Amino acid dipepetide frequency for Streptococcus phage Javan253

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.055AlaAla: 3.055 ± 0.579
0.248AlaCys: 0.248 ± 0.149
6.522AlaAsp: 6.522 ± 0.709
7.182AlaGlu: 7.182 ± 0.964
2.477AlaPhe: 2.477 ± 0.784
5.118AlaGly: 5.118 ± 0.608
0.908AlaHis: 0.908 ± 0.393
5.201AlaIle: 5.201 ± 0.892
6.935AlaLys: 6.935 ± 0.631
6.852AlaLeu: 6.852 ± 0.603
2.064AlaMet: 2.064 ± 0.59
4.623AlaAsn: 4.623 ± 0.887
2.229AlaPro: 2.229 ± 0.529
2.972AlaGln: 2.972 ± 0.773
2.724AlaArg: 2.724 ± 0.447
3.88AlaSer: 3.88 ± 0.516
4.21AlaThr: 4.21 ± 0.592
3.385AlaVal: 3.385 ± 0.696
1.073AlaTrp: 1.073 ± 0.395
2.477AlaTyr: 2.477 ± 0.495
0.0AlaXaa: 0.0 ± 0.0
Cys
0.165CysAla: 0.165 ± 0.116
0.0CysCys: 0.0 ± 0.0
0.33CysAsp: 0.33 ± 0.161
0.66CysGlu: 0.66 ± 0.266
0.33CysPhe: 0.33 ± 0.137
0.248CysGly: 0.248 ± 0.142
0.083CysHis: 0.083 ± 0.077
0.248CysIle: 0.248 ± 0.164
0.413CysLys: 0.413 ± 0.229
0.248CysLeu: 0.248 ± 0.153
0.248CysMet: 0.248 ± 0.167
0.495CysAsn: 0.495 ± 0.187
0.413CysPro: 0.413 ± 0.193
0.165CysGln: 0.165 ± 0.154
0.578CysArg: 0.578 ± 0.205
0.66CysSer: 0.66 ± 0.249
0.0CysThr: 0.0 ± 0.0
0.33CysVal: 0.33 ± 0.219
0.0CysTrp: 0.0 ± 0.0
0.083CysTyr: 0.083 ± 0.086
0.0CysXaa: 0.0 ± 0.0
Asp
4.458AspAla: 4.458 ± 0.672
0.826AspCys: 0.826 ± 0.334
3.798AspAsp: 3.798 ± 0.597
6.027AspGlu: 6.027 ± 0.95
3.632AspPhe: 3.632 ± 0.476
3.715AspGly: 3.715 ± 0.644
0.66AspHis: 0.66 ± 0.309
3.963AspIle: 3.963 ± 0.739
5.531AspLys: 5.531 ± 0.601
4.953AspLeu: 4.953 ± 0.742
1.981AspMet: 1.981 ± 0.484
3.715AspAsn: 3.715 ± 0.621
1.238AspPro: 1.238 ± 0.384
1.569AspGln: 1.569 ± 0.383
2.477AspArg: 2.477 ± 0.46
4.541AspSer: 4.541 ± 0.533
3.88AspThr: 3.88 ± 0.482
3.715AspVal: 3.715 ± 0.478
1.403AspTrp: 1.403 ± 0.292
3.302AspTyr: 3.302 ± 0.6
0.0AspXaa: 0.0 ± 0.0
Glu
5.614GluAla: 5.614 ± 0.742
0.165GluCys: 0.165 ± 0.122
3.385GluAsp: 3.385 ± 0.516
5.614GluGlu: 5.614 ± 1.093
2.889GluPhe: 2.889 ± 0.531
3.55GluGly: 3.55 ± 0.588
1.486GluHis: 1.486 ± 0.394
7.1GluIle: 7.1 ± 0.631
6.604GluLys: 6.604 ± 1.188
8.421GluLeu: 8.421 ± 1.204
3.302GluMet: 3.302 ± 0.849
3.963GluAsn: 3.963 ± 0.733
1.981GluPro: 1.981 ± 0.434
3.302GluGln: 3.302 ± 0.647
3.385GluArg: 3.385 ± 0.581
3.963GluSer: 3.963 ± 0.709
3.88GluThr: 3.88 ± 0.704
5.118GluVal: 5.118 ± 0.754
1.073GluTrp: 1.073 ± 0.269
2.642GluTyr: 2.642 ± 0.49
0.0GluXaa: 0.0 ± 0.0
Phe
2.064PheAla: 2.064 ± 0.522
0.165PheCys: 0.165 ± 0.134
4.623PheAsp: 4.623 ± 0.497
3.137PheGlu: 3.137 ± 0.547
1.403PhePhe: 1.403 ± 0.321
2.064PheGly: 2.064 ± 0.534
0.495PheHis: 0.495 ± 0.242
1.981PheIle: 1.981 ± 0.45
3.22PheLys: 3.22 ± 0.592
2.477PheLeu: 2.477 ± 0.387
1.651PheMet: 1.651 ± 0.418
2.724PheAsn: 2.724 ± 0.753
0.66PhePro: 0.66 ± 0.202
0.66PheGln: 0.66 ± 0.273
1.403PheArg: 1.403 ± 0.398
2.972PheSer: 2.972 ± 0.731
2.146PheThr: 2.146 ± 0.472
2.972PheVal: 2.972 ± 0.572
0.413PheTrp: 0.413 ± 0.212
1.073PheTyr: 1.073 ± 0.281
0.0PheXaa: 0.0 ± 0.0
Gly
3.632GlyAla: 3.632 ± 0.596
0.495GlyCys: 0.495 ± 0.21
3.798GlyAsp: 3.798 ± 0.646
2.889GlyGlu: 2.889 ± 0.364
2.889GlyPhe: 2.889 ± 0.422
3.715GlyGly: 3.715 ± 0.951
0.743GlyHis: 0.743 ± 0.213
4.458GlyIle: 4.458 ± 0.838
5.614GlyLys: 5.614 ± 0.662
4.623GlyLeu: 4.623 ± 0.545
1.816GlyMet: 1.816 ± 0.372
3.055GlyAsn: 3.055 ± 0.385
0.743GlyPro: 0.743 ± 0.277
3.302GlyGln: 3.302 ± 0.524
2.807GlyArg: 2.807 ± 0.475
4.293GlySer: 4.293 ± 0.904
3.137GlyThr: 3.137 ± 0.426
4.21GlyVal: 4.21 ± 0.572
1.073GlyTrp: 1.073 ± 0.401
2.229GlyTyr: 2.229 ± 0.398
0.0GlyXaa: 0.0 ± 0.0
His
0.908HisAla: 0.908 ± 0.252
0.083HisCys: 0.083 ± 0.085
0.66HisAsp: 0.66 ± 0.232
0.908HisGlu: 0.908 ± 0.472
0.908HisPhe: 0.908 ± 0.33
1.321HisGly: 1.321 ± 0.376
0.578HisHis: 0.578 ± 0.218
1.403HisIle: 1.403 ± 0.377
0.991HisLys: 0.991 ± 0.262
0.991HisLeu: 0.991 ± 0.341
0.248HisMet: 0.248 ± 0.125
0.495HisAsn: 0.495 ± 0.188
0.413HisPro: 0.413 ± 0.222
0.66HisGln: 0.66 ± 0.273
0.413HisArg: 0.413 ± 0.161
0.743HisSer: 0.743 ± 0.249
0.908HisThr: 0.908 ± 0.339
0.743HisVal: 0.743 ± 0.224
0.165HisTrp: 0.165 ± 0.116
0.908HisTyr: 0.908 ± 0.327
0.0HisXaa: 0.0 ± 0.0
Ile
6.687IleAla: 6.687 ± 0.843
0.33IleCys: 0.33 ± 0.154
5.036IleAsp: 5.036 ± 0.591
6.77IleGlu: 6.77 ± 0.81
2.807IlePhe: 2.807 ± 0.422
5.036IleGly: 5.036 ± 0.874
0.743IleHis: 0.743 ± 0.275
4.21IleIle: 4.21 ± 0.503
7.265IleLys: 7.265 ± 0.847
4.706IleLeu: 4.706 ± 0.698
0.991IleMet: 0.991 ± 0.355
4.293IleAsn: 4.293 ± 0.559
1.981IlePro: 1.981 ± 0.498
1.899IleGln: 1.899 ± 0.456
2.312IleArg: 2.312 ± 0.439
4.045IleSer: 4.045 ± 0.725
4.706IleThr: 4.706 ± 1.631
3.302IleVal: 3.302 ± 0.4
0.826IleTrp: 0.826 ± 0.216
2.724IleTyr: 2.724 ± 0.654
0.0IleXaa: 0.0 ± 0.0
Lys
6.77LysAla: 6.77 ± 0.706
0.33LysCys: 0.33 ± 0.177
3.963LysAsp: 3.963 ± 0.565
7.513LysGlu: 7.513 ± 1.05
2.394LysPhe: 2.394 ± 0.564
4.541LysGly: 4.541 ± 0.637
1.981LysHis: 1.981 ± 0.638
5.449LysIle: 5.449 ± 0.73
6.357LysLys: 6.357 ± 0.995
8.09LysLeu: 8.09 ± 0.766
2.477LysMet: 2.477 ± 0.538
4.458LysAsn: 4.458 ± 0.598
3.22LysPro: 3.22 ± 0.541
3.798LysGln: 3.798 ± 0.745
3.715LysArg: 3.715 ± 0.772
4.871LysSer: 4.871 ± 0.656
5.284LysThr: 5.284 ± 0.77
5.036LysVal: 5.036 ± 0.807
0.991LysTrp: 0.991 ± 0.333
3.798LysTyr: 3.798 ± 0.537
0.0LysXaa: 0.0 ± 0.0
Leu
7.265LeuAla: 7.265 ± 0.793
0.578LeuCys: 0.578 ± 0.285
7.1LeuAsp: 7.1 ± 0.812
7.678LeuGlu: 7.678 ± 0.993
2.724LeuPhe: 2.724 ± 0.489
4.293LeuGly: 4.293 ± 0.56
1.238LeuHis: 1.238 ± 0.311
4.706LeuIle: 4.706 ± 0.692
7.843LeuLys: 7.843 ± 0.83
6.77LeuLeu: 6.77 ± 0.932
2.146LeuMet: 2.146 ± 0.438
3.632LeuAsn: 3.632 ± 0.447
3.137LeuPro: 3.137 ± 0.645
3.385LeuGln: 3.385 ± 0.517
3.963LeuArg: 3.963 ± 0.644
4.623LeuSer: 4.623 ± 0.545
4.871LeuThr: 4.871 ± 0.741
3.632LeuVal: 3.632 ± 0.653
0.413LeuTrp: 0.413 ± 0.175
2.394LeuTyr: 2.394 ± 0.454
0.0LeuXaa: 0.0 ± 0.0
Met
2.724MetAla: 2.724 ± 0.589
0.0MetCys: 0.0 ± 0.0
1.651MetAsp: 1.651 ± 0.361
1.816MetGlu: 1.816 ± 0.425
1.073MetPhe: 1.073 ± 0.313
1.651MetGly: 1.651 ± 0.464
0.165MetHis: 0.165 ± 0.109
1.651MetIle: 1.651 ± 0.435
1.816MetLys: 1.816 ± 0.505
2.146MetLeu: 2.146 ± 0.342
0.743MetMet: 0.743 ± 0.328
1.734MetAsn: 1.734 ± 0.496
1.486MetPro: 1.486 ± 0.37
0.66MetGln: 0.66 ± 0.289
1.156MetArg: 1.156 ± 0.371
1.486MetSer: 1.486 ± 0.42
1.651MetThr: 1.651 ± 0.365
1.486MetVal: 1.486 ± 0.475
0.248MetTrp: 0.248 ± 0.15
0.826MetTyr: 0.826 ± 0.21
0.0MetXaa: 0.0 ± 0.0
Asn
4.293AsnAla: 4.293 ± 0.738
0.248AsnCys: 0.248 ± 0.167
3.055AsnAsp: 3.055 ± 0.434
2.477AsnGlu: 2.477 ± 0.369
1.486AsnPhe: 1.486 ± 0.457
4.128AsnGly: 4.128 ± 0.593
0.743AsnHis: 0.743 ± 0.235
3.798AsnIle: 3.798 ± 0.528
4.706AsnLys: 4.706 ± 0.636
4.871AsnLeu: 4.871 ± 0.715
1.403AsnMet: 1.403 ± 0.352
2.807AsnAsn: 2.807 ± 0.577
2.229AsnPro: 2.229 ± 0.664
3.055AsnGln: 3.055 ± 0.524
2.312AsnArg: 2.312 ± 0.399
2.642AsnSer: 2.642 ± 0.571
3.055AsnThr: 3.055 ± 0.716
3.55AsnVal: 3.55 ± 0.655
0.991AsnTrp: 0.991 ± 0.312
1.899AsnTyr: 1.899 ± 0.35
0.0AsnXaa: 0.0 ± 0.0
Pro
2.477ProAla: 2.477 ± 0.441
0.165ProCys: 0.165 ± 0.116
2.312ProAsp: 2.312 ± 0.63
2.477ProGlu: 2.477 ± 0.734
0.908ProPhe: 0.908 ± 0.267
0.991ProGly: 0.991 ± 0.329
0.33ProHis: 0.33 ± 0.159
1.816ProIle: 1.816 ± 0.379
2.807ProLys: 2.807 ± 0.591
2.559ProLeu: 2.559 ± 0.446
0.578ProMet: 0.578 ± 0.191
1.321ProAsn: 1.321 ± 0.38
0.495ProPro: 0.495 ± 0.197
1.486ProGln: 1.486 ± 0.601
0.578ProArg: 0.578 ± 0.273
1.486ProSer: 1.486 ± 0.44
2.477ProThr: 2.477 ± 0.535
2.477ProVal: 2.477 ± 0.419
0.248ProTrp: 0.248 ± 0.174
1.321ProTyr: 1.321 ± 0.333
0.0ProXaa: 0.0 ± 0.0
Gln
4.375GlnAla: 4.375 ± 0.854
0.165GlnCys: 0.165 ± 0.116
0.578GlnAsp: 0.578 ± 0.253
3.88GlnGlu: 3.88 ± 0.777
1.651GlnPhe: 1.651 ± 0.403
1.569GlnGly: 1.569 ± 0.373
0.578GlnHis: 0.578 ± 0.212
4.458GlnIle: 4.458 ± 0.69
3.055GlnLys: 3.055 ± 0.648
3.385GlnLeu: 3.385 ± 0.432
1.073GlnMet: 1.073 ± 0.338
1.734GlnAsn: 1.734 ± 0.366
2.064GlnPro: 2.064 ± 0.883
3.55GlnGln: 3.55 ± 0.905
2.229GlnArg: 2.229 ± 0.482
2.477GlnSer: 2.477 ± 0.532
2.807GlnThr: 2.807 ± 0.578
2.146GlnVal: 2.146 ± 0.459
0.578GlnTrp: 0.578 ± 0.168
1.899GlnTyr: 1.899 ± 0.525
0.0GlnXaa: 0.0 ± 0.0
Arg
1.899ArgAla: 1.899 ± 0.413
0.495ArgCys: 0.495 ± 0.224
2.312ArgAsp: 2.312 ± 0.452
2.559ArgGlu: 2.559 ± 0.575
2.146ArgPhe: 2.146 ± 0.404
2.312ArgGly: 2.312 ± 0.344
0.743ArgHis: 0.743 ± 0.237
2.642ArgIle: 2.642 ± 0.404
4.128ArgLys: 4.128 ± 0.605
3.22ArgLeu: 3.22 ± 0.553
1.156ArgMet: 1.156 ± 0.344
2.312ArgAsn: 2.312 ± 0.558
0.743ArgPro: 0.743 ± 0.248
2.146ArgGln: 2.146 ± 0.495
1.403ArgArg: 1.403 ± 0.387
2.229ArgSer: 2.229 ± 0.38
2.559ArgThr: 2.559 ± 0.55
2.724ArgVal: 2.724 ± 0.484
0.248ArgTrp: 0.248 ± 0.136
1.899ArgTyr: 1.899 ± 0.484
0.0ArgXaa: 0.0 ± 0.0
Ser
4.458SerAla: 4.458 ± 0.587
0.248SerCys: 0.248 ± 0.142
4.541SerAsp: 4.541 ± 0.684
4.293SerGlu: 4.293 ± 0.696
2.807SerPhe: 2.807 ± 0.412
4.21SerGly: 4.21 ± 0.954
0.908SerHis: 0.908 ± 0.237
5.118SerIle: 5.118 ± 0.56
4.045SerLys: 4.045 ± 0.522
4.21SerLeu: 4.21 ± 0.773
1.486SerMet: 1.486 ± 0.334
2.146SerAsn: 2.146 ± 0.451
1.156SerPro: 1.156 ± 0.363
3.22SerGln: 3.22 ± 0.537
2.807SerArg: 2.807 ± 0.59
3.88SerSer: 3.88 ± 0.529
4.458SerThr: 4.458 ± 1.651
3.467SerVal: 3.467 ± 0.476
1.073SerTrp: 1.073 ± 0.365
2.146SerTyr: 2.146 ± 0.462
0.0SerXaa: 0.0 ± 0.0
Thr
6.109ThrAla: 6.109 ± 1.106
0.248ThrCys: 0.248 ± 0.135
3.798ThrAsp: 3.798 ± 0.505
4.458ThrGlu: 4.458 ± 0.585
2.064ThrPhe: 2.064 ± 0.571
4.293ThrGly: 4.293 ± 0.524
0.826ThrHis: 0.826 ± 0.237
4.953ThrIle: 4.953 ± 0.845
4.128ThrLys: 4.128 ± 0.757
4.953ThrLeu: 4.953 ± 0.63
0.66ThrMet: 0.66 ± 0.227
3.137ThrAsn: 3.137 ± 0.63
1.403ThrPro: 1.403 ± 0.256
2.889ThrGln: 2.889 ± 0.822
1.569ThrArg: 1.569 ± 0.316
3.88ThrSer: 3.88 ± 0.982
3.88ThrThr: 3.88 ± 0.859
5.284ThrVal: 5.284 ± 0.711
0.495ThrTrp: 0.495 ± 0.173
2.394ThrTyr: 2.394 ± 0.502
0.0ThrXaa: 0.0 ± 0.0
Val
4.375ValAla: 4.375 ± 0.614
0.578ValCys: 0.578 ± 0.244
5.449ValAsp: 5.449 ± 0.76
3.963ValGlu: 3.963 ± 0.536
1.651ValPhe: 1.651 ± 0.306
3.302ValGly: 3.302 ± 0.536
0.578ValHis: 0.578 ± 0.222
3.715ValIle: 3.715 ± 0.653
5.696ValLys: 5.696 ± 0.691
4.788ValLeu: 4.788 ± 0.871
1.238ValMet: 1.238 ± 0.329
4.293ValAsn: 4.293 ± 0.598
2.064ValPro: 2.064 ± 0.346
2.394ValGln: 2.394 ± 0.492
1.734ValArg: 1.734 ± 0.351
4.623ValSer: 4.623 ± 0.642
3.467ValThr: 3.467 ± 0.463
4.293ValVal: 4.293 ± 0.815
0.33ValTrp: 0.33 ± 0.186
1.899ValTyr: 1.899 ± 0.379
0.0ValXaa: 0.0 ± 0.0
Trp
1.156TrpAla: 1.156 ± 0.385
0.083TrpCys: 0.083 ± 0.07
0.991TrpAsp: 0.991 ± 0.364
0.826TrpGlu: 0.826 ± 0.312
0.578TrpPhe: 0.578 ± 0.343
0.743TrpGly: 0.743 ± 0.225
0.083TrpHis: 0.083 ± 0.088
0.578TrpIle: 0.578 ± 0.311
0.991TrpLys: 0.991 ± 0.4
1.569TrpLeu: 1.569 ± 0.358
0.165TrpMet: 0.165 ± 0.131
0.743TrpAsn: 0.743 ± 0.277
0.33TrpPro: 0.33 ± 0.177
0.495TrpGln: 0.495 ± 0.237
0.248TrpArg: 0.248 ± 0.145
0.578TrpSer: 0.578 ± 0.161
0.991TrpThr: 0.991 ± 0.332
0.578TrpVal: 0.578 ± 0.245
0.083TrpTrp: 0.083 ± 0.087
0.495TrpTyr: 0.495 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.651TyrAla: 1.651 ± 0.441
0.248TyrCys: 0.248 ± 0.161
1.486TyrAsp: 1.486 ± 0.289
2.312TyrGlu: 2.312 ± 0.6
1.486TyrPhe: 1.486 ± 0.459
2.724TyrGly: 2.724 ± 0.597
0.578TyrHis: 0.578 ± 0.226
3.302TyrIle: 3.302 ± 0.618
2.889TyrLys: 2.889 ± 0.641
2.559TyrLeu: 2.559 ± 0.4
0.66TyrMet: 0.66 ± 0.251
2.064TyrAsn: 2.064 ± 0.478
1.321TyrPro: 1.321 ± 0.344
2.642TyrGln: 2.642 ± 0.509
2.064TyrArg: 2.064 ± 0.532
2.807TyrSer: 2.807 ± 0.401
3.055TyrThr: 3.055 ± 0.529
1.981TyrVal: 1.981 ± 0.461
0.578TyrTrp: 0.578 ± 0.188
2.394TyrTyr: 2.394 ± 0.578
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (12114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski