Amino acid dipepetide frequency for Aspergillus novofumigatus IBT 16806

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.939AlaAla: 8.939 ± 0.055	1.145AlaCys: 1.145 ± 0.018	4.294AlaAsp: 4.294 ± 0.026	5.164AlaGlu: 5.164 ± 0.044	3.214AlaPhe: 3.214 ± 0.022	5.84AlaGly: 5.84 ± 0.04	1.831AlaHis: 1.831 ± 0.022	4.284AlaIle: 4.284 ± 0.028	3.854AlaLys: 3.854 ± 0.029	7.91AlaLeu: 7.91 ± 0.043	1.997AlaMet: 1.997 ± 0.019	2.916AlaAsn: 2.916 ± 0.023	4.562AlaPro: 4.562 ± 0.039	3.416AlaGln: 3.416 ± 0.028	5.1AlaArg: 5.1 ± 0.036	7.337AlaSer: 7.337 ± 0.045	5.196AlaThr: 5.196 ± 0.033	5.607AlaVal: 5.607 ± 0.034	1.192AlaTrp: 1.192 ± 0.016	2.224AlaTyr: 2.224 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.009CysAla: 1.009 ± 0.016	0.286CysCys: 0.286 ± 0.009	0.722CysAsp: 0.722 ± 0.013	0.62CysGlu: 0.62 ± 0.013	0.561CysPhe: 0.561 ± 0.012	0.976CysGly: 0.976 ± 0.017	0.368CysHis: 0.368 ± 0.01	0.72CysIle: 0.72 ± 0.012	0.523CysLys: 0.523 ± 0.011	1.422CysLeu: 1.422 ± 0.021	0.296CysMet: 0.296 ± 0.008	0.456CysAsn: 0.456 ± 0.01	0.73CysPro: 0.73 ± 0.012	0.505CysGln: 0.505 ± 0.01	0.875CysArg: 0.875 ± 0.014	1.043CysSer: 1.043 ± 0.018	0.727CysThr: 0.727 ± 0.013	0.863CysVal: 0.863 ± 0.014	0.221CysTrp: 0.221 ± 0.007	0.385CysTyr: 0.385 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.64AspAla: 4.64 ± 0.032	0.658AspCys: 0.658 ± 0.012	3.796AspAsp: 3.796 ± 0.042	4.262AspGlu: 4.262 ± 0.039	2.138AspPhe: 2.138 ± 0.023	3.915AspGly: 3.915 ± 0.034	1.278AspHis: 1.278 ± 0.014	3.032AspIle: 3.032 ± 0.025	2.204AspLys: 2.204 ± 0.024	5.118AspLeu: 5.118 ± 0.031	1.22AspMet: 1.22 ± 0.015	1.82AspAsn: 1.82 ± 0.017	3.371AspPro: 3.371 ± 0.028	1.907AspGln: 1.907 ± 0.019	3.176AspArg: 3.176 ± 0.03	4.109AspSer: 4.109 ± 0.032	2.885AspThr: 2.885 ± 0.023	3.597AspVal: 3.597 ± 0.029	0.872AspTrp: 0.872 ± 0.015	1.64AspTyr: 1.64 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.226GluAla: 5.226 ± 0.037	0.66GluCys: 0.66 ± 0.014	4.032GluAsp: 4.032 ± 0.041	5.32GluGlu: 5.32 ± 0.055	1.933GluPhe: 1.933 ± 0.02	3.613GluGly: 3.613 ± 0.031	1.403GluHis: 1.403 ± 0.019	3.076GluIle: 3.076 ± 0.029	3.5GluLys: 3.5 ± 0.036	5.197GluLeu: 5.197 ± 0.041	1.429GluMet: 1.429 ± 0.018	2.265GluAsn: 2.265 ± 0.022	2.76GluPro: 2.76 ± 0.032	2.504GluGln: 2.504 ± 0.022	3.967GluArg: 3.967 ± 0.029	4.361GluSer: 4.361 ± 0.03	3.463GluThr: 3.463 ± 0.03	3.487GluVal: 3.487 ± 0.031	0.873GluTrp: 0.873 ± 0.013	1.704GluTyr: 1.704 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.094PheAla: 3.094 ± 0.029	0.607PheCys: 0.607 ± 0.011	2.264PheAsp: 2.264 ± 0.018	2.087PheGlu: 2.087 ± 0.021	1.681PhePhe: 1.681 ± 0.021	2.769PheGly: 2.769 ± 0.029	0.938PheHis: 0.938 ± 0.013	1.829PheIle: 1.829 ± 0.02	1.437PheLys: 1.437 ± 0.017	3.687PheLeu: 3.687 ± 0.031	0.796PheMet: 0.796 ± 0.013	1.404PheAsn: 1.404 ± 0.017	2.027PhePro: 2.027 ± 0.02	1.413PheGln: 1.413 ± 0.019	2.073PheArg: 2.073 ± 0.019	3.043PheSer: 3.043 ± 0.027	2.113PheThr: 2.113 ± 0.022	2.431PheVal: 2.431 ± 0.026	0.668PheTrp: 0.668 ± 0.013	1.169PheTyr: 1.169 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.25GlyAla: 5.25 ± 0.037	0.944GlyCys: 0.944 ± 0.017	3.528GlyAsp: 3.528 ± 0.027	3.525GlyGlu: 3.525 ± 0.03	2.761GlyPhe: 2.761 ± 0.027	5.159GlyGly: 5.159 ± 0.058	1.704GlyHis: 1.704 ± 0.021	3.473GlyIle: 3.473 ± 0.03	3.29GlyLys: 3.29 ± 0.026	6.189GlyLeu: 6.189 ± 0.036	1.557GlyMet: 1.557 ± 0.021	2.422GlyAsn: 2.422 ± 0.025	3.349GlyPro: 3.349 ± 0.029	2.61GlyGln: 2.61 ± 0.027	4.138GlyArg: 4.138 ± 0.037	5.665GlySer: 5.665 ± 0.046	3.922GlyThr: 3.922 ± 0.035	4.401GlyVal: 4.401 ± 0.035	1.191GlyTrp: 1.191 ± 0.015	2.145GlyTyr: 2.145 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.908HisAla: 1.908 ± 0.017	0.37HisCys: 0.37 ± 0.009	1.303HisAsp: 1.303 ± 0.017	1.314HisGlu: 1.314 ± 0.018	0.947HisPhe: 0.947 ± 0.015	1.744HisGly: 1.744 ± 0.023	0.89HisHis: 0.89 ± 0.019	1.246HisIle: 1.246 ± 0.016	0.849HisLys: 0.849 ± 0.014	2.325HisLeu: 2.325 ± 0.022	0.503HisMet: 0.503 ± 0.01	0.855HisAsn: 0.855 ± 0.013	1.753HisPro: 1.753 ± 0.019	0.994HisGln: 0.994 ± 0.015	1.643HisArg: 1.643 ± 0.017	1.933HisSer: 1.933 ± 0.021	1.281HisThr: 1.281 ± 0.015	1.437HisVal: 1.437 ± 0.018	0.361HisTrp: 0.361 ± 0.008	0.721HisTyr: 0.721 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.257IleAla: 4.257 ± 0.035	0.82IleCys: 0.82 ± 0.015	2.781IleAsp: 2.781 ± 0.025	2.801IleGlu: 2.801 ± 0.024	2.052IlePhe: 2.052 ± 0.023	3.18IleGly: 3.18 ± 0.027	1.254IleHis: 1.254 ± 0.016	2.542IleIle: 2.542 ± 0.027	2.053IleLys: 2.053 ± 0.022	4.796IleLeu: 4.796 ± 0.038	0.986IleMet: 0.986 ± 0.015	1.766IleAsn: 1.766 ± 0.019	3.116IlePro: 3.116 ± 0.024	1.934IleGln: 1.934 ± 0.022	2.942IleArg: 2.942 ± 0.024	3.909IleSer: 3.909 ± 0.033	2.773IleThr: 2.773 ± 0.025	3.24IleVal: 3.24 ± 0.028	0.737IleTrp: 0.737 ± 0.015	1.5IleTyr: 1.5 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.989LysAla: 3.989 ± 0.034	0.525LysCys: 0.525 ± 0.011	2.654LysAsp: 2.654 ± 0.023	3.274LysGlu: 3.274 ± 0.034	1.371LysPhe: 1.371 ± 0.015	2.82LysGly: 2.82 ± 0.026	1.102LysHis: 1.102 ± 0.015	2.157LysIle: 2.157 ± 0.022	2.964LysLys: 2.964 ± 0.04	3.905LysLeu: 3.905 ± 0.028	0.93LysMet: 0.93 ± 0.014	1.641LysAsn: 1.641 ± 0.019	2.583LysPro: 2.583 ± 0.029	1.812LysGln: 1.812 ± 0.02	3.342LysArg: 3.342 ± 0.031	3.31LysSer: 3.31 ± 0.027	2.627LysThr: 2.627 ± 0.025	2.731LysVal: 2.731 ± 0.025	0.646LysTrp: 0.646 ± 0.012	1.366LysTyr: 1.366 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.088LeuAla: 8.088 ± 0.044	1.354LeuCys: 1.354 ± 0.018	5.184LeuAsp: 5.184 ± 0.035	5.504LeuGlu: 5.504 ± 0.037	3.493LeuPhe: 3.493 ± 0.033	6.018LeuGly: 6.018 ± 0.038	2.345LeuHis: 2.345 ± 0.025	4.114LeuIle: 4.114 ± 0.03	4.092LeuLys: 4.092 ± 0.035	8.921LeuLeu: 8.921 ± 0.06	1.854LeuMet: 1.854 ± 0.019	3.245LeuAsn: 3.245 ± 0.026	5.585LeuPro: 5.585 ± 0.036	3.954LeuGln: 3.954 ± 0.034	6.126LeuArg: 6.126 ± 0.042	7.74LeuSer: 7.74 ± 0.043	4.919LeuThr: 4.919 ± 0.032	5.634LeuVal: 5.634 ± 0.039	1.262LeuTrp: 1.262 ± 0.019	2.517LeuTyr: 2.517 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.193MetAla: 2.193 ± 0.02	0.254MetCys: 0.254 ± 0.007	1.231MetAsp: 1.231 ± 0.015	1.296MetGlu: 1.296 ± 0.016	0.742MetPhe: 0.742 ± 0.012	1.431MetGly: 1.431 ± 0.019	0.489MetHis: 0.489 ± 0.01	1.023MetIle: 1.023 ± 0.014	0.968MetLys: 0.968 ± 0.013	1.864MetLeu: 1.864 ± 0.018	0.56MetMet: 0.56 ± 0.011	0.804MetAsn: 0.804 ± 0.014	1.189MetPro: 1.189 ± 0.016	0.874MetGln: 0.874 ± 0.013	1.28MetArg: 1.28 ± 0.017	1.823MetSer: 1.823 ± 0.019	1.332MetThr: 1.332 ± 0.015	1.362MetVal: 1.362 ± 0.018	0.268MetTrp: 0.268 ± 0.007	0.544MetTyr: 0.544 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.127AsnAla: 3.127 ± 0.024	0.478AsnCys: 0.478 ± 0.011	1.889AsnAsp: 1.889 ± 0.022	2.001AsnGlu: 2.001 ± 0.02	1.332AsnPhe: 1.332 ± 0.015	2.938AsnGly: 2.938 ± 0.026	0.867AsnHis: 0.867 ± 0.013	1.988AsnIle: 1.988 ± 0.02	1.441AsnLys: 1.441 ± 0.018	3.264AsnLeu: 3.264 ± 0.027	0.805AsnMet: 0.805 ± 0.012	1.388AsnAsn: 1.388 ± 0.017	2.444AsnPro: 2.444 ± 0.024	1.317AsnGln: 1.317 ± 0.019	2.02AsnArg: 2.02 ± 0.019	2.655AsnSer: 2.655 ± 0.024	2.054AsnThr: 2.054 ± 0.022	2.284AsnVal: 2.284 ± 0.022	0.57AsnTrp: 0.57 ± 0.012	1.062AsnTyr: 1.062 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.165ProAla: 5.165 ± 0.042	0.61ProCys: 0.61 ± 0.011	3.219ProAsp: 3.219 ± 0.027	3.811ProGlu: 3.811 ± 0.034	2.114ProPhe: 2.114 ± 0.022	3.889ProGly: 3.889 ± 0.029	1.349ProHis: 1.349 ± 0.017	2.461ProIle: 2.461 ± 0.023	2.463ProLys: 2.463 ± 0.024	4.842ProLeu: 4.842 ± 0.035	1.035ProMet: 1.035 ± 0.015	2.105ProAsn: 2.105 ± 0.018	4.548ProPro: 4.548 ± 0.062	2.395ProGln: 2.395 ± 0.029	3.493ProArg: 3.493 ± 0.031	6.195ProSer: 6.195 ± 0.052	3.762ProThr: 3.762 ± 0.034	3.677ProVal: 3.677 ± 0.031	0.789ProTrp: 0.789 ± 0.012	1.563ProTyr: 1.563 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.431GlnAla: 3.431 ± 0.031	0.488GlnCys: 0.488 ± 0.009	1.995GlnAsp: 1.995 ± 0.021	2.404GlnGlu: 2.404 ± 0.022	1.319GlnPhe: 1.319 ± 0.016	2.431GlnGly: 2.431 ± 0.024	1.049GlnHis: 1.049 ± 0.017	1.937GlnIle: 1.937 ± 0.022	1.939GlnLys: 1.939 ± 0.021	3.584GlnLeu: 3.584 ± 0.029	0.895GlnMet: 0.895 ± 0.013	1.547GlnAsn: 1.547 ± 0.017	2.502GlnPro: 2.502 ± 0.024	2.294GlnGln: 2.294 ± 0.041	2.726GlnArg: 2.726 ± 0.027	3.282GlnSer: 3.282 ± 0.026	2.388GlnThr: 2.388 ± 0.021	2.228GlnVal: 2.228 ± 0.021	0.6GlnTrp: 0.6 ± 0.011	1.156GlnTyr: 1.156 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.857ArgAla: 4.857 ± 0.036	0.784ArgCys: 0.784 ± 0.015	3.33ArgAsp: 3.33 ± 0.032	3.913ArgGlu: 3.913 ± 0.034	2.286ArgPhe: 2.286 ± 0.023	3.665ArgGly: 3.665 ± 0.033	1.619ArgHis: 1.619 ± 0.02	3.016ArgIle: 3.016 ± 0.024	3.443ArgLys: 3.443 ± 0.028	5.909ArgLeu: 5.909 ± 0.036	1.376ArgMet: 1.376 ± 0.017	2.318ArgAsn: 2.318 ± 0.023	3.571ArgPro: 3.571 ± 0.031	2.709ArgGln: 2.709 ± 0.025	5.355ArgArg: 5.355 ± 0.045	5.008ArgSer: 5.008 ± 0.04	3.413ArgThr: 3.413 ± 0.027	3.578ArgVal: 3.578 ± 0.028	0.986ArgTrp: 0.986 ± 0.014	1.771ArgTyr: 1.771 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.886SerAla: 6.886 ± 0.042	0.982SerCys: 0.982 ± 0.016	4.258SerAsp: 4.258 ± 0.028	4.222SerGlu: 4.222 ± 0.035	3.075SerPhe: 3.075 ± 0.025	5.561SerGly: 5.561 ± 0.041	2.033SerHis: 2.033 ± 0.022	4.071SerIle: 4.071 ± 0.028	3.623SerLys: 3.623 ± 0.031	7.652SerLeu: 7.652 ± 0.048	1.732SerMet: 1.732 ± 0.019	2.967SerAsn: 2.967 ± 0.027	5.484SerPro: 5.484 ± 0.049	3.392SerGln: 3.392 ± 0.03	5.198SerArg: 5.198 ± 0.043	8.89SerSer: 8.89 ± 0.07	5.554SerThr: 5.554 ± 0.049	4.812SerVal: 4.812 ± 0.032	1.163SerTrp: 1.163 ± 0.016	2.102SerTyr: 2.102 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.302ThrAla: 5.302 ± 0.039	0.785ThrCys: 0.785 ± 0.014	2.876ThrAsp: 2.876 ± 0.023	3.078ThrGlu: 3.078 ± 0.027	2.229ThrPhe: 2.229 ± 0.023	4.242ThrGly: 4.242 ± 0.037	1.246ThrHis: 1.246 ± 0.018	3.054ThrIle: 3.054 ± 0.024	2.417ThrLys: 2.417 ± 0.02	5.32ThrLeu: 5.32 ± 0.032	1.197ThrMet: 1.197 ± 0.015	1.995ThrAsn: 1.995 ± 0.02	4.065ThrPro: 4.065 ± 0.033	2.032ThrGln: 2.032 ± 0.02	3.09ThrArg: 3.09 ± 0.027	5.249ThrSer: 5.249 ± 0.036	4.048ThrThr: 4.048 ± 0.041	3.947ThrVal: 3.947 ± 0.03	0.866ThrTrp: 0.866 ± 0.016	1.633ThrTyr: 1.633 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.287ValAla: 5.287 ± 0.032	0.911ValCys: 0.911 ± 0.012	3.735ValAsp: 3.735 ± 0.03	3.78ValGlu: 3.78 ± 0.034	2.507ValPhe: 2.507 ± 0.022	3.997ValGly: 3.997 ± 0.027	1.465ValHis: 1.465 ± 0.018	3.133ValIle: 3.133 ± 0.028	2.815ValLys: 2.815 ± 0.023	5.803ValLeu: 5.803 ± 0.044	1.33ValMet: 1.33 ± 0.016	2.254ValAsn: 2.254 ± 0.022	3.631ValPro: 3.631 ± 0.026	2.439ValGln: 2.439 ± 0.022	3.607ValArg: 3.607 ± 0.03	4.904ValSer: 4.904 ± 0.032	3.601ValThr: 3.601 ± 0.033	4.288ValVal: 4.288 ± 0.035	0.904ValTrp: 0.904 ± 0.015	1.833ValTyr: 1.833 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.142TrpAla: 1.142 ± 0.015	0.196TrpCys: 0.196 ± 0.007	0.921TrpAsp: 0.921 ± 0.014	0.856TrpGlu: 0.856 ± 0.014	0.556TrpPhe: 0.556 ± 0.01	0.932TrpGly: 0.932 ± 0.015	0.36TrpHis: 0.36 ± 0.008	0.799TrpIle: 0.799 ± 0.014	0.803TrpLys: 0.803 ± 0.013	1.42TrpLeu: 1.42 ± 0.018	0.398TrpMet: 0.398 ± 0.009	0.631TrpAsn: 0.631 ± 0.012	0.628TrpPro: 0.628 ± 0.012	0.567TrpGln: 0.567 ± 0.012	1.034TrpArg: 1.034 ± 0.016	1.079TrpSer: 1.079 ± 0.014	0.962TrpThr: 0.962 ± 0.016	0.898TrpVal: 0.898 ± 0.014	0.281TrpTrp: 0.281 ± 0.008	0.459TrpTyr: 0.459 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.233TyrAla: 2.233 ± 0.021	0.453TyrCys: 0.453 ± 0.01	1.626TyrAsp: 1.626 ± 0.019	1.543TyrGlu: 1.543 ± 0.018	1.217TyrPhe: 1.217 ± 0.015	2.103TyrGly: 2.103 ± 0.026	0.789TyrHis: 0.789 ± 0.012	1.481TyrIle: 1.481 ± 0.02	1.07TyrLys: 1.07 ± 0.016	2.817TyrLeu: 2.817 ± 0.028	0.631TyrMet: 0.631 ± 0.011	1.124TyrAsn: 1.124 ± 0.015	1.588TyrPro: 1.588 ± 0.017	1.13TyrGln: 1.13 ± 0.014	1.721TyrArg: 1.721 ± 0.018	2.121TyrSer: 2.121 ± 0.024	1.652TyrThr: 1.652 ± 0.018	1.722TyrVal: 1.722 ± 0.019	0.472TyrTrp: 0.472 ± 0.01	0.988TyrTyr: 0.988 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11480 proteins (5199030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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