Amino acid dipepetide frequency for Streptomyces sp. 1-11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.489AlaAla: 22.489 ± 0.172	1.076AlaCys: 1.076 ± 0.023	8.281AlaAsp: 8.281 ± 0.078	8.965AlaGlu: 8.965 ± 0.085	3.451AlaPhe: 3.451 ± 0.045	14.551AlaGly: 14.551 ± 0.111	3.021AlaHis: 3.021 ± 0.039	3.022AlaIle: 3.022 ± 0.039	2.721AlaLys: 2.721 ± 0.049	14.751AlaLeu: 14.751 ± 0.119	2.355AlaMet: 2.355 ± 0.031	1.859AlaAsn: 1.859 ± 0.03	7.585AlaPro: 7.585 ± 0.09	3.78AlaGln: 3.78 ± 0.045	11.221AlaArg: 11.221 ± 0.097	5.807AlaSer: 5.807 ± 0.061	6.786AlaThr: 6.786 ± 0.069	12.646AlaVal: 12.646 ± 0.091	1.893AlaTrp: 1.893 ± 0.031	2.812AlaTyr: 2.812 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.141CysAla: 1.141 ± 0.02	0.097CysCys: 0.097 ± 0.008	0.464CysAsp: 0.464 ± 0.013	0.396CysGlu: 0.396 ± 0.014	0.226CysPhe: 0.226 ± 0.011	0.959CysGly: 0.959 ± 0.019	0.198CysHis: 0.198 ± 0.009	0.144CysIle: 0.144 ± 0.009	0.109CysLys: 0.109 ± 0.007	0.779CysLeu: 0.779 ± 0.019	0.123CysMet: 0.123 ± 0.007	0.14CysAsn: 0.14 ± 0.008	0.502CysPro: 0.502 ± 0.016	0.171CysGln: 0.171 ± 0.007	0.634CysArg: 0.634 ± 0.018	0.416CysSer: 0.416 ± 0.014	0.512CysThr: 0.512 ± 0.018	0.678CysVal: 0.678 ± 0.019	0.128CysTrp: 0.128 ± 0.007	0.147CysTyr: 0.147 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.636AspAla: 7.636 ± 0.068	0.419AspCys: 0.419 ± 0.014	3.546AspAsp: 3.546 ± 0.049	3.801AspGlu: 3.801 ± 0.048	1.635AspPhe: 1.635 ± 0.023	6.506AspGly: 6.506 ± 0.066	1.373AspHis: 1.373 ± 0.03	1.737AspIle: 1.737 ± 0.03	1.15AspLys: 1.15 ± 0.03	6.153AspLeu: 6.153 ± 0.056	0.807AspMet: 0.807 ± 0.018	0.945AspAsn: 0.945 ± 0.023	4.539AspPro: 4.539 ± 0.05	1.433AspGln: 1.433 ± 0.028	5.095AspArg: 5.095 ± 0.06	2.498AspSer: 2.498 ± 0.036	3.241AspThr: 3.241 ± 0.053	4.748AspVal: 4.748 ± 0.049	1.043AspTrp: 1.043 ± 0.025	1.075AspTyr: 1.075 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.385GluAla: 7.385 ± 0.077	0.359GluCys: 0.359 ± 0.014	2.858GluAsp: 2.858 ± 0.038	3.583GluGlu: 3.583 ± 0.055	1.422GluPhe: 1.422 ± 0.024	4.195GluGly: 4.195 ± 0.047	1.504GluHis: 1.504 ± 0.03	2.104GluIle: 2.104 ± 0.033	1.335GluLys: 1.335 ± 0.03	6.766GluLeu: 6.766 ± 0.07	0.866GluMet: 0.866 ± 0.02	0.985GluAsn: 0.985 ± 0.022	3.522GluPro: 3.522 ± 0.05	2.141GluGln: 2.141 ± 0.035	5.719GluArg: 5.719 ± 0.059	2.405GluSer: 2.405 ± 0.035	2.823GluThr: 2.823 ± 0.038	4.385GluVal: 4.385 ± 0.049	0.737GluTrp: 0.737 ± 0.02	1.091GluTyr: 1.091 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.601PheAla: 3.601 ± 0.044	0.275PheCys: 0.275 ± 0.01	1.861PheAsp: 1.861 ± 0.032	1.399PheGlu: 1.399 ± 0.027	0.844PhePhe: 0.844 ± 0.019	2.951PheGly: 2.951 ± 0.043	0.6PheHis: 0.6 ± 0.018	0.628PheIle: 0.628 ± 0.018	0.494PheLys: 0.494 ± 0.017	2.549PheLeu: 2.549 ± 0.043	0.389PheMet: 0.389 ± 0.014	0.527PheAsn: 0.527 ± 0.015	1.37PhePro: 1.37 ± 0.025	0.656PheGln: 0.656 ± 0.017	1.884PheArg: 1.884 ± 0.03	1.381PheSer: 1.381 ± 0.029	1.977PheThr: 1.977 ± 0.035	2.157PheVal: 2.157 ± 0.036	0.397PheTrp: 0.397 ± 0.012	0.595PheTyr: 0.595 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.931GlyAla: 11.931 ± 0.09	0.847GlyCys: 0.847 ± 0.021	5.402GlyAsp: 5.402 ± 0.053	5.219GlyGlu: 5.219 ± 0.054	2.836GlyPhe: 2.836 ± 0.045	9.352GlyGly: 9.352 ± 0.107	2.518GlyHis: 2.518 ± 0.034	3.143GlyIle: 3.143 ± 0.04	2.348GlyLys: 2.348 ± 0.037	9.483GlyLeu: 9.483 ± 0.069	1.993GlyMet: 1.993 ± 0.029	1.749GlyAsn: 1.749 ± 0.036	5.595GlyPro: 5.595 ± 0.067	2.707GlyGln: 2.707 ± 0.042	8.612GlyArg: 8.612 ± 0.081	5.399GlySer: 5.399 ± 0.059	6.503GlyThr: 6.503 ± 0.066	7.666GlyVal: 7.666 ± 0.065	1.748GlyTrp: 1.748 ± 0.029	2.33GlyTyr: 2.33 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.765HisAla: 2.765 ± 0.037	0.214HisCys: 0.214 ± 0.01	1.414HisAsp: 1.414 ± 0.028	1.216HisGlu: 1.216 ± 0.026	0.636HisPhe: 0.636 ± 0.018	2.553HisGly: 2.553 ± 0.034	0.694HisHis: 0.694 ± 0.021	0.632HisIle: 0.632 ± 0.015	0.379HisLys: 0.379 ± 0.012	2.435HisLeu: 2.435 ± 0.038	0.327HisMet: 0.327 ± 0.011	0.362HisAsn: 0.362 ± 0.013	1.862HisPro: 1.862 ± 0.027	0.638HisGln: 0.638 ± 0.018	2.246HisArg: 2.246 ± 0.031	0.998HisSer: 0.998 ± 0.02	1.34HisThr: 1.34 ± 0.022	1.699HisVal: 1.699 ± 0.028	0.378HisTrp: 0.378 ± 0.014	0.477HisTyr: 0.477 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.436IleAla: 4.436 ± 0.053	0.245IleCys: 0.245 ± 0.011	1.975IleAsp: 1.975 ± 0.034	1.755IleGlu: 1.755 ± 0.033	0.597IlePhe: 0.597 ± 0.018	3.369IleGly: 3.369 ± 0.047	0.557IleHis: 0.557 ± 0.019	0.745IleIle: 0.745 ± 0.023	0.666IleLys: 0.666 ± 0.019	2.208IleLeu: 2.208 ± 0.04	0.404IleMet: 0.404 ± 0.013	0.618IleAsn: 0.618 ± 0.018	1.58IlePro: 1.58 ± 0.025	0.676IleGln: 0.676 ± 0.019	2.126IleArg: 2.126 ± 0.027	1.461IleSer: 1.461 ± 0.029	2.046IleThr: 2.046 ± 0.032	2.541IleVal: 2.541 ± 0.041	0.325IleTrp: 0.325 ± 0.012	0.47IleTyr: 0.47 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.885LysAla: 2.885 ± 0.047	0.126LysCys: 0.126 ± 0.008	1.337LysAsp: 1.337 ± 0.029	1.117LysGlu: 1.117 ± 0.025	0.425LysPhe: 0.425 ± 0.014	1.829LysGly: 1.829 ± 0.037	0.413LysHis: 0.413 ± 0.014	0.776LysIle: 0.776 ± 0.023	0.838LysLys: 0.838 ± 0.027	1.909LysLeu: 1.909 ± 0.028	0.353LysMet: 0.353 ± 0.012	0.487LysAsn: 0.487 ± 0.017	1.275LysPro: 1.275 ± 0.032	0.684LysGln: 0.684 ± 0.021	1.398LysArg: 1.398 ± 0.029	1.093LysSer: 1.093 ± 0.027	1.213LysThr: 1.213 ± 0.031	1.861LysVal: 1.861 ± 0.036	0.269LysTrp: 0.269 ± 0.011	0.46LysTyr: 0.46 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.222LeuAla: 15.222 ± 0.121	0.843LeuCys: 0.843 ± 0.021	6.615LeuAsp: 6.615 ± 0.066	4.742LeuGlu: 4.742 ± 0.05	2.548LeuPhe: 2.548 ± 0.042	9.379LeuGly: 9.379 ± 0.077	2.278LeuHis: 2.278 ± 0.038	3.06LeuIle: 3.06 ± 0.04	1.993LeuLys: 1.993 ± 0.032	11.494LeuLeu: 11.494 ± 0.107	1.62LeuMet: 1.62 ± 0.033	1.664LeuAsn: 1.664 ± 0.026	6.609LeuPro: 6.609 ± 0.061	2.146LeuGln: 2.146 ± 0.036	8.956LeuArg: 8.956 ± 0.081	5.159LeuSer: 5.159 ± 0.056	6.915LeuThr: 6.915 ± 0.07	8.824LeuVal: 8.824 ± 0.072	1.286LeuTrp: 1.286 ± 0.033	1.862LeuTyr: 1.862 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.031	0.15MetCys: 0.15 ± 0.008	0.883MetAsp: 0.883 ± 0.022	0.698MetGlu: 0.698 ± 0.016	0.44MetPhe: 0.44 ± 0.015	1.267MetGly: 1.267 ± 0.025	0.351MetHis: 0.351 ± 0.013	0.59MetIle: 0.59 ± 0.018	0.392MetLys: 0.392 ± 0.013	1.587MetLeu: 1.587 ± 0.031	0.265MetMet: 0.265 ± 0.011	0.408MetAsn: 0.408 ± 0.014	1.104MetPro: 1.104 ± 0.021	0.432MetGln: 0.432 ± 0.014	1.441MetArg: 1.441 ± 0.025	1.293MetSer: 1.293 ± 0.025	1.523MetThr: 1.523 ± 0.026	1.238MetVal: 1.238 ± 0.025	0.203MetTrp: 0.203 ± 0.009	0.321MetTyr: 0.321 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.116AsnAla: 2.116 ± 0.034	0.169AsnCys: 0.169 ± 0.01	0.929AsnAsp: 0.929 ± 0.023	0.778AsnGlu: 0.778 ± 0.019	0.466AsnPhe: 0.466 ± 0.013	1.849AsnGly: 1.849 ± 0.038	0.4AsnHis: 0.4 ± 0.012	0.589AsnIle: 0.589 ± 0.018	0.392AsnLys: 0.392 ± 0.015	1.569AsnLeu: 1.569 ± 0.031	0.299AsnMet: 0.299 ± 0.011	0.403AsnAsn: 0.403 ± 0.014	1.312AsnPro: 1.312 ± 0.025	0.494AsnGln: 0.494 ± 0.017	1.228AsnArg: 1.228 ± 0.026	0.897AsnSer: 0.897 ± 0.024	1.067AsnThr: 1.067 ± 0.029	1.364AsnVal: 1.364 ± 0.027	0.279AsnTrp: 0.279 ± 0.011	0.398AsnTyr: 0.398 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.808ProAla: 9.808 ± 0.116	0.362ProCys: 