Amino acid dipepetide frequency for Pasteurellaceae bacterium RH1A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.473AlaAla: 7.473 ± 0.192
1.226AlaCys: 1.226 ± 0.048
5.252AlaAsp: 5.252 ± 0.226
6.44AlaGlu: 6.44 ± 0.262
3.966AlaPhe: 3.966 ± 0.09
6.573AlaGly: 6.573 ± 0.112
1.712AlaHis: 1.712 ± 0.049
5.914AlaIle: 5.914 ± 0.108
6.043AlaLys: 6.043 ± 0.123
11.047AlaLeu: 11.047 ± 0.242
2.426AlaMet: 2.426 ± 0.06
3.995AlaAsn: 3.995 ± 0.117
2.778AlaPro: 2.778 ± 0.08
5.228AlaGln: 5.228 ± 0.096
3.761AlaArg: 3.761 ± 0.09
5.051AlaSer: 5.051 ± 0.112
4.181AlaThr: 4.181 ± 0.127
6.249AlaVal: 6.249 ± 0.122
0.964AlaTrp: 0.964 ± 0.042
2.75AlaTyr: 2.75 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.706CysAla: 0.706 ± 0.033
0.133CysCys: 0.133 ± 0.015
0.565CysAsp: 0.565 ± 0.034
0.518CysGlu: 0.518 ± 0.031
0.438CysPhe: 0.438 ± 0.027
0.867CysGly: 0.867 ± 0.037
0.269CysHis: 0.269 ± 0.022
0.51CysIle: 0.51 ± 0.032
0.472CysLys: 0.472 ± 0.03
1.091CysLeu: 1.091 ± 0.039
0.141CysMet: 0.141 ± 0.014
0.317CysAsn: 0.317 ± 0.024
0.412CysPro: 0.412 ± 0.028
0.534CysGln: 0.534 ± 0.033
0.431CysArg: 0.431 ± 0.023
0.554CysSer: 0.554 ± 0.026
0.419CysThr: 0.419 ± 0.024
0.553CysVal: 0.553 ± 0.034
0.1CysTrp: 0.1 ± 0.012
0.34CysTyr: 0.34 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.483AspAla: 3.483 ± 0.119
0.52AspCys: 0.52 ± 0.031
2.328AspAsp: 2.328 ± 0.062
3.665AspGlu: 3.665 ± 0.083
2.837AspPhe: 2.837 ± 0.076
3.733AspGly: 3.733 ± 0.383
0.926AspHis: 0.926 ± 0.046
3.135AspIle: 3.135 ± 0.064
3.612AspLys: 3.612 ± 0.141
6.102AspLeu: 6.102 ± 0.149
1.15AspMet: 1.15 ± 0.043
2.2AspAsn: 2.2 ± 0.073
2.071AspPro: 2.071 ± 0.065
2.057AspGln: 2.057 ± 0.058
2.297AspArg: 2.297 ± 0.073
2.572AspSer: 2.572 ± 0.059
2.096AspThr: 2.096 ± 0.08
3.42AspVal: 3.42 ± 0.098
0.87AspTrp: 0.87 ± 0.04
2.196AspTyr: 2.196 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
6.592GluAla: 6.592 ± 0.149
0.368GluCys: 0.368 ± 0.026
2.793GluAsp: 2.793 ± 0.081
4.29GluGlu: 4.29 ± 0.107
2.308GluPhe: 2.308 ± 0.058
3.955GluGly: 3.955 ± 0.074
1.15GluHis: 1.15 ± 0.044
4.312GluIle: 4.312 ± 0.086
4.664GluLys: 4.664 ± 0.097
6.494GluLeu: 6.494 ± 0.124
1.684GluMet: 1.684 ± 0.052
3.23GluAsn: 3.23 ± 0.074
2.09GluPro: 2.09 ± 0.078
3.875GluGln: 3.875 ± 0.098
3.406GluArg: 3.406 ± 0.085
3.093GluSer: 3.093 ± 0.247
2.829GluThr: 2.829 ± 0.073
4.289GluVal: 4.289 ± 0.098
0.76GluTrp: 0.76 ± 0.039
1.54GluTyr: 1.54 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.104PheAla: 4.104 ± 0.084
0.608PheCys: 0.608 ± 0.034
2.838PheAsp: 2.838 ± 0.072
2.748PheGlu: 2.748 ± 0.071
1.993PhePhe: 1.993 ± 0.073
3.526PheGly: 3.526 ± 0.082
0.785PheHis: 0.785 ± 0.042
2.897PheIle: 2.897 ± 0.078
2.246PheLys: 2.246 ± 0.057
4.189PheLeu: 4.189 ± 0.096
1.057PheMet: 1.057 ± 0.044
2.053PheAsn: 2.053 ± 0.063
1.516PhePro: 1.516 ± 0.047
1.455PheGln: 1.455 ± 0.048
1.589PheArg: 1.589 ± 0.053
3.113PheSer: 3.113 ± 0.072
2.121PheThr: 2.121 ± 0.07
2.924PheVal: 2.924 ± 0.073
0.564PheTrp: 0.564 ± 0.032
1.595PheTyr: 1.595 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
5.314GlyAla: 5.314 ± 0.128
0.72GlyCys: 0.72 ± 0.037
3.406GlyAsp: 3.406 ± 0.142
3.987GlyGlu: 3.987 ± 0.079
3.383GlyPhe: 3.383 ± 0.072
4.729GlyGly: 4.729 ± 0.099
1.276GlyHis: 1.276 ± 0.05
4.676GlyIle: 4.676 ± 0.093
5.219GlyLys: 5.219 ± 0.156
8.28GlyLeu: 8.28 ± 0.137
1.796GlyMet: 1.796 ± 0.057
2.745GlyAsn: 2.745 ± 0.101
1.273GlyPro: 1.273 ± 0.044
3.565GlyGln: 3.565 ± 0.093
3.113GlyArg: 3.113 ± 0.075
3.939GlySer: 3.939 ± 0.094
3.442GlyThr: 3.442 ± 0.2
5.088GlyVal: 5.088 ± 0.098
1.0GlyTrp: 1.0 ± 0.037
2.455GlyTyr: 2.455 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.298HisAla: 1.298 ± 0.046
0.308HisCys: 0.308 ± 0.021
0.825HisAsp: 0.825 ± 0.041
0.839HisGlu: 0.839 ± 0.037
1.253HisPhe: 1.253 ± 0.047
1.191HisGly: 1.191 ± 0.046
0.58HisHis: 0.58 ± 0.034
1.46HisIle: 1.46 ± 0.049
1.174HisLys: 1.174 ± 0.043
2.311HisLeu: 2.311 ± 0.076
0.327HisMet: 0.327 ± 0.022
0.964HisAsn: 0.964 ± 0.038
1.087HisPro: 1.087 ± 0.043
1.172HisGln: 1.172 ± 0.048
0.994HisArg: 0.994 ± 0.043
1.237HisSer: 1.237 ± 0.045
1.069HisThr: 1.069 ± 0.06
0.812HisVal: 0.812 ± 0.037
0.295HisTrp: 0.295 ± 0.022
0.891HisTyr: 0.891 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.032IleAla: 6.032 ± 0.107
0.709IleCys: 0.709 ± 0.034
3.6IleAsp: 3.6 ± 0.083
4.347IleGlu: 4.347 ± 0.089
2.696IlePhe: 2.696 ± 0.072
4.693IleGly: 4.693 ± 0.108
1.128IleHis: 1.128 ± 0.045
3.753IleIle: 3.753 ± 0.098
3.393IleLys: 3.393 ± 0.08
6.062IleLeu: 6.062 ± 0.119
1.242IleMet: 1.242 ± 0.045
2.706IleAsn: 2.706 ± 0.071
2.417IlePro: 2.417 ± 0.068
2.42IleGln: 2.42 ± 0.062
2.739IleArg: 2.739 ± 0.08
4.197IleSer: 4.197 ± 0.084
3.355IleThr: 3.355 ± 0.094
4.012IleVal: 4.012 ± 0.089
0.595IleTrp: 0.595 ± 0.032
1.877IleTyr: 1.877 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
6.517LysAla: 6.517 ± 0.269
0.303LysCys: 0.303 ± 0.024
3.347LysAsp: 3.347 ± 0.161
3.636LysGlu: 3.636 ± 0.086
2.016LysPhe: 2.016 ± 0.059
4.036LysGly: 4.036 ± 0.091
1.232LysHis: 1.232 ± 0.044
3.712LysIle: 3.712 ± 0.084
3.451LysLys: 3.451 ± 0.085
6.072LysLeu: 6.072 ± 0.112
1.715LysMet: 1.715 ± 0.051
2.714LysAsn: 2.714 ± 0.069
2.613LysPro: 2.613 ± 0.073
3.263LysGln: 3.263 ± 0.087
2.829LysArg: 2.829 ± 0.074
3.161LysSer: 3.161 ± 0.087
3.202LysThr: 3.202 ± 0.08
4.107LysVal: 4.107 ± 0.098
0.665LysTrp: 0.665 ± 0.029
1.52LysTyr: 1.52 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
11.964LeuAla: 11.964 ± 0.228
1.014LeuCys: 1.014 ± 0.043
5.863LeuAsp: 5.863 ± 0.116
6.784LeuGlu: 6.784 ± 0.158
4.617LeuPhe: 4.617 ± 0.108
7.765LeuGly: 7.765 ± 0.152
2.066LeuHis: 2.066 ± 0.058
6.415LeuIle: 6.415 ± 0.127
6.429LeuLys: 6.429 ± 0.118
10.97LeuLeu: 10.97 ± 0.217
2.534LeuMet: 2.534 ± 0.067
5.007LeuAsn: 5.007 ± 0.102
5.063LeuPro: 5.063 ± 0.096
4.252LeuGln: 4.252 ± 0.091
4.508LeuArg: 4.508 ± 0.104
7.465LeuSer: 7.465 ± 0.133
5.633LeuThr: 5.633 ± 0.09
7.212LeuVal: 7.212 ± 0.119
1.136LeuTrp: 1.136 ± 0.037
2.755LeuTyr: 2.755 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.48MetAla: 2.48 ± 0.067
0.166MetCys: 0.166 ± 0.016
0.97MetAsp: 0.97 ± 0.039
1.133MetGlu: 1.133 ± 0.045
0.823MetPhe: 0.823 ± 0.038
1.726MetGly: 1.726 ± 0.06
0.403MetHis: 0.403 ± 0.024
1.434MetIle: 1.434 ± 0.052
1.58MetLys: 1.58 ± 0.056
2.472MetLeu: 2.472 ± 0.074
0.698MetMet: 0.698 ± 0.037
1.055MetAsn: 1.055 ± 0.044
1.137MetPro: 1.137 ± 0.047
1.289MetGln: 1.289 ± 0.053
1.025MetArg: 1.025 ± 0.046
1.494MetSer: 1.494 ± 0.053
1.272MetThr: 1.272 ± 0.049
1.501MetVal: 1.501 ± 0.05
0.259MetTrp: 0.259 ± 0.021
0.474MetTyr: 0.474 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.443AsnAla: 3.443 ± 0.09
0.354AsnCys: 0.354 ± 0.025
1.897AsnAsp: 1.897 ± 0.056
2.365AsnGlu: 2.365 ± 0.058
1.801AsnPhe: 1.801 ± 0.054
3.098AsnGly: 3.098 ± 0.166
0.986AsnHis: 0.986 ± 0.04
2.696AsnIle: 2.696 ± 0.079
2.502AsnLys: 2.502 ± 0.078
4.944AsnLeu: 4.944 ± 0.1
0.94AsnMet: 0.94 ± 0.043
1.902AsnAsn: 1.902 ± 0.085
2.567AsnPro: 2.567 ± 0.068
2.712AsnGln: 2.712 ± 0.072
2.095AsnArg: 2.095 ± 0.061
2.322AsnSer: 2.322 ± 0.075
2.042AsnThr: 2.042 ± 0.08
2.857AsnVal: 2.857 ± 0.093
0.61AsnTrp: 0.61 ± 0.029
1.466AsnTyr: 1.466 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.537ProAla: 3.537 ± 0.094
0.289ProCys: 0.289 ± 0.023
2.099ProAsp: 2.099 ± 0.067
3.364ProGlu: 3.364 ± 0.078
1.905ProPhe: 1.905 ± 0.058
1.433ProGly: 1.433 ± 0.051
0.957ProHis: 0.957 ± 0.039
2.365ProIle: 2.365 ± 0.068
2.322ProLys: 2.322 ± 0.068
4.266ProLeu: 4.266 ± 0.102
0.982ProMet: 0.982 ± 0.043
2.087ProAsn: 2.087 ± 0.056
1.164ProPro: 1.164 ± 0.051
2.071ProGln: 2.071 ± 0.062
1.369ProArg: 1.369 ± 0.045
2.325ProSer: 2.325 ± 0.062
2.085ProThr: 2.085 ± 0.064
2.714ProVal: 2.714 ± 0.081
0.425ProTrp: 0.425 ± 0.024
1.379ProTyr: 1.379 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
6.653GlnAla: 6.653 ± 0.131
0.306GlnCys: 0.306 ± 0.025
2.409GlnAsp: 2.409 ± 0.072
3.161GlnGlu: 3.161 ± 0.086
1.924GlnPhe: 1.924 ± 0.058
3.507GlnGly: 3.507 ± 0.089
1.11GlnHis: 1.11 ± 0.046
3.167GlnIle: 3.167 ± 0.077
2.797GlnLys: 2.797 ± 0.074
4.865GlnLeu: 4.865 ± 0.108
1.047GlnMet: 1.047 ± 0.039
2.061GlnAsn: 2.061 ± 0.057
2.101GlnPro: 2.101 ± 0.072
2.625GlnGln: 2.625 ± 0.095
2.194GlnArg: 2.194 ± 0.076
2.415GlnSer: 2.415 ± 0.066
2.655GlnThr: 2.655 ± 0.076
3.382GlnVal: 3.382 ± 0.083
0.591GlnTrp: 0.591 ± 0.035
1.373GlnTyr: 1.373 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.461ArgAla: 3.461 ± 0.085
0.382ArgCys: 0.382 ± 0.027
2.216ArgAsp: 2.216 ± 0.071
3.151ArgGlu: 3.151 ± 0.076
2.368ArgPhe: 2.368 ± 0.07
2.625ArgGly: 2.625 ± 0.066
0.973ArgHis: 0.973 ± 0.041
2.75ArgIle: 2.75 ± 0.072
2.573ArgLys: 2.573 ± 0.069
5.178ArgLeu: 5.178 ± 0.108
1.006ArgMet: 1.006 ± 0.04
1.81ArgAsn: 1.81 ± 0.063
1.711ArgPro: 1.711 ± 0.052
2.355ArgGln: 2.355 ± 0.073
2.063ArgArg: 2.063 ± 0.081
2.327ArgSer: 2.327 ± 0.065
1.954ArgThr: 1.954 ± 0.053
3.05ArgVal: 3.05 ± 0.084
0.539ArgTrp: 0.539 ± 0.032
1.668ArgTyr: 1.668 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.903SerAla: 4.903 ± 0.104
0.491SerCys: 0.491 ± 0.032
2.842SerAsp: 2.842 ± 0.105
3.349SerGlu: 3.349 ± 0.121
2.564SerPhe: 2.564 ± 0.066
4.454SerGly: 4.454 ± 0.097
1.354SerHis: 1.354 ± 0.046
3.191SerIle: 3.191 ± 0.083
2.748SerLys: 2.748 ± 0.069
7.302SerLeu: 7.302 ± 0.134
1.17SerMet: 1.17 ± 0.041
2.24SerAsn: 2.24 ± 0.066
2.633SerPro: 2.633 ± 0.065
3.39SerGln: 3.39 ± 0.085
2.639SerArg: 2.639 ± 0.067
3.42SerSer: 3.42 ± 0.077
2.646SerThr: 2.646 ± 0.073
3.827SerVal: 3.827 ± 0.085
0.693SerTrp: 0.693 ± 0.034
1.837SerTyr: 1.837 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.849ThrAla: 4.849 ± 0.104
0.406ThrCys: 0.406 ± 0.027
2.434ThrAsp: 2.434 ± 0.068
2.81ThrGlu: 2.81 ± 0.068
2.107ThrPhe: 2.107 ± 0.065
3.848ThrGly: 3.848 ± 0.075
1.085ThrHis: 1.085 ± 0.061
2.913ThrIle: 2.913 ± 0.093
2.543ThrLys: 2.543 ± 0.107
5.588ThrLeu: 5.588 ± 0.103
0.937ThrMet: 0.937 ± 0.041
2.027ThrAsn: 2.027 ± 0.111
2.282ThrPro: 2.282 ± 0.062
2.377ThrGln: 2.377 ± 0.058
1.911ThrArg: 1.911 ± 0.056
2.66ThrSer: 2.66 ± 0.07
2.772ThrThr: 2.772 ± 0.259
3.633ThrVal: 3.633 ± 0.207
0.469ThrTrp: 0.469 ± 0.025
1.482ThrTyr: 1.482 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.588ValAla: 6.588 ± 0.115
0.613ValCys: 0.613 ± 0.037
3.524ValAsp: 3.524 ± 0.127
4.911ValGlu: 4.911 ± 0.109
2.69ValPhe: 2.69 ± 0.071
4.685ValGly: 4.685 ± 0.091
1.025ValHis: 1.025 ± 0.038
4.319ValIle: 4.319 ± 0.104
4.249ValLys: 4.249 ± 0.092
6.999ValLeu: 6.999 ± 0.125
1.703ValMet: 1.703 ± 0.058
2.838ValAsn: 2.838 ± 0.11
2.562ValPro: 2.562 ± 0.072
2.644ValGln: 2.644 ± 0.067
2.97ValArg: 2.97 ± 0.071
4.102ValSer: 4.102 ± 0.09
3.456ValThr: 3.456 ± 0.128
5.08ValVal: 5.08 ± 0.114
0.69ValTrp: 0.69 ± 0.033
1.828ValTyr: 1.828 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.041TrpAla: 1.041 ± 0.04
0.142TrpCys: 0.142 ± 0.014
0.548TrpAsp: 0.548 ± 0.032
0.603TrpGlu: 0.603 ± 0.031
0.58TrpPhe: 0.58 ± 0.03
0.752TrpGly: 0.752 ± 0.043
0.302TrpHis: 0.302 ± 0.022
0.711TrpIle: 0.711 ± 0.036
0.627TrpLys: 0.627 ± 0.029
1.7TrpLeu: 1.7 ± 0.069
0.223TrpMet: 0.223 ± 0.017
0.494TrpAsn: 0.494 ± 0.03
0.186TrpPro: 0.186 ± 0.017
1.091TrpGln: 1.091 ± 0.048
0.54TrpArg: 0.54 ± 0.028
0.515TrpSer: 0.515 ± 0.029
0.474TrpThr: 0.474 ± 0.027
0.848TrpVal: 0.848 ± 0.033
0.19TrpTrp: 0.19 ± 0.02
0.33TrpTyr: 0.33 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.592TyrAla: 2.592 ± 0.066
0.311TyrCys: 0.311 ± 0.024
1.512TyrAsp: 1.512 ± 0.049
1.619TyrGlu: 1.619 ± 0.056
1.655TyrPhe: 1.655 ± 0.058
2.213TyrGly: 2.213 ± 0.066
0.766TyrHis: 0.766 ± 0.036
1.644TyrIle: 1.644 ± 0.063
1.464TyrLys: 1.464 ± 0.045
3.518TyrLeu: 3.518 ± 0.087
0.611TyrMet: 0.611 ± 0.03
1.152TyrAsn: 1.152 ± 0.046
1.475TyrPro: 1.475 ± 0.05
1.968TyrGln: 1.968 ± 0.054
1.687TyrArg: 1.687 ± 0.058
1.731TyrSer: 1.731 ± 0.058
1.431TyrThr: 1.431 ± 0.049
1.919TyrVal: 1.919 ± 0.059
0.483TyrTrp: 0.483 ± 0.026
1.082TyrTyr: 1.082 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2012 proteins (633087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski