Amino acid dipepetide frequency for Nootka lupine vein clearing virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.949AlaAla: 7.949 ± 2.463
2.385AlaCys: 2.385 ± 1.636
2.385AlaAsp: 2.385 ± 1.415
6.359AlaGlu: 6.359 ± 1.112
0.795AlaPhe: 0.795 ± 0.681
4.769AlaGly: 4.769 ± 1.142
0.795AlaHis: 0.795 ± 1.236
3.18AlaIle: 3.18 ± 1.335
4.769AlaLys: 4.769 ± 3.074
7.154AlaLeu: 7.154 ± 2.234
0.0AlaMet: 0.0 ± 0.0
1.59AlaAsn: 1.59 ± 0.968
4.769AlaPro: 4.769 ± 1.19
2.385AlaGln: 2.385 ± 1.42
5.564AlaArg: 5.564 ± 0.986
2.385AlaSer: 2.385 ± 1.728
3.975AlaThr: 3.975 ± 3.405
10.334AlaVal: 10.334 ± 4.213
2.385AlaTrp: 2.385 ± 0.571
1.59AlaTyr: 1.59 ± 0.737
0.0AlaXaa: 0.0 ± 0.0
Cys
0.795CysAla: 0.795 ± 0.545
0.795CysCys: 0.795 ± 0.887
1.59CysAsp: 1.59 ± 0.628
0.795CysGlu: 0.795 ± 0.545
1.59CysPhe: 1.59 ± 0.628
1.59CysGly: 1.59 ± 1.091
0.795CysHis: 0.795 ± 0.545
0.795CysIle: 0.795 ± 0.545
0.795CysLys: 0.795 ± 0.887
2.385CysLeu: 2.385 ± 1.458
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.795CysPro: 0.795 ± 0.545
1.59CysGln: 1.59 ± 1.091
3.18CysArg: 3.18 ± 1.795
0.0CysSer: 0.0 ± 0.0
1.59CysThr: 1.59 ± 0.737
0.795CysVal: 0.795 ± 0.545
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.18AspAla: 3.18 ± 1.45
1.59AspCys: 1.59 ± 1.091
1.59AspAsp: 1.59 ± 0.628
2.385AspGlu: 2.385 ± 0.945
2.385AspPhe: 2.385 ± 1.42
3.18AspGly: 3.18 ± 1.255
0.0AspHis: 0.0 ± 0.0
0.795AspIle: 0.795 ± 0.887
0.795AspLys: 0.795 ± 1.236
3.18AspLeu: 3.18 ± 1.255
2.385AspMet: 2.385 ± 1.636
0.0AspAsn: 0.0 ± 0.0
3.975AspPro: 3.975 ± 1.491
2.385AspGln: 2.385 ± 1.537
2.385AspArg: 2.385 ± 0.959
7.154AspSer: 7.154 ± 3.362
2.385AspThr: 2.385 ± 2.036
3.18AspVal: 3.18 ± 0.556
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
3.18GluAla: 3.18 ± 2.4
0.0GluCys: 0.0 ± 0.0
0.795GluAsp: 0.795 ± 0.887
4.769GluGlu: 4.769 ± 1.387
3.18GluPhe: 3.18 ± 0.556
5.564GluGly: 5.564 ± 0.986
2.385GluHis: 2.385 ± 1.536
6.359GluIle: 6.359 ± 3.094
3.975GluLys: 3.975 ± 1.838
7.154GluLeu: 7.154 ± 2.836
0.795GluMet: 0.795 ± 0.545
1.59GluAsn: 1.59 ± 0.628
0.0GluPro: 0.0 ± 0.0
2.385GluGln: 2.385 ± 0.945
2.385GluArg: 2.385 ± 1.636
1.59GluSer: 1.59 ± 1.091
0.795GluThr: 0.795 ± 0.545
6.359GluVal: 6.359 ± 1.416
0.795GluTrp: 0.795 ± 0.681
0.795GluTyr: 0.795 ± 0.681
0.0GluXaa: 0.0 ± 0.0
Phe
2.385PheAla: 2.385 ± 1.889
0.795PheCys: 0.795 ± 0.545
2.385PheAsp: 2.385 ± 1.636
3.18PheGlu: 3.18 ± 1.428
0.0PhePhe: 0.0 ± 0.0
3.975PheGly: 3.975 ± 1.135
0.795PheHis: 0.795 ± 0.545
0.795PheIle: 0.795 ± 0.681
1.59PheLys: 1.59 ± 1.091
3.18PheLeu: 3.18 ± 4.24
0.795PheMet: 0.795 ± 0.959
3.18PheAsn: 3.18 ± 1.101
0.795PhePro: 0.795 ± 0.681
1.59PheGln: 1.59 ± 0.968
0.795PheArg: 0.795 ± 0.681
6.359PheSer: 6.359 ± 1.281
1.59PheThr: 1.59 ± 0.968
6.359PheVal: 6.359 ± 1.697
0.0PheTrp: 0.0 ± 0.0
2.385PheTyr: 2.385 ± 1.636
0.0PheXaa: 0.0 ± 0.0
Gly
3.18GlyAla: 3.18 ± 1.018
3.18GlyCys: 3.18 ± 1.354
6.359GlyAsp: 6.359 ± 3.02
2.385GlyGlu: 2.385 ± 0.959
2.385GlyPhe: 2.385 ± 1.636
8.744GlyGly: 8.744 ± 2.178
0.0GlyHis: 0.0 ± 0.0
4.769GlyIle: 4.769 ± 1.145
6.359GlyLys: 6.359 ± 2.54
6.359GlyLeu: 6.359 ± 2.712
1.59GlyMet: 1.59 ± 0.628
3.18GlyAsn: 3.18 ± 1.259
3.18GlyPro: 3.18 ± 1.255
3.18GlyGln: 3.18 ± 0.556
3.18GlyArg: 3.18 ± 1.259
6.359GlySer: 6.359 ± 2.656
3.975GlyThr: 3.975 ± 2.688
7.154GlyVal: 7.154 ± 0.874
1.59GlyTrp: 1.59 ± 0.628
4.769GlyTyr: 4.769 ± 1.436
0.0GlyXaa: 0.0 ± 0.0
His
2.385HisAla: 2.385 ± 1.39
0.0HisCys: 0.0 ± 0.0
0.795HisAsp: 0.795 ± 0.887
1.59HisGlu: 1.59 ± 0.628
1.59HisPhe: 1.59 ± 0.968
0.795HisGly: 0.795 ± 0.681
0.0HisHis: 0.0 ± 0.0
0.795HisIle: 0.795 ± 0.545
0.795HisLys: 0.795 ± 1.236
2.385HisLeu: 2.385 ± 1.458
0.0HisMet: 0.0 ± 0.0
0.795HisAsn: 0.795 ± 0.545
2.385HisPro: 2.385 ± 0.571
0.795HisGln: 0.795 ± 0.887
0.795HisArg: 0.795 ± 1.464
3.18HisSer: 3.18 ± 2.182
1.59HisThr: 1.59 ± 0.628
1.59HisVal: 1.59 ± 1.091
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.385IleAla: 2.385 ± 1.537
0.0IleCys: 0.0 ± 0.0
1.59IleAsp: 1.59 ± 0.737
2.385IleGlu: 2.385 ± 1.113
0.795IlePhe: 0.795 ± 1.464
2.385IleGly: 2.385 ± 0.945
0.795IleHis: 0.795 ± 0.545
1.59IleIle: 1.59 ± 1.381
1.59IleLys: 1.59 ± 2.097
3.18IleLeu: 3.18 ± 2.733
0.795IleMet: 0.795 ± 0.545
2.385IleAsn: 2.385 ± 0.959
0.795IlePro: 0.795 ± 0.887
2.385IleGln: 2.385 ± 0.571
6.359IleArg: 6.359 ± 2.319
7.154IleSer: 7.154 ± 2.689
4.769IleThr: 4.769 ± 2.675
3.975IleVal: 3.975 ± 2.222
0.795IleTrp: 0.795 ± 0.545
0.795IleTyr: 0.795 ± 0.545
0.0IleXaa: 0.0 ± 0.0
Lys
3.975LysAla: 3.975 ± 1.493
0.795LysCys: 0.795 ± 0.545
2.385LysAsp: 2.385 ± 1.536
4.769LysGlu: 4.769 ± 3.498
2.385LysPhe: 2.385 ± 1.505
5.564LysGly: 5.564 ± 2.159
2.385LysHis: 2.385 ± 0.945
3.18LysIle: 3.18 ± 1.259
4.769LysLys: 4.769 ± 2.637
6.359LysLeu: 6.359 ± 1.02
3.18LysMet: 3.18 ± 2.522
2.385LysAsn: 2.385 ± 0.959
2.385LysPro: 2.385 ± 1.536
1.59LysGln: 1.59 ± 1.091
5.564LysArg: 5.564 ± 1.276
1.59LysSer: 1.59 ± 0.628
1.59LysThr: 1.59 ± 1.091
3.18LysVal: 3.18 ± 2.006
0.795LysTrp: 0.795 ± 0.545
0.795LysTyr: 0.795 ± 0.887
0.0LysXaa: 0.0 ± 0.0
Leu
5.564LeuAla: 5.564 ± 0.986
1.59LeuCys: 1.59 ± 1.704
5.564LeuAsp: 5.564 ± 2.228
3.18LeuGlu: 3.18 ± 1.474
1.59LeuPhe: 1.59 ± 1.381
5.564LeuGly: 5.564 ± 2.145
2.385LeuHis: 2.385 ± 1.458
3.975LeuIle: 3.975 ± 2.837
1.59LeuLys: 1.59 ± 1.091
4.769LeuLeu: 4.769 ± 2.502
2.385LeuMet: 2.385 ± 0.959
4.769LeuAsn: 4.769 ± 2.495
0.795LeuPro: 0.795 ± 1.464
1.59LeuGln: 1.59 ± 1.091
7.154LeuArg: 7.154 ± 3.266
6.359LeuSer: 6.359 ± 1.297
3.18LeuThr: 3.18 ± 1.612
7.154LeuVal: 7.154 ± 2.767
0.795LeuTrp: 0.795 ± 1.464
4.769LeuTyr: 4.769 ± 1.436
0.0LeuXaa: 0.0 ± 0.0
Met
3.18MetAla: 3.18 ± 1.255
0.795MetCys: 0.795 ± 0.545
0.795MetAsp: 0.795 ± 0.887
3.975MetGlu: 3.975 ± 2.777
0.795MetPhe: 0.795 ± 0.545
1.59MetGly: 1.59 ± 0.737
2.385MetHis: 2.385 ± 1.458
0.795MetIle: 0.795 ± 0.681
1.59MetLys: 1.59 ± 0.628
0.795MetLeu: 0.795 ± 0.887
0.0MetMet: 0.0 ± 0.658
0.795MetAsn: 0.795 ± 0.545
0.795MetPro: 0.795 ± 0.681
2.385MetGln: 2.385 ± 1.636
0.795MetArg: 0.795 ± 1.464
0.0MetSer: 0.0 ± 0.0
2.385MetThr: 2.385 ± 1.191
3.18MetVal: 3.18 ± 0.556
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.795AsnAla: 0.795 ± 0.545
1.59AsnCys: 1.59 ± 1.381
0.795AsnAsp: 0.795 ± 0.545
1.59AsnGlu: 1.59 ± 0.968
1.59AsnPhe: 1.59 ± 1.283
4.769AsnGly: 4.769 ± 0.929
1.59AsnHis: 1.59 ± 1.362
0.795AsnIle: 0.795 ± 0.681
3.18AsnLys: 3.18 ± 1.101
3.975AsnLeu: 3.975 ± 1.493
1.59AsnMet: 1.59 ± 1.091
2.385AsnAsn: 2.385 ± 0.959
2.385AsnPro: 2.385 ± 1.191
2.385AsnGln: 2.385 ± 1.338
2.385AsnArg: 2.385 ± 0.571
4.769AsnSer: 4.769 ± 1.422
2.385AsnThr: 2.385 ± 0.945
2.385AsnVal: 2.385 ± 0.959
0.795AsnTrp: 0.795 ± 0.681
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
3.18ProAla: 3.18 ± 1.255
0.795ProCys: 0.795 ± 0.545
3.18ProAsp: 3.18 ± 0.556
2.385ProGlu: 2.385 ± 1.636
0.795ProPhe: 0.795 ± 0.887
1.59ProGly: 1.59 ± 0.628
0.795ProHis: 0.795 ± 0.681
0.795ProIle: 0.795 ± 0.545
2.385ProLys: 2.385 ± 1.113
3.18ProLeu: 3.18 ± 2.827
0.795ProMet: 0.795 ± 0.545
1.59ProAsn: 1.59 ± 0.968
2.385ProPro: 2.385 ± 1.458
0.795ProGln: 0.795 ± 0.887
4.769ProArg: 4.769 ± 2.057
2.385ProSer: 2.385 ± 0.571
5.564ProThr: 5.564 ± 2.41
3.18ProVal: 3.18 ± 1.255
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.975GlnAla: 3.975 ± 1.59
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
0.795GlnGlu: 0.795 ± 0.545
3.975GlnPhe: 3.975 ± 1.605
3.18GlnGly: 3.18 ± 0.556
3.18GlnHis: 3.18 ± 1.356
3.18GlnIle: 3.18 ± 1.924
3.18GlnLys: 3.18 ± 0.556
0.795GlnLeu: 0.795 ± 0.545
1.59GlnMet: 1.59 ± 0.628
1.59GlnAsn: 1.59 ± 0.628
1.59GlnPro: 1.59 ± 1.091
2.385GlnGln: 2.385 ± 0.571
0.795GlnArg: 0.795 ± 0.681
2.385GlnSer: 2.385 ± 1.537
2.385GlnThr: 2.385 ± 1.191
0.795GlnVal: 0.795 ± 0.887
0.795GlnTrp: 0.795 ± 0.887
2.385GlnTyr: 2.385 ± 0.571
0.0GlnXaa: 0.0 ± 0.0
Arg
7.154ArgAla: 7.154 ± 1.713
0.0ArgCys: 0.0 ± 0.0
1.59ArgAsp: 1.59 ± 1.362
1.59ArgGlu: 1.59 ± 0.737
5.564ArgPhe: 5.564 ± 2.128
7.154ArgGly: 7.154 ± 2.388
0.795ArgHis: 0.795 ± 0.887
2.385ArgIle: 2.385 ± 0.959
4.769ArgLys: 4.769 ± 2.21
4.769ArgLeu: 4.769 ± 1.893
2.385ArgMet: 2.385 ± 1.768
3.18ArgAsn: 3.18 ± 1.259
2.385ArgPro: 2.385 ± 1.636
1.59ArgGln: 1.59 ± 1.22
5.564ArgArg: 5.564 ± 1.957
2.385ArgSer: 2.385 ± 1.889
3.18ArgThr: 3.18 ± 2.182
5.564ArgVal: 5.564 ± 1.258
1.59ArgTrp: 1.59 ± 1.381
2.385ArgTyr: 2.385 ± 0.959
0.0ArgXaa: 0.0 ± 0.0
Ser
3.18SerAla: 3.18 ± 1.018
1.59SerCys: 1.59 ± 0.628
3.975SerAsp: 3.975 ± 1.636
3.18SerGlu: 3.18 ± 1.301
4.769SerPhe: 4.769 ± 2.675
5.564SerGly: 5.564 ± 1.245
1.59SerHis: 1.59 ± 0.737
2.385SerIle: 2.385 ± 1.458
6.359SerLys: 6.359 ± 1.137
3.975SerLeu: 3.975 ± 1.526
2.385SerMet: 2.385 ± 1.42
2.385SerAsn: 2.385 ± 0.959
3.18SerPro: 3.18 ± 1.937
1.59SerGln: 1.59 ± 1.362
3.18SerArg: 3.18 ± 1.018
3.975SerSer: 3.975 ± 2.5
7.949SerThr: 7.949 ± 2.351
3.975SerVal: 3.975 ± 1.526
1.59SerTrp: 1.59 ± 0.968
3.975SerTyr: 3.975 ± 1.192
0.0SerXaa: 0.0 ± 0.0
Thr
2.385ThrAla: 2.385 ± 1.191
0.0ThrCys: 0.0 ± 0.0
2.385ThrAsp: 2.385 ± 2.043
3.975ThrGlu: 3.975 ± 0.942
3.18ThrPhe: 3.18 ± 1.612
7.949ThrGly: 7.949 ± 2.727
0.0ThrHis: 0.0 ± 0.0
4.769ThrIle: 4.769 ± 2.646
3.975ThrLys: 3.975 ± 0.808
4.769ThrLeu: 4.769 ± 3.819
2.385ThrMet: 2.385 ± 1.507
5.564ThrAsn: 5.564 ± 2.956
1.59ThrPro: 1.59 ± 1.775
0.0ThrGln: 0.0 ± 0.0
2.385ThrArg: 2.385 ± 1.458
3.975ThrSer: 3.975 ± 2.5
1.59ThrThr: 1.59 ± 1.362
7.154ThrVal: 7.154 ± 2.535
0.795ThrTrp: 0.795 ± 0.545
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
11.924ValAla: 11.924 ± 3.592
2.385ValCys: 2.385 ± 1.636
3.975ValAsp: 3.975 ± 1.59
5.564ValGlu: 5.564 ± 2.273
4.769ValPhe: 4.769 ± 2.78
7.154ValGly: 7.154 ± 2.06
1.59ValHis: 1.59 ± 1.362
3.18ValIle: 3.18 ± 1.301
4.769ValLys: 4.769 ± 0.929
1.59ValLeu: 1.59 ± 0.737
3.18ValMet: 3.18 ± 0.556
3.975ValAsn: 3.975 ± 1.787
5.564ValPro: 5.564 ± 1.292
3.18ValGln: 3.18 ± 1.354
6.359ValArg: 6.359 ± 1.02
6.359ValSer: 6.359 ± 2.998
3.975ValThr: 3.975 ± 2.326
13.514ValVal: 13.514 ± 4.864
0.0ValTrp: 0.0 ± 0.0
0.795ValTyr: 0.795 ± 0.545
0.0ValXaa: 0.0 ± 0.0
Trp
3.18TrpAla: 3.18 ± 1.018
0.795TrpCys: 0.795 ± 0.545
0.795TrpAsp: 0.795 ± 0.545
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.795TrpGly: 0.795 ± 0.545
0.0TrpHis: 0.0 ± 0.0
0.795TrpIle: 0.795 ± 1.464
0.795TrpLys: 0.795 ± 1.464
2.385TrpLeu: 2.385 ± 0.945
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.795TrpArg: 0.795 ± 0.681
0.0TrpSer: 0.0 ± 0.0
0.795TrpThr: 0.795 ± 0.681
0.795TrpVal: 0.795 ± 0.681
0.795TrpTrp: 0.795 ± 0.887
0.795TrpTyr: 0.795 ± 0.887
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.59TyrAla: 1.59 ± 1.775
0.795TyrCys: 0.795 ± 0.545
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
0.795TyrPhe: 0.795 ± 0.681
0.0TyrGly: 0.0 ± 0.0
0.0TyrHis: 0.0 ± 0.0
1.59TyrIle: 1.59 ± 0.628
1.59TyrLys: 1.59 ± 1.091
2.385TyrLeu: 2.385 ± 1.636
0.795TyrMet: 0.795 ± 0.545
0.795TyrAsn: 0.795 ± 0.545
0.795TyrPro: 0.795 ± 0.887
4.769TyrGln: 4.769 ± 2.463
1.59TyrArg: 1.59 ± 0.737
2.385TyrSer: 2.385 ± 0.571
3.18TyrThr: 3.18 ± 1.018
3.18TyrVal: 3.18 ± 1.101
0.0TyrTrp: 0.0 ± 0.0
0.795TyrTyr: 0.795 ± 0.545
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski