Amino acid dipepetide frequency for Reichenbachiella faecimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.721AlaAla: 4.721 ± 0.074	0.617AlaCys: 0.617 ± 0.023	3.961AlaAsp: 3.961 ± 0.07	4.366AlaGlu: 4.366 ± 0.063	3.389AlaPhe: 3.389 ± 0.051	4.62AlaGly: 4.62 ± 0.076	1.297AlaHis: 1.297 ± 0.031	5.162AlaIle: 5.162 ± 0.06	4.348AlaLys: 4.348 ± 0.079	6.523AlaLeu: 6.523 ± 0.08	1.741AlaMet: 1.741 ± 0.039	3.381AlaAsn: 3.381 ± 0.053	1.958AlaPro: 1.958 ± 0.04	2.651AlaGln: 2.651 ± 0.048	2.225AlaArg: 2.225 ± 0.046	4.666AlaSer: 4.666 ± 0.087	3.787AlaThr: 3.787 ± 0.086	4.16AlaVal: 4.16 ± 0.057	0.702AlaTrp: 0.702 ± 0.022	2.679AlaTyr: 2.679 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.476CysAla: 0.476 ± 0.019	0.1CysCys: 0.1 ± 0.009	0.446CysAsp: 0.446 ± 0.02	0.529CysGlu: 0.529 ± 0.021	0.381CysPhe: 0.381 ± 0.017	0.61CysGly: 0.61 ± 0.023	0.197CysHis: 0.197 ± 0.012	0.472CysIle: 0.472 ± 0.016	0.405CysLys: 0.405 ± 0.018	0.767CysLeu: 0.767 ± 0.024	0.182CysMet: 0.182 ± 0.011	0.325CysAsn: 0.325 ± 0.014	0.293CysPro: 0.293 ± 0.016	0.321CysGln: 0.321 ± 0.019	0.25CysArg: 0.25 ± 0.012	0.545CysSer: 0.545 ± 0.021	0.413CysThr: 0.413 ± 0.019	0.427CysVal: 0.427 ± 0.017	0.083CysTrp: 0.083 ± 0.009	0.27CysTyr: 0.27 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.731AspAla: 3.731 ± 0.075	0.423AspCys: 0.423 ± 0.018	3.346AspAsp: 3.346 ± 0.088	4.348AspGlu: 4.348 ± 0.062	3.459AspPhe: 3.459 ± 0.073	4.491AspGly: 4.491 ± 0.153	1.315AspHis: 1.315 ± 0.03	4.304AspIle: 4.304 ± 0.065	3.524AspLys: 3.524 ± 0.058	5.935AspLeu: 5.935 ± 0.072	1.353AspMet: 1.353 ± 0.035	2.878AspAsn: 2.878 ± 0.084	2.172AspPro: 2.172 ± 0.047	2.772AspGln: 2.772 ± 0.05	2.186AspArg: 2.186 ± 0.044	3.557AspSer: 3.557 ± 0.077	2.569AspThr: 2.569 ± 0.054	3.484AspVal: 3.484 ± 0.067	0.803AspTrp: 0.803 ± 0.025	2.805AspTyr: 2.805 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.63GluAla: 4.63 ± 0.07	0.358GluCys: 0.358 ± 0.019	3.682GluAsp: 3.682 ± 0.061	5.304GluGlu: 5.304 ± 0.086	2.969GluPhe: 2.969 ± 0.049	4.226GluGly: 4.226 ± 0.054	1.229GluHis: 1.229 ± 0.031	5.507GluIle: 5.507 ± 0.067	5.341GluLys: 5.341 ± 0.079	6.703GluLeu: 6.703 ± 0.074	1.863GluMet: 1.863 ± 0.038	4.049GluAsn: 4.049 ± 0.057	1.831GluPro: 1.831 ± 0.036	2.424GluGln: 2.424 ± 0.043	2.576GluArg: 2.576 ± 0.053	4.276GluSer: 4.276 ± 0.058	3.408GluThr: 3.408 ± 0.05	4.803GluVal: 4.803 ± 0.064	0.726GluTrp: 0.726 ± 0.023	2.448GluTyr: 2.448 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.1PheAla: 3.1 ± 0.053	0.414PheCys: 0.414 ± 0.017	3.623PheAsp: 3.623 ± 0.07	3.762PheGlu: 3.762 ± 0.058	2.498PhePhe: 2.498 ± 0.053	3.592PheGly: 3.592 ± 0.053	0.913PheHis: 0.913 ± 0.027	3.37PheIle: 3.37 ± 0.058	3.023PheLys: 3.023 ± 0.053	4.347PheLeu: 4.347 ± 0.081	1.147PheMet: 1.147 ± 0.03	2.779PheAsn: 2.779 ± 0.045	1.585PhePro: 1.585 ± 0.034	1.604PheGln: 1.604 ± 0.029	1.775PheArg: 1.775 ± 0.033	3.879PheSer: 3.879 ± 0.06	2.779PheThr: 2.779 ± 0.06	3.188PheVal: 3.188 ± 0.055	0.572PheTrp: 0.572 ± 0.024	2.054PheTyr: 2.054 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.489GlyAla: 4.489 ± 0.08	0.601GlyCys: 0.601 ± 0.023	3.895GlyAsp: 3.895 ± 0.082	4.157GlyGlu: 4.157 ± 0.054	3.584GlyPhe: 3.584 ± 0.059	4.783GlyGly: 4.783 ± 0.087	1.313GlyHis: 1.313 ± 0.034	5.296GlyIle: 5.296 ± 0.062	4.491GlyLys: 4.491 ± 0.077	6.56GlyLeu: 6.56 ± 0.091	1.839GlyMet: 1.839 ± 0.04	3.478GlyAsn: 3.478 ± 0.071	1.376GlyPro: 1.376 ± 0.029	2.432GlyGln: 2.432 ± 0.043	2.416GlyArg: 2.416 ± 0.047	4.6GlySer: 4.6 ± 0.107	4.275GlyThr: 4.275 ± 0.109	4.528GlyVal: 4.528 ± 0.073	0.886GlyTrp: 0.886 ± 0.024	2.821GlyTyr: 2.821 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.235HisAla: 1.235 ± 0.028	0.168HisCys: 0.168 ± 0.011	0.954HisAsp: 0.954 ± 0.023	1.181HisGlu: 1.181 ± 0.032	1.203HisPhe: 1.203 ± 0.031	1.283HisGly: 1.283 ± 0.033	0.541HisHis: 0.541 ± 0.022	1.415HisIle: 1.415 ± 0.033	1.07HisLys: 1.07 ± 0.032	2.036HisLeu: 2.036 ± 0.045	0.365HisMet: 0.365 ± 0.017	0.822HisAsn: 0.822 ± 0.026	0.918HisPro: 0.918 ± 0.03	0.846HisGln: 0.846 ± 0.027	0.695HisArg: 0.695 ± 0.022	1.216HisSer: 1.216 ± 0.028	0.986HisThr: 0.986 ± 0.031	1.119HisVal: 1.119 ± 0.026	0.274HisTrp: 0.274 ± 0.015	0.86HisTyr: 0.86 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.074IleAla: 5.074 ± 0.073	0.638IleCys: 0.638 ± 0.022	4.85IleAsp: 4.85 ± 0.069	5.232IleGlu: 5.232 ± 0.062	3.403IlePhe: 3.403 ± 0.052	5.079IleGly: 5.079 ± 0.07	1.47IleHis: 1.47 ± 0.033	4.982IleIle: 4.982 ± 0.07	4.965IleLys: 4.965 ± 0.087	6.665IleLeu: 6.665 ± 0.079	1.393IleMet: 1.393 ± 0.037	4.254IleAsn: 4.254 ± 0.053	2.879IlePro: 2.879 ± 0.052	2.652IleGln: 2.652 ± 0.046	2.774IleArg: 2.774 ± 0.046	5.74IleSer: 5.74 ± 0.067	4.17IleThr: 4.17 ± 0.071	4.345IleVal: 4.345 ± 0.059	0.817IleTrp: 0.817 ± 0.026	2.822IleTyr: 2.822 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.412LysAla: 4.412 ± 0.075	0.389LysCys: 0.389 ± 0.019	3.737LysAsp: 3.737 ± 0.062	5.278LysGlu: 5.278 ± 0.09	2.749LysPhe: 2.749 ± 0.057	4.081LysGly: 4.081 ± 0.065	1.242LysHis: 1.242 ± 0.03	5.126LysIle: 5.126 ± 0.076	5.711LysLys: 5.711 ± 0.093	5.947LysLeu: 5.947 ± 0.095	1.837LysMet: 1.837 ± 0.04	3.943LysAsn: 3.943 ± 0.067	2.184LysPro: 2.184 ± 0.047	2.225LysGln: 2.225 ± 0.044	2.582LysArg: 2.582 ± 0.049	4.547LysSer: 4.547 ± 0.07	3.605LysThr: 3.605 ± 0.06	4.316LysVal: 4.316 ± 0.064	0.704LysTrp: 0.704 ± 0.022	2.853LysTyr: 2.853 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.818LeuAla: 6.818 ± 0.092	0.651LeuCys: 0.651 ± 0.025	5.868LeuAsp: 5.868 ± 0.07	6.253LeuGlu: 6.253 ± 0.064	4.513LeuPhe: 4.513 ± 0.075	6.165LeuGly: 6.165 ± 0.074	1.558LeuHis: 1.558 ± 0.034	7.215LeuIle: 7.215 ± 0.087	6.846LeuLys: 6.846 ± 0.106	8.698LeuLeu: 8.698 ± 0.111	2.364LeuMet: 2.364 ± 0.049	5.418LeuAsn: 5.418 ± 0.066	3.353LeuPro: 3.353 ± 0.054	2.834LeuGln: 2.834 ± 0.05	3.242LeuArg: 3.242 ± 0.05	7.394LeuSer: 7.394 ± 0.088	5.407LeuThr: 5.407 ± 0.062	5.922LeuVal: 5.922 ± 0.075	0.875LeuTrp: 0.875 ± 0.028	3.133LeuTyr: 3.133 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.94MetAla: 1.94 ± 0.041	0.156MetCys: 0.156 ± 0.01	1.363MetAsp: 1.363 ± 0.032	1.536MetGlu: 1.536 ± 0.03	0.807MetPhe: 0.807 ± 0.029	1.666MetGly: 1.666 ± 0.043	0.44MetHis: 0.44 ± 0.02	1.86MetIle: 1.86 ± 0.041	2.097MetLys: 2.097 ± 0.042	2.029MetLeu: 2.029 ± 0.044	0.658MetMet: 0.658 ± 0.023	1.454MetAsn: 1.454 ± 0.031	0.913MetPro: 0.913 ± 0.03	0.788MetGln: 0.788 ± 0.023	0.987MetArg: 0.987 ± 0.028	1.64MetSer: 1.64 ± 0.039	1.476MetThr: 1.476 ± 0.038	1.523MetVal: 1.523 ± 0.033	0.154MetTrp: 0.154 ± 0.011	0.673MetTyr: 0.673 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.059	0.393AsnCys: 0.393 ± 0.016	3.059AsnAsp: 3.059 ± 0.063	3.592AsnGlu: 3.592 ± 0.046	2.753AsnPhe: 2.753 ± 0.049	3.915AsnGly: 3.915 ± 0.082	1.12AsnHis: 1.12 ± 0.028	3.993AsnIle: 3.993 ± 0.052	3.272AsnLys: 3.272 ± 0.052	5.216AsnLeu: 5.216 ± 0.062	1.217AsnMet: 1.217 ± 0.028	2.929AsnAsn: 2.929 ± 0.065	2.544AsnPro: 2.544 ± 0.043	2.46AsnGln: 2.46 ± 0.048	2.012AsnArg: 2.012 ± 0.04	3.475AsnSer: 3.475 ± 0.06	2.927AsnThr: 2.927 ± 0.063	3.114AsnVal: 3.114 ± 0.049	0.715AsnTrp: 0.715 ± 0.024	2.54AsnTyr: 2.54 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.225ProAla: 2.225 ± 0.048	0.212ProCys: 0.212 ± 0.012	2.358ProAsp: 2.358 ± 0.048	2.755ProGlu: 2.755 ± 0.045	1.742ProPhe: 1.742 ± 0.035	2.113ProGly: 2.113 ± 0.038	0.658ProHis: 0.658 ± 0.023	2.48ProIle: 2.48 ± 0.043	2.137ProLys: 2.137 ± 0.047	2.869ProLeu: 2.869 ± 0.05	0.795ProMet: 0.795 ± 0.025	1.986ProAsn: 1.986 ± 0.035	0.83ProPro: 0.83 ± 0.027	1.019ProGln: 1.019 ± 0.026	0.957ProArg: 0.957 ± 0.025	2.32ProSer: 2.32 ± 0.042	1.943ProThr: 1.943 ± 0.047	2.381ProVal: 2.381 ± 0.04	0.389ProTrp: 0.389 ± 0.018	1.327ProTyr: 1.327 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.512GlnAla: 2.512 ± 0.046	0.189GlnCys: 0.189 ± 0.014	1.787GlnAsp: 1.787 ± 0.039	2.331GlnGlu: 2.331 ± 0.044	1.871GlnPhe: 1.871 ± 0.04	2.049GlnGly: 2.049 ± 0.043	0.621GlnHis: 0.621 ± 0.021	2.806GlnIle: 2.806 ± 0.047	2.577GlnLys: 2.577 ± 0.046	3.827GlnLeu: 3.827 ± 0.058	1.028GlnMet: 1.028 ± 0.031	1.958GlnAsn: 1.958 ± 0.034	1.121GlnPro: 1.121 ± 0.029	1.374GlnGln: 1.374 ± 0.037	1.311GlnArg: 1.311 ± 0.034	2.542GlnSer: 2.542 ± 0.044	2.028GlnThr: 2.028 ± 0.039	2.443GlnVal: 2.443 ± 0.046	0.485GlnTrp: 0.485 ± 0.018	1.496GlnTyr: 1.496 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.284ArgAla: 2.284 ± 0.045	0.223ArgCys: 0.223 ± 0.012	1.873ArgAsp: 1.873 ± 0.035	2.413ArgGlu: 2.413 ± 0.04	1.885ArgPhe: 1.885 ± 0.041	2.056ArgGly: 2.056 ± 0.041	0.662ArgHis: 0.662 ± 0.022	2.809ArgIle: 2.809 ± 0.049	2.728ArgLys: 2.728 ± 0.057	3.542ArgLeu: 3.542 ± 0.059	1.075ArgMet: 1.075 ± 0.029	1.958ArgAsn: 1.958 ± 0.041	1.2ArgPro: 1.2 ± 0.034	1.294ArgGln: 1.294 ± 0.033	1.494ArgArg: 1.494 ± 0.034	2.246ArgSer: 2.246 ± 0.044	1.909ArgThr: 1.909 ± 0.041	2.338ArgVal: 2.338 ± 0.044	0.422ArgTrp: 0.422 ± 0.018	1.515ArgTyr: 1.515 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.61SerAla: 4.61 ± 0.068	0.614SerCys: 0.614 ± 0.024	4.075SerAsp: 4.075 ± 0.087	4.403SerGlu: 4.403 ± 0.061	3.896SerPhe: 3.896 ± 0.054	5.352SerGly: 5.352 ± 0.125	1.304SerHis: 1.304 ± 0.032	5.382SerIle: 5.382 ± 0.064	4.406SerLys: 4.406 ± 0.066	6.578SerLeu: 6.578 ± 0.061	1.565SerMet: 1.565 ± 0.031	3.812SerAsn: 3.812 ± 0.071	2.235SerPro: 2.235 ± 0.045	2.467SerGln: 2.467 ± 0.045	2.38SerArg: 2.38 ± 0.049	5.054SerSer: 5.054 ± 0.084	3.919SerThr: 3.919 ± 0.081	4.16SerVal: 4.16 ± 0.075	0.825SerTrp: 0.825 ± 0.029	2.859SerTyr: 2.859 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.774ThrAla: 3.774 ± 0.074	0.383ThrCys: 0.383 ± 0.017	3.287ThrAsp: 3.287 ± 0.089	3.366ThrGlu: 3.366 ± 0.051	2.823ThrPhe: 2.823 ± 0.06	4.23ThrGly: 4.23 ± 0.084	1.03ThrHis: 1.03 ± 0.027	4.2ThrIle: 4.2 ± 0.071	3.299ThrLys: 3.299 ± 0.064	5.224ThrLeu: 5.224 ± 0.062	1.072ThrMet: 1.072 ± 0.033	2.93ThrAsn: 2.93 ± 0.064	2.219ThrPro: 2.219 ± 0.044	1.839ThrGln: 1.839 ± 0.039	1.785ThrArg: 1.785 ± 0.035	3.878ThrSer: 3.878 ± 0.08	3.233ThrThr: 3.233 ± 0.081	3.648ThrVal: 3.648 ± 0.092	0.643ThrTrp: 0.643 ± 0.024	2.329ThrTyr: 2.329 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.392ValAla: 4.392 ± 0.054	0.531ValCys: 0.531 ± 0.019	3.963ValAsp: 3.963 ± 0.068	4.311ValGlu: 4.311 ± 0.064	3.122ValPhe: 3.122 ± 0.053	4.191ValGly: 4.191 ± 0.061	1.09ValHis: 1.09 ± 0.029	4.71ValIle: 4.71 ± 0.065	4.033ValLys: 4.033 ± 0.069	5.966ValLeu: 5.966 ± 0.064	1.518ValMet: 1.518 ± 0.036	3.413ValAsn: 3.413 ± 0.048	2.131ValPro: 2.131 ± 0.036	2.01ValGln: 2.01 ± 0.038	2.256ValArg: 2.256 ± 0.039	4.774ValSer: 4.774 ± 0.069	3.533ValThr: 3.533 ± 0.084	4.392ValVal: 4.392 ± 0.065	0.666ValTrp: 0.666 ± 0.022	2.281ValTyr: 2.281 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.665TrpAla: 0.665 ± 0.022	0.089TrpCys: 0.089 ± 0.008	0.717TrpAsp: 0.717 ± 0.027	0.73TrpGlu: 0.73 ± 0.025	0.574TrpPhe: 0.574 ± 0.022	0.728TrpGly: 0.728 ± 0.023	0.249TrpHis: 0.249 ± 0.012	0.783TrpIle: 0.783 ± 0.025	0.767TrpLys: 0.767 ± 0.03	1.097TrpLeu: 1.097 ± 0.029	0.351TrpMet: 0.351 ± 0.015	0.645TrpAsn: 0.645 ± 0.024	0.292TrpPro: 0.292 ± 0.015	0.492TrpGln: 0.492 ± 0.018	0.434TrpArg: 0.434 ± 0.016	0.786TrpSer: 0.786 ± 0.021	0.624TrpThr: 0.624 ± 0.027	0.791TrpVal: 0.791 ± 0.022	0.166TrpTrp: 0.166 ± 0.012	0.484TrpTyr: 0.484 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.549TyrAla: 2.549 ± 0.046	0.341TyrCys: 0.341 ± 0.015	2.61TyrAsp: 2.61 ± 0.051	2.508TyrGlu: 2.508 ± 0.045	2.382TyrPhe: 2.382 ± 0.045	2.59TyrGly: 2.59 ± 0.049	0.938TyrHis: 0.938 ± 0.025	2.331TyrIle: 2.331 ± 0.039	2.429TyrLys: 2.429 ± 0.047	3.998TyrLeu: 3.998 ± 0.06	0.797TyrMet: 0.797 ± 0.026	2.149TyrAsn: 2.149 ± 0.044	1.465TyrPro: 1.465 ± 0.034	1.852TyrGln: 1.852 ± 0.038	1.591TyrArg: 1.591 ± 0.04	2.761TyrSer: 2.761 ± 0.047	2.203TyrThr: 2.203 ± 0.05	2.2TyrVal: 2.2 ± 0.046	0.555TyrTrp: 0.555 ± 0.022	1.952TyrTyr: 1.952 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3972 proteins (1432065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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