Amino acid dipepetide frequency for Candida viswanathii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.998AlaAla: 4.998 ± 0.058
0.649AlaCys: 0.649 ± 0.013
2.846AlaAsp: 2.846 ± 0.025
3.609AlaGlu: 3.609 ± 0.045
2.319AlaPhe: 2.319 ± 0.024
3.601AlaGly: 3.601 ± 0.083
1.091AlaHis: 1.091 ± 0.017
3.766AlaIle: 3.766 ± 0.032
4.184AlaLys: 4.184 ± 0.043
5.31AlaLeu: 5.31 ± 0.042
1.174AlaMet: 1.174 ± 0.015
3.23AlaAsn: 3.23 ± 0.026
2.978AlaPro: 2.978 ± 0.039
2.277AlaGln: 2.277 ± 0.029
2.498AlaArg: 2.498 ± 0.024
5.092AlaSer: 5.092 ± 0.042
4.186AlaThr: 4.186 ± 0.042
3.616AlaVal: 3.616 ± 0.035
0.512AlaTrp: 0.512 ± 0.011
1.836AlaTyr: 1.836 ± 0.023
0.0AlaXaa: 0.0 ± 0.0
Cys
0.56CysAla: 0.56 ± 0.012
0.237CysCys: 0.237 ± 0.009
0.613CysAsp: 0.613 ± 0.012
0.536CysGlu: 0.536 ± 0.011
0.565CysPhe: 0.565 ± 0.012
0.777CysGly: 0.777 ± 0.016
0.268CysHis: 0.268 ± 0.009
0.759CysIle: 0.759 ± 0.013
0.618CysLys: 0.618 ± 0.013
1.16CysLeu: 1.16 ± 0.017
0.22CysMet: 0.22 ± 0.007
0.492CysAsn: 0.492 ± 0.011
0.489CysPro: 0.489 ± 0.015
0.368CysGln: 0.368 ± 0.008
0.455CysArg: 0.455 ± 0.011
0.8CysSer: 0.8 ± 0.015
0.535CysThr: 0.535 ± 0.012
0.695CysVal: 0.695 ± 0.014
0.151CysTrp: 0.151 ± 0.006
0.408CysTyr: 0.408 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
3.463AspAla: 3.463 ± 0.031
0.574AspCys: 0.574 ± 0.011
5.553AspAsp: 5.553 ± 0.064
5.615AspGlu: 5.615 ± 0.05
2.746AspPhe: 2.746 ± 0.027
3.146AspGly: 3.146 ± 0.038
1.18AspHis: 1.18 ± 0.018
3.793AspIle: 3.793 ± 0.031
3.831AspLys: 3.831 ± 0.033
5.845AspLeu: 5.845 ± 0.041
1.022AspMet: 1.022 ± 0.014
2.994AspAsn: 2.994 ± 0.028
2.589AspPro: 2.589 ± 0.026
1.967AspGln: 1.967 ± 0.022
2.021AspArg: 2.021 ± 0.02
4.563AspSer: 4.563 ± 0.114
2.956AspThr: 2.956 ± 0.032
3.722AspVal: 3.722 ± 0.035
0.598AspTrp: 0.598 ± 0.011
2.389AspTyr: 2.389 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
3.656GluAla: 3.656 ± 0.041
0.595GluCys: 0.595 ± 0.013
4.722GluAsp: 4.722 ± 0.049
7.36GluGlu: 7.36 ± 0.091
3.024GluPhe: 3.024 ± 0.031
2.853GluGly: 2.853 ± 0.025
1.24GluHis: 1.24 ± 0.021
4.301GluIle: 4.301 ± 0.031
4.715GluLys: 4.715 ± 0.042
6.826GluLeu: 6.826 ± 0.046
1.277GluMet: 1.277 ± 0.015
3.345GluAsn: 3.345 ± 0.028
2.57GluPro: 2.57 ± 0.053
2.657GluGln: 2.657 ± 0.028
2.648GluArg: 2.648 ± 0.025
5.007GluSer: 5.007 ± 0.062
3.774GluThr: 3.774 ± 0.054
4.043GluVal: 4.043 ± 0.05
0.615GluTrp: 0.615 ± 0.011
2.45GluTyr: 2.45 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
2.591PheAla: 2.591 ± 0.027
0.484PheCys: 0.484 ± 0.012
2.935PheAsp: 2.935 ± 0.027
2.755PheGlu: 2.755 ± 0.023
1.94PhePhe: 1.94 ± 0.026
2.83PheGly: 2.83 ± 0.035
0.919PheHis: 0.919 ± 0.014
2.936PheIle: 2.936 ± 0.026
3.01PheLys: 3.01 ± 0.027
4.032PheLeu: 4.032 ± 0.036
0.887PheMet: 0.887 ± 0.015
2.641PheAsn: 2.641 ± 0.025
1.926PhePro: 1.926 ± 0.027
1.7PheGln: 1.7 ± 0.02
1.685PheArg: 1.685 ± 0.021
2.985PheSer: 2.985 ± 0.029
2.635PheThr: 2.635 ± 0.043
2.817PheVal: 2.817 ± 0.027
0.567PheTrp: 0.567 ± 0.019
1.584PheTyr: 1.584 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
3.499GlyAla: 3.499 ± 0.04
0.668GlyCys: 0.668 ± 0.013
3.189GlyAsp: 3.189 ± 0.032
3.19GlyGlu: 3.19 ± 0.027
2.599GlyPhe: 2.599 ± 0.026
4.177GlyGly: 4.177 ± 0.054
1.15GlyHis: 1.15 ± 0.017
3.432GlyIle: 3.432 ± 0.038
3.633GlyLys: 3.633 ± 0.047
4.905GlyLeu: 4.905 ± 0.037
0.946GlyMet: 0.946 ± 0.015
2.736GlyAsn: 2.736 ± 0.027
1.788GlyPro: 1.788 ± 0.038
1.705GlyGln: 1.705 ± 0.021
2.135GlyArg: 2.135 ± 0.026
4.906GlySer: 4.906 ± 0.084
3.136GlyThr: 3.136 ± 0.04
3.782GlyVal: 3.782 ± 0.099
0.632GlyTrp: 0.632 ± 0.012
2.136GlyTyr: 2.136 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.015
0.262HisCys: 0.262 ± 0.007
1.291HisAsp: 1.291 ± 0.019
1.411HisGlu: 1.411 ± 0.024
0.907HisPhe: 0.907 ± 0.014
1.189HisGly: 1.189 ± 0.018
1.015HisHis: 1.015 ± 0.023
1.281HisIle: 1.281 ± 0.014
1.275HisLys: 1.275 ± 0.017
2.096HisLeu: 2.096 ± 0.023
0.351HisMet: 0.351 ± 0.008
1.174HisAsn: 1.174 ± 0.017
1.23HisPro: 1.23 ± 0.018
1.086HisGln: 1.086 ± 0.018
0.968HisArg: 0.968 ± 0.016
1.571HisSer: 1.571 ± 0.022
1.041HisThr: 1.041 ± 0.015
1.181HisVal: 1.181 ± 0.015
0.231HisTrp: 0.231 ± 0.007
0.792HisTyr: 0.792 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.845IleAla: 3.845 ± 0.031
0.717IleCys: 0.717 ± 0.012
4.173IleAsp: 4.173 ± 0.029
4.095IleGlu: 4.095 ± 0.035
2.664IlePhe: 2.664 ± 0.026
3.315IleGly: 3.315 ± 0.033
1.369IleHis: 1.369 ± 0.017
4.058IleIle: 4.058 ± 0.033
4.231IleLys: 4.231 ± 0.036
5.811IleLeu: 5.811 ± 0.043
1.186IleMet: 1.186 ± 0.019
3.619IleAsn: 3.619 ± 0.033
3.341IlePro: 3.341 ± 0.027
2.33IleGln: 2.33 ± 0.021
2.619IleArg: 2.619 ± 0.021
4.89IleSer: 4.89 ± 0.034
3.744IleThr: 3.744 ± 0.033
3.94IleVal: 3.94 ± 0.035
0.694IleTrp: 0.694 ± 0.012
2.1IleTyr: 2.1 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.397LysAla: 3.397 ± 0.037
0.654LysCys: 0.654 ± 0.013
3.891LysAsp: 3.891 ± 0.035
4.898LysGlu: 4.898 ± 0.047
3.185LysPhe: 3.185 ± 0.028
2.779LysGly: 2.779 ± 0.037
1.432LysHis: 1.432 ± 0.02
4.235LysIle: 4.235 ± 0.036
6.102LysLys: 6.102 ± 0.057
7.451LysLeu: 7.451 ± 0.053
1.249LysMet: 1.249 ± 0.016
3.588LysAsn: 3.588 ± 0.03
3.128LysPro: 3.128 ± 0.034
2.946LysGln: 2.946 ± 0.03
3.383LysArg: 3.383 ± 0.031
5.054LysSer: 5.054 ± 0.04
3.479LysThr: 3.479 ± 0.027
3.958LysVal: 3.958 ± 0.031
0.67LysTrp: 0.67 ± 0.013
2.725LysTyr: 2.725 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
5.86LeuAla: 5.86 ± 0.043
1.068LeuCys: 1.068 ± 0.015
5.578LeuAsp: 5.578 ± 0.039
6.01LeuGlu: 6.01 ± 0.045
4.022LeuPhe: 4.022 ± 0.039
4.926LeuGly: 4.926 ± 0.036
2.027LeuHis: 2.027 ± 0.02
6.055LeuIle: 6.055 ± 0.047
6.858LeuLys: 6.858 ± 0.043
9.15LeuLeu: 9.15 ± 0.063
1.854LeuMet: 1.854 ± 0.022
5.448LeuAsn: 5.448 ± 0.041
4.793LeuPro: 4.793 ± 0.038
4.163LeuGln: 4.163 ± 0.039
4.192LeuArg: 4.192 ± 0.033
7.692LeuSer: 7.692 ± 0.044
5.564LeuThr: 5.564 ± 0.043
5.944LeuVal: 5.944 ± 0.04
0.8LeuTrp: 0.8 ± 0.014
3.076LeuTyr: 3.076 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
1.241MetAla: 1.241 ± 0.016
0.217MetCys: 0.217 ± 0.006
1.059MetAsp: 1.059 ± 0.016
1.019MetGlu: 1.019 ± 0.015
0.835MetPhe: 0.835 ± 0.014
1.012MetGly: 1.012 ± 0.016
0.309MetHis: 0.309 ± 0.008
1.188MetIle: 1.188 ± 0.017
1.354MetLys: 1.354 ± 0.016
1.623MetLeu: 1.623 ± 0.019
0.465MetMet: 0.465 ± 0.011
1.097MetAsn: 1.097 ± 0.016
0.803MetPro: 0.803 ± 0.014
0.619MetGln: 0.619 ± 0.013
0.738MetArg: 0.738 ± 0.013
1.855MetSer: 1.855 ± 0.017
1.129MetThr: 1.129 ± 0.015
1.135MetVal: 1.135 ± 0.014
0.17MetTrp: 0.17 ± 0.006
0.606MetTyr: 0.606 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.937AsnAla: 2.937 ± 0.024
0.576AsnCys: 0.576 ± 0.01
3.407AsnAsp: 3.407 ± 0.027
3.44AsnGlu: 3.44 ± 0.027
2.437AsnPhe: 2.437 ± 0.023
3.328AsnGly: 3.328 ± 0.038
1.256AsnHis: 1.256 ± 0.016
3.151AsnIle: 3.151 ± 0.031
3.556AsnLys: 3.556 ± 0.029
5.323AsnLeu: 5.323 ± 0.038
0.936AsnMet: 0.936 ± 0.013
3.899AsnAsn: 3.899 ± 0.048
2.711AsnPro: 2.711 ± 0.034
2.187AsnGln: 2.187 ± 0.025
2.032AsnArg: 2.032 ± 0.021
4.467AsnSer: 4.467 ± 0.044
2.986AsnThr: 2.986 ± 0.031
2.978AsnVal: 2.978 ± 0.023
0.634AsnTrp: 0.634 ± 0.012
2.245AsnTyr: 2.245 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
3.044ProAla: 3.044 ± 0.048
0.344ProCys: 0.344 ± 0.011
2.482ProAsp: 2.482 ± 0.024
3.469ProGlu: 3.469 ± 0.035
1.89ProPhe: 1.89 ± 0.02
2.39ProGly: 2.39 ± 0.033
1.072ProHis: 1.072 ± 0.017
2.903ProIle: 2.903 ± 0.028
3.164ProLys: 3.164 ± 0.031
3.896ProLeu: 3.896 ± 0.032
0.799ProMet: 0.799 ± 0.014
2.462ProAsn: 2.462 ± 0.029
3.828ProPro: 3.828 ± 0.069
2.51ProGln: 2.51 ± 0.041
1.953ProArg: 1.953 ± 0.028
4.187ProSer: 4.187 ± 0.046
3.471ProThr: 3.471 ± 0.052
3.211ProVal: 3.211 ± 0.032
0.391ProTrp: 0.391 ± 0.009
1.452ProTyr: 1.452 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
2.322GlnAla: 2.322 ± 0.029
0.373GlnCys: 0.373 ± 0.009
2.133GlnAsp: 2.133 ± 0.021
2.897GlnGlu: 2.897 ± 0.026
1.799GlnPhe: 1.799 ± 0.02
1.878GlnGly: 1.878 ± 0.025
1.063GlnHis: 1.063 ± 0.018
2.288GlnIle: 2.288 ± 0.027
2.31GlnLys: 2.31 ± 0.023
4.351GlnLeu: 4.351 ± 0.038
0.764GlnMet: 0.764 ± 0.015
1.783GlnAsn: 1.783 ± 0.02
2.453GlnPro: 2.453 ± 0.041
4.639GlnGln: 4.639 ± 0.132
1.799GlnArg: 1.799 ± 0.022
2.901GlnSer: 2.901 ± 0.034
1.973GlnThr: 1.973 ± 0.023
2.268GlnVal: 2.268 ± 0.023
0.378GlnTrp: 0.378 ± 0.009
1.418GlnTyr: 1.418 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
2.377ArgAla: 2.377 ± 0.026
0.459ArgCys: 0.459 ± 0.01
2.39ArgAsp: 2.39 ± 0.023
2.636ArgGlu: 2.636 ± 0.028
1.915ArgPhe: 1.915 ± 0.02
2.124ArgGly: 2.124 ± 0.028
0.965ArgHis: 0.965 ± 0.014
2.688ArgIle: 2.688 ± 0.027
3.236ArgLys: 3.236 ± 0.031
4.106ArgLeu: 4.106 ± 0.031
0.831ArgMet: 0.831 ± 0.013
2.222ArgAsn: 2.222 ± 0.023
1.702ArgPro: 1.702 ± 0.024
1.712ArgGln: 1.712 ± 0.018
2.605ArgArg: 2.605 ± 0.026
3.25ArgSer: 3.25 ± 0.029
2.227ArgThr: 2.227 ± 0.021
2.36ArgVal: 2.36 ± 0.025
0.436ArgTrp: 0.436 ± 0.011
1.499ArgTyr: 1.499 ± 0.016
0.0ArgXaa: 0.0 ± 0.0
Ser
4.747SerAla: 4.747 ± 0.088
0.787SerCys: 0.787 ± 0.014
4.307SerAsp: 4.307 ± 0.038
4.437SerGlu: 4.437 ± 0.063
3.496SerPhe: 3.496 ± 0.035
4.675SerGly: 4.675 ± 0.079
1.678SerHis: 1.678 ± 0.023
5.407SerIle: 5.407 ± 0.039
5.359SerLys: 5.359 ± 0.044
7.565SerLeu: 7.565 ± 0.052
1.499SerMet: 1.499 ± 0.017
4.624SerAsn: 4.624 ± 0.043
3.985SerPro: 3.985 ± 0.046
3.056SerGln: 3.056 ± 0.039
3.443SerArg: 3.443 ± 0.031
9.878SerSer: 9.878 ± 0.12
6.079SerThr: 6.079 ± 0.083
4.597SerVal: 4.597 ± 0.051
0.785SerTrp: 0.785 ± 0.013
2.563SerTyr: 2.563 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
3.756ThrAla: 3.756 ± 0.041
0.626ThrCys: 0.626 ± 0.013
2.994ThrAsp: 2.994 ± 0.04
3.47ThrGlu: 3.47 ± 0.076
2.458ThrPhe: 2.458 ± 0.029
3.457ThrGly: 3.457 ± 0.051
1.164ThrHis: 1.164 ± 0.016
3.892ThrIle: 3.892 ± 0.033
3.86ThrLys: 3.86 ± 0.029
5.165ThrLeu: 5.165 ± 0.04
0.998ThrMet: 0.998 ± 0.013
3.405ThrAsn: 3.405 ± 0.036
3.743ThrPro: 3.743 ± 0.054
1.961ThrGln: 1.961 ± 0.025
2.366ThrArg: 2.366 ± 0.021
5.665ThrSer: 5.665 ± 0.059
5.759ThrThr: 5.759 ± 0.12
3.582ThrVal: 3.582 ± 0.058
0.647ThrTrp: 0.647 ± 0.023
1.839ThrTyr: 1.839 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
3.901ValAla: 3.901 ± 0.036
0.695ValCys: 0.695 ± 0.013
4.081ValAsp: 4.081 ± 0.113
4.107ValGlu: 4.107 ± 0.042
2.731ValPhe: 2.731 ± 0.026
3.297ValGly: 3.297 ± 0.03
1.196ValHis: 1.196 ± 0.016
3.84ValIle: 3.84 ± 0.034
3.897ValLys: 3.897 ± 0.029
5.806ValLeu: 5.806 ± 0.042
1.164ValMet: 1.164 ± 0.017
3.077ValAsn: 3.077 ± 0.026
3.101ValPro: 3.101 ± 0.041
2.071ValGln: 2.071 ± 0.024
2.279ValArg: 2.279 ± 0.022
4.838ValSer: 4.838 ± 0.045
3.712ValThr: 3.712 ± 0.06
4.414ValVal: 4.414 ± 0.049
0.623ValTrp: 0.623 ± 0.016
2.14ValTyr: 2.14 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
0.541TrpAla: 0.541 ± 0.011
0.203TrpCys: 0.203 ± 0.007
0.603TrpAsp: 0.603 ± 0.013
0.622TrpGlu: 0.622 ± 0.024
0.555TrpPhe: 0.555 ± 0.011
0.562TrpGly: 0.562 ± 0.012
0.195TrpHis: 0.195 ± 0.008
0.681TrpIle: 0.681 ± 0.013
0.774TrpLys: 0.774 ± 0.013
1.008TrpLeu: 1.008 ± 0.015
0.219TrpMet: 0.219 ± 0.007
0.575TrpAsn: 0.575 ± 0.012
0.292TrpPro: 0.292 ± 0.008
0.334TrpGln: 0.334 ± 0.009
0.473TrpArg: 0.473 ± 0.01
0.773TrpSer: 0.773 ± 0.013
0.55TrpThr: 0.55 ± 0.013
0.619TrpVal: 0.619 ± 0.013
0.179TrpTrp: 0.179 ± 0.006
0.405TrpTyr: 0.405 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.941TyrAla: 1.941 ± 0.021
0.517TyrCys: 0.517 ± 0.011
2.318TyrAsp: 2.318 ± 0.025
2.102TyrGlu: 2.102 ± 0.025
1.771TyrPhe: 1.771 ± 0.019
2.029TyrGly: 2.029 ± 0.024
0.859TyrHis: 0.859 ± 0.014
2.086TyrIle: 2.086 ± 0.02
2.237TyrLys: 2.237 ± 0.022
3.653TyrLeu: 3.653 ± 0.031
0.634TyrMet: 0.634 ± 0.011
2.077TyrAsn: 2.077 ± 0.021
1.47TyrPro: 1.47 ± 0.021
1.504TyrGln: 1.504 ± 0.02
1.446TyrArg: 1.446 ± 0.018
2.591TyrSer: 2.591 ± 0.025
1.87TyrThr: 1.87 ± 0.025
2.109TyrVal: 2.109 ± 0.024
0.448TyrTrp: 0.448 ± 0.011
1.604TyrTyr: 1.604 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10576 proteins (5109780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski