Amino acid dipepetide frequency for Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.279AlaAla: 3.279 ± 1.725
1.192AlaCys: 1.192 ± 0.788
2.385AlaAsp: 2.385 ± 0.383
3.577AlaGlu: 3.577 ± 0.725
2.086AlaPhe: 2.086 ± 1.249
2.385AlaGly: 2.385 ± 1.183
0.894AlaHis: 0.894 ± 0.476
2.086AlaIle: 2.086 ± 0.79
2.385AlaLys: 2.385 ± 1.057
5.663AlaLeu: 5.663 ± 1.659
0.596AlaMet: 0.596 ± 0.318
2.086AlaAsn: 2.086 ± 0.727
0.894AlaPro: 0.894 ± 1.267
1.192AlaGln: 1.192 ± 0.901
1.49AlaArg: 1.49 ± 0.53
2.385AlaSer: 2.385 ± 1.522
1.192AlaThr: 1.192 ± 0.302
3.279AlaVal: 3.279 ± 1.49
0.298AlaTrp: 0.298 ± 0.447
0.894AlaTyr: 0.894 ± 0.396
0.0AlaXaa: 0.0 ± 0.0
Cys
0.596CysAla: 0.596 ± 0.38
0.298CysCys: 0.298 ± 0.159
2.086CysAsp: 2.086 ± 0.798
0.894CysGlu: 0.894 ± 0.476
1.788CysPhe: 1.788 ± 0.6
1.192CysGly: 1.192 ± 1.47
1.192CysHis: 1.192 ± 0.684
2.086CysIle: 2.086 ± 0.79
2.086CysLys: 2.086 ± 1.395
3.875CysLeu: 3.875 ± 0.8
0.894CysMet: 0.894 ± 0.374
1.49CysAsn: 1.49 ± 1.382
2.086CysPro: 2.086 ± 0.786
1.192CysGln: 1.192 ± 0.431
1.49CysArg: 1.49 ± 0.916
1.49CysSer: 1.49 ± 1.382
0.596CysThr: 0.596 ± 0.436
0.894CysVal: 0.894 ± 0.476
0.596CysTrp: 0.596 ± 1.105
0.596CysTyr: 0.596 ± 0.318
0.0CysXaa: 0.0 ± 0.0
Asp
1.192AspAla: 1.192 ± 0.901
1.49AspCys: 1.49 ± 0.53
2.981AspAsp: 2.981 ± 1.061
2.683AspGlu: 2.683 ± 1.009
2.385AspPhe: 2.385 ± 0.376
3.577AspGly: 3.577 ± 0.999
1.788AspHis: 1.788 ± 0.798
2.981AspIle: 2.981 ± 0.753
4.769AspLys: 4.769 ± 1.904
9.24AspLeu: 9.24 ± 3.816
2.385AspMet: 2.385 ± 1.228
1.192AspAsn: 1.192 ± 0.417
2.385AspPro: 2.385 ± 0.861
3.279AspGln: 3.279 ± 0.649
2.086AspArg: 2.086 ± 0.683
4.173AspSer: 4.173 ± 0.755
0.894AspThr: 0.894 ± 0.693
3.875AspVal: 3.875 ± 1.106
1.49AspTrp: 1.49 ± 0.794
2.981AspTyr: 2.981 ± 0.984
0.0AspXaa: 0.0 ± 0.0
Glu
3.577GluAla: 3.577 ± 0.667
1.49GluCys: 1.49 ± 0.794
5.663GluAsp: 5.663 ± 1.733
6.557GluGlu: 6.557 ± 2.301
4.471GluPhe: 4.471 ± 1.59
2.683GluGly: 2.683 ± 0.953
1.49GluHis: 1.49 ± 0.492
3.577GluIle: 3.577 ± 0.977
4.173GluLys: 4.173 ± 0.762
4.769GluLeu: 4.769 ± 0.752
1.788GluMet: 1.788 ± 0.565
2.981GluAsn: 2.981 ± 0.336
1.788GluPro: 1.788 ± 0.654
2.086GluGln: 2.086 ± 0.231
3.875GluArg: 3.875 ± 1.442
5.067GluSer: 5.067 ± 1.425
3.577GluThr: 3.577 ± 1.2
2.683GluVal: 2.683 ± 0.392
0.596GluTrp: 0.596 ± 0.318
2.086GluTyr: 2.086 ± 0.79
0.0GluXaa: 0.0 ± 0.0
Phe
1.49PheAla: 1.49 ± 0.817
0.894PheCys: 0.894 ± 0.949
2.385PheAsp: 2.385 ± 1.09
5.663PheGlu: 5.663 ± 2.107
2.385PhePhe: 2.385 ± 0.865
2.981PheGly: 2.981 ± 0.903
0.596PheHis: 0.596 ± 0.318
2.683PheIle: 2.683 ± 1.081
5.067PheLys: 5.067 ± 1.266
4.769PheLeu: 4.769 ± 1.73
1.192PheMet: 1.192 ± 0.635
2.385PheAsn: 2.385 ± 0.605
1.192PhePro: 1.192 ± 0.635
2.385PheGln: 2.385 ± 0.861
3.577PheArg: 3.577 ± 0.667
5.961PheSer: 5.961 ± 1.0
2.981PheThr: 2.981 ± 0.903
2.683PheVal: 2.683 ± 1.081
0.298PheTrp: 0.298 ± 0.523
1.788PheTyr: 1.788 ± 0.654
0.0PheXaa: 0.0 ± 0.0
Gly
3.279GlyAla: 3.279 ± 2.21
0.894GlyCys: 0.894 ± 0.476
2.086GlyAsp: 2.086 ± 0.79
4.173GlyGlu: 4.173 ± 1.315
1.192GlyPhe: 1.192 ± 0.635
2.385GlyGly: 2.385 ± 1.183
0.596GlyHis: 0.596 ± 0.318
3.875GlyIle: 3.875 ± 1.185
2.385GlyLys: 2.385 ± 1.09
6.259GlyLeu: 6.259 ± 1.019
1.788GlyMet: 1.788 ± 1.354
2.086GlyAsn: 2.086 ± 0.753
2.981GlyPro: 2.981 ± 0.956
1.49GlyGln: 1.49 ± 0.916
3.875GlyArg: 3.875 ± 0.458
4.769GlySer: 4.769 ± 1.24
1.788GlyThr: 1.788 ± 1.277
4.471GlyVal: 4.471 ± 1.06
1.49GlyTrp: 1.49 ± 1.06
1.49GlyTyr: 1.49 ± 0.168
0.0GlyXaa: 0.0 ± 0.0
His
0.298HisAla: 0.298 ± 0.523
0.894HisCys: 0.894 ± 1.18
1.192HisAsp: 1.192 ± 1.044
0.596HisGlu: 0.596 ± 0.318
0.596HisPhe: 0.596 ± 0.608
0.596HisGly: 0.596 ± 0.38
0.894HisHis: 0.894 ± 0.396
1.49HisIle: 1.49 ± 0.817
0.894HisLys: 0.894 ± 0.476
5.365HisLeu: 5.365 ± 2.007
0.596HisMet: 0.596 ± 0.318
2.086HisAsn: 2.086 ± 0.231
0.894HisPro: 0.894 ± 0.374
0.596HisGln: 0.596 ± 0.318
1.192HisArg: 1.192 ± 0.872
1.192HisSer: 1.192 ± 0.431
0.894HisThr: 0.894 ± 0.453
0.894HisVal: 0.894 ± 0.476
0.298HisTrp: 0.298 ± 0.159
1.192HisTyr: 1.192 ± 0.91
0.0HisXaa: 0.0 ± 0.0
Ile
1.788IleAla: 1.788 ± 0.748
1.788IleCys: 1.788 ± 0.6
5.365IleAsp: 5.365 ± 0.785
2.683IleGlu: 2.683 ± 0.529
3.577IlePhe: 3.577 ± 0.539
2.086IleGly: 2.086 ± 0.79
0.298IleHis: 0.298 ± 0.447
2.385IleIle: 2.385 ± 1.684
4.471IleLys: 4.471 ± 0.504
6.259IleLeu: 6.259 ± 0.674
1.49IleMet: 1.49 ± 0.738
2.385IleAsn: 2.385 ± 0.376
1.49IlePro: 1.49 ± 0.492
2.385IleGln: 2.385 ± 0.835
2.385IleArg: 2.385 ± 0.376
5.961IleSer: 5.961 ± 1.361
3.577IleThr: 3.577 ± 0.678
4.173IleVal: 4.173 ± 1.807
0.0IleTrp: 0.0 ± 0.0
0.298IleTyr: 0.298 ± 0.523
0.0IleXaa: 0.0 ± 0.0
Lys
2.981LysAla: 2.981 ± 2.131
2.086LysCys: 2.086 ± 1.249
4.471LysAsp: 4.471 ± 1.931
4.173LysGlu: 4.173 ± 0.883
5.961LysPhe: 5.961 ± 1.738
4.173LysGly: 4.173 ± 1.757
1.192LysHis: 1.192 ± 0.431
2.385LysIle: 2.385 ± 0.621
2.683LysLys: 2.683 ± 1.318
9.24LysLeu: 9.24 ± 3.589
1.49LysMet: 1.49 ± 0.53
3.279LysAsn: 3.279 ± 1.384
1.49LysPro: 1.49 ± 1.198
2.385LysGln: 2.385 ± 1.106
3.279LysArg: 3.279 ± 0.25
5.663LysSer: 5.663 ± 1.291
4.173LysThr: 4.173 ± 2.35
5.961LysVal: 5.961 ± 1.616
0.894LysTrp: 0.894 ± 0.396
2.385LysTyr: 2.385 ± 1.302
0.0LysXaa: 0.0 ± 0.0
Leu
4.769LeuAla: 4.769 ± 0.949
4.769LeuCys: 4.769 ± 1.61
5.067LeuAsp: 5.067 ± 1.232
6.557LeuGlu: 6.557 ± 1.323
3.577LeuPhe: 3.577 ± 0.999
5.365LeuGly: 5.365 ± 1.56
2.683LeuHis: 2.683 ± 1.188
8.942LeuIle: 8.942 ± 1.414
8.346LeuLys: 8.346 ± 1.68
15.797LeuLeu: 15.797 ± 1.993
4.471LeuMet: 4.471 ± 1.903
8.346LeuAsn: 8.346 ± 1.378
2.981LeuPro: 2.981 ± 1.821
3.279LeuGln: 3.279 ± 1.217
5.961LeuArg: 5.961 ± 1.0
10.432LeuSer: 10.432 ± 0.891
7.75LeuThr: 7.75 ± 1.249
6.557LeuVal: 6.557 ± 1.408
0.596LeuTrp: 0.596 ± 0.318
2.981LeuTyr: 2.981 ± 1.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.49MetAla: 1.49 ± 0.738
0.596MetCys: 0.596 ± 0.318
2.086MetAsp: 2.086 ± 0.435
0.298MetGlu: 0.298 ± 0.159
2.385MetPhe: 2.385 ± 1.06
2.981MetGly: 2.981 ± 1.49
0.596MetHis: 0.596 ± 0.38
1.49MetIle: 1.49 ± 0.817
2.385MetLys: 2.385 ± 1.27
2.981MetLeu: 2.981 ± 0.336
0.894MetMet: 0.894 ± 0.476
0.298MetAsn: 0.298 ± 0.159
1.192MetPro: 1.192 ± 0.302
0.298MetGln: 0.298 ± 0.159
2.385MetArg: 2.385 ± 1.057
2.683MetSer: 2.683 ± 1.044
1.192MetThr: 1.192 ± 0.431
1.192MetVal: 1.192 ± 0.431
0.0MetTrp: 0.0 ± 0.0
0.894MetTyr: 0.894 ± 0.396
0.0MetXaa: 0.0 ± 0.0
Asn
2.683AsnAla: 2.683 ± 0.392
0.0AsnCys: 0.0 ± 0.0
3.875AsnAsp: 3.875 ± 0.806
1.49AsnGlu: 1.49 ± 0.492
3.577AsnPhe: 3.577 ± 0.667
2.385AsnGly: 2.385 ± 0.605
1.192AsnHis: 1.192 ± 1.47
1.788AsnIle: 1.788 ± 1.078
3.875AsnLys: 3.875 ± 1.312
5.961AsnLeu: 5.961 ± 0.406
1.788AsnMet: 1.788 ± 0.532
2.086AsnAsn: 2.086 ± 0.544
2.683AsnPro: 2.683 ± 0.529
2.385AsnGln: 2.385 ± 0.861
2.385AsnArg: 2.385 ± 0.621
5.365AsnSer: 5.365 ± 0.667
2.385AsnThr: 2.385 ± 0.376
2.385AsnVal: 2.385 ± 0.874
0.298AsnTrp: 0.298 ± 0.159
1.788AsnTyr: 1.788 ± 0.792
0.0AsnXaa: 0.0 ± 0.0
Pro
1.192ProAla: 1.192 ± 0.761
0.298ProCys: 0.298 ± 0.159
2.683ProAsp: 2.683 ± 0.579
2.385ProGlu: 2.385 ± 1.27
2.086ProPhe: 2.086 ± 0.727
2.086ProGly: 2.086 ± 0.753
1.788ProHis: 1.788 ± 0.906
0.894ProIle: 0.894 ± 0.476
2.385ProLys: 2.385 ± 0.835
4.471ProLeu: 4.471 ± 1.963
0.894ProMet: 0.894 ± 0.476
1.788ProAsn: 1.788 ± 1.078
0.894ProPro: 0.894 ± 1.723
1.49ProGln: 1.49 ± 2.237
0.894ProArg: 0.894 ± 0.374
2.683ProSer: 2.683 ± 0.847
1.788ProThr: 1.788 ± 0.798
1.788ProVal: 1.788 ± 1.141
0.0ProTrp: 0.0 ± 0.0
1.192ProTyr: 1.192 ± 1.401
0.0ProXaa: 0.0 ± 0.0
Gln
1.192GlnAla: 1.192 ± 1.259
0.596GlnCys: 0.596 ± 0.436
0.596GlnAsp: 0.596 ± 0.38
1.49GlnGlu: 1.49 ± 0.817
1.788GlnPhe: 1.788 ± 1.078
2.683GlnGly: 2.683 ± 1.176
0.298GlnHis: 0.298 ± 0.159
2.385GlnIle: 2.385 ± 0.605
2.981GlnLys: 2.981 ± 0.891
2.981GlnLeu: 2.981 ± 0.685
0.596GlnMet: 0.596 ± 0.318
2.981GlnAsn: 2.981 ± 0.46
0.894GlnPro: 0.894 ± 0.815
0.894GlnGln: 0.894 ± 1.342
2.385GlnArg: 2.385 ± 1.106
3.875GlnSer: 3.875 ± 0.458
1.192GlnThr: 1.192 ± 1.327
2.385GlnVal: 2.385 ± 0.861
0.298GlnTrp: 0.298 ± 0.447
1.192GlnTyr: 1.192 ± 0.872
0.0GlnXaa: 0.0 ± 0.0
Arg
1.192ArgAla: 1.192 ± 0.77
2.086ArgCys: 2.086 ± 1.367
2.981ArgAsp: 2.981 ± 0.46
4.471ArgGlu: 4.471 ± 1.44
3.279ArgPhe: 3.279 ± 1.384
2.385ArgGly: 2.385 ± 0.475
0.894ArgHis: 0.894 ± 1.0
2.385ArgIle: 2.385 ± 0.376
4.471ArgLys: 4.471 ± 1.481
7.75ArgLeu: 7.75 ± 0.507
1.788ArgMet: 1.788 ± 0.624
2.385ArgAsn: 2.385 ± 0.376
1.49ArgPro: 1.49 ± 0.738
2.385ArgGln: 2.385 ± 0.865
3.875ArgArg: 3.875 ± 0.792
5.067ArgSer: 5.067 ± 0.625
2.981ArgThr: 2.981 ± 0.903
1.192ArgVal: 1.192 ± 0.302
0.298ArgTrp: 0.298 ± 0.159
0.894ArgTyr: 0.894 ± 0.476
0.0ArgXaa: 0.0 ± 0.0
Ser
3.875SerAla: 3.875 ± 1.809
4.769SerCys: 4.769 ± 2.046
6.259SerAsp: 6.259 ± 1.402
7.452SerGlu: 7.452 ± 2.749
5.365SerPhe: 5.365 ± 1.578
5.365SerGly: 5.365 ± 0.573
3.279SerHis: 3.279 ± 0.858
3.875SerIle: 3.875 ± 1.331
5.663SerLys: 5.663 ± 0.84
9.836SerLeu: 9.836 ± 1.843
1.788SerMet: 1.788 ± 0.6
2.086SerAsn: 2.086 ± 0.435
2.086SerPro: 2.086 ± 0.683
2.683SerGln: 2.683 ± 1.793
4.173SerArg: 4.173 ± 0.917
6.259SerSer: 6.259 ± 0.67
4.173SerThr: 4.173 ± 1.379
5.961SerVal: 5.961 ± 1.37
0.596SerTrp: 0.596 ± 0.318
2.385SerTyr: 2.385 ± 0.475
0.0SerXaa: 0.0 ± 0.0
Thr
1.49ThrAla: 1.49 ± 1.313
0.298ThrCys: 0.298 ± 0.523
2.086ThrAsp: 2.086 ± 0.79
2.683ThrGlu: 2.683 ± 0.529
1.788ThrPhe: 1.788 ± 2.513
2.683ThrGly: 2.683 ± 0.972
1.788ThrHis: 1.788 ± 0.792
2.683ThrIle: 2.683 ± 0.529
4.173ThrLys: 4.173 ± 1.454
4.769ThrLeu: 4.769 ± 1.213
1.49ThrMet: 1.49 ± 1.506
4.173ThrAsn: 4.173 ± 1.739
2.086ThrPro: 2.086 ± 0.435
0.596ThrGln: 0.596 ± 0.895
2.683ThrArg: 2.683 ± 0.579
5.663ThrSer: 5.663 ± 1.659
3.279ThrThr: 3.279 ± 0.822
2.385ThrVal: 2.385 ± 1.057
1.49ThrTrp: 1.49 ± 1.402
0.596ThrTyr: 0.596 ± 1.105
0.0ThrXaa: 0.0 ± 0.0
Val
2.683ValAla: 2.683 ± 1.009
1.788ValCys: 1.788 ± 0.654
1.49ValAsp: 1.49 ± 0.738
3.875ValGlu: 3.875 ± 0.592
2.385ValPhe: 2.385 ± 1.27
3.279ValGly: 3.279 ± 1.869
0.596ValHis: 0.596 ± 0.895
3.875ValIle: 3.875 ± 0.763
4.173ValLys: 4.173 ± 1.395
5.365ValLeu: 5.365 ± 0.785
0.596ValMet: 0.596 ± 0.318
4.471ValAsn: 4.471 ± 1.068
2.683ValPro: 2.683 ± 1.188
1.192ValGln: 1.192 ± 0.761
4.769ValArg: 4.769 ± 1.406
6.259ValSer: 6.259 ± 0.782
1.788ValThr: 1.788 ± 0.646
5.067ValVal: 5.067 ± 1.833
1.49ValTrp: 1.49 ± 0.653
1.788ValTyr: 1.788 ± 0.646
0.0ValXaa: 0.0 ± 0.0
Trp
0.298TrpAla: 0.298 ± 0.159
0.298TrpCys: 0.298 ± 0.523
1.49TrpAsp: 1.49 ± 0.738
0.894TrpGlu: 0.894 ± 0.453
1.192TrpPhe: 1.192 ± 0.635
0.894TrpGly: 0.894 ± 0.396
0.298TrpHis: 0.298 ± 0.159
0.596TrpIle: 0.596 ± 0.38
0.596TrpLys: 0.596 ± 0.436
1.49TrpLeu: 1.49 ± 0.168
0.298TrpMet: 0.298 ± 0.523
0.0TrpAsn: 0.0 ± 0.0
0.298TrpPro: 0.298 ± 0.447
0.298TrpGln: 0.298 ± 0.809
0.0TrpArg: 0.0 ± 0.0
0.298TrpSer: 0.298 ± 0.159
0.894TrpThr: 0.894 ± 1.042
0.596TrpVal: 0.596 ± 0.318
0.0TrpTrp: 0.0 ± 0.0
0.298TrpTyr: 0.298 ± 0.523
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.894TyrAla: 0.894 ± 0.396
0.894TyrCys: 0.894 ± 0.949
0.596TyrAsp: 0.596 ± 0.318
2.683TyrGlu: 2.683 ± 0.847
1.49TyrPhe: 1.49 ± 0.794
1.192TyrGly: 1.192 ± 0.302
0.298TyrHis: 0.298 ± 0.159
2.385TyrIle: 2.385 ± 0.475
2.385TyrLys: 2.385 ± 0.475
2.385TyrLeu: 2.385 ± 2.831
1.192TyrMet: 1.192 ± 0.302
1.788TyrAsn: 1.788 ± 1.279
1.192TyrPro: 1.192 ± 0.77
1.192TyrGln: 1.192 ± 0.872
1.49TyrArg: 1.49 ± 0.53
2.683TyrSer: 2.683 ± 0.392
1.788TyrThr: 1.788 ± 0.654
1.192TyrVal: 1.192 ± 0.635
0.0TyrTrp: 0.0 ± 0.0
0.298TyrTyr: 0.298 ± 0.159
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3356 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski