Amino acid dipepetide frequency for Flavonifractor sp. An135

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.9AlaAla: 11.9 ± 0.158	1.488AlaCys: 1.488 ± 0.038	5.394AlaAsp: 5.394 ± 0.077	6.678AlaGlu: 6.678 ± 0.087	3.491AlaPhe: 3.491 ± 0.066	7.892AlaGly: 7.892 ± 0.105	1.564AlaHis: 1.564 ± 0.041	4.884AlaIle: 4.884 ± 0.071	3.791AlaLys: 3.791 ± 0.07	11.276AlaLeu: 11.276 ± 0.149	2.676AlaMet: 2.676 ± 0.049	2.34AlaAsn: 2.34 ± 0.053	3.947AlaPro: 3.947 ± 0.071	3.671AlaGln: 3.671 ± 0.061	5.237AlaArg: 5.237 ± 0.078	4.27AlaSer: 4.27 ± 0.068	3.967AlaThr: 3.967 ± 0.062	8.417AlaVal: 8.417 ± 0.095	1.104AlaTrp: 1.104 ± 0.028	2.742AlaTyr: 2.742 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.649CysAla: 1.649 ± 0.038	0.362CysCys: 0.362 ± 0.019	0.895CysAsp: 0.895 ± 0.03	0.807CysGlu: 0.807 ± 0.025	0.628CysPhe: 0.628 ± 0.022	1.711CysGly: 1.711 ± 0.049	0.36CysHis: 0.36 ± 0.016	0.796CysIle: 0.796 ± 0.027	0.626CysLys: 0.626 ± 0.024	1.414CysLeu: 1.414 ± 0.04	0.363CysMet: 0.363 ± 0.019	0.435CysAsn: 0.435 ± 0.024	0.944CysPro: 0.944 ± 0.034	0.496CysGln: 0.496 ± 0.021	1.075CysArg: 1.075 ± 0.032	0.906CysSer: 0.906 ± 0.033	1.019CysThr: 1.019 ± 0.037	1.054CysVal: 1.054 ± 0.032	0.196CysTrp: 0.196 ± 0.013	0.549CysTyr: 0.549 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	5.182AspAla: 5.182 ± 0.073	0.898AspCys: 0.898 ± 0.029	2.666AspAsp: 2.666 ± 0.062	4.016AspGlu: 4.016 ± 0.067	2.413AspPhe: 2.413 ± 0.046	5.404AspGly: 5.404 ± 0.096	1.056AspHis: 1.056 ± 0.031	3.0AspIle: 3.0 ± 0.063	2.24AspLys: 2.24 ± 0.048	5.932AspLeu: 5.932 ± 0.07	1.424AspMet: 1.424 ± 0.038	1.468AspAsn: 1.468 ± 0.043	2.925AspPro: 2.925 ± 0.048	1.867AspGln: 1.867 ± 0.047	3.347AspArg: 3.347 ± 0.053	2.619AspSer: 2.619 ± 0.049	3.209AspThr: 3.209 ± 0.071	3.78AspVal: 3.78 ± 0.07	0.802AspTrp: 0.802 ± 0.025	2.36AspTyr: 2.36 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.701GluAla: 6.701 ± 0.083	0.745GluCys: 0.745 ± 0.027	4.118GluAsp: 4.118 ± 0.078	6.507GluGlu: 6.507 ± 0.09	2.015GluPhe: 2.015 ± 0.053	5.197GluGly: 5.197 ± 0.072	1.592GluHis: 1.592 ± 0.042	3.524GluIle: 3.524 ± 0.062	3.773GluLys: 3.773 ± 0.075	7.417GluLeu: 7.417 ± 0.085	1.867GluMet: 1.867 ± 0.04	2.697GluAsn: 2.697 ± 0.048	2.693GluPro: 2.693 ± 0.063	3.213GluGln: 3.213 ± 0.065	4.716GluArg: 4.716 ± 0.102	3.108GluSer: 3.108 ± 0.049	3.519GluThr: 3.519 ± 0.063	4.463GluVal: 4.463 ± 0.06	0.686GluTrp: 0.686 ± 0.026	2.227GluTyr: 2.227 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.2PheAla: 3.2 ± 0.058	0.735PheCys: 0.735 ± 0.027	2.302PheAsp: 2.302 ± 0.049	1.98PheGlu: 1.98 ± 0.038	1.548PhePhe: 1.548 ± 0.044	2.853PheGly: 2.853 ± 0.059	0.85PheHis: 0.85 ± 0.029	1.642PheIle: 1.642 ± 0.044	1.072PheLys: 1.072 ± 0.038	4.053PheLeu: 4.053 ± 0.078	0.709PheMet: 0.709 ± 0.028	1.068PheAsn: 1.068 ± 0.032	1.679PhePro: 1.679 ± 0.044	1.509PheGln: 1.509 ± 0.035	2.178PheArg: 2.178 ± 0.05	2.619PheSer: 2.619 ± 0.043	2.413PheThr: 2.413 ± 0.049	2.38PheVal: 2.38 ± 0.048	0.449PheTrp: 0.449 ± 0.019	1.41PheTyr: 1.41 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.002GlyAla: 7.002 ± 0.102	1.518GlyCys: 1.518 ± 0.038	4.118GlyAsp: 4.118 ± 0.067	5.786GlyGlu: 5.786 ± 0.082	2.819GlyPhe: 2.819 ± 0.056	6.605GlyGly: 6.605 ± 0.1	1.468GlyHis: 1.468 ± 0.036	4.27GlyIle: 4.27 ± 0.07	4.387GlyLys: 4.387 ± 0.072	7.484GlyLeu: 7.484 ± 0.105	2.434GlyMet: 2.434 ± 0.051	2.368GlyAsn: 2.368 ± 0.045	2.273GlyPro: 2.273 ± 0.06	2.709GlyGln: 2.709 ± 0.047	4.549GlyArg: 4.549 ± 0.067	4.528GlySer: 4.528 ± 0.08	4.794GlyThr: 4.794 ± 0.077	6.36GlyVal: 6.36 ± 0.085	1.07GlyTrp: 1.07 ± 0.034	3.046GlyTyr: 3.046 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.474HisAla: 1.474 ± 0.036	0.396HisCys: 0.396 ± 0.019	0.969HisAsp: 0.969 ± 0.03	0.994HisGlu: 0.994 ± 0.033	0.844HisPhe: 0.844 ± 0.027	1.534HisGly: 1.534 ± 0.039	0.429HisHis: 0.429 ± 0.024	1.211HisIle: 1.211 ± 0.035	0.696HisLys: 0.696 ± 0.026	1.863HisLeu: 1.863 ± 0.041	0.479HisMet: 0.479 ± 0.021	0.614HisAsn: 0.614 ± 0.022	1.197HisPro: 1.197 ± 0.036	0.619HisGln: 0.619 ± 0.024	1.156HisArg: 1.156 ± 0.03	0.927HisSer: 0.927 ± 0.032	1.169HisThr: 1.169 ± 0.035	1.121HisVal: 1.121 ± 0.032	0.248HisTrp: 0.248 ± 0.015	0.697HisTyr: 0.697 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.61IleAla: 4.61 ± 0.078	0.922IleCys: 0.922 ± 0.033	2.793IleAsp: 2.793 ± 0.057	2.791IleGlu: 2.791 ± 0.059	1.858IlePhe: 1.858 ± 0.047	3.692IleGly: 3.692 ± 0.078	1.082IleHis: 1.082 ± 0.032	2.488IleIle: 2.488 ± 0.056	1.848IleLys: 1.848 ± 0.045	5.643IleLeu: 5.643 ± 0.09	1.058IleMet: 1.058 ± 0.033	1.547IleAsn: 1.547 ± 0.04	2.803IlePro: 2.803 ± 0.055	1.988IleGln: 1.988 ± 0.044	3.265IleArg: 3.265 ± 0.049	3.111IleSer: 3.111 ± 0.062	3.422IleThr: 3.422 ± 0.059	3.494IleVal: 3.494 ± 0.067	0.514IleTrp: 0.514 ± 0.023	1.719IleTyr: 1.719 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.332LysAla: 4.332 ± 0.07	0.471LysCys: 0.471 ± 0.021	2.415LysAsp: 2.415 ± 0.057	3.481LysGlu: 3.481 ± 0.06	1.106LysPhe: 1.106 ± 0.033	3.141LysGly: 3.141 ± 0.063	0.772LysHis: 0.772 ± 0.027	2.186LysIle: 2.186 ± 0.052	2.767LysLys: 2.767 ± 0.075	4.126LysLeu: 4.126 ± 0.067	1.179LysMet: 1.179 ± 0.034	1.672LysAsn: 1.672 ± 0.039	1.838LysPro: 1.838 ± 0.042	1.6LysGln: 1.6 ± 0.042	2.686LysArg: 2.686 ± 0.048	2.193LysSer: 2.193 ± 0.044	2.47LysThr: 2.47 ± 0.052	3.086LysVal: 3.086 ± 0.062	0.458LysTrp: 0.458 ± 0.02	1.511LysTyr: 1.511 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	9.921LeuAla: 9.921 ± 0.127	2.064LeuCys: 2.064 ± 0.054	6.283LeuAsp: 6.283 ± 0.079	7.486LeuGlu: 7.486 ± 0.082	3.897LeuPhe: 3.897 ± 0.075	7.463LeuGly: 7.463 ± 0.108	1.801LeuHis: 1.801 ± 0.036	4.736LeuIle: 4.736 ± 0.076	4.161LeuLys: 4.161 ± 0.063	11.168LeuLeu: 11.168 ± 0.158	2.574LeuMet: 2.574 ± 0.044	3.042LeuAsn: 3.042 ± 0.054	5.149LeuPro: 5.149 ± 0.09	2.923LeuGln: 2.923 ± 0.05	6.467LeuArg: 6.467 ± 0.091	7.117LeuSer: 7.117 ± 0.103	6.656LeuThr: 6.656 ± 0.091	6.61LeuVal: 6.61 ± 0.089	1.267LeuTrp: 1.267 ± 0.042	3.253LeuTyr: 3.253 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.65MetAla: 2.65 ± 0.05	0.295MetCys: 0.295 ± 0.017	1.762MetAsp: 1.762 ± 0.044	2.224MetGlu: 2.224 ± 0.05	0.681MetPhe: 0.681 ± 0.024	2.118MetGly: 2.118 ± 0.044	0.338MetHis: 0.338 ± 0.017	1.114MetIle: 1.114 ± 0.033	1.587MetLys: 1.587 ± 0.035	2.548MetLeu: 2.548 ± 0.051	0.672MetMet: 0.672 ± 0.023	0.988MetAsn: 0.988 ± 0.03	1.062MetPro: 1.062 ± 0.035	0.784MetGln: 0.784 ± 0.023	1.301MetArg: 1.301 ± 0.036	1.551MetSer: 1.551 ± 0.038	1.556MetThr: 1.556 ± 0.032	1.834MetVal: 1.834 ± 0.043	0.209MetTrp: 0.209 ± 0.013	0.561MetTyr: 0.561 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.868AsnAla: 2.868 ± 0.053	0.491AsnCys: 0.491 ± 0.022	1.494AsnAsp: 1.494 ± 0.032	1.715AsnGlu: 1.715 ± 0.04	1.055AsnPhe: 1.055 ± 0.035	2.797AsnGly: 2.797 ± 0.055	0.613AsnHis: 0.613 ± 0.024	1.815AsnIle: 1.815 ± 0.041	1.188AsnLys: 1.188 ± 0.042	3.109AsnLeu: 3.109 ± 0.06	0.814AsnMet: 0.814 ± 0.029	0.959AsnAsn: 0.959 ± 0.033	1.75AsnPro: 1.75 ± 0.036	1.169AsnGln: 1.169 ± 0.03	1.832AsnArg: 1.832 ± 0.044	1.522AsnSer: 1.522 ± 0.035	1.786AsnThr: 1.786 ± 0.043	2.034AsnVal: 2.034 ± 0.043	0.404AsnTrp: 0.404 ± 0.02	1.165AsnTyr: 1.165 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.55ProAla: 4.55 ± 0.08	0.635ProCys: 0.635 ± 0.024	3.065ProAsp: 3.065 ± 0.067	4.332ProGlu: 4.332 ± 0.077	1.689ProPhe: 1.689 ± 0.041	3.587ProGly: 3.587 ± 0.058	0.804ProHis: 0.804 ± 0.028	1.995ProIle: 1.995 ± 0.044	1.691ProLys: 1.691 ± 0.043	3.927ProLeu: 3.927 ± 0.067	1.125ProMet: 1.125 ± 0.035	1.267ProAsn: 1.267 ± 0.036	1.714ProPro: 1.714 ± 0.047	1.559ProGln: 1.559 ± 0.041	1.986ProArg: 1.986 ± 0.044	2.275ProSer: 2.275 ± 0.049	2.381ProThr: 2.381 ± 0.055	3.82ProVal: 3.82 ± 0.063	0.533ProTrp: 0.533 ± 0.02	1.529ProTyr: 1.529 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.778GlnAla: 3.778 ± 0.058	0.434GlnCys: 0.434 ± 0.021	1.741GlnAsp: 1.741 ± 0.046	2.693GlnGlu: 2.693 ± 0.055	1.173GlnPhe: 1.173 ± 0.033	2.445GlnGly: 2.445 ± 0.048	0.549GlnHis: 0.549 ± 0.019	2.013GlnIle: 2.013 ± 0.041	1.892GlnLys: 1.892 ± 0.049	3.385GlnLeu: 3.385 ± 0.064	1.058GlnMet: 1.058 ± 0.03	1.299GlnAsn: 1.299 ± 0.035	1.398GlnPro: 1.398 ± 0.035	1.439GlnGln: 1.439 ± 0.044	2.293GlnArg: 2.293 ± 0.051	1.863GlnSer: 1.863 ± 0.044	1.92GlnThr: 1.92 ± 0.043	2.737GlnVal: 2.737 ± 0.046	0.44GlnTrp: 0.44 ± 0.019	1.288GlnTyr: 1.288 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.302ArgAla: 5.302 ± 0.082	1.01ArgCys: 1.01 ± 0.033	3.119ArgAsp: 3.119 ± 0.053	4.603ArgGlu: 4.603 ± 0.074	2.247ArgPhe: 2.247 ± 0.044	3.841ArgGly: 3.841 ± 0.055	1.186ArgHis: 1.186 ± 0.032	3.02ArgIle: 3.02 ± 0.055	2.872ArgLys: 2.872 ± 0.058	6.253ArgLeu: 6.253 ± 0.093	1.71ArgMet: 1.71 ± 0.039	1.797ArgAsn: 1.797 ± 0.042	2.364ArgPro: 2.364 ± 0.05	2.515ArgGln: 2.515 ± 0.057	4.652ArgArg: 4.652 ± 0.089	2.973ArgSer: 2.973 ± 0.053	3.252ArgThr: 3.252 ± 0.058	3.714ArgVal: 3.714 ± 0.064	0.806ArgTrp: 0.806 ± 0.028	2.265ArgTyr: 2.265 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.361SerAla: 5.361 ± 0.081	0.806SerCys: 0.806 ± 0.024	3.017SerAsp: 3.017 ± 0.059	3.046SerGlu: 3.046 ± 0.056	2.321SerPhe: 2.321 ± 0.046	5.39SerGly: 5.39 ± 0.089	1.03SerHis: 1.03 ± 0.028	2.887SerIle: 2.887 ± 0.058	2.137SerLys: 2.137 ± 0.046	5.308SerLeu: 5.308 ± 0.076	1.533SerMet: 1.533 ± 0.039	1.605SerAsn: 1.605 ± 0.045	2.416SerPro: 2.416 ± 0.053	1.818SerGln: 1.818 ± 0.041	3.012SerArg: 3.012 ± 0.052	2.969SerSer: 2.969 ± 0.057	2.931SerThr: 2.931 ± 0.064	3.923SerVal: 3.923 ± 0.071	0.697SerTrp: 0.697 ± 0.025	1.944SerTyr: 1.944 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.034ThrAla: 6.034 ± 0.085	0.785ThrCys: 0.785 ± 0.027	3.101ThrAsp: 3.101 ± 0.061	3.325ThrGlu: 3.325 ± 0.053	2.19ThrPhe: 2.19 ± 0.048	5.168ThrGly: 5.168 ± 0.082	1.02ThrHis: 1.02 ± 0.03	3.205ThrIle: 3.205 ± 0.061	1.9ThrLys: 1.9 ± 0.047	6.022ThrLeu: 6.022 ± 0.089	1.412ThrMet: 1.412 ± 0.032	1.514ThrAsn: 1.514 ± 0.037	3.065ThrPro: 3.065 ± 0.064	1.781ThrGln: 1.781 ± 0.044	2.764ThrArg: 2.764 ± 0.048	2.662ThrSer: 2.662 ± 0.052	3.069ThrThr: 3.069 ± 0.064	5.346ThrVal: 5.346 ± 0.084	0.698ThrTrp: 0.698 ± 0.029	1.967ThrTyr: 1.967 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	6.069ValAla: 6.069 ± 0.081	1.387ValCys: 1.387 ± 0.039	4.345ValAsp: 4.345 ± 0.066	5.196ValGlu: 5.196 ± 0.078	2.807ValPhe: 2.807 ± 0.061	5.064ValGly: 5.064 ± 0.081	1.135ValHis: 1.135 ± 0.035	3.711ValIle: 3.711 ± 0.059	3.112ValLys: 3.112 ± 0.061	8.23ValLeu: 8.23 ± 0.099	1.721ValMet: 1.721 ± 0.039	2.213ValAsn: 2.213 ± 0.051	3.316ValPro: 3.316 ± 0.063	2.219ValGln: 2.219 ± 0.045	4.061ValArg: 4.061 ± 0.071	4.494ValSer: 4.494 ± 0.065	4.683ValThr: 4.683 ± 0.092	5.567ValVal: 5.567 ± 0.083	0.941ValTrp: 0.941 ± 0.033	2.343ValTyr: 2.343 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.055TrpAla: 1.055 ± 0.034	0.245TrpCys: 0.245 ± 0.014	0.76TrpAsp: 0.76 ± 0.03	0.862TrpGlu: 0.862 ± 0.029	0.458TrpPhe: 0.458 ± 0.021	0.909TrpGly: 0.909 ± 0.028	0.239TrpHis: 0.239 ± 0.017	0.441TrpIle: 0.441 ± 0.02	0.588TrpLys: 0.588 ± 0.023	1.292TrpLeu: 1.292 ± 0.034	0.349TrpMet: 0.349 ± 0.018	0.512TrpAsn: 0.512 ± 0.02	0.423TrpPro: 0.423 ± 0.022	0.516TrpGln: 0.516 ± 0.023	0.692TrpArg: 0.692 ± 0.029	0.71TrpSer: 0.71 ± 0.027	0.627TrpThr: 0.627 ± 0.024	0.73TrpVal: 0.73 ± 0.026	0.154TrpTrp: 0.154 ± 0.014	0.5TrpTyr: 0.5 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.086TyrAla: 3.086 ± 0.053	0.599TyrCys: 0.599 ± 0.022	2.249TyrAsp: 2.249 ± 0.046	2.259TyrGlu: 2.259 ± 0.05	1.411TyrPhe: 1.411 ± 0.036	2.777TyrGly: 2.777 ± 0.047	0.749TyrHis: 0.749 ± 0.027	1.709TyrIle: 1.709 ± 0.042	1.163TyrLys: 1.163 ± 0.034	3.589TyrLeu: 3.589 ± 0.067	0.676TyrMet: 0.676 ± 0.026	1.178TyrAsn: 1.178 ± 0.03	1.51TyrPro: 1.51 ± 0.038	1.441TyrGln: 1.441 ± 0.037	2.234TyrArg: 2.234 ± 0.048	1.732TyrSer: 1.732 ± 0.041	2.185TyrThr: 2.185 ± 0.049	2.144TyrVal: 2.144 ± 0.042	0.386TyrTrp: 0.386 ± 0.019	1.395TyrTyr: 1.395 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3700 proteins (1150233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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