Amino acid dipepetide frequency for Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.1AlaAla: 6.1 ± 0.091	0.75AlaCys: 0.75 ± 0.022	3.408AlaAsp: 3.408 ± 0.053	5.115AlaGlu: 5.115 ± 0.067	2.658AlaPhe: 2.658 ± 0.047	4.836AlaGly: 4.836 ± 0.073	1.212AlaHis: 1.212 ± 0.031	7.111AlaIle: 7.111 ± 0.085	4.341AlaLys: 4.341 ± 0.057	7.832AlaLeu: 7.832 ± 0.08	1.475AlaMet: 1.475 ± 0.034	3.484AlaAsn: 3.484 ± 0.07	2.254AlaPro: 2.254 ± 0.041	4.122AlaGln: 4.122 ± 0.058	3.226AlaArg: 3.226 ± 0.043	4.497AlaSer: 4.497 ± 0.058	4.424AlaThr: 4.424 ± 0.056	4.986AlaVal: 4.986 ± 0.072	0.99AlaTrp: 0.99 ± 0.028	2.288AlaTyr: 2.288 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.558CysAla: 0.558 ± 0.02	0.174CysCys: 0.174 ± 0.011	0.605CysAsp: 0.605 ± 0.019	0.488CysGlu: 0.488 ± 0.018	0.461CysPhe: 0.461 ± 0.019	0.733CysGly: 0.733 ± 0.021	0.254CysHis: 0.254 ± 0.014	0.537CysIle: 0.537 ± 0.019	0.326CysLys: 0.326 ± 0.018	1.363CysLeu: 1.363 ± 0.034	0.135CysMet: 0.135 ± 0.009	0.386CysAsn: 0.386 ± 0.015	0.526CysPro: 0.526 ± 0.02	0.786CysGln: 0.786 ± 0.024	0.532CysArg: 0.532 ± 0.018	0.688CysSer: 0.688 ± 0.022	0.428CysThr: 0.428 ± 0.019	0.515CysVal: 0.515 ± 0.022	0.151CysTrp: 0.151 ± 0.011	0.407CysTyr: 0.407 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.043AspAla: 3.043 ± 0.048	0.571AspCys: 0.571 ± 0.019	1.998AspAsp: 1.998 ± 0.051	2.71AspGlu: 2.71 ± 0.045	2.393AspPhe: 2.393 ± 0.04	2.957AspGly: 2.957 ± 0.066	0.803AspHis: 0.803 ± 0.024	2.887AspIle: 2.887 ± 0.049	2.042AspLys: 2.042 ± 0.042	6.258AspLeu: 6.258 ± 0.064	0.6AspMet: 0.6 ± 0.021	2.224AspAsn: 2.224 ± 0.046	1.984AspPro: 1.984 ± 0.039	1.85AspGln: 1.85 ± 0.038	3.452AspArg: 3.452 ± 0.059	3.007AspSer: 3.007 ± 0.048	2.314AspThr: 2.314 ± 0.054	2.62AspVal: 2.62 ± 0.049	0.939AspTrp: 0.939 ± 0.027	2.003AspTyr: 2.003 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.266GluAla: 5.266 ± 0.069	0.445GluCys: 0.445 ± 0.022	2.782GluAsp: 2.782 ± 0.046	4.615GluGlu: 4.615 ± 0.06	2.415GluPhe: 2.415 ± 0.046	3.224GluGly: 3.224 ± 0.053	0.98GluHis: 0.98 ± 0.023	5.752GluIle: 5.752 ± 0.07	3.887GluLys: 3.887 ± 0.058	7.296GluLeu: 7.296 ± 0.09	1.248GluMet: 1.248 ± 0.028	2.902GluAsn: 2.902 ± 0.049	2.341GluPro: 2.341 ± 0.044	4.377GluGln: 4.377 ± 0.056	3.161GluArg: 3.161 ± 0.054	3.436GluSer: 3.436 ± 0.049	3.661GluThr: 3.661 ± 0.059	4.191GluVal: 4.191 ± 0.056	0.731GluTrp: 0.731 ± 0.024	1.936GluTyr: 1.936 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.036PheAla: 3.036 ± 0.044	0.56PheCys: 0.56 ± 0.02	2.183PheAsp: 2.183 ± 0.04	2.321PheGlu: 2.321 ± 0.041	1.828PhePhe: 1.828 ± 0.038	2.83PheGly: 2.83 ± 0.059	0.714PheHis: 0.714 ± 0.021	2.592PheIle: 2.592 ± 0.046	1.806PheLys: 1.806 ± 0.04	4.363PheLeu: 4.363 ± 0.07	0.617PheMet: 0.617 ± 0.017	2.177PheAsn: 2.177 ± 0.04	1.85PhePro: 1.85 ± 0.037	1.858PheGln: 1.858 ± 0.034	1.663PheArg: 1.663 ± 0.036	3.019PheSer: 3.019 ± 0.044	2.307PheThr: 2.307 ± 0.043	2.349PheVal: 2.349 ± 0.039	0.8PheTrp: 0.8 ± 0.026	1.467PheTyr: 1.467 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.144GlyAla: 4.144 ± 0.078	0.768GlyCys: 0.768 ± 0.022	2.963GlyAsp: 2.963 ± 0.064	3.917GlyGlu: 3.917 ± 0.062	2.772GlyPhe: 2.772 ± 0.047	4.284GlyGly: 4.284 ± 0.077	1.086GlyHis: 1.086 ± 0.036	5.44GlyIle: 5.44 ± 0.071	4.339GlyLys: 4.339 ± 0.06	6.574GlyLeu: 6.574 ± 0.085	1.377GlyMet: 1.377 ± 0.035	3.139GlyAsn: 3.139 ± 0.084	0.919GlyPro: 0.919 ± 0.027	2.63GlyGln: 2.63 ± 0.042	2.706GlyArg: 2.706 ± 0.042	3.73GlySer: 3.73 ± 0.057	3.588GlyThr: 3.588 ± 0.063	4.163GlyVal: 4.163 ± 0.056	1.089GlyTrp: 1.089 ± 0.027	2.409GlyTyr: 2.409 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	0.936HisAla: 0.936 ± 0.027	0.266HisCys: 0.266 ± 0.014	0.685HisAsp: 0.685 ± 0.021	0.8HisGlu: 0.8 ± 0.022	0.768HisPhe: 0.768 ± 0.025	1.044HisGly: 1.044 ± 0.028	0.621HisHis: 0.621 ± 0.025	0.945HisIle: 0.945 ± 0.024	0.751HisLys: 0.751 ± 0.025	2.279HisLeu: 2.279 ± 0.039	0.189HisMet: 0.189 ± 0.011	0.898HisAsn: 0.898 ± 0.028	1.212HisPro: 1.212 ± 0.031	1.393HisGln: 1.393 ± 0.033	0.993HisArg: 0.993 ± 0.027	1.175HisSer: 1.175 ± 0.029	0.855HisThr: 0.855 ± 0.029	0.659HisVal: 0.659 ± 0.023	0.344HisTrp: 0.344 ± 0.016	0.665HisTyr: 0.665 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.391IleAla: 7.391 ± 0.086	0.882IleCys: 0.882 ± 0.024	4.08IleAsp: 4.08 ± 0.059	5.291IleGlu: 5.291 ± 0.059	2.991IlePhe: 2.991 ± 0.057	4.685IleGly: 4.685 ± 0.06	1.167IleHis: 1.167 ± 0.029	5.186IleIle: 5.186 ± 0.074	4.118IleLys: 4.118 ± 0.062	7.555IleLeu: 7.555 ± 0.09	0.937IleMet: 0.937 ± 0.026	4.054IleAsn: 4.054 ± 0.064	3.683IlePro: 3.683 ± 0.057	3.141IleGln: 3.141 ± 0.046	3.06IleArg: 3.06 ± 0.045	4.808IleSer: 4.808 ± 0.057	4.098IleThr: 4.098 ± 0.05	4.709IleVal: 4.709 ± 0.069	0.96IleTrp: 0.96 ± 0.029	2.283IleTyr: 2.283 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.899LysAla: 3.899 ± 0.055	0.336LysCys: 0.336 ± 0.017	2.267LysAsp: 2.267 ± 0.045	3.247LysGlu: 3.247 ± 0.053	1.959LysPhe: 1.959 ± 0.041	2.638LysGly: 2.638 ± 0.047	0.858LysHis: 0.858 ± 0.021	4.761LysIle: 4.761 ± 0.058	2.965LysLys: 2.965 ± 0.063	6.17LysLeu: 6.17 ± 0.08	0.975LysMet: 0.975 ± 0.026	2.629LysAsn: 2.629 ± 0.045	2.463LysPro: 2.463 ± 0.04	3.57LysGln: 3.57 ± 0.064	2.328LysArg: 2.328 ± 0.043	3.151LysSer: 3.151 ± 0.061	3.37LysThr: 3.37 ± 0.052	3.252LysVal: 3.252 ± 0.047	0.53LysTrp: 0.53 ± 0.021	1.727LysTyr: 1.727 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	9.755LeuAla: 9.755 ± 0.091	0.995LeuCys: 0.995 ± 0.027	5.363LeuAsp: 5.363 ± 0.072	7.754LeuGlu: 7.754 ± 0.091	4.081LeuPhe: 4.081 ± 0.062	7.324LeuGly: 7.324 ± 0.076	1.71LeuHis: 1.71 ± 0.034	8.578LeuIle: 8.578 ± 0.099	6.49LeuLys: 6.49 ± 0.076	11.644LeuLeu: 11.644 ± 0.123	1.91LeuMet: 1.91 ± 0.037	5.541LeuAsn: 5.541 ± 0.073	5.475LeuPro: 5.475 ± 0.065	5.666LeuGln: 5.666 ± 0.082	4.753LeuArg: 4.753 ± 0.057	7.707LeuSer: 7.707 ± 0.074	6.88LeuThr: 6.88 ± 0.073	7.14LeuVal: 7.14 ± 0.077	1.408LeuTrp: 1.408 ± 0.039	2.717LeuTyr: 2.717 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.487MetAla: 1.487 ± 0.031	0.107MetCys: 0.107 ± 0.008	0.629MetAsp: 0.629 ± 0.022	0.856MetGlu: 0.856 ± 0.026	0.611MetPhe: 0.611 ± 0.021	1.219MetGly: 1.219 ± 0.035	0.224MetHis: 0.224 ± 0.013	1.179MetIle: 1.179 ± 0.028	0.985MetLys: 0.985 ± 0.025	1.797MetLeu: 1.797 ± 0.033	0.456MetMet: 0.456 ± 0.022	0.952MetAsn: 0.952 ± 0.024	0.778MetPro: 0.778 ± 0.023	0.705MetGln: 0.705 ± 0.02	0.813MetArg: 0.813 ± 0.023	1.365MetSer: 1.365 ± 0.027	1.237MetThr: 1.237 ± 0.032	1.11MetVal: 1.11 ± 0.026	0.137MetTrp: 0.137 ± 0.011	0.35MetTyr: 0.35 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.769AsnAla: 2.769 ± 0.053	0.587AsnCys: 0.587 ± 0.02	1.845AsnAsp: 1.845 ± 0.045	1.997AsnGlu: 1.997 ± 0.036	2.362AsnPhe: 2.362 ± 0.043	2.567AsnGly: 2.567 ± 0.057	1.069AsnHis: 1.069 ± 0.028	3.059AsnIle: 3.059 ± 0.057	2.207AsnLys: 2.207 ± 0.043	6.934AsnLeu: 6.934 ± 0.091	0.736AsnMet: 0.736 ± 0.022	3.016AsnAsn: 3.016 ± 0.059	2.867AsnPro: 2.867 ± 0.043	3.795AsnGln: 3.795 ± 0.064	2.504AsnArg: 2.504 ± 0.042	3.774AsnSer: 3.774 ± 0.07	2.343AsnThr: 2.343 ± 0.051	2.213AsnVal: 2.213 ± 0.047	0.893AsnTrp: 0.893 ± 0.028	2.108AsnTyr: 2.108 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.595ProAla: 2.595 ± 0.048	0.358ProCys: 0.358 ± 0.016	2.419ProAsp: 2.419 ± 0.044	3.759ProGlu: 3.759 ± 0.051	1.613ProPhe: 1.613 ± 0.031	2.564ProGly: 2.564 ± 0.056	0.81ProHis: 0.81 ± 0.023	3.115ProIle: 3.115 ± 0.046	2.072ProLys: 2.072 ± 0.04	4.361ProLeu: 4.361 ± 0.051	0.649ProMet: 0.649 ± 0.021	2.333ProAsn: 2.333 ± 0.041	1.765ProPro: 1.765 ± 0.046	2.694ProGln: 2.694 ± 0.053	1.534ProArg: 1.534 ± 0.036	2.535ProSer: 2.535 ± 0.047	2.559ProThr: 2.559 ± 0.048	2.804ProVal: 2.804 ± 0.044	0.615ProTrp: 0.615 ± 0.021	1.344ProTyr: 1.344 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.841GlnAla: 4.841 ± 0.06	0.357GlnCys: 0.357 ± 0.017	2.205GlnAsp: 2.205 ± 0.044	4.04GlnGlu: 4.04 ± 0.066	1.956GlnPhe: 1.956 ± 0.038	3.224GlnGly: 3.224 ± 0.045	0.859GlnHis: 0.859 ± 0.024	4.563GlnIle: 4.563 ± 0.057	3.377GlnLys: 3.377 ± 0.055	6.63GlnLeu: 6.63 ± 0.082	0.982GlnMet: 0.982 ± 0.026	2.535GlnAsn: 2.535 ± 0.05	2.709GlnPro: 2.709 ± 0.051	4.562GlnGln: 4.562 ± 0.087	2.476GlnArg: 2.476 ± 0.043	3.311GlnSer: 3.311 ± 0.053	3.35GlnThr: 3.35 ± 0.061	3.649GlnVal: 3.649 ± 0.053	0.795GlnTrp: 0.795 ± 0.021	1.526GlnTyr: 1.526 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.806ArgAla: 2.806 ± 0.043	0.472ArgCys: 0.472 ± 0.016	2.293ArgAsp: 2.293 ± 0.043	3.067ArgGlu: 3.067 ± 0.049	2.004ArgPhe: 2.004 ± 0.039	2.644ArgGly: 2.644 ± 0.047	0.903ArgHis: 0.903 ± 0.025	3.241ArgIle: 3.241 ± 0.053	2.338ArgLys: 2.338 ± 0.046	5.542ArgLeu: 5.542 ± 0.066	0.826ArgMet: 0.826 ± 0.026	2.125ArgAsn: 2.125 ± 0.044	1.683ArgPro: 1.683 ± 0.034	3.081ArgGln: 3.081 ± 0.045	2.549ArgArg: 2.549 ± 0.047	2.946ArgSer: 2.946 ± 0.049	2.214ArgThr: 2.214 ± 0.039	2.86ArgVal: 2.86 ± 0.049	0.77ArgTrp: 0.77 ± 0.026	1.842ArgTyr: 1.842 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.036SerAla: 4.036 ± 0.055	0.687SerCys: 0.687 ± 0.021	3.188SerAsp: 3.188 ± 0.052	4.075SerGlu: 4.075 ± 0.054	2.78SerPhe: 2.78 ± 0.048	4.126SerGly: 4.126 ± 0.069	1.239SerHis: 1.239 ± 0.028	4.263SerIle: 4.263 ± 0.052	2.897SerLys: 2.897 ± 0.049	7.988SerLeu: 7.988 ± 0.086	1.097SerMet: 1.097 ± 0.028	3.296SerAsn: 3.296 ± 0.058	2.976SerPro: 2.976 ± 0.04	3.953SerGln: 3.953 ± 0.052	2.832SerArg: 2.832 ± 0.047	4.748SerSer: 4.748 ± 0.077	3.36SerThr: 3.36 ± 0.053	3.799SerVal: 3.799 ± 0.047	1.002SerTrp: 1.002 ± 0.03	2.017SerTyr: 2.017 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.38ThrAla: 4.38 ± 0.055	0.475ThrCys: 0.475 ± 0.018	2.453ThrAsp: 2.453 ± 0.047	3.722ThrGlu: 3.722 ± 0.059	2.036ThrPhe: 2.036 ± 0.038	4.01ThrGly: 4.01 ± 0.065	0.935ThrHis: 0.935 ± 0.024	4.597ThrIle: 4.597 ± 0.063	2.988ThrLys: 2.988 ± 0.045	5.857ThrLeu: 5.857 ± 0.071	0.809ThrMet: 0.809 ± 0.025	2.901ThrAsn: 2.901 ± 0.055	2.887ThrPro: 2.887 ± 0.049	2.935ThrGln: 2.935 ± 0.048	2.102ThrArg: 2.102 ± 0.036	3.503ThrSer: 3.503 ± 0.045	3.495ThrThr: 3.495 ± 0.067	3.909ThrVal: 3.909 ± 0.062	0.729ThrTrp: 0.729 ± 0.022	1.667ThrTyr: 1.667 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.38ValAla: 5.38 ± 0.068	0.677ValCys: 0.677 ± 0.022	3.163ValAsp: 3.163 ± 0.051	4.28ValGlu: 4.28 ± 0.06	2.452ValPhe: 2.452 ± 0.043	4.149ValGly: 4.149 ± 0.061	0.871ValHis: 0.871 ± 0.022	4.715ValIle: 4.715 ± 0.068	3.382ValLys: 3.382 ± 0.052	5.927ValLeu: 5.927 ± 0.067	1.294ValMet: 1.294 ± 0.03	3.007ValAsn: 3.007 ± 0.05	2.353ValPro: 2.353 ± 0.047	2.48ValGln: 2.48 ± 0.04	2.76ValArg: 2.76 ± 0.048	3.88ValSer: 3.88 ± 0.056	3.773ValThr: 3.773 ± 0.063	4.413ValVal: 4.413 ± 0.075	0.817ValTrp: 0.817 ± 0.024	1.849ValTyr: 1.849 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.771TrpAla: 0.771 ± 0.029	0.161TrpCys: 0.161 ± 0.011	0.586TrpAsp: 0.586 ± 0.022	0.863TrpGlu: 0.863 ± 0.028	0.67TrpPhe: 0.67 ± 0.021	0.942TrpGly: 0.942 ± 0.026	0.4TrpHis: 0.4 ± 0.016	0.854TrpIle: 0.854 ± 0.027	0.589TrpLys: 0.589 ± 0.021	2.221TrpLeu: 2.221 ± 0.046	0.284TrpMet: 0.284 ± 0.017	0.657TrpAsn: 0.657 ± 0.025	0.157TrpPro: 0.157 ± 0.012	1.65TrpGln: 1.65 ± 0.046	0.755TrpArg: 0.755 ± 0.024	0.918TrpSer: 0.918 ± 0.024	0.621TrpThr: 0.621 ± 0.021	0.741TrpVal: 0.741 ± 0.023	0.28TrpTrp: 0.28 ± 0.013	0.476TrpTyr: 0.476 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.916TyrAla: 1.916 ± 0.037	0.425TyrCys: 0.425 ± 0.017	1.541TyrAsp: 1.541 ± 0.038	1.728TyrGlu: 1.728 ± 0.035	1.531TyrPhe: 1.531 ± 0.034	2.036TyrGly: 2.036 ± 0.042	0.763TyrHis: 0.763 ± 0.023	1.707TyrIle: 1.707 ± 0.033	1.194TyrLys: 1.194 ± 0.034	4.297TyrLeu: 4.297 ± 0.059	0.403TyrMet: 0.403 ± 0.017	1.388TyrAsn: 1.388 ± 0.036	1.615TyrPro: 1.615 ± 0.039	2.7TyrGln: 2.7 ± 0.05	2.01TyrArg: 2.01 ± 0.039	2.162TyrSer: 2.162 ± 0.041	1.51TyrThr: 1.51 ± 0.035	1.539TyrVal: 1.539 ± 0.034	0.617TyrTrp: 0.617 ± 0.02	1.282TyrTyr: 1.282 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4751 proteins (1501324 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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