Amino acid dipepetide frequency for Coemansia reversa (strain ATCC 12441 / NRRL 1564)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.791AlaAla: 10.791 ± 0.124	1.211AlaCys: 1.211 ± 0.022	5.024AlaAsp: 5.024 ± 0.049	5.348AlaGlu: 5.348 ± 0.043	2.982AlaPhe: 2.982 ± 0.039	5.601AlaGly: 5.601 ± 0.057	2.135AlaHis: 2.135 ± 0.031	4.434AlaIle: 4.434 ± 0.045	3.951AlaLys: 3.951 ± 0.041	8.561AlaLeu: 8.561 ± 0.084	2.339AlaMet: 2.339 ± 0.03	3.338AlaAsn: 3.338 ± 0.038	4.162AlaPro: 4.162 ± 0.055	3.89AlaGln: 3.89 ± 0.038	5.354AlaArg: 5.354 ± 0.056	7.101AlaSer: 7.101 ± 0.063	5.467AlaThr: 5.467 ± 0.047	6.257AlaVal: 6.257 ± 0.065	0.909AlaTrp: 0.909 ± 0.018	2.283AlaTyr: 2.283 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.243CysAla: 1.243 ± 0.025	0.297CysCys: 0.297 ± 0.011	0.761CysAsp: 0.761 ± 0.017	0.76CysGlu: 0.76 ± 0.019	0.553CysPhe: 0.553 ± 0.015	1.112CysGly: 1.112 ± 0.023	0.373CysHis: 0.373 ± 0.011	0.851CysIle: 0.851 ± 0.02	0.67CysLys: 0.67 ± 0.017	1.397CysLeu: 1.397 ± 0.026	0.382CysMet: 0.382 ± 0.012	0.607CysAsn: 0.607 ± 0.016	0.668CysPro: 0.668 ± 0.017	0.514CysGln: 0.514 ± 0.012	0.868CysArg: 0.868 ± 0.017	1.109CysSer: 1.109 ± 0.022	0.83CysThr: 0.83 ± 0.016	1.021CysVal: 1.021 ± 0.022	0.176CysTrp: 0.176 ± 0.007	0.419CysTyr: 0.419 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.222AspAla: 5.222 ± 0.057	0.767AspCys: 0.767 ± 0.019	3.958AspAsp: 3.958 ± 0.053	3.889AspGlu: 3.889 ± 0.048	1.989AspPhe: 1.989 ± 0.029	3.745AspGly: 3.745 ± 0.041	1.144AspHis: 1.144 ± 0.018	3.572AspIle: 3.572 ± 0.039	2.568AspLys: 2.568 ± 0.037	4.427AspLeu: 4.427 ± 0.048	1.585AspMet: 1.585 ± 0.026	2.53AspAsn: 2.53 ± 0.035	2.543AspPro: 2.543 ± 0.031	1.711AspGln: 1.711 ± 0.023	2.762AspArg: 2.762 ± 0.033	4.833AspSer: 4.833 ± 0.051	3.436AspThr: 3.436 ± 0.036	3.868AspVal: 3.868 ± 0.04	0.662AspTrp: 0.662 ± 0.017	1.741AspTyr: 1.741 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	4.849GluAla: 4.849 ± 0.047	0.809GluCys: 0.809 ± 0.015	3.714GluAsp: 3.714 ± 0.049	4.316GluGlu: 4.316 ± 0.069	2.174GluPhe: 2.174 ± 0.028	2.853GluGly: 2.853 ± 0.038	1.587GluHis: 1.587 ± 0.022	3.116GluIle: 3.116 ± 0.041	2.975GluLys: 2.975 ± 0.041	5.897GluLeu: 5.897 ± 0.057	1.512GluMet: 1.512 ± 0.026	2.455GluAsn: 2.455 ± 0.032	2.316GluPro: 2.316 ± 0.032	2.843GluGln: 2.843 ± 0.036	3.819GluArg: 3.819 ± 0.044	4.457GluSer: 4.457 ± 0.042	3.174GluThr: 3.174 ± 0.037	3.247GluVal: 3.247 ± 0.05	0.751GluTrp: 0.751 ± 0.016	1.924GluTyr: 1.924 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.102PheAla: 3.102 ± 0.038	0.606PheCys: 0.606 ± 0.013	2.242PheAsp: 2.242 ± 0.03	2.083PheGlu: 2.083 ± 0.026	1.38PhePhe: 1.38 ± 0.026	2.707PheGly: 2.707 ± 0.038	0.795PheHis: 0.795 ± 0.017	1.859PheIle: 1.859 ± 0.03	1.528PheLys: 1.528 ± 0.023	2.861PheLeu: 2.861 ± 0.035	0.92PheMet: 0.92 ± 0.018	1.447PheAsn: 1.447 ± 0.023	1.484PhePro: 1.484 ± 0.025	1.133PheGln: 1.133 ± 0.021	1.811PheArg: 1.811 ± 0.028	2.952PheSer: 2.952 ± 0.037	1.94PheThr: 1.94 ± 0.027	2.766PheVal: 2.766 ± 0.034	0.482PheTrp: 0.482 ± 0.013	1.154PheTyr: 1.154 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	5.302GlyAla: 5.302 ± 0.051	0.898GlyCys: 0.898 ± 0.02	3.459GlyAsp: 3.459 ± 0.036	3.186GlyGlu: 3.186 ± 0.044	2.473GlyPhe: 2.473 ± 0.032	4.935GlyGly: 4.935 ± 0.068	1.631GlyHis: 1.631 ± 0.023	3.573GlyIle: 3.573 ± 0.039	3.01GlyLys: 3.01 ± 0.04	5.475GlyLeu: 5.475 ± 0.052	1.653GlyMet: 1.653 ± 0.026	2.651GlyAsn: 2.651 ± 0.037	2.269GlyPro: 2.269 ± 0.032	2.2GlyGln: 2.2 ± 0.037	3.854GlyArg: 3.854 ± 0.045	5.602GlySer: 5.602 ± 0.058	3.661GlyThr: 3.661 ± 0.043	4.173GlyVal: 4.173 ± 0.045	0.809GlyTrp: 0.809 ± 0.018	2.045GlyTyr: 2.045 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.13HisAla: 2.13 ± 0.029	0.405HisCys: 0.405 ± 0.011	1.165HisAsp: 1.165 ± 0.022	1.221HisGlu: 1.221 ± 0.018	0.87HisPhe: 0.87 ± 0.017	1.706HisGly: 1.706 ± 0.028	0.804HisHis: 0.804 ± 0.023	1.483HisIle: 1.483 ± 0.023	1.065HisLys: 1.065 ± 0.021	2.123HisLeu: 2.123 ± 0.03	0.758HisMet: 0.758 ± 0.016	1.002HisAsn: 1.002 ± 0.021	1.421HisPro: 1.421 ± 0.023	1.058HisGln: 1.058 ± 0.02	1.661HisArg: 1.661 ± 0.025	2.04HisSer: 2.04 ± 0.031	1.528HisThr: 1.528 ± 0.023	1.721HisVal: 1.721 ± 0.027	0.312HisTrp: 0.312 ± 0.01	0.763HisTyr: 0.763 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.515IleAla: 4.515 ± 0.043	0.893IleCys: 0.893 ± 0.018	3.273IleAsp: 3.273 ± 0.038	3.237IleGlu: 3.237 ± 0.042	1.788IlePhe: 1.788 ± 0.028	3.403IleGly: 3.403 ± 0.037	1.216IleHis: 1.216 ± 0.02	2.649IleIle: 2.649 ± 0.04	2.454IleLys: 2.454 ± 0.035	4.13IleLeu: 4.13 ± 0.045	1.211IleMet: 1.211 ± 0.019	2.164IleAsn: 2.164 ± 0.035	2.725IlePro: 2.725 ± 0.033	1.858IleGln: 1.858 ± 0.026	2.969IleArg: 2.969 ± 0.039	4.324IleSer: 4.324 ± 0.048	2.782IleThr: 2.782 ± 0.036	3.562IleVal: 3.562 ± 0.038	0.575IleTrp: 0.575 ± 0.014	1.569IleTyr: 1.569 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.692LysAla: 3.692 ± 0.04	0.678LysCys: 0.678 ± 0.018	2.562LysAsp: 2.562 ± 0.03	2.826LysGlu: 2.826 ± 0.039	1.381LysPhe: 1.381 ± 0.024	2.343LysGly: 2.343 ± 0.033	1.344LysHis: 1.344 ± 0.025	2.224LysIle: 2.224 ± 0.035	2.704LysLys: 2.704 ± 0.052	4.149LysLeu: 4.149 ± 0.045	1.059LysMet: 1.059 ± 0.02	1.784LysAsn: 1.784 ± 0.027	2.25LysPro: 2.25 ± 0.034	2.168LysGln: 2.168 ± 0.032	3.306LysArg: 3.306 ± 0.043	3.315LysSer: 3.315 ± 0.041	2.602LysThr: 2.602 ± 0.033	2.549LysVal: 2.549 ± 0.037	0.559LysTrp: 0.559 ± 0.013	1.527LysTyr: 1.527 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	8.558LeuAla: 8.558 ± 0.081	1.627LeuCys: 1.627 ± 0.028	5.153LeuAsp: 5.153 ± 0.049	5.41LeuGlu: 5.41 ± 0.054	3.367LeuPhe: 3.367 ± 0.037	5.662LeuGly: 5.662 ± 0.053	2.4LeuHis: 2.4 ± 0.031	3.857LeuIle: 3.857 ± 0.043	3.868LeuLys: 3.868 ± 0.054	8.995LeuLeu: 8.995 ± 0.08	2.002LeuMet: 2.002 ± 0.026	3.235LeuAsn: 3.235 ± 0.031	5.01LeuPro: 5.01 ± 0.052	4.069LeuGln: 4.069 ± 0.045	6.217LeuArg: 6.217 ± 0.057	7.266LeuSer: 7.266 ± 0.056	4.587LeuThr: 4.587 ± 0.043	6.335LeuVal: 6.335 ± 0.063	1.038LeuTrp: 1.038 ± 0.024	2.494LeuTyr: 2.494 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.48MetAla: 2.48 ± 0.034	0.366MetCys: 0.366 ± 0.011	1.437MetAsp: 1.437 ± 0.02	1.35MetGlu: 1.35 ± 0.022	0.927MetPhe: 0.927 ± 0.02	1.417MetGly: 1.417 ± 0.024	0.677MetHis: 0.677 ± 0.014	0.959MetIle: 0.959 ± 0.021	0.839MetLys: 0.839 ± 0.019	2.603MetLeu: 2.603 ± 0.027	0.586MetMet: 0.586 ± 0.014	0.775MetAsn: 0.775 ± 0.015	1.403MetPro: 1.403 ± 0.024	1.178MetGln: 1.178 ± 0.023	1.743MetArg: 1.743 ± 0.021	2.093MetSer: 2.093 ± 0.03	1.375MetThr: 1.375 ± 0.022	1.684MetVal: 1.684 ± 0.027	0.293MetTrp: 0.293 ± 0.01	0.73MetTyr: 0.73 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.395AsnAla: 3.395 ± 0.036	0.553AsnCys: 0.553 ± 0.014	2.207AsnAsp: 2.207 ± 0.03	2.146AsnGlu: 2.146 ± 0.029	1.261AsnPhe: 1.261 ± 0.022	2.762AsnGly: 2.762 ± 0.039	0.881AsnHis: 0.881 ± 0.019	2.568AsnIle: 2.568 ± 0.033	1.906AsnLys: 1.906 ± 0.033	3.007AsnLeu: 3.007 ± 0.039	1.166AsnMet: 1.166 ± 0.021	2.148AsnAsn: 2.148 ± 0.036	2.075AsnPro: 2.075 ± 0.031	1.364AsnGln: 1.364 ± 0.027	2.074AsnArg: 2.074 ± 0.026	3.443AsnSer: 3.443 ± 0.043	2.616AsnThr: 2.616 ± 0.036	2.649AsnVal: 2.649 ± 0.03	0.469AsnTrp: 0.469 ± 0.012	1.193AsnTyr: 1.193 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.497ProAla: 4.497 ± 0.057	0.496ProCys: 0.496 ± 0.013	2.576ProAsp: 2.576 ± 0.031	3.185ProGlu: 3.185 ± 0.047	1.707ProPhe: 1.707 ± 0.026	2.947ProGly: 2.947 ± 0.036	1.241ProHis: 1.241 ± 0.024	2.326ProIle: 2.326 ± 0.032	2.033ProLys: 2.033 ± 0.029	4.487ProLeu: 4.487 ± 0.045	1.105ProMet: 1.105 ± 0.02	1.821ProAsn: 1.821 ± 0.031	3.552ProPro: 3.552 ± 0.07	2.284ProGln: 2.284 ± 0.038	2.84ProArg: 2.84 ± 0.041	4.38ProSer: 4.38 ± 0.051	3.237ProThr: 3.237 ± 0.047	3.412ProVal: 3.412 ± 0.039	0.527ProTrp: 0.527 ± 0.013	1.355ProTyr: 1.355 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.39GlnAla: 3.39 ± 0.041	0.59GlnCys: 0.59 ± 0.015	1.687GlnAsp: 1.687 ± 0.023	2.051GlnGlu: 2.051 ± 0.028	1.406GlnPhe: 1.406 ± 0.024	2.086GlnGly: 2.086 ± 0.031	1.364GlnHis: 1.364 ± 0.025	2.05GlnIle: 2.05 ± 0.025	1.827GlnLys: 1.827 ± 0.024	4.547GlnLeu: 4.547 ± 0.046	1.155GlnMet: 1.155 ± 0.022	1.593GlnAsn: 1.593 ± 0.025	2.354GlnPro: 2.354 ± 0.035	3.844GlnGln: 3.844 ± 0.092	3.28GlnArg: 3.28 ± 0.042	3.196GlnSer: 3.196 ± 0.033	2.342GlnThr: 2.342 ± 0.03	2.289GlnVal: 2.289 ± 0.032	0.546GlnTrp: 0.546 ± 0.014	1.195GlnTyr: 1.195 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	5.144ArgAla: 5.144 ± 0.057	0.84ArgCys: 0.84 ± 0.017	3.146ArgAsp: 3.146 ± 0.036	3.609ArgGlu: 3.609 ± 0.042	2.244ArgPhe: 2.244 ± 0.029	3.487ArgGly: 3.487 ± 0.033	1.739ArgHis: 1.739 ± 0.025	3.351ArgIle: 3.351 ± 0.036	3.09ArgLys: 3.09 ± 0.036	6.199ArgLeu: 6.199 ± 0.059	1.622ArgMet: 1.622 ± 0.025	2.403ArgAsn: 2.403 ± 0.031	2.883ArgPro: 2.883 ± 0.041	2.992ArgGln: 2.992 ± 0.036	5.482ArgArg: 5.482 ± 0.066	4.622ArgSer: 4.622 ± 0.051	3.293ArgThr: 3.293 ± 0.036	4.021ArgVal: 4.021 ± 0.041	0.805ArgTrp: 0.805 ± 0.018	1.744ArgTyr: 1.744 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.676SerAla: 7.676 ± 0.071	0.962SerCys: 0.962 ± 0.018	4.86SerAsp: 4.86 ± 0.055	4.76SerGlu: 4.76 ± 0.047	2.524SerPhe: 2.524 ± 0.031	5.694SerGly: 5.694 ± 0.057	1.864SerHis: 1.864 ± 0.028	4.13SerIle: 4.13 ± 0.045	3.564SerLys: 3.564 ± 0.038	6.847SerLeu: 6.847 ± 0.06	1.942SerMet: 1.942 ± 0.028	3.443SerAsn: 3.443 ± 0.041	4.152SerPro: 4.152 ± 0.052	3.216SerGln: 3.216 ± 0.036	4.752SerArg: 4.752 ± 0.056	8.467SerSer: 8.467 ± 0.098	5.527SerThr: 5.527 ± 0.053	5.138SerVal: 5.138 ± 0.051	0.828SerTrp: 0.828 ± 0.017	1.983SerTyr: 1.983 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.533ThrAla: 5.533 ± 0.053	0.802ThrCys: 0.802 ± 0.016	3.032ThrAsp: 3.032 ± 0.039	3.255ThrGlu: 3.255 ± 0.046	1.963ThrPhe: 1.963 ± 0.029	3.819ThrGly: 3.819 ± 0.042	1.407ThrHis: 1.407 ± 0.025	3.024ThrIle: 3.024 ± 0.029	2.482ThrLys: 2.482 ± 0.028	5.208ThrLeu: 5.208 ± 0.045	1.377ThrMet: 1.377 ± 0.023	2.312ThrAsn: 2.312 ± 0.03	3.419ThrPro: 3.419 ± 0.042	2.387ThrGln: 2.387 ± 0.028	3.334ThrArg: 3.334 ± 0.039	4.852ThrSer: 4.852 ± 0.05	4.069ThrThr: 4.069 ± 0.064	3.76ThrVal: 3.76 ± 0.04	0.644ThrTrp: 0.644 ± 0.019	1.483ThrTyr: 1.483 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	6.336ValAla: 6.336 ± 0.069	1.12ValCys: 1.12 ± 0.02	4.335ValAsp: 4.335 ± 0.05	3.917ValGlu: 3.917 ± 0.042	2.605ValPhe: 2.605 ± 0.033	4.023ValGly: 4.023 ± 0.045	1.597ValHis: 1.597 ± 0.024	3.065ValIle: 3.065 ± 0.041	2.643ValLys: 2.643 ± 0.036	6.366ValLeu: 6.366 ± 0.061	1.402ValMet: 1.402 ± 0.023	2.358ValAsn: 2.358 ± 0.032	3.481ValPro: 3.481 ± 0.047	2.508ValGln: 2.508 ± 0.029	3.997ValArg: 3.997 ± 0.041	5.167ValSer: 5.167 ± 0.047	3.369ValThr: 3.369 ± 0.039	5.187ValVal: 5.187 ± 0.051	0.747ValTrp: 0.747 ± 0.019	1.973ValTyr: 1.973 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.879TrpAla: 0.879 ± 0.019	0.187TrpCys: 0.187 ± 0.008	0.725TrpAsp: 0.725 ± 0.019	0.608TrpGlu: 0.608 ± 0.014	0.439TrpPhe: 0.439 ± 0.013	0.631TrpGly: 0.631 ± 0.016	0.316TrpHis: 0.316 ± 0.011	0.667TrpIle: 0.667 ± 0.014	0.569TrpLys: 0.569 ± 0.018	1.219TrpLeu: 1.219 ± 0.023	0.336TrpMet: 0.336 ± 0.011	0.523TrpAsn: 0.523 ± 0.013	0.471TrpPro: 0.471 ± 0.013	0.47TrpGln: 0.47 ± 0.013	0.861TrpArg: 0.861 ± 0.018	0.884TrpSer: 0.884 ± 0.017	0.663TrpThr: 0.663 ± 0.016	0.706TrpVal: 0.706 ± 0.016	0.204TrpTrp: 0.204 ± 0.009	0.349TrpTyr: 0.349 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.032	0.5TyrCys: 0.5 ± 0.013	1.635TyrAsp: 1.635 ± 0.027	1.63TyrGlu: 1.63 ± 0.022	1.219TyrPhe: 1.219 ± 0.021	1.927TyrGly: 1.927 ± 0.032	0.721TyrHis: 0.721 ± 0.018	1.538TyrIle: 1.538 ± 0.023	1.278TyrLys: 1.278 ± 0.024	2.652TyrLeu: 2.652 ± 0.034	0.806TyrMet: 0.806 ± 0.018	1.293TyrAsn: 1.293 ± 0.023	1.37TyrPro: 1.37 ± 0.025	1.104TyrGln: 1.104 ± 0.02	1.733TyrArg: 1.733 ± 0.022	2.226TyrSer: 2.226 ± 0.032	1.662TyrThr: 1.662 ± 0.025	1.852TyrVal: 1.852 ± 0.028	0.37TyrTrp: 0.37 ± 0.012	1.06TyrTyr: 1.06 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 7317 proteins (2997087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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