Amino acid dipepetide frequency for Verrucomicrobiales bacterium VVV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.055AlaAla: 13.055 ± 0.135	1.072AlaCys: 1.072 ± 0.03	5.614AlaAsp: 5.614 ± 0.069	6.123AlaGlu: 6.123 ± 0.09	4.01AlaPhe: 4.01 ± 0.061	9.47AlaGly: 9.47 ± 0.112	1.712AlaHis: 1.712 ± 0.039	5.168AlaIle: 5.168 ± 0.066	4.831AlaLys: 4.831 ± 0.082	10.398AlaLeu: 10.398 ± 0.108	2.559AlaMet: 2.559 ± 0.046	3.498AlaAsn: 3.498 ± 0.061	4.963AlaPro: 4.963 ± 0.066	2.893AlaGln: 2.893 ± 0.051	5.816AlaArg: 5.816 ± 0.089	6.855AlaSer: 6.855 ± 0.086	6.56AlaThr: 6.56 ± 0.103	6.998AlaVal: 6.998 ± 0.072	1.681AlaTrp: 1.681 ± 0.038	2.149AlaTyr: 2.149 ± 0.039	0.001AlaXaa: 0.001 ± 0.001
Cys	0.857CysAla: 0.857 ± 0.028	0.138CysCys: 0.138 ± 0.011	0.515CysAsp: 0.515 ± 0.02	0.535CysGlu: 0.535 ± 0.02	0.417CysPhe: 0.417 ± 0.018	0.96CysGly: 0.96 ± 0.03	0.355CysHis: 0.355 ± 0.02	0.427CysIle: 0.427 ± 0.017	0.277CysLys: 0.277 ± 0.016	0.974CysLeu: 0.974 ± 0.031	0.169CysMet: 0.169 ± 0.012	0.229CysAsn: 0.229 ± 0.011	0.493CysPro: 0.493 ± 0.017	0.285CysGln: 0.285 ± 0.014	0.637CysArg: 0.637 ± 0.019	0.589CysSer: 0.589 ± 0.022	0.447CysThr: 0.447 ± 0.017	0.583CysVal: 0.583 ± 0.021	0.142CysTrp: 0.142 ± 0.01	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.422AspAla: 5.422 ± 0.077	0.492AspCys: 0.492 ± 0.02	2.687AspAsp: 2.687 ± 0.049	3.243AspGlu: 3.243 ± 0.051	2.537AspPhe: 2.537 ± 0.039	5.247AspGly: 5.247 ± 0.07	1.285AspHis: 1.285 ± 0.034	2.133AspIle: 2.133 ± 0.041	2.003AspLys: 2.003 ± 0.036	5.719AspLeu: 5.719 ± 0.072	0.829AspMet: 0.829 ± 0.021	1.372AspAsn: 1.372 ± 0.035	3.651AspPro: 3.651 ± 0.057	1.845AspGln: 1.845 ± 0.037	3.499AspArg: 3.499 ± 0.054	3.057AspSer: 3.057 ± 0.045	2.526AspThr: 2.526 ± 0.038	3.302AspVal: 3.302 ± 0.052	1.086AspTrp: 1.086 ± 0.025	1.544AspTyr: 1.544 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.237GluAla: 6.237 ± 0.106	0.427GluCys: 0.427 ± 0.021	2.576GluAsp: 2.576 ± 0.041	3.374GluGlu: 3.374 ± 0.062	2.264GluPhe: 2.264 ± 0.038	4.179GluGly: 4.179 ± 0.065	1.137GluHis: 1.137 ± 0.033	3.437GluIle: 3.437 ± 0.059	3.321GluLys: 3.321 ± 0.057	5.88GluLeu: 5.88 ± 0.073	1.348GluMet: 1.348 ± 0.032	1.867GluAsn: 1.867 ± 0.034	2.581GluPro: 2.581 ± 0.05	1.909GluGln: 1.909 ± 0.043	3.799GluArg: 3.799 ± 0.063	3.493GluSer: 3.493 ± 0.057	3.352GluThr: 3.352 ± 0.052	3.985GluVal: 3.985 ± 0.064	0.923GluTrp: 0.923 ± 0.027	1.044GluTyr: 1.044 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.843PheAla: 3.843 ± 0.052	0.428PheCys: 0.428 ± 0.015	2.484PheAsp: 2.484 ± 0.035	2.329PheGlu: 2.329 ± 0.043	1.641PhePhe: 1.641 ± 0.037	3.44PheGly: 3.44 ± 0.051	0.974PheHis: 0.974 ± 0.027	1.864PheIle: 1.864 ± 0.038	1.444PheLys: 1.444 ± 0.033	3.798PheLeu: 3.798 ± 0.06	0.748PheMet: 0.748 ± 0.023	1.459PheAsn: 1.459 ± 0.036	1.993PhePro: 1.993 ± 0.041	1.272PheGln: 1.272 ± 0.032	2.418PheArg: 2.418 ± 0.046	2.992PheSer: 2.992 ± 0.05	2.823PheThr: 2.823 ± 0.051	2.525PheVal: 2.525 ± 0.045	0.587PheTrp: 0.587 ± 0.021	0.981PheTyr: 0.981 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.885GlyAla: 7.885 ± 0.124	0.832GlyCys: 0.832 ± 0.026	4.439GlyAsp: 4.439 ± 0.062	4.484GlyGlu: 4.484 ± 0.062	3.6GlyPhe: 3.6 ± 0.047	7.914GlyGly: 7.914 ± 0.149	1.755GlyHis: 1.755 ± 0.038	4.347GlyIle: 4.347 ± 0.06	4.589GlyLys: 4.589 ± 0.068	7.964GlyLeu: 7.964 ± 0.072	1.849GlyMet: 1.849 ± 0.037	3.335GlyAsn: 3.335 ± 0.075	3.218GlyPro: 3.218 ± 0.052	2.628GlyGln: 2.628 ± 0.044	4.817GlyArg: 4.817 ± 0.069	6.432GlySer: 6.432 ± 0.119	6.658GlyThr: 6.658 ± 0.174	5.638GlyVal: 5.638 ± 0.067	1.52GlyTrp: 1.52 ± 0.032	2.279GlyTyr: 2.279 ± 0.049	0.001GlyXaa: 0.001 ± 0.001
His	2.097HisAla: 2.097 ± 0.042	0.255HisCys: 0.255 ± 0.014	1.161HisAsp: 1.161 ± 0.028	1.196HisGlu: 1.196 ± 0.033	0.983HisPhe: 0.983 ± 0.028	1.856HisGly: 1.856 ± 0.038	0.651HisHis: 0.651 ± 0.025	0.76HisIle: 0.76 ± 0.026	0.543HisLys: 0.543 ± 0.018	2.237HisLeu: 2.237 ± 0.045	0.322HisMet: 0.322 ± 0.017	0.501HisAsn: 0.501 ± 0.018	1.462HisPro: 1.462 ± 0.032	0.696HisGln: 0.696 ± 0.022	1.431HisArg: 1.431 ± 0.034	1.155HisSer: 1.155 ± 0.029	0.936HisThr: 0.936 ± 0.022	1.294HisVal: 1.294 ± 0.034	0.374HisTrp: 0.374 ± 0.018	0.601HisTyr: 0.601 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.518IleAla: 5.518 ± 0.061	0.514IleCys: 0.514 ± 0.019	3.033IleAsp: 3.033 ± 0.046	3.34IleGlu: 3.34 ± 0.056	1.607IlePhe: 1.607 ± 0.039	4.258IleGly: 4.258 ± 0.061	1.104IleHis: 1.104 ± 0.034	2.025IleIle: 2.025 ± 0.04	1.606IleLys: 1.606 ± 0.034	4.676IleLeu: 4.676 ± 0.069	0.651IleMet: 0.651 ± 0.022	1.592IleAsn: 1.592 ± 0.037	2.748IlePro: 2.748 ± 0.046	1.534IleGln: 1.534 ± 0.034	3.209IleArg: 3.209 ± 0.055	3.446IleSer: 3.446 ± 0.055	3.193IleThr: 3.193 ± 0.068	3.374IleVal: 3.374 ± 0.048	0.578IleTrp: 0.578 ± 0.022	1.05IleTyr: 1.05 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.505LysAla: 4.505 ± 0.067	0.272LysCys: 0.272 ± 0.014	2.577LysAsp: 2.577 ± 0.046	2.652LysGlu: 2.652 ± 0.048	1.422LysPhe: 1.422 ± 0.031	3.219LysGly: 3.219 ± 0.059	0.85LysHis: 0.85 ± 0.028	2.173LysIle: 2.173 ± 0.037	2.285LysLys: 2.285 ± 0.052	4.489LysLeu: 4.489 ± 0.062	0.975LysMet: 0.975 ± 0.025	1.354LysAsn: 1.354 ± 0.034	2.873LysPro: 2.873 ± 0.053	1.401LysGln: 1.401 ± 0.031	2.676LysArg: 2.676 ± 0.051	2.849LysSer: 2.849 ± 0.058	2.538LysThr: 2.538 ± 0.046	2.945LysVal: 2.945 ± 0.058	0.723LysTrp: 0.723 ± 0.021	0.744LysTyr: 0.744 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.662LeuAla: 11.662 ± 0.097	1.036LeuCys: 1.036 ± 0.031	5.638LeuAsp: 5.638 ± 0.059	5.63LeuGlu: 5.63 ± 0.076	3.494LeuPhe: 3.494 ± 0.049	7.926LeuGly: 7.926 ± 0.078	2.019LeuHis: 2.019 ± 0.041	4.683LeuIle: 4.683 ± 0.063	4.593LeuLys: 4.593 ± 0.067	9.815LeuLeu: 9.815 ± 0.123	2.033LeuMet: 2.033 ± 0.044	3.237LeuAsn: 3.237 ± 0.055	5.843LeuPro: 5.843 ± 0.071	2.938LeuGln: 2.938 ± 0.043	6.429LeuArg: 6.429 ± 0.072	6.998LeuSer: 6.998 ± 0.077	6.619LeuThr: 6.619 ± 0.095	6.704LeuVal: 6.704 ± 0.072	1.276LeuTrp: 1.276 ± 0.032	1.884LeuTyr: 1.884 ± 0.035	0.002LeuXaa: 0.002 ± 0.001
Met	2.172MetAla: 2.172 ± 0.039	0.12MetCys: 0.12 ± 0.009	0.997MetAsp: 0.997 ± 0.026	1.167MetGlu: 1.167 ± 0.029	0.672MetPhe: 0.672 ± 0.023	1.452MetGly: 1.452 ± 0.035	0.375MetHis: 0.375 ± 0.016	1.18MetIle: 1.18 ± 0.031	1.384MetLys: 1.384 ± 0.032	2.031MetLeu: 2.031 ± 0.044	0.483MetMet: 0.483 ± 0.02	0.881MetAsn: 0.881 ± 0.024	1.33MetPro: 1.33 ± 0.031	0.659MetGln: 0.659 ± 0.023	1.331MetArg: 1.331 ± 0.032	1.365MetSer: 1.365 ± 0.031	1.314MetThr: 1.314 ± 0.032	1.356MetVal: 1.356 ± 0.029	0.209MetTrp: 0.209 ± 0.012	0.238MetTyr: 0.238 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.43AsnAla: 3.43 ± 0.056	0.287AsnCys: 0.287 ± 0.015	1.616AsnAsp: 1.616 ± 0.034	1.554AsnGlu: 1.554 ± 0.034	1.339AsnPhe: 1.339 ± 0.031	3.608AsnGly: 3.608 ± 0.084	0.736AsnHis: 0.736 ± 0.023	1.382AsnIle: 1.382 ± 0.037	0.934AsnLys: 0.934 ± 0.03	3.471AsnLeu: 3.471 ± 0.053	0.461AsnMet: 0.461 ± 0.019	1.281AsnAsn: 1.281 ± 0.045	2.417AsnPro: 2.417 ± 0.047	1.067AsnGln: 1.067 ± 0.027	1.92AsnArg: 1.92 ± 0.038	2.22AsnSer: 2.22 ± 0.059	2.081AsnThr: 2.081 ± 0.069	2.216AsnVal: 2.216 ± 0.05	0.602AsnTrp: 0.602 ± 0.023	0.89AsnTyr: 0.89 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.296ProAla: 6.296 ± 0.08	0.372ProCys: 0.372 ± 0.018	3.474ProAsp: 3.474 ± 0.053	4.036ProGlu: 4.036 ± 0.064	2.046ProPhe: 2.046 ± 0.039	4.761ProGly: 4.761 ± 0.055	1.003ProHis: 1.003 ± 0.032	2.321ProIle: 2.321 ± 0.04	2.357ProLys: 2.357 ± 0.046	4.837ProLeu: 4.837 ± 0.051	1.282ProMet: 1.282 ± 0.032	1.732ProAsn: 1.732 ± 0.04	2.837ProPro: 2.837 ± 0.061	1.597ProGln: 1.597 ± 0.036	2.452ProArg: 2.452 ± 0.043	3.394ProSer: 3.394 ± 0.053	3.063ProThr: 3.063 ± 0.046	4.143ProVal: 4.143 ± 0.061	0.839ProTrp: 0.839 ± 0.023	1.115ProTyr: 1.115 ± 0.028	0.001ProXaa: 0.001 ± 0.001
Gln	3.502GlnAla: 3.502 ± 0.058	0.257GlnCys: 0.257 ± 0.013	1.323GlnAsp: 1.323 ± 0.031	1.558GlnGlu: 1.558 ± 0.04	1.19GlnPhe: 1.19 ± 0.028	2.295GlnGly: 2.295 ± 0.041	0.627GlnHis: 0.627 ± 0.024	1.689GlnIle: 1.689 ± 0.033	1.406GlnLys: 1.406 ± 0.037	3.11GlnLeu: 3.11 ± 0.051	0.7GlnMet: 0.7 ± 0.022	1.002GlnAsn: 1.002 ± 0.029	1.852GlnPro: 1.852 ± 0.04	1.247GlnGln: 1.247 ± 0.035	2.162GlnArg: 2.162 ± 0.043	2.048GlnSer: 2.048 ± 0.043	1.889GlnThr: 1.889 ± 0.043	2.213GlnVal: 2.213 ± 0.038	0.55GlnTrp: 0.55 ± 0.019	0.597GlnTyr: 0.597 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	5.363ArgAla: 5.363 ± 0.065	0.553ArgCys: 0.553 ± 0.02	3.279ArgAsp: 3.279 ± 0.051	4.031ArgGlu: 4.031 ± 0.076	2.966ArgPhe: 2.966 ± 0.046	3.973ArgGly: 3.973 ± 0.057	1.431ArgHis: 1.431 ± 0.039	3.47ArgIle: 3.47 ± 0.05	2.652ArgLys: 2.652 ± 0.054	6.585ArgLeu: 6.585 ± 0.076	1.581ArgMet: 1.581 ± 0.035	1.903ArgAsn: 1.903 ± 0.033	2.922ArgPro: 2.922 ± 0.05	2.175ArgGln: 2.175 ± 0.048	4.248ArgArg: 4.248 ± 0.072	3.747ArgSer: 3.747 ± 0.05	3.088ArgThr: 3.088 ± 0.047	4.064ArgVal: 4.064 ± 0.061	1.113ArgTrp: 1.113 ± 0.027	1.576ArgTyr: 1.576 ± 0.032	0.002ArgXaa: 0.002 ± 0.001
Ser	6.74SerAla: 6.74 ± 0.084	0.625SerCys: 0.625 ± 0.023	3.404SerAsp: 3.404 ± 0.048	3.242SerGlu: 3.242 ± 0.049	2.697SerPhe: 2.697 ± 0.044	7.508SerGly: 7.508 ± 0.161	1.25SerHis: 1.25 ± 0.028	3.325SerIle: 3.325 ± 0.049	2.571SerLys: 2.571 ± 0.046	6.614SerLeu: 6.614 ± 0.079	1.355SerMet: 1.355 ± 0.03	2.314SerAsn: 2.314 ± 0.056	3.748SerPro: 3.748 ± 0.058	1.88SerGln: 1.88 ± 0.035	3.744SerArg: 3.744 ± 0.054	4.721SerSer: 4.721 ± 0.074	4.104SerThr: 4.104 ± 0.086	4.218SerVal: 4.218 ± 0.057	1.017SerTrp: 1.017 ± 0.027	1.534SerTyr: 1.534 ± 0.037	0.001SerXaa: 0.001 ± 0.001
Thr	6.517ThrAla: 6.517 ± 0.102	0.457ThrCys: 0.457 ± 0.017	3.009ThrAsp: 3.009 ± 0.048	2.669ThrGlu: 2.669 ± 0.044	2.668ThrPhe: 2.668 ± 0.056	6.353ThrGly: 6.353 ± 0.124	1.084ThrHis: 1.084 ± 0.028	3.204ThrIle: 3.204 ± 0.061	2.162ThrLys: 2.162 ± 0.039	7.228ThrLeu: 7.228 ± 0.119	1.066ThrMet: 1.066 ± 0.028	2.202ThrAsn: 2.202 ± 0.066	3.724ThrPro: 3.724 ± 0.059	1.594ThrGln: 1.594 ± 0.031	3.215ThrArg: 3.215 ± 0.049	3.935ThrSer: 3.935 ± 0.084	4.186ThrThr: 4.186 ± 0.108	4.606ThrVal: 4.606 ± 0.088	0.959ThrTrp: 0.959 ± 0.031	1.612ThrTyr: 1.612 ± 0.042	0.001ThrXaa: 0.001 ± 0.001
Val	7.091ValAla: 7.091 ± 0.083	0.72ValCys: 0.72 ± 0.022	3.464ValAsp: 3.464 ± 0.055	3.946ValGlu: 3.946 ± 0.06	2.719ValPhe: 2.719 ± 0.045	4.848ValGly: 4.848 ± 0.06	1.253ValHis: 1.253 ± 0.029	3.806ValIle: 3.806 ± 0.056	2.922ValLys: 2.922 ± 0.054	6.533ValLeu: 6.533 ± 0.077	1.536ValMet: 1.536 ± 0.038	2.353ValAsn: 2.353 ± 0.057	3.534ValPro: 3.534 ± 0.055	1.905ValGln: 1.905 ± 0.037	4.091ValArg: 4.091 ± 0.055	4.734ValSer: 4.734 ± 0.065	4.672ValThr: 4.672 ± 0.089	4.935ValVal: 4.935 ± 0.064	0.997ValTrp: 0.997 ± 0.025	1.356ValTyr: 1.356 ± 0.034	0.001ValXaa: 0.001 ± 0.001
Trp	1.205TrpAla: 1.205 ± 0.032	0.168TrpCys: 0.168 ± 0.01	0.798TrpAsp: 0.798 ± 0.023	0.741TrpGlu: 0.741 ± 0.026	0.681TrpPhe: 0.681 ± 0.022	0.966TrpGly: 0.966 ± 0.027	0.365TrpHis: 0.365 ± 0.014	0.899TrpIle: 0.899 ± 0.024	0.948TrpLys: 0.948 ± 0.028	1.832TrpLeu: 1.832 ± 0.041	0.466TrpMet: 0.466 ± 0.019	0.671TrpAsn: 0.671 ± 0.023	0.663TrpPro: 0.663 ± 0.022	0.715TrpGln: 0.715 ± 0.023	1.1TrpArg: 1.1 ± 0.03	1.138TrpSer: 1.138 ± 0.027	0.992TrpThr: 0.992 ± 0.03	0.905TrpVal: 0.905 ± 0.025	0.332TrpTrp: 0.332 ± 0.016	0.309TrpTyr: 0.309 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.028TyrAla: 2.028 ± 0.041	0.241TyrCys: 0.241 ± 0.014	1.39TyrAsp: 1.39 ± 0.031	1.284TyrGlu: 1.284 ± 0.028	1.092TyrPhe: 1.092 ± 0.028	1.952TyrGly: 1.952 ± 0.039	0.545TyrHis: 0.545 ± 0.019	0.764TyrIle: 0.764 ± 0.023	0.692TyrLys: 0.692 ± 0.023	2.267TyrLeu: 2.267 ± 0.043	0.3TyrMet: 0.3 ± 0.013	0.727TyrAsn: 0.727 ± 0.023	1.103TyrPro: 1.103 ± 0.026	0.977TyrGln: 0.977 ± 0.027	1.726TyrArg: 1.726 ± 0.039	1.446TyrSer: 1.446 ± 0.036	1.407TyrThr: 1.407 ± 0.039	1.411TyrVal: 1.411 ± 0.035	0.387TyrTrp: 0.387 ± 0.016	0.657TyrTyr: 0.657 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.018XaaXaa: 0.018 ± 0.006

Statistics based on 5352 proteins (1447052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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