Amino acid dipepetide frequency for Slackia isoflavoniconvertens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.544AlaAla: 15.544 ± 0.268
2.473AlaCys: 2.473 ± 0.082
6.459AlaAsp: 6.459 ± 0.121
7.791AlaGlu: 7.791 ± 0.146
4.67AlaPhe: 4.67 ± 0.097
8.996AlaGly: 8.996 ± 0.136
2.343AlaHis: 2.343 ± 0.066
6.335AlaIle: 6.335 ± 0.108
5.442AlaLys: 5.442 ± 0.119
10.771AlaLeu: 10.771 ± 0.159
3.247AlaMet: 3.247 ± 0.076
3.567AlaAsn: 3.567 ± 0.079
4.309AlaPro: 4.309 ± 0.093
3.941AlaGln: 3.941 ± 0.1
6.317AlaArg: 6.317 ± 0.138
7.263AlaSer: 7.263 ± 0.123
5.832AlaThr: 5.832 ± 0.135
8.015AlaVal: 8.015 ± 0.131
1.163AlaTrp: 1.163 ± 0.048
2.919AlaTyr: 2.919 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
2.026CysAla: 2.026 ± 0.066
0.29CysCys: 0.29 ± 0.025
1.232CysAsp: 1.232 ± 0.051
1.194CysGlu: 1.194 ± 0.055
0.627CysPhe: 0.627 ± 0.032
1.904CysGly: 1.904 ± 0.068
0.312CysHis: 0.312 ± 0.025
0.828CysIle: 0.828 ± 0.041
0.6CysLys: 0.6 ± 0.028
1.186CysLeu: 1.186 ± 0.045
0.513CysMet: 0.513 ± 0.029
0.431CysAsn: 0.431 ± 0.027
0.759CysPro: 0.759 ± 0.041
0.392CysGln: 0.392 ± 0.023
0.796CysArg: 0.796 ± 0.037
0.966CysSer: 0.966 ± 0.044
0.823CysThr: 0.823 ± 0.035
1.506CysVal: 1.506 ± 0.057
0.15CysTrp: 0.15 ± 0.016
0.423CysTyr: 0.423 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
7.914AspAla: 7.914 ± 0.133
0.847AspCys: 0.847 ± 0.04
3.756AspAsp: 3.756 ± 0.088
5.314AspGlu: 5.314 ± 0.102
2.55AspPhe: 2.55 ± 0.059
5.147AspGly: 5.147 ± 0.13
0.915AspHis: 0.915 ± 0.034
3.483AspIle: 3.483 ± 0.091
2.305AspLys: 2.305 ± 0.071
4.578AspLeu: 4.578 ± 0.094
1.802AspMet: 1.802 ± 0.052
1.565AspAsn: 1.565 ± 0.064
2.531AspPro: 2.531 ± 0.08
1.253AspGln: 1.253 ± 0.048
2.725AspArg: 2.725 ± 0.071
3.285AspSer: 3.285 ± 0.088
2.742AspThr: 2.742 ± 0.066
4.929AspVal: 4.929 ± 0.098
0.715AspTrp: 0.715 ± 0.038
1.826AspTyr: 1.826 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
8.031GluAla: 8.031 ± 0.139
0.965GluCys: 0.965 ± 0.039
3.347GluAsp: 3.347 ± 0.091
4.691GluGlu: 4.691 ± 0.1
2.44GluPhe: 2.44 ± 0.069
5.458GluGly: 5.458 ± 0.124
1.563GluHis: 1.563 ± 0.059
3.586GluIle: 3.586 ± 0.083
3.384GluLys: 3.384 ± 0.076
6.145GluLeu: 6.145 ± 0.116
1.959GluMet: 1.959 ± 0.058
2.54GluAsn: 2.54 ± 0.065
2.561GluPro: 2.561 ± 0.071
2.376GluGln: 2.376 ± 0.07
4.463GluArg: 4.463 ± 0.113
3.731GluSer: 3.731 ± 0.078
3.549GluThr: 3.549 ± 0.081
4.791GluVal: 4.791 ± 0.081
0.626GluTrp: 0.626 ± 0.033
1.935GluTyr: 1.935 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.442PheAla: 4.442 ± 0.094
0.718PheCys: 0.718 ± 0.035
3.065PheAsp: 3.065 ± 0.076
2.749PheGlu: 2.749 ± 0.064
1.574PhePhe: 1.574 ± 0.058
3.726PheGly: 3.726 ± 0.081
0.578PheHis: 0.578 ± 0.035
1.951PheIle: 1.951 ± 0.065
1.471PheLys: 1.471 ± 0.044
3.115PheLeu: 3.115 ± 0.078
1.103PheMet: 1.103 ± 0.043
1.179PheAsn: 1.179 ± 0.044
1.38PhePro: 1.38 ± 0.044
0.875PheGln: 0.875 ± 0.041
1.617PheArg: 1.617 ± 0.054
2.661PheSer: 2.661 ± 0.07
2.052PheThr: 2.052 ± 0.064
3.296PheVal: 3.296 ± 0.082
0.466PheTrp: 0.466 ± 0.026
1.036PheTyr: 1.036 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
8.592GlyAla: 8.592 ± 0.143
1.561GlyCys: 1.561 ± 0.054
4.745GlyAsp: 4.745 ± 0.098
5.334GlyGlu: 5.334 ± 0.105
3.49GlyPhe: 3.49 ± 0.071
6.3GlyGly: 6.3 ± 0.141
1.52GlyHis: 1.52 ± 0.05
5.05GlyIle: 5.05 ± 0.115
4.194GlyLys: 4.194 ± 0.091
6.792GlyLeu: 6.792 ± 0.112
2.488GlyMet: 2.488 ± 0.069
2.655GlyAsn: 2.655 ± 0.081
2.095GlyPro: 2.095 ± 0.062
2.117GlyGln: 2.117 ± 0.067
4.215GlyArg: 4.215 ± 0.103
5.077GlySer: 5.077 ± 0.116
4.472GlyThr: 4.472 ± 0.12
7.002GlyVal: 7.002 ± 0.105
1.023GlyTrp: 1.023 ± 0.051
2.515GlyTyr: 2.515 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.249HisAla: 2.249 ± 0.063
0.304HisCys: 0.304 ± 0.022
1.159HisAsp: 1.159 ± 0.042
1.308HisGlu: 1.308 ± 0.045
0.702HisPhe: 0.702 ± 0.031
1.676HisGly: 1.676 ± 0.054
0.396HisHis: 0.396 ± 0.032
1.093HisIle: 1.093 ± 0.04
0.645HisLys: 0.645 ± 0.034
1.35HisLeu: 1.35 ± 0.046
0.565HisMet: 0.565 ± 0.028
0.568HisAsn: 0.568 ± 0.034
0.985HisPro: 0.985 ± 0.041
0.406HisGln: 0.406 ± 0.028
1.009HisArg: 1.009 ± 0.043
1.058HisSer: 1.058 ± 0.039
0.925HisThr: 0.925 ± 0.034
1.743HisVal: 1.743 ± 0.05
0.193HisTrp: 0.193 ± 0.016
0.622HisTyr: 0.622 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.228IleAla: 7.228 ± 0.133
0.848IleCys: 0.848 ± 0.036
4.259IleAsp: 4.259 ± 0.085
4.234IleGlu: 4.234 ± 0.084
1.643IlePhe: 1.643 ± 0.054
4.213IleGly: 4.213 ± 0.1
0.845IleHis: 0.845 ± 0.038
2.606IleIle: 2.606 ± 0.081
1.97IleLys: 1.97 ± 0.069
3.78IleLeu: 3.78 ± 0.087
1.413IleMet: 1.413 ± 0.056
1.547IleAsn: 1.547 ± 0.05
2.472IlePro: 2.472 ± 0.063
1.273IleGln: 1.273 ± 0.049
2.343IleArg: 2.343 ± 0.069
3.362IleSer: 3.362 ± 0.063
2.964IleThr: 2.964 ± 0.088
4.894IleVal: 4.894 ± 0.105
0.449IleTrp: 0.449 ± 0.028
1.3IleTyr: 1.3 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.936LysAla: 4.936 ± 0.102
0.543LysCys: 0.543 ± 0.032
2.079LysAsp: 2.079 ± 0.066
2.739LysGlu: 2.739 ± 0.076
1.229LysPhe: 1.229 ± 0.043
3.365LysGly: 3.365 ± 0.087
0.914LysHis: 0.914 ± 0.037
2.08LysIle: 2.08 ± 0.062
2.852LysLys: 2.852 ± 0.079
3.85LysLeu: 3.85 ± 0.081
1.199LysMet: 1.199 ± 0.045
1.66LysAsn: 1.66 ± 0.06
1.994LysPro: 1.994 ± 0.069
1.509LysGln: 1.509 ± 0.049
3.005LysArg: 3.005 ± 0.077
2.613LysSer: 2.613 ± 0.07
2.741LysThr: 2.741 ± 0.087
3.185LysVal: 3.185 ± 0.086
0.428LysTrp: 0.428 ± 0.028
1.189LysTyr: 1.189 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
10.29LeuAla: 10.29 ± 0.172
1.493LeuCys: 1.493 ± 0.056
5.416LeuAsp: 5.416 ± 0.11
5.322LeuGlu: 5.322 ± 0.112
3.443LeuPhe: 3.443 ± 0.098
7.0LeuGly: 7.0 ± 0.126
1.49LeuHis: 1.49 ± 0.049
4.146LeuIle: 4.146 ± 0.107
3.42LeuLys: 3.42 ± 0.074
7.245LeuLeu: 7.245 ± 0.17
2.266LeuMet: 2.266 ± 0.066
2.454LeuAsn: 2.454 ± 0.063
3.938LeuPro: 3.938 ± 0.08
2.177LeuGln: 2.177 ± 0.063
4.781LeuArg: 4.781 ± 0.111
5.97LeuSer: 5.97 ± 0.104
4.332LeuThr: 4.332 ± 0.091
6.986LeuVal: 6.986 ± 0.133
0.756LeuTrp: 0.756 ± 0.036
2.152LeuTyr: 2.152 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.096MetAla: 3.096 ± 0.065
0.438MetCys: 0.438 ± 0.029
1.404MetAsp: 1.404 ± 0.047
1.501MetGlu: 1.501 ± 0.052
0.936MetPhe: 0.936 ± 0.041
2.344MetGly: 2.344 ± 0.062
0.579MetHis: 0.579 ± 0.028
1.171MetIle: 1.171 ± 0.053
1.343MetLys: 1.343 ± 0.057
2.575MetLeu: 2.575 ± 0.08
0.704MetMet: 0.704 ± 0.03
1.125MetAsn: 1.125 ± 0.047
1.506MetPro: 1.506 ± 0.052
0.974MetGln: 0.974 ± 0.042
1.827MetArg: 1.827 ± 0.063
1.802MetSer: 1.802 ± 0.06
1.436MetThr: 1.436 ± 0.047
2.018MetVal: 2.018 ± 0.058
0.272MetTrp: 0.272 ± 0.022
0.622MetTyr: 0.622 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.92AsnAla: 3.92 ± 0.09
0.473AsnCys: 0.473 ± 0.032
1.916AsnAsp: 1.916 ± 0.063
2.082AsnGlu: 2.082 ± 0.064
1.054AsnPhe: 1.054 ± 0.039
2.793AsnGly: 2.793 ± 0.085
0.632AsnHis: 0.632 ± 0.031
1.754AsnIle: 1.754 ± 0.055
1.186AsnLys: 1.186 ± 0.047
2.524AsnLeu: 2.524 ± 0.057
0.867AsnMet: 0.867 ± 0.041
1.041AsnAsn: 1.041 ± 0.051
1.972AsnPro: 1.972 ± 0.058
0.837AsnGln: 0.837 ± 0.036
1.733AsnArg: 1.733 ± 0.055
1.705AsnSer: 1.705 ± 0.056
1.649AsnThr: 1.649 ± 0.065
2.648AsnVal: 2.648 ± 0.101
0.38AsnTrp: 0.38 ± 0.026
0.99AsnTyr: 0.99 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
4.423ProAla: 4.423 ± 0.1
0.684ProCys: 0.684 ± 0.034
2.655ProAsp: 2.655 ± 0.064
3.483ProGlu: 3.483 ± 0.084
1.794ProPhe: 1.794 ± 0.063
3.069ProGly: 3.069 ± 0.071
0.847ProHis: 0.847 ± 0.036
2.093ProIle: 2.093 ± 0.053
1.848ProLys: 1.848 ± 0.059
3.307ProLeu: 3.307 ± 0.078
0.952ProMet: 0.952 ± 0.039
1.444ProAsn: 1.444 ± 0.05
1.001ProPro: 1.001 ± 0.049
1.364ProGln: 1.364 ± 0.049
1.983ProArg: 1.983 ± 0.061
2.572ProSer: 2.572 ± 0.066
2.141ProThr: 2.141 ± 0.064
3.252ProVal: 3.252 ± 0.073
0.452ProTrp: 0.452 ± 0.027
1.339ProTyr: 1.339 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.71GlnAla: 3.71 ± 0.091
0.345GlnCys: 0.345 ± 0.025
1.167GlnAsp: 1.167 ± 0.044
1.671GlnGlu: 1.671 ± 0.059
1.062GlnPhe: 1.062 ± 0.044
2.243GlnGly: 2.243 ± 0.069
0.559GlnHis: 0.559 ± 0.027
1.652GlnIle: 1.652 ± 0.048
1.351GlnLys: 1.351 ± 0.043
2.462GlnLeu: 2.462 ± 0.066
0.855GlnMet: 0.855 ± 0.038
1.001GlnAsn: 1.001 ± 0.045
1.203GlnPro: 1.203 ± 0.052
1.113GlnGln: 1.113 ± 0.049
1.838GlnArg: 1.838 ± 0.072
1.577GlnSer: 1.577 ± 0.064
1.666GlnThr: 1.666 ± 0.055
2.111GlnVal: 2.111 ± 0.058
0.312GlnTrp: 0.312 ± 0.024
0.78GlnTyr: 0.78 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.774ArgAla: 5.774 ± 0.134
0.888ArgCys: 0.888 ± 0.041
3.393ArgAsp: 3.393 ± 0.095
4.437ArgGlu: 4.437 ± 0.101
2.383ArgPhe: 2.383 ± 0.064
4.051ArgGly: 4.051 ± 0.102
1.111ArgHis: 1.111 ± 0.045
3.354ArgIle: 3.354 ± 0.09
2.535ArgLys: 2.535 ± 0.077
4.449ArgLeu: 4.449 ± 0.097
1.786ArgMet: 1.786 ± 0.061
1.748ArgAsn: 1.748 ± 0.053
1.945ArgPro: 1.945 ± 0.068
1.573ArgGln: 1.573 ± 0.053
3.979ArgArg: 3.979 ± 0.128
2.833ArgSer: 2.833 ± 0.073
2.569ArgThr: 2.569 ± 0.072
4.256ArgVal: 4.256 ± 0.098
0.578ArgTrp: 0.578 ± 0.035
1.654ArgTyr: 1.654 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
6.538SerAla: 6.538 ± 0.119
0.882SerCys: 0.882 ± 0.04
3.68SerAsp: 3.68 ± 0.099
3.65SerGlu: 3.65 ± 0.073
2.537SerPhe: 2.537 ± 0.06
5.294SerGly: 5.294 ± 0.119
1.165SerHis: 1.165 ± 0.037
3.422SerIle: 3.422 ± 0.085
2.563SerLys: 2.563 ± 0.079
5.286SerLeu: 5.286 ± 0.101
1.783SerMet: 1.783 ± 0.057
2.087SerAsn: 2.087 ± 0.062
2.302SerPro: 2.302 ± 0.064
1.92SerGln: 1.92 ± 0.061
3.395SerArg: 3.395 ± 0.078
4.216SerSer: 4.216 ± 0.12
3.293SerThr: 3.293 ± 0.079
4.546SerVal: 4.546 ± 0.091
0.629SerTrp: 0.629 ± 0.035
1.826SerTyr: 1.826 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
5.146ThrAla: 5.146 ± 0.121
0.925ThrCys: 0.925 ± 0.043
2.841ThrAsp: 2.841 ± 0.079
2.972ThrGlu: 2.972 ± 0.079
2.095ThrPhe: 2.095 ± 0.065
4.523ThrGly: 4.523 ± 0.115
1.036ThrHis: 1.036 ± 0.037
3.051ThrIle: 3.051 ± 0.08
2.185ThrLys: 2.185 ± 0.069
4.907ThrLeu: 4.907 ± 0.101
1.353ThrMet: 1.353 ± 0.049
1.681ThrAsn: 1.681 ± 0.085
2.825ThrPro: 2.825 ± 0.074
1.464ThrGln: 1.464 ± 0.049
2.407ThrArg: 2.407 ± 0.073
3.007ThrSer: 3.007 ± 0.075
2.956ThrThr: 2.956 ± 0.087
4.398ThrVal: 4.398 ± 0.132
0.597ThrTrp: 0.597 ± 0.037
1.638ThrTyr: 1.638 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
9.407ValAla: 9.407 ± 0.132
1.593ValCys: 1.593 ± 0.058
4.899ValAsp: 4.899 ± 0.093
5.246ValGlu: 5.246 ± 0.1
3.299ValPhe: 3.299 ± 0.088
5.884ValGly: 5.884 ± 0.107
1.429ValHis: 1.429 ± 0.046
4.07ValIle: 4.07 ± 0.08
3.258ValLys: 3.258 ± 0.079
7.264ValLeu: 7.264 ± 0.145
1.787ValMet: 1.787 ± 0.061
2.577ValAsn: 2.577 ± 0.068
3.389ValPro: 3.389 ± 0.078
1.959ValGln: 1.959 ± 0.06
4.434ValArg: 4.434 ± 0.09
5.112ValSer: 5.112 ± 0.103
3.928ValThr: 3.928 ± 0.18
7.053ValVal: 7.053 ± 0.139
0.737ValTrp: 0.737 ± 0.037
2.082ValTyr: 2.082 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
1.06TrpAla: 1.06 ± 0.041
0.193TrpCys: 0.193 ± 0.018
0.589TrpAsp: 0.589 ± 0.033
0.605TrpGlu: 0.605 ± 0.031
0.433TrpPhe: 0.433 ± 0.024
0.82TrpGly: 0.82 ± 0.04
0.239TrpHis: 0.239 ± 0.019
0.549TrpIle: 0.549 ± 0.029
0.482TrpLys: 0.482 ± 0.025
1.087TrpLeu: 1.087 ± 0.043
0.328TrpMet: 0.328 ± 0.027
0.377TrpAsn: 0.377 ± 0.023
0.372TrpPro: 0.372 ± 0.027
0.364TrpGln: 0.364 ± 0.024
0.71TrpArg: 0.71 ± 0.036
0.552TrpSer: 0.552 ± 0.031
0.43TrpThr: 0.43 ± 0.027
0.708TrpVal: 0.708 ± 0.035
0.115TrpTrp: 0.115 ± 0.015
0.325TrpTyr: 0.325 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.07TyrAla: 3.07 ± 0.075
0.493TyrCys: 0.493 ± 0.029
2.118TyrAsp: 2.118 ± 0.068
1.819TyrGlu: 1.819 ± 0.056
1.097TyrPhe: 1.097 ± 0.048
2.43TyrGly: 2.43 ± 0.068
0.484TyrHis: 0.484 ± 0.026
1.369TyrIle: 1.369 ± 0.053
1.076TyrLys: 1.076 ± 0.051
2.407TyrLeu: 2.407 ± 0.071
0.704TyrMet: 0.704 ± 0.036
0.91TyrAsn: 0.91 ± 0.049
1.163TyrPro: 1.163 ± 0.04
0.791TyrGln: 0.791 ± 0.034
1.717TyrArg: 1.717 ± 0.053
1.647TyrSer: 1.647 ± 0.057
1.506TyrThr: 1.506 ± 0.09
2.072TyrVal: 2.072 ± 0.055
0.298TyrTrp: 0.298 ± 0.026
0.809TyrTyr: 0.809 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1842 proteins (628285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski