058 ± 0.087	1.781ProGln: 1.781 ± 0.052	3.257ProArg: 3.257 ± 0.079	2.986ProSer: 2.986 ± 0.068	2.522ProThr: 2.522 ± 0.062	4.012ProVal: 4.012 ± 0.085	0.708ProTrp: 0.708 ± 0.03	1.351ProTyr: 1.351 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.968GlnAla: 3.968 ± 0.075	0.216GlnCys: 0.216 ± 0.018	1.555GlnAsp: 1.555 ± 0.044	1.63GlnGlu: 1.63 ± 0.05	1.006GlnPhe: 1.006 ± 0.038	2.532GlnGly: 2.532 ± 0.058	0.585GlnHis: 0.585 ± 0.025	1.562GlnIle: 1.562 ± 0.048	1.045GlnLys: 1.045 ± 0.037	2.772GlnLeu: 2.772 ± 0.058	0.782GlnMet: 0.782 ± 0.035	0.741GlnAsn: 0.741 ± 0.038	1.644GlnPro: 1.644 ± 0.049	1.05GlnGln: 1.05 ± 0.045	2.216GlnArg: 2.216 ± 0.063	1.668GlnSer: 1.668 ± 0.054	1.666GlnThr: 1.666 ± 0.049	2.17GlnVal: 2.17 ± 0.056	0.394GlnTrp: 0.394 ± 0.026	0.59GlnTyr: 0.59 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.06ArgAla: 8.06 ± 0.12	0.649ArgCys: 0.649 ± 0.032	3.879ArgAsp: 3.879 ± 0.081	3.968ArgGlu: 3.968 ± 0.088	2.798ArgPhe: 2.798 ± 0.068	4.881ArgGly: 4.881 ± 0.091	1.646ArgHis: 1.646 ± 0.052	3.506ArgIle: 3.506 ± 0.073	2.548ArgLys: 2.548 ± 0.066	7.724ArgLeu: 7.724 ± 0.117	1.746ArgMet: 1.746 ± 0.051	1.707ArgAsn: 1.707 ± 0.049	3.599ArgPro: 3.599 ± 0.084	2.366ArgGln: 2.366 ± 0.062	5.741ArgArg: 5.741 ± 0.123	3.75ArgSer: 3.75 ± 0.089	3.154ArgThr: 3.154 ± 0.067	4.674ArgVal: 4.674 ± 0.085	0.955ArgTrp: 0.955 ± 0.037	1.821ArgTyr: 1.821 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.068SerAla: 6.068 ± 0.1	0.503SerCys: 0.503 ± 0.034	2.76SerAsp: 2.76 ± 0.052	2.805SerGlu: 2.805 ± 0.068	2.18SerPhe: 2.18 ± 0.054	5.181SerGly: 5.181 ± 0.093	1.104SerHis: 1.104 ± 0.044	2.42SerIle: 2.42 ± 0.061	1.789SerLys: 1.789 ± 0.059	5.558SerLeu: 5.558 ± 0.098	1.323SerMet: 1.323 ± 0.046	1.271SerAsn: 1.271 ± 0.051	3.104SerPro: 3.104 ± 0.071	1.571SerGln: 1.571 ± 0.049	3.561SerArg: 3.561 ± 0.077	2.874SerSer: 2.874 ± 0.074	2.554SerThr: 2.554 ± 0.065	3.711SerVal: 3.711 ± 0.069	0.719SerTrp: 0.719 ± 0.031	1.314SerTyr: 1.314 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.355ThrAla: 6.355 ± 0.105	0.495ThrCys: 0.495 ± 0.031	2.745ThrAsp: 2.745 ± 0.06	2.815ThrGlu: 2.815 ± 0.057	1.958ThrPhe: 1.958 ± 0.061	4.918ThrGly: 4.918 ± 0.085	1.052ThrHis: 1.052 ± 0.041	2.647ThrIle: 2.647 ± 0.062	1.756ThrLys: 1.756 ± 0.054	5.635ThrLeu: 5.635 ± 0.079	1.17ThrMet: 1.17 ± 0.043	1.138ThrAsn: 1.138 ± 0.041	3.377ThrPro: 3.377 ± 0.068	1.445ThrGln: 1.445 ± 0.043	3.294ThrArg: 3.294 ± 0.063	2.645ThrSer: 2.645 ± 0.06	2.681ThrThr: 2.681 ± 0.056	4.306ThrVal: 4.306 ± 0.073	0.642ThrTrp: 0.642 ± 0.032	1.287ThrTyr: 1.287 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	8.897ValAla: 8.897 ± 0.117	0.689ValCys: 0.689 ± 0.031	4.171ValAsp: 4.171 ± 0.079	4.604ValGlu: 4.604 ± 0.084	2.784ValPhe: 2.784 ± 0.07	5.435ValGly: 5.435 ± 0.095	1.372ValHis: 1.372 ± 0.043	4.024ValIle: 4.024 ± 0.085	2.747ValLys: 2.747 ± 0.063	7.753ValLeu: 7.753 ± 0.116	1.795ValMet: 1.795 ± 0.052	1.82ValAsn: 1.82 ± 0.051	3.889ValPro: 3.889 ± 0.075	1.886ValGln: 1.886 ± 0.054	4.799ValArg: 4.799 ± 0.085	4.231ValSer: 4.231 ± 0.074	4.53ValThr: 4.53 ± 0.078	6.136ValVal: 6.136 ± 0.114	0.989ValTrp: 0.989 ± 0.04	1.709ValTyr: 1.709 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.204TrpAla: 1.204 ± 0.046	0.159TrpCys: 0.159 ± 0.016	0.615TrpAsp: 0.615 ± 0.031	0.579TrpGlu: 0.579 ± 0.027	0.531TrpPhe: 0.531 ± 0.031	0.89TrpGly: 0.89 ± 0.035	0.323TrpHis: 0.323 ± 0.024	0.71TrpIle: 0.71 ± 0.034	0.477TrpLys: 0.477 ± 0.025	1.688TrpLeu: 1.688 ± 0.053	0.305TrpMet: 0.305 ± 0.021	0.377TrpAsn: 0.377 ± 0.023	0.701TrpPro: 0.701 ± 0.033	0.582TrpGln: 0.582 ± 0.032	1.242TrpArg: 1.242 ± 0.039	0.776TrpSer: 0.776 ± 0.036	0.751TrpThr: 0.751 ± 0.033	0.854TrpVal: 0.854 ± 0.04	0.259TrpTrp: 0.259 ± 0.021	0.32TrpTyr: 0.32 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.601TyrAla: 2.601 ± 0.057	0.327TyrCys: 0.327 ± 0.023	1.529TyrAsp: 1.529 ± 0.044	1.337TyrGlu: 1.337 ± 0.042	1.034TyrPhe: 1.034 ± 0.036	2.192TyrGly: 2.192 ± 0.062	0.485TyrHis: 0.485 ± 0.025	0.922TyrIle: 0.922 ± 0.034	0.711TyrLys: 0.711 ± 0.034	2.456TyrLeu: 2.456 ± 0.062	0.488TyrMet: 0.488 ± 0.027	0.557TyrAsn: 0.557 ± 0.033	1.132TyrPro: 1.132 ± 0.045	0.746TyrGln: 0.746 ± 0.033	1.829TyrArg: 1.829 ± 0.056	1.139TyrSer: 1.139 ± 0.042	1.02TyrThr: 1.02 ± 0.041	1.754TyrVal: 1.754 ± 0.052	0.406TyrTrp: 0.406 ± 0.026	0.71TyrTyr: 0.71 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2686 proteins (721614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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