0.362 ± 0.013	4.478ProAsp: 4.478 ± 0.049	4.363ProGlu: 4.363 ± 0.055	1.498ProPhe: 1.498 ± 0.027	7.279ProGly: 7.279 ± 0.076	1.475ProHis: 1.475 ± 0.025	1.085ProIle: 1.085 ± 0.023	1.094ProLys: 1.094 ± 0.028	5.44ProLeu: 5.44 ± 0.057	0.943ProMet: 0.943 ± 0.021	0.852ProAsn: 0.852 ± 0.02	3.739ProPro: 3.739 ± 0.074	1.727ProGln: 1.727 ± 0.037	4.247ProArg: 4.247 ± 0.047	3.126ProSer: 3.126 ± 0.041	2.849ProThr: 2.849 ± 0.039	5.69ProVal: 5.69 ± 0.057	0.87ProTrp: 0.87 ± 0.02	1.427ProTyr: 1.427 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.76GlnAla: 3.76 ± 0.053	0.17GlnCys: 0.17 ± 0.01	1.397GlnAsp: 1.397 ± 0.027	1.456GlnGlu: 1.456 ± 0.028	0.63GlnPhe: 0.63 ± 0.016	2.336GlnGly: 2.336 ± 0.037	0.648GlnHis: 0.648 ± 0.02	0.994GlnIle: 0.994 ± 0.023	0.625GlnLys: 0.625 ± 0.019	2.838GlnLeu: 2.838 ± 0.04	0.458GlnMet: 0.458 ± 0.015	0.481GlnAsn: 0.481 ± 0.015	1.724GlnPro: 1.724 ± 0.045	1.224GlnGln: 1.224 ± 0.033	2.333GlnArg: 2.333 ± 0.035	1.262GlnSer: 1.262 ± 0.029	1.315GlnThr: 1.315 ± 0.023	2.335GlnVal: 2.335 ± 0.034	0.457GlnTrp: 0.457 ± 0.013	0.613GlnTyr: 0.613 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.598ArgAla: 10.598 ± 0.093	0.626ArgCys: 0.626 ± 0.017	4.435ArgAsp: 4.435 ± 0.055	4.901ArgGlu: 4.901 ± 0.057	2.385ArgPhe: 2.385 ± 0.031	6.186ArgGly: 6.186 ± 0.069	2.29ArgHis: 2.29 ± 0.034	3.135ArgIle: 3.135 ± 0.036	1.609ArgLys: 1.609 ± 0.029	9.465ArgLeu: 9.465 ± 0.082	1.749ArgMet: 1.749 ± 0.028	1.327ArgAsn: 1.327 ± 0.026	5.535ArgPro: 5.535 ± 0.064	2.35ArgGln: 2.35 ± 0.034	8.394ArgArg: 8.394 ± 0.082	4.027ArgSer: 4.027 ± 0.048	5.616ArgThr: 5.616 ± 0.056	6.154ArgVal: 6.154 ± 0.06	1.424ArgTrp: 1.424 ± 0.024	1.861ArgTyr: 1.861 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.829SerAla: 6.829 ± 0.063	0.424SerCys: 0.424 ± 0.017	2.581SerAsp: 2.581 ± 0.039	2.199SerGlu: 2.199 ± 0.035	1.479SerPhe: 1.479 ± 0.027	5.958SerGly: 5.958 ± 0.06	0.988SerHis: 0.988 ± 0.025	1.265SerIle: 1.265 ± 0.025	0.985SerLys: 0.985 ± 0.026	4.71SerLeu: 4.71 ± 0.048	1.014SerMet: 1.014 ± 0.022	0.826SerAsn: 0.826 ± 0.019	3.116SerPro: 3.116 ± 0.043	1.2SerGln: 1.2 ± 0.027	3.7SerArg: 3.7 ± 0.044	2.663SerSer: 2.663 ± 0.046	2.943SerThr: 2.943 ± 0.05	4.193SerVal: 4.193 ± 0.042	0.842SerTrp: 0.842 ± 0.02	1.216SerTyr: 1.216 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.163ThrAla: 9.163 ± 0.079	0.431ThrCys: 0.431 ± 0.017	3.564ThrAsp: 3.564 ± 0.05	3.14ThrGlu: 3.14 ± 0.039	1.472ThrPhe: 1.472 ± 0.028	7.109ThrGly: 7.109 ± 0.074	1.174ThrHis: 1.174 ± 0.024	1.501ThrIle: 1.501 ± 0.031	1.085ThrLys: 1.085 ± 0.031	5.597ThrLeu: 5.597 ± 0.056	0.886ThrMet: 0.886 ± 0.02	0.953ThrAsn: 0.953 ± 0.023	4.026ThrPro: 4.026 ± 0.044	1.292ThrGln: 1.292 ± 0.029	4.049ThrArg: 4.049 ± 0.049	3.017ThrSer: 3.017 ± 0.053	3.675ThrThr: 3.675 ± 0.063	6.076ThrVal: 6.076 ± 0.061	0.874ThrTrp: 0.874 ± 0.022	1.318ThrTyr: 1.318 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.646ValAla: 10.646 ± 0.092	0.806ValCys: 0.806 ± 0.02	4.913ValAsp: 4.913 ± 0.06	4.519ValGlu: 4.519 ± 0.053	2.404ValPhe: 2.404 ± 0.034	6.329ValGly: 6.329 ± 0.063	2.029ValHis: 2.029 ± 0.028	2.675ValIle: 2.675 ± 0.041	1.753ValLys: 1.753 ± 0.036	9.672ValLeu: 9.672 ± 0.085	1.386ValMet: 1.386 ± 0.028	1.629ValAsn: 1.629 ± 0.028	5.516ValPro: 5.516 ± 0.058	2.063ValGln: 2.063 ± 0.033	7.55ValArg: 7.55 ± 0.063	4.331ValSer: 4.331 ± 0.046	5.842ValThr: 5.842 ± 0.064	7.943ValVal: 7.943 ± 0.067	1.181ValTrp: 1.181 ± 0.022	1.593ValTyr: 1.593 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.708TrpAla: 1.708 ± 0.031	0.153TrpCys: 0.153 ± 0.007	0.843TrpAsp: 0.843 ± 0.02	0.692TrpGlu: 0.692 ± 0.019	0.487TrpPhe: 0.487 ± 0.015	1.051TrpGly: 1.051 ± 0.023	0.377TrpHis: 0.377 ± 0.012	0.515TrpIle: 0.515 ± 0.014	0.369TrpLys: 0.369 ± 0.015	1.759TrpLeu: 1.759 ± 0.029	0.269TrpMet: 0.269 ± 0.012	0.384TrpAsn: 0.384 ± 0.015	0.799TrpPro: 0.799 ± 0.022	0.628TrpGln: 0.628 ± 0.018	1.399TrpArg: 1.399 ± 0.027	0.914TrpSer: 0.914 ± 0.023	1.041TrpThr: 1.041 ± 0.026	0.955TrpVal: 0.955 ± 0.023	0.343TrpTrp: 0.343 ± 0.014	0.353TrpTyr: 0.353 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.782TyrAla: 2.782 ± 0.035	0.171TyrCys: 0.171 ± 0.009	1.605TyrAsp: 1.605 ± 0.036	1.248TyrGlu: 1.248 ± 0.023	0.656TyrPhe: 0.656 ± 0.018	2.372TyrGly: 2.372 ± 0.035	0.376TyrHis: 0.376 ± 0.013	0.461TyrIle: 0.461 ± 0.016	0.408TyrLys: 0.408 ± 0.014	2.051TyrLeu: 2.051 ± 0.029	0.25TyrMet: 0.25 ± 0.012	0.397TyrAsn: 0.397 ± 0.016	1.045TyrPro: 1.045 ± 0.026	0.613TyrGln: 0.613 ± 0.018	1.833TyrArg: 1.833 ± 0.035	0.986TyrSer: 0.986 ± 0.022	1.177TyrThr: 1.177 ± 0.031	1.627TyrVal: 1.627 ± 0.027	0.36TyrTrp: 0.36 ± 0.013	0.453TyrTyr: 0.453 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7037 proteins (2285382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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