Amino acid dipepetide frequency for Parashewanella curva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.227AlaAla: 6.227 ± 0.089	1.047AlaCys: 1.047 ± 0.034	4.097AlaAsp: 4.097 ± 0.067	5.169AlaGlu: 5.169 ± 0.072	3.126AlaPhe: 3.126 ± 0.054	4.845AlaGly: 4.845 ± 0.073	1.622AlaHis: 1.622 ± 0.036	5.77AlaIle: 5.77 ± 0.074	5.459AlaLys: 5.459 ± 0.062	8.402AlaLeu: 8.402 ± 0.082	2.086AlaMet: 2.086 ± 0.047	3.624AlaAsn: 3.624 ± 0.055	2.642AlaPro: 2.642 ± 0.052	3.575AlaGln: 3.575 ± 0.055	3.054AlaArg: 3.054 ± 0.051	5.117AlaSer: 5.117 ± 0.065	4.096AlaThr: 4.096 ± 0.071	5.083AlaVal: 5.083 ± 0.06	0.81AlaTrp: 0.81 ± 0.027	2.185AlaTyr: 2.185 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.794CysAla: 0.794 ± 0.031	0.246CysCys: 0.246 ± 0.015	0.682CysAsp: 0.682 ± 0.023	0.678CysGlu: 0.678 ± 0.023	0.593CysPhe: 0.593 ± 0.021	0.848CysGly: 0.848 ± 0.027	0.381CysHis: 0.381 ± 0.019	0.742CysIle: 0.742 ± 0.023	0.642CysLys: 0.642 ± 0.024	1.19CysLeu: 1.19 ± 0.032	0.222CysMet: 0.222 ± 0.013	0.527CysAsn: 0.527 ± 0.02	0.486CysPro: 0.486 ± 0.02	0.578CysGln: 0.578 ± 0.023	0.522CysArg: 0.522 ± 0.019	0.921CysSer: 0.921 ± 0.031	0.548CysThr: 0.548 ± 0.025	0.68CysVal: 0.68 ± 0.024	0.145CysTrp: 0.145 ± 0.011	0.401CysTyr: 0.401 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.119AspAla: 4.119 ± 0.057	0.637AspCys: 0.637 ± 0.026	3.107AspAsp: 3.107 ± 0.054	3.82AspGlu: 3.82 ± 0.061	2.573AspPhe: 2.573 ± 0.048	3.502AspGly: 3.502 ± 0.06	1.041AspHis: 1.041 ± 0.028	4.109AspIle: 4.109 ± 0.058	3.737AspLys: 3.737 ± 0.052	4.924AspLeu: 4.924 ± 0.056	1.15AspMet: 1.15 ± 0.033	2.621AspAsn: 2.621 ± 0.05	1.965AspPro: 1.965 ± 0.039	1.707AspGln: 1.707 ± 0.038	2.03AspArg: 2.03 ± 0.041	3.67AspSer: 3.67 ± 0.053	2.797AspThr: 2.797 ± 0.054	3.577AspVal: 3.577 ± 0.057	0.772AspTrp: 0.772 ± 0.026	1.906AspTyr: 1.906 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.77GluAla: 4.77 ± 0.078	0.621GluCys: 0.621 ± 0.024	2.7GluAsp: 2.7 ± 0.052	3.402GluGlu: 3.402 ± 0.063	2.725GluPhe: 2.725 ± 0.045	3.111GluGly: 3.111 ± 0.062	1.786GluHis: 1.786 ± 0.038	3.894GluIle: 3.894 ± 0.055	4.107GluLys: 4.107 ± 0.053	7.519GluLeu: 7.519 ± 0.08	1.527GluMet: 1.527 ± 0.031	2.808GluAsn: 2.808 ± 0.049	2.24GluPro: 2.24 ± 0.053	4.344GluGln: 4.344 ± 0.077	2.985GluArg: 2.985 ± 0.055	3.968GluSer: 3.968 ± 0.058	3.239GluThr: 3.239 ± 0.05	4.173GluVal: 4.173 ± 0.063	0.68GluTrp: 0.68 ± 0.024	1.929GluTyr: 1.929 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.184PheAla: 3.184 ± 0.052	0.618PheCys: 0.618 ± 0.024	2.917PheAsp: 2.917 ± 0.047	2.722PheGlu: 2.722 ± 0.045	1.812PhePhe: 1.812 ± 0.044	2.854PheGly: 2.854 ± 0.052	1.009PheHis: 1.009 ± 0.023	2.885PheIle: 2.885 ± 0.046	2.521PheLys: 2.521 ± 0.046	3.484PheLeu: 3.484 ± 0.062	0.979PheMet: 0.979 ± 0.026	2.273PheAsn: 2.273 ± 0.042	1.487PhePro: 1.487 ± 0.03	1.455PheGln: 1.455 ± 0.035	1.574PheArg: 1.574 ± 0.031	3.498PheSer: 3.498 ± 0.052	2.421PheThr: 2.421 ± 0.044	2.51PheVal: 2.51 ± 0.044	0.456PheTrp: 0.456 ± 0.021	1.458PheTyr: 1.458 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.421GlyAla: 4.421 ± 0.068	0.799GlyCys: 0.799 ± 0.026	3.396GlyAsp: 3.396 ± 0.063	3.837GlyGlu: 3.837 ± 0.059	3.063GlyPhe: 3.063 ± 0.055	4.027GlyGly: 4.027 ± 0.071	1.535GlyHis: 1.535 ± 0.032	4.294GlyIle: 4.294 ± 0.063	4.204GlyLys: 4.204 ± 0.069	6.084GlyLeu: 6.084 ± 0.08	1.651GlyMet: 1.651 ± 0.039	2.772GlyAsn: 2.772 ± 0.064	1.181GlyPro: 1.181 ± 0.03	2.515GlyGln: 2.515 ± 0.045	2.708GlyArg: 2.708 ± 0.051	3.905GlySer: 3.905 ± 0.067	3.071GlyThr: 3.071 ± 0.053	4.456GlyVal: 4.456 ± 0.068	0.756GlyTrp: 0.756 ± 0.025	2.336GlyTyr: 2.336 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.521HisAla: 1.521 ± 0.034	0.371HisCys: 0.371 ± 0.014	1.125HisAsp: 1.125 ± 0.029	1.17HisGlu: 1.17 ± 0.033	1.199HisPhe: 1.199 ± 0.033	1.447HisGly: 1.447 ± 0.037	0.725HisHis: 0.725 ± 0.028	1.584HisIle: 1.584 ± 0.037	1.33HisLys: 1.33 ± 0.031	2.449HisLeu: 2.449 ± 0.048	0.441HisMet: 0.441 ± 0.019	1.058HisAsn: 1.058 ± 0.024	1.147HisPro: 1.147 ± 0.031	1.486HisGln: 1.486 ± 0.032	1.094HisArg: 1.094 ± 0.028	1.695HisSer: 1.695 ± 0.038	1.196HisThr: 1.196 ± 0.031	1.233HisVal: 1.233 ± 0.033	0.362HisTrp: 0.362 ± 0.016	0.918HisTyr: 0.918 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.802IleAla: 5.802 ± 0.071	0.774IleCys: 0.774 ± 0.023	4.147IleAsp: 4.147 ± 0.056	4.977IleGlu: 4.977 ± 0.067	2.279IlePhe: 2.279 ± 0.045	4.259IleGly: 4.259 ± 0.058	1.384IleHis: 1.384 ± 0.032	3.822IleIle: 3.822 ± 0.066	4.449IleLys: 4.449 ± 0.064	5.205IleLeu: 5.205 ± 0.072	1.206IleMet: 1.206 ± 0.031	3.605IleAsn: 3.605 ± 0.052	2.79IlePro: 2.79 ± 0.048	2.593IleGln: 2.593 ± 0.048	2.681IleArg: 2.681 ± 0.043	5.049IleSer: 5.049 ± 0.066	3.848IleThr: 3.848 ± 0.054	3.809IleVal: 3.809 ± 0.055	0.588IleTrp: 0.588 ± 0.021	1.851IleTyr: 1.851 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	5.505LysAla: 5.505 ± 0.08	0.526LysCys: 0.526 ± 0.027	3.147LysAsp: 3.147 ± 0.052	3.727LysGlu: 3.727 ± 0.053	2.079LysPhe: 2.079 ± 0.035	3.787LysGly: 3.787 ± 0.056	1.613LysHis: 1.613 ± 0.034	3.555LysIle: 3.555 ± 0.064	3.961LysLys: 3.961 ± 0.071	6.848LysLeu: 6.848 ± 0.076	1.538LysMet: 1.538 ± 0.039	2.851LysAsn: 2.851 ± 0.057	2.813LysPro: 2.813 ± 0.049	4.129LysGln: 4.129 ± 0.069	2.986LysArg: 2.986 ± 0.04	4.159LysSer: 4.159 ± 0.065	3.466LysThr: 3.466 ± 0.055	4.518LysVal: 4.518 ± 0.066	0.663LysTrp: 0.663 ± 0.019	1.855LysTyr: 1.855 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	8.606LeuAla: 8.606 ± 0.092	1.173LeuCys: 1.173 ± 0.03	5.444LeuAsp: 5.444 ± 0.063	6.255LeuGlu: 6.255 ± 0.077	4.148LeuPhe: 4.148 ± 0.061	5.958LeuGly: 5.958 ± 0.081	2.155LeuHis: 2.155 ± 0.049	6.378LeuIle: 6.378 ± 0.091	6.776LeuLys: 6.776 ± 0.076	10.512LeuLeu: 10.512 ± 0.116	2.534LeuMet: 2.534 ± 0.049	5.247LeuAsn: 5.247 ± 0.065	4.782LeuPro: 4.782 ± 0.067	4.196LeuGln: 4.196 ± 0.063	4.036LeuArg: 4.036 ± 0.061	8.466LeuSer: 8.466 ± 0.086	6.329LeuThr: 6.329 ± 0.069	6.275LeuVal: 6.275 ± 0.079	0.99LeuTrp: 0.99 ± 0.029	2.59LeuTyr: 2.59 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.049	0.205MetCys: 0.205 ± 0.014	1.137MetAsp: 1.137 ± 0.029	1.166MetGlu: 1.166 ± 0.03	0.814MetPhe: 0.814 ± 0.027	1.399MetGly: 1.399 ± 0.033	0.436MetHis: 0.436 ± 0.019	1.348MetIle: 1.348 ± 0.029	1.577MetLys: 1.577 ± 0.031	2.513MetLeu: 2.513 ± 0.047	0.654MetMet: 0.654 ± 0.02	1.031MetAsn: 1.031 ± 0.029	1.097MetPro: 1.097 ± 0.027	1.057MetGln: 1.057 ± 0.024	0.977MetArg: 0.977 ± 0.029	1.874MetSer: 1.874 ± 0.039	1.455MetThr: 1.455 ± 0.032	1.475MetVal: 1.475 ± 0.03	0.197MetTrp: 0.197 ± 0.011	0.485MetTyr: 0.485 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.522AsnAla: 3.522 ± 0.058	0.535AsnCys: 0.535 ± 0.021	2.591AsnAsp: 2.591 ± 0.052	2.901AsnGlu: 2.901 ± 0.052	1.882AsnPhe: 1.882 ± 0.042	3.251AsnGly: 3.251 ± 0.062	1.185AsnHis: 1.185 ± 0.033	3.179AsnIle: 3.179 ± 0.059	2.99AsnLys: 2.99 ± 0.051	4.437AsnLeu: 4.437 ± 0.066	0.953AsnMet: 0.953 ± 0.031	2.44AsnAsn: 2.44 ± 0.054	2.287AsnPro: 2.287 ± 0.043	2.626AsnGln: 2.626 ± 0.052	2.158AsnArg: 2.158 ± 0.039	3.322AsnSer: 3.322 ± 0.047	2.641AsnThr: 2.641 ± 0.052	2.821AsnVal: 2.821 ± 0.045	0.585AsnTrp: 0.585 ± 0.021	1.553AsnTyr: 1.553 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.707ProAla: 2.707 ± 0.05	0.369ProCys: 0.369 ± 0.016	2.262ProAsp: 2.262 ± 0.039	3.304ProGlu: 3.304 ± 0.059	1.695ProPhe: 1.695 ± 0.033	1.538ProGly: 1.538 ± 0.039	0.895ProHis: 0.895 ± 0.028	2.68ProIle: 2.68 ± 0.049	2.837ProLys: 2.837 ± 0.052	4.085ProLeu: 4.085 ± 0.057	0.885ProMet: 0.885 ± 0.026	2.176ProAsn: 2.176 ± 0.037	1.27ProPro: 1.27 ± 0.041	2.031ProGln: 2.031 ± 0.041	1.281ProArg: 1.281 ± 0.03	2.882ProSer: 2.882 ± 0.045	2.268ProThr: 2.268 ± 0.039	2.753ProVal: 2.753 ± 0.05	0.42ProTrp: 0.42 ± 0.016	1.221ProTyr: 1.221 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.389GlnAla: 4.389 ± 0.056	0.527GlnCys: 0.527 ± 0.019	2.1GlnAsp: 2.1 ± 0.039	2.461GlnGlu: 2.461 ± 0.043	1.982GlnPhe: 1.982 ± 0.037	2.924GlnGly: 2.924 ± 0.049	1.377GlnHis: 1.377 ± 0.032	2.925GlnIle: 2.925 ± 0.049	2.858GlnLys: 2.858 ± 0.058	6.01GlnLeu: 6.01 ± 0.093	1.117GlnMet: 1.117 ± 0.029	2.035GlnAsn: 2.035 ± 0.043	1.989GlnPro: 1.989 ± 0.046	3.864GlnGln: 3.864 ± 0.079	2.247GlnArg: 2.247 ± 0.04	3.269GlnSer: 3.269 ± 0.061	2.581GlnThr: 2.581 ± 0.046	3.301GlnVal: 3.301 ± 0.046	0.675GlnTrp: 0.675 ± 0.025	1.505GlnTyr: 1.505 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.879ArgAla: 2.879 ± 0.045	0.511ArgCys: 0.511 ± 0.019	2.152ArgAsp: 2.152 ± 0.045	2.581ArgGlu: 2.581 ± 0.044	2.171ArgPhe: 2.171 ± 0.039	2.298ArgGly: 2.298 ± 0.047	1.071ArgHis: 1.071 ± 0.03	2.896ArgIle: 2.896 ± 0.052	2.529ArgLys: 2.529 ± 0.046	4.733ArgLeu: 4.733 ± 0.058	1.048ArgMet: 1.048 ± 0.029	1.996ArgAsn: 1.996 ± 0.036	1.515ArgPro: 1.515 ± 0.035	2.135ArgGln: 2.135 ± 0.038	2.111ArgArg: 2.111 ± 0.041	2.59ArgSer: 2.59 ± 0.041	2.067ArgThr: 2.067 ± 0.041	2.86ArgVal: 2.86 ± 0.047	0.561ArgTrp: 0.561 ± 0.021	1.684ArgTyr: 1.684 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.165SerAla: 5.165 ± 0.066	0.844SerCys: 0.844 ± 0.027	3.825SerAsp: 3.825 ± 0.054	4.488SerGlu: 4.488 ± 0.059	3.065SerPhe: 3.065 ± 0.044	4.769SerGly: 4.769 ± 0.068	1.713SerHis: 1.713 ± 0.039	4.748SerIle: 4.748 ± 0.065	4.314SerLys: 4.314 ± 0.061	7.353SerLeu: 7.353 ± 0.087	1.664SerMet: 1.664 ± 0.036	3.377SerAsn: 3.377 ± 0.057	2.889SerPro: 2.889 ± 0.045	3.549SerGln: 3.549 ± 0.055	2.943SerArg: 2.943 ± 0.05	5.351SerSer: 5.351 ± 0.081	3.748SerThr: 3.748 ± 0.058	4.495SerVal: 4.495 ± 0.055	0.787SerTrp: 0.787 ± 0.023	2.214SerTyr: 2.214 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.239ThrAla: 4.239 ± 0.064	0.599ThrCys: 0.599 ± 0.023	2.97ThrAsp: 2.97 ± 0.051	3.526ThrGlu: 3.526 ± 0.059	2.127ThrPhe: 2.127 ± 0.039	3.634ThrGly: 3.634 ± 0.062	1.296ThrHis: 1.296 ± 0.035	3.475ThrIle: 3.475 ± 0.055	3.055ThrLys: 3.055 ± 0.049	5.88ThrLeu: 5.88 ± 0.073	1.034ThrMet: 1.034 ± 0.027	2.415ThrAsn: 2.415 ± 0.054	2.93ThrPro: 2.93 ± 0.053	2.895ThrGln: 2.895 ± 0.049	2.153ThrArg: 2.153 ± 0.045	3.807ThrSer: 3.807 ± 0.062	2.897ThrThr: 2.897 ± 0.048	3.657ThrVal: 3.657 ± 0.055	0.503ThrTrp: 0.503 ± 0.019	1.532ThrTyr: 1.532 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	5.269ValAla: 5.269 ± 0.074	0.823ValCys: 0.823 ± 0.033	3.833ValAsp: 3.833 ± 0.056	4.269ValGlu: 4.269 ± 0.066	2.662ValPhe: 2.662 ± 0.043	3.968ValGly: 3.968 ± 0.063	1.152ValHis: 1.152 ± 0.027	4.503ValIle: 4.503 ± 0.062	4.101ValLys: 4.101 ± 0.055	6.15ValLeu: 6.15 ± 0.074	1.607ValMet: 1.607 ± 0.035	3.295ValAsn: 3.295 ± 0.054	2.363ValPro: 2.363 ± 0.044	2.254ValGln: 2.254 ± 0.046	2.604ValArg: 2.604 ± 0.052	4.814ValSer: 4.814 ± 0.058	3.998ValThr: 3.998 ± 0.058	4.477ValVal: 4.477 ± 0.068	0.621ValTrp: 0.621 ± 0.024	1.808ValTyr: 1.808 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.643TrpAla: 0.643 ± 0.022	0.158TrpCys: 0.158 ± 0.011	0.544TrpAsp: 0.544 ± 0.02	0.558TrpGlu: 0.558 ± 0.02	0.549TrpPhe: 0.549 ± 0.021	0.662TrpGly: 0.662 ± 0.023	0.322TrpHis: 0.322 ± 0.015	0.591TrpIle: 0.591 ± 0.023	0.622TrpLys: 0.622 ± 0.022	1.574TrpLeu: 1.574 ± 0.045	0.263TrpMet: 0.263 ± 0.012	0.48TrpAsn: 0.48 ± 0.02	0.369TrpPro: 0.369 ± 0.018	0.88TrpGln: 0.88 ± 0.028	0.572TrpArg: 0.572 ± 0.021	0.669TrpSer: 0.669 ± 0.026	0.451TrpThr: 0.451 ± 0.022	0.742TrpVal: 0.742 ± 0.025	0.164TrpTrp: 0.164 ± 0.012	0.339TrpTyr: 0.339 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.027TyrAla: 2.027 ± 0.036	0.443TyrCys: 0.443 ± 0.017	1.587TyrAsp: 1.587 ± 0.035	1.515TyrGlu: 1.515 ± 0.034	1.574TyrPhe: 1.574 ± 0.039	1.929TyrGly: 1.929 ± 0.041	0.853TyrHis: 0.853 ± 0.025	1.739TyrIle: 1.739 ± 0.039	1.654TyrLys: 1.654 ± 0.034	3.498TyrLeu: 3.498 ± 0.055	0.583TyrMet: 0.583 ± 0.022	1.229TyrAsn: 1.229 ± 0.033	1.318TyrPro: 1.318 ± 0.032	2.265TyrGln: 2.265 ± 0.043	1.673TyrArg: 1.673 ± 0.035	2.276TyrSer: 2.276 ± 0.047	1.508TyrThr: 1.508 ± 0.034	1.675TyrVal: 1.675 ± 0.038	0.42TyrTrp: 0.42 ± 0.017	0.98TyrTyr: 0.98 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4117 proteins (1363167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---