Amino acid dipepetide frequency for Acetobacter cerevisiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.0AlaAla: 15.0 ± 0.209	1.455AlaCys: 1.455 ± 0.043	6.145AlaAsp: 6.145 ± 0.097	6.904AlaGlu: 6.904 ± 0.103	3.994AlaPhe: 3.994 ± 0.077	10.126AlaGly: 10.126 ± 0.131	2.567AlaHis: 2.567 ± 0.049	5.119AlaIle: 5.119 ± 0.074	3.296AlaLys: 3.296 ± 0.062	13.396AlaLeu: 13.396 ± 0.163	3.191AlaMet: 3.191 ± 0.065	2.642AlaAsn: 2.642 ± 0.058	6.342AlaPro: 6.342 ± 0.118	4.793AlaGln: 4.793 ± 0.088	8.167AlaArg: 8.167 ± 0.114	6.672AlaSer: 6.672 ± 0.095	6.277AlaThr: 6.277 ± 0.096	7.909AlaVal: 7.909 ± 0.103	1.539AlaTrp: 1.539 ± 0.045	2.487AlaTyr: 2.487 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.273CysAla: 1.273 ± 0.041	0.149CysCys: 0.149 ± 0.014	0.492CysAsp: 0.492 ± 0.025	0.393CysGlu: 0.393 ± 0.022	0.383CysPhe: 0.383 ± 0.022	1.084CysGly: 1.084 ± 0.039	0.315CysHis: 0.315 ± 0.019	0.471CysIle: 0.471 ± 0.025	0.223CysLys: 0.223 ± 0.016	1.167CysLeu: 1.167 ± 0.042	0.199CysMet: 0.199 ± 0.014	0.228CysAsn: 0.228 ± 0.017	0.576CysPro: 0.576 ± 0.032	0.329CysGln: 0.329 ± 0.022	0.647CysArg: 0.647 ± 0.026	0.602CysSer: 0.602 ± 0.029	0.577CysThr: 0.577 ± 0.029	0.847CysVal: 0.847 ± 0.035	0.11CysTrp: 0.11 ± 0.012	0.185CysTyr: 0.185 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.619AspAla: 6.619 ± 0.109	0.486AspCys: 0.486 ± 0.027	2.697AspAsp: 2.697 ± 0.059	2.864AspGlu: 2.864 ± 0.064	1.9AspPhe: 1.9 ± 0.048	4.725AspGly: 4.725 ± 0.082	1.328AspHis: 1.328 ± 0.038	2.907AspIle: 2.907 ± 0.061	1.675AspLys: 1.675 ± 0.042	5.688AspLeu: 5.688 ± 0.087	1.482AspMet: 1.482 ± 0.036	1.361AspAsn: 1.361 ± 0.042	3.098AspPro: 3.098 ± 0.061	1.771AspGln: 1.771 ± 0.044	3.57AspArg: 3.57 ± 0.072	2.287AspSer: 2.287 ± 0.053	2.891AspThr: 2.891 ± 0.055	4.237AspVal: 4.237 ± 0.073	0.932AspTrp: 0.932 ± 0.032	1.443AspTyr: 1.443 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.869GluAla: 6.869 ± 0.129	0.376GluCys: 0.376 ± 0.024	2.786GluAsp: 2.786 ± 0.065	3.342GluGlu: 3.342 ± 0.077	1.384GluPhe: 1.384 ± 0.039	4.215GluGly: 4.215 ± 0.078	1.345GluHis: 1.345 ± 0.046	2.905GluIle: 2.905 ± 0.052	2.576GluLys: 2.576 ± 0.061	4.318GluLeu: 4.318 ± 0.071	1.292GluMet: 1.292 ± 0.042	1.785GluAsn: 1.785 ± 0.049	2.221GluPro: 2.221 ± 0.05	2.482GluGln: 2.482 ± 0.061	4.046GluArg: 4.046 ± 0.094	2.42GluSer: 2.42 ± 0.057	3.441GluThr: 3.441 ± 0.068	3.104GluVal: 3.104 ± 0.066	0.683GluTrp: 0.683 ± 0.025	0.919GluTyr: 0.919 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.778PheAla: 3.778 ± 0.073	0.536PheCys: 0.536 ± 0.025	2.165PheAsp: 2.165 ± 0.049	1.715PheGlu: 1.715 ± 0.05	1.401PhePhe: 1.401 ± 0.049	3.312PheGly: 3.312 ± 0.065	0.856PheHis: 0.856 ± 0.03	1.561PheIle: 1.561 ± 0.043	0.899PheLys: 0.899 ± 0.033	3.599PheLeu: 3.599 ± 0.069	0.901PheMet: 0.901 ± 0.033	1.089PheAsn: 1.089 ± 0.041	1.704PhePro: 1.704 ± 0.047	1.068PheGln: 1.068 ± 0.034	2.25PheArg: 2.25 ± 0.054	2.618PheSer: 2.618 ± 0.057	2.079PheThr: 2.079 ± 0.049	2.588PheVal: 2.588 ± 0.059	0.544PheTrp: 0.544 ± 0.022	0.998PheTyr: 0.998 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.33GlyAla: 8.33 ± 0.108	0.979GlyCys: 0.979 ± 0.037	3.626GlyAsp: 3.626 ± 0.066	3.994GlyGlu: 3.994 ± 0.072	3.349GlyPhe: 3.349 ± 0.064	7.219GlyGly: 7.219 ± 0.141	2.097GlyHis: 2.097 ± 0.052	4.029GlyIle: 4.029 ± 0.077	3.385GlyLys: 3.385 ± 0.074	9.062GlyLeu: 9.062 ± 0.118	2.44GlyMet: 2.44 ± 0.052	2.246GlyAsn: 2.246 ± 0.055	3.56GlyPro: 3.56 ± 0.066	3.445GlyGln: 3.445 ± 0.07	5.5GlyArg: 5.5 ± 0.079	4.734GlySer: 4.734 ± 0.081	5.042GlyThr: 5.042 ± 0.093	6.285GlyVal: 6.285 ± 0.084	1.527GlyTrp: 1.527 ± 0.044	2.231GlyTyr: 2.231 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.767HisAla: 2.767 ± 0.057	0.255HisCys: 0.255 ± 0.015	1.367HisAsp: 1.367 ± 0.039	1.166HisGlu: 1.166 ± 0.036	0.968HisPhe: 0.968 ± 0.034	2.136HisGly: 2.136 ± 0.056	0.717HisHis: 0.717 ± 0.032	1.136HisIle: 1.136 ± 0.039	0.708HisLys: 0.708 ± 0.029	2.379HisLeu: 2.379 ± 0.055	0.593HisMet: 0.593 ± 0.027	0.631HisAsn: 0.631 ± 0.033	1.592HisPro: 1.592 ± 0.046	0.772HisGln: 0.772 ± 0.034	1.376HisArg: 1.376 ± 0.038	1.116HisSer: 1.116 ± 0.038	1.358HisThr: 1.358 ± 0.035	1.814HisVal: 1.814 ± 0.054	0.384HisTrp: 0.384 ± 0.023	0.651HisTyr: 0.651 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.771IleAla: 5.771 ± 0.088	0.531IleCys: 0.531 ± 0.023	2.616IleAsp: 2.616 ± 0.06	2.708IleGlu: 2.708 ± 0.057	1.529IlePhe: 1.529 ± 0.049	4.175IleGly: 4.175 ± 0.076	0.888IleHis: 0.888 ± 0.031	2.063IleIle: 2.063 ± 0.053	1.337IleLys: 1.337 ± 0.043	4.536IleLeu: 4.536 ± 0.077	1.106IleMet: 1.106 ± 0.035	1.399IleAsn: 1.399 ± 0.046	2.513IlePro: 2.513 ± 0.054	1.374IleGln: 1.374 ± 0.044	3.059IleArg: 3.059 ± 0.068	3.04IleSer: 3.04 ± 0.069	2.995IleThr: 2.995 ± 0.056	3.401IleVal: 3.401 ± 0.069	0.612IleTrp: 0.612 ± 0.023	1.024IleTyr: 1.024 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.397LysAla: 4.397 ± 0.084	0.177LysCys: 0.177 ± 0.016	1.927LysAsp: 1.927 ± 0.048	1.688LysGlu: 1.688 ± 0.047	0.861LysPhe: 0.861 ± 0.032	2.712LysGly: 2.712 ± 0.058	0.715LysHis: 0.715 ± 0.026	1.703LysIle: 1.703 ± 0.054	1.647LysLys: 1.647 ± 0.053	3.157LysLeu: 3.157 ± 0.062	0.761LysMet: 0.761 ± 0.027	1.121LysAsn: 1.121 ± 0.043	2.053LysPro: 2.053 ± 0.046	1.317LysGln: 1.317 ± 0.039	2.151LysArg: 2.151 ± 0.052	1.771LysSer: 1.771 ± 0.052	2.28LysThr: 2.28 ± 0.058	2.121LysVal: 2.121 ± 0.057	0.378LysTrp: 0.378 ± 0.022	0.587LysTyr: 0.587 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.93LeuAla: 12.93 ± 0.145	1.225LeuCys: 1.225 ± 0.035	5.842LeuAsp: 5.842 ± 0.09	5.057LeuGlu: 5.057 ± 0.085	3.771LeuPhe: 3.771 ± 0.077	7.77LeuGly: 7.77 ± 0.106	2.61LeuHis: 2.61 ± 0.058	4.422LeuIle: 4.422 ± 0.086	3.708LeuLys: 3.708 ± 0.07	10.241LeuLeu: 10.241 ± 0.142	2.506LeuMet: 2.506 ± 0.054	2.929LeuAsn: 2.929 ± 0.06	6.733LeuPro: 6.733 ± 0.098	3.315LeuGln: 3.315 ± 0.057	7.216LeuArg: 7.216 ± 0.128	7.005LeuSer: 7.005 ± 0.103	6.407LeuThr: 6.407 ± 0.093	7.048LeuVal: 7.048 ± 0.106	1.293LeuTrp: 1.293 ± 0.045	2.252LeuTyr: 2.252 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.106MetAla: 3.106 ± 0.063	0.152MetCys: 0.152 ± 0.014	1.232MetAsp: 1.232 ± 0.034	1.128MetGlu: 1.128 ± 0.04	0.668MetPhe: 0.668 ± 0.031	1.935MetGly: 1.935 ± 0.05	0.518MetHis: 0.518 ± 0.023	1.205MetIle: 1.205 ± 0.037	0.953MetLys: 0.953 ± 0.033	2.671MetLeu: 2.671 ± 0.057	0.702MetMet: 0.702 ± 0.03	0.749MetAsn: 0.749 ± 0.025	1.659MetPro: 1.659 ± 0.042	1.16MetGln: 1.16 ± 0.035	1.726MetArg: 1.726 ± 0.04	1.593MetSer: 1.593 ± 0.047	2.008MetThr: 2.008 ± 0.044	1.721MetVal: 1.721 ± 0.043	0.222MetTrp: 0.222 ± 0.016	0.303MetTyr: 0.303 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.281AsnAla: 3.281 ± 0.068	0.23AsnCys: 0.23 ± 0.016	1.32AsnAsp: 1.32 ± 0.045	1.134AsnGlu: 1.134 ± 0.04	0.976AsnPhe: 0.976 ± 0.039	2.737AsnGly: 2.737 ± 0.068	0.598AsnHis: 0.598 ± 0.027	1.369AsnIle: 1.369 ± 0.042	0.833AsnLys: 0.833 ± 0.036	2.534AsnLeu: 2.534 ± 0.054	0.658AsnMet: 0.658 ± 0.028	0.799AsnAsn: 0.799 ± 0.036	1.978AsnPro: 1.978 ± 0.051	0.915AsnGln: 0.915 ± 0.034	1.758AsnArg: 1.758 ± 0.046	1.43AsnSer: 1.43 ± 0.052	1.627AsnThr: 1.627 ± 0.05	1.989AsnVal: 1.989 ± 0.052	0.479AsnTrp: 0.479 ± 0.024	0.724AsnTyr: 0.724 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	7.037ProAla: 7.037 ± 0.112	0.435ProCys: 0.435 ± 0.024	4.179ProAsp: 4.179 ± 0.08	4.136ProGlu: 4.136 ± 0.089	2.052ProPhe: 2.052 ± 0.044	4.608ProGly: 4.608 ± 0.072	1.376ProHis: 1.376 ± 0.041	1.961ProIle: 1.961 ± 0.047	1.579ProLys: 1.579 ± 0.047	5.31ProLeu: 5.31 ± 0.094	1.225ProMet: 1.225 ± 0.032	1.381ProAsn: 1.381 ± 0.048	2.966ProPro: 2.966 ± 0.074	2.035ProGln: 2.035 ± 0.054	2.862ProArg: 2.862 ± 0.066	3.188ProSer: 3.188 ± 0.067	2.862ProThr: 2.862 ± 0.058	4.894ProVal: 4.894 ± 0.081	0.735ProTrp: 0.735 ± 0.034	1.27ProTyr: 1.27 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.178GlnAla: 5.178 ± 0.096	0.259GlnCys: 0.259 ± 0.017	2.344GlnAsp: 2.344 ± 0.055	1.851GlnGlu: 1.851 ± 0.041	1.182GlnPhe: 1.182 ± 0.04	2.6GlnGly: 2.6 ± 0.057	0.873GlnHis: 0.873 ± 0.031	2.173GlnIle: 2.173 ± 0.046	1.579GlnLys: 1.579 ± 0.045	2.911GlnLeu: 2.911 ± 0.053	0.956GlnMet: 0.956 ± 0.031	1.204GlnAsn: 1.204 ± 0.04	2.264GlnPro: 2.264 ± 0.049	1.667GlnGln: 1.667 ± 0.059	2.234GlnArg: 2.234 ± 0.057	2.056GlnSer: 2.056 ± 0.051	2.537GlnThr: 2.537 ± 0.055	2.443GlnVal: 2.443 ± 0.052	0.421GlnTrp: 0.421 ± 0.021	0.783GlnTyr: 0.783 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.812ArgAla: 6.812 ± 0.106	0.568ArgCys: 0.568 ± 0.03	3.428ArgAsp: 3.428 ± 0.062	3.497ArgGlu: 3.497 ± 0.075	2.692ArgPhe: 2.692 ± 0.055	4.242ArgGly: 4.242 ± 0.068	1.784ArgHis: 1.784 ± 0.051	3.508ArgIle: 3.508 ± 0.075	2.647ArgLys: 2.647 ± 0.053	7.832ArgLeu: 7.832 ± 0.121	1.778ArgMet: 1.778 ± 0.044	1.889ArgAsn: 1.889 ± 0.042	3.357ArgPro: 3.357 ± 0.069	2.731ArgGln: 2.731 ± 0.057	4.957ArgArg: 4.957 ± 0.097	3.508ArgSer: 3.508 ± 0.06	3.701ArgThr: 3.701 ± 0.068	4.379ArgVal: 4.379 ± 0.076	0.943ArgTrp: 0.943 ± 0.029	1.799ArgTyr: 1.799 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.552SerAla: 6.552 ± 0.1	0.587SerCys: 0.587 ± 0.029	2.893SerAsp: 2.893 ± 0.058	2.598SerGlu: 2.598 ± 0.061	2.419SerPhe: 2.419 ± 0.061	5.71SerGly: 5.71 ± 0.097	1.308SerHis: 1.308 ± 0.042	2.531SerIle: 2.531 ± 0.068	1.5SerLys: 1.5 ± 0.046	6.198SerLeu: 6.198 ± 0.093	1.459SerMet: 1.459 ± 0.044	1.355SerAsn: 1.355 ± 0.038	3.288SerPro: 3.288 ± 0.062	1.833SerGln: 1.833 ± 0.051	3.719SerArg: 3.719 ± 0.071	3.692SerSer: 3.692 ± 0.086	3.113SerThr: 3.113 ± 0.069	4.483SerVal: 4.483 ± 0.085	0.865SerTrp: 0.865 ± 0.034	1.517SerTyr: 1.517 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.519ThrAla: 6.519 ± 0.092	0.567ThrCys: 0.567 ± 0.026	3.144ThrAsp: 3.144 ± 0.055	2.766ThrGlu: 2.766 ± 0.061	2.051ThrPhe: 2.051 ± 0.047	5.406ThrGly: 5.406 ± 0.089	1.499ThrHis: 1.499 ± 0.044	2.703ThrIle: 2.703 ± 0.062	1.503ThrLys: 1.503 ± 0.046	7.258ThrLeu: 7.258 ± 0.107	1.217ThrMet: 1.217 ± 0.033	1.472ThrAsn: 1.472 ± 0.044	4.277ThrPro: 4.277 ± 0.08	2.252ThrGln: 2.252 ± 0.051	3.475ThrArg: 3.475 ± 0.063	3.202ThrSer: 3.202 ± 0.067	3.323ThrThr: 3.323 ± 0.07	4.53ThrVal: 4.53 ± 0.079	0.758ThrTrp: 0.758 ± 0.029	1.398ThrTyr: 1.398 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	8.003ValAla: 8.003 ± 0.108	0.826ValCys: 0.826 ± 0.029	3.569ValAsp: 3.569 ± 0.072	3.827ValGlu: 3.827 ± 0.068	2.724ValPhe: 2.724 ± 0.065	5.161ValGly: 5.161 ± 0.092	1.482ValHis: 1.482 ± 0.044	3.452ValIle: 3.452 ± 0.067	2.209ValLys: 2.209 ± 0.055	8.071ValLeu: 8.071 ± 0.112	2.07ValMet: 2.07 ± 0.051	1.863ValAsn: 1.863 ± 0.052	4.064ValPro: 4.064 ± 0.083	2.608ValGln: 2.608 ± 0.055	4.608ValArg: 4.608 ± 0.077	4.62ValSer: 4.62 ± 0.079	4.663ValThr: 4.663 ± 0.077	5.455ValVal: 5.455 ± 0.104	1.017ValTrp: 1.017 ± 0.038	1.429ValTyr: 1.429 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.039	0.184TrpCys: 0.184 ± 0.014	0.691TrpAsp: 0.691 ± 0.033	0.568TrpGlu: 0.568 ± 0.027	0.525TrpPhe: 0.525 ± 0.026	0.987TrpGly: 0.987 ± 0.041	0.42TrpHis: 0.42 ± 0.025	0.603TrpIle: 0.603 ± 0.024	0.562TrpLys: 0.562 ± 0.027	1.772TrpLeu: 1.772 ± 0.054	0.4TrpMet: 0.4 ± 0.022	0.464TrpAsn: 0.464 ± 0.025	0.707TrpPro: 0.707 ± 0.029	0.729TrpGln: 0.729 ± 0.03	1.115TrpArg: 1.115 ± 0.036	0.832TrpSer: 0.832 ± 0.038	0.784TrpThr: 0.784 ± 0.037	0.882TrpVal: 0.882 ± 0.031	0.234TrpTrp: 0.234 ± 0.018	0.334TrpTyr: 0.334 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.589TyrAla: 2.589 ± 0.058	0.273TyrCys: 0.273 ± 0.018	1.498TyrAsp: 1.498 ± 0.049	1.17TyrGlu: 1.17 ± 0.038	0.829TyrPhe: 0.829 ± 0.034	2.219TyrGly: 2.219 ± 0.055	0.588TyrHis: 0.588 ± 0.023	0.858TyrIle: 0.858 ± 0.03	0.703TyrLys: 0.703 ± 0.034	2.18TyrLeu: 2.18 ± 0.053	0.475TyrMet: 0.475 ± 0.024	0.765TyrAsn: 0.765 ± 0.041	1.138TyrPro: 1.138 ± 0.039	0.921TyrGln: 0.921 ± 0.037	1.617TyrArg: 1.617 ± 0.041	1.234TyrSer: 1.234 ± 0.051	1.355TyrThr: 1.355 ± 0.051	1.591TyrVal: 1.591 ± 0.047	0.33TyrTrp: 0.33 ± 0.02	0.706TyrTyr: 0.706 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2662 proteins (864380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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