Amino acid dipepetide frequency for Vibrio palustris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.388AlaAla: 7.388 ± 0.098	0.99AlaCys: 0.99 ± 0.032	4.52AlaAsp: 4.52 ± 0.082	4.797AlaGlu: 4.797 ± 0.08	3.243AlaPhe: 3.243 ± 0.064	5.828AlaGly: 5.828 ± 0.086	1.896AlaHis: 1.896 ± 0.046	5.795AlaIle: 5.795 ± 0.082	4.764AlaLys: 4.764 ± 0.073	9.737AlaLeu: 9.737 ± 0.114	2.859AlaMet: 2.859 ± 0.06	3.41AlaAsn: 3.41 ± 0.063	2.815AlaPro: 2.815 ± 0.058	4.424AlaGln: 4.424 ± 0.083	3.812AlaArg: 3.812 ± 0.063	5.337AlaSer: 5.337 ± 0.081	4.586AlaThr: 4.586 ± 0.074	5.694AlaVal: 5.694 ± 0.082	0.988AlaTrp: 0.988 ± 0.035	2.421AlaTyr: 2.421 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.867CysAla: 0.867 ± 0.027	0.157CysCys: 0.157 ± 0.013	0.665CysAsp: 0.665 ± 0.024	0.628CysGlu: 0.628 ± 0.025	0.472CysPhe: 0.472 ± 0.02	0.929CysGly: 0.929 ± 0.031	0.376CysHis: 0.376 ± 0.019	0.626CysIle: 0.626 ± 0.025	0.354CysLys: 0.354 ± 0.019	1.03CysLeu: 1.03 ± 0.032	0.277CysMet: 0.277 ± 0.017	0.324CysAsn: 0.324 ± 0.019	0.455CysPro: 0.455 ± 0.023	0.572CysGln: 0.572 ± 0.023	0.512CysArg: 0.512 ± 0.025	0.748CysSer: 0.748 ± 0.024	0.484CysThr: 0.484 ± 0.024	0.724CysVal: 0.724 ± 0.027	0.137CysTrp: 0.137 ± 0.012	0.355CysTyr: 0.355 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.557AspAla: 4.557 ± 0.079	0.551AspCys: 0.551 ± 0.025	3.495AspAsp: 3.495 ± 0.09	3.816AspGlu: 3.816 ± 0.079	2.323AspPhe: 2.323 ± 0.045	3.647AspGly: 3.647 ± 0.066	1.276AspHis: 1.276 ± 0.032	4.238AspIle: 4.238 ± 0.062	3.124AspLys: 3.124 ± 0.055	4.982AspLeu: 4.982 ± 0.08	1.573AspMet: 1.573 ± 0.043	2.718AspAsn: 2.718 ± 0.05	2.052AspPro: 2.052 ± 0.043	2.007AspGln: 2.007 ± 0.042	2.246AspArg: 2.246 ± 0.049	3.245AspSer: 3.245 ± 0.055	3.027AspThr: 3.027 ± 0.065	4.213AspVal: 4.213 ± 0.065	0.823AspTrp: 0.823 ± 0.028	2.229AspTyr: 2.229 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.655GluAla: 4.655 ± 0.084	0.589GluCys: 0.589 ± 0.027	2.62GluAsp: 2.62 ± 0.063	3.437GluGlu: 3.437 ± 0.089	2.343GluPhe: 2.343 ± 0.053	3.222GluGly: 3.222 ± 0.064	1.893GluHis: 1.893 ± 0.041	3.266GluIle: 3.266 ± 0.056	3.535GluLys: 3.535 ± 0.065	6.493GluLeu: 6.493 ± 0.108	1.716GluMet: 1.716 ± 0.043	2.385GluAsn: 2.385 ± 0.053	2.052GluPro: 2.052 ± 0.075	3.907GluGln: 3.907 ± 0.075	3.458GluArg: 3.458 ± 0.064	3.558GluSer: 3.558 ± 0.059	2.962GluThr: 2.962 ± 0.061	3.886GluVal: 3.886 ± 0.06	0.807GluTrp: 0.807 ± 0.033	1.744GluTyr: 1.744 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.411PheAla: 3.411 ± 0.076	0.527PheCys: 0.527 ± 0.024	2.631PheAsp: 2.631 ± 0.053	2.159PheGlu: 2.159 ± 0.047	1.722PhePhe: 1.722 ± 0.054	3.16PheGly: 3.16 ± 0.065	0.914PheHis: 0.914 ± 0.028	2.819PheIle: 2.819 ± 0.058	1.833PheLys: 1.833 ± 0.043	3.349PheLeu: 3.349 ± 0.072	1.022PheMet: 1.022 ± 0.037	1.873PheAsn: 1.873 ± 0.04	1.395PhePro: 1.395 ± 0.035	1.285PheGln: 1.285 ± 0.033	1.451PheArg: 1.451 ± 0.044	3.185PheSer: 3.185 ± 0.063	2.352PheThr: 2.352 ± 0.052	2.786PheVal: 2.786 ± 0.058	0.514PheTrp: 0.514 ± 0.02	1.321PheTyr: 1.321 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.228GlyAla: 5.228 ± 0.087	0.877GlyCys: 0.877 ± 0.027	3.535GlyAsp: 3.535 ± 0.064	4.051GlyGlu: 4.051 ± 0.069	3.155GlyPhe: 3.155 ± 0.059	4.718GlyGly: 4.718 ± 0.09	1.729GlyHis: 1.729 ± 0.037	4.853GlyIle: 4.853 ± 0.087	3.785GlyLys: 3.785 ± 0.061	6.908GlyLeu: 6.908 ± 0.106	2.034GlyMet: 2.034 ± 0.046	2.422GlyAsn: 2.422 ± 0.056	1.71GlyPro: 1.71 ± 0.045	3.05GlyGln: 3.05 ± 0.057	3.173GlyArg: 3.173 ± 0.058	4.0GlySer: 4.0 ± 0.061	3.441GlyThr: 3.441 ± 0.059	5.166GlyVal: 5.166 ± 0.082	0.995GlyTrp: 0.995 ± 0.03	2.518GlyTyr: 2.518 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.995HisAla: 1.995 ± 0.047	0.387HisCys: 0.387 ± 0.018	1.498HisAsp: 1.498 ± 0.036	1.326HisGlu: 1.326 ± 0.037	1.172HisPhe: 1.172 ± 0.036	1.663HisGly: 1.663 ± 0.036	0.904HisHis: 0.904 ± 0.038	1.704HisIle: 1.704 ± 0.041	1.122HisLys: 1.122 ± 0.035	2.519HisLeu: 2.519 ± 0.055	0.625HisMet: 0.625 ± 0.023	1.103HisAsn: 1.103 ± 0.031	1.299HisPro: 1.299 ± 0.035	1.463HisGln: 1.463 ± 0.041	1.189HisArg: 1.189 ± 0.038	1.687HisSer: 1.687 ± 0.04	1.407HisThr: 1.407 ± 0.035	1.512HisVal: 1.512 ± 0.038	0.458HisTrp: 0.458 ± 0.023	1.072HisTyr: 1.072 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.378IleAla: 6.378 ± 0.087	0.659IleCys: 0.659 ± 0.025	4.333IleAsp: 4.333 ± 0.068	4.515IleGlu: 4.515 ± 0.07	2.236IlePhe: 2.236 ± 0.052	4.764IleGly: 4.764 ± 0.091	1.508IleHis: 1.508 ± 0.04	3.821IleIle: 3.821 ± 0.075	3.14IleLys: 3.14 ± 0.052	5.279IleLeu: 5.279 ± 0.082	1.488IleMet: 1.488 ± 0.04	2.965IleAsn: 2.965 ± 0.062	2.645IlePro: 2.645 ± 0.051	2.443IleGln: 2.443 ± 0.05	2.892IleArg: 2.892 ± 0.052	4.34IleSer: 4.34 ± 0.077	3.807IleThr: 3.807 ± 0.061	4.318IleVal: 4.318 ± 0.078	0.612IleTrp: 0.612 ± 0.024	1.703IleTyr: 1.703 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.533LysAla: 4.533 ± 0.085	0.316LysCys: 0.316 ± 0.018	2.707LysAsp: 2.707 ± 0.05	3.086LysGlu: 3.086 ± 0.066	1.37LysPhe: 1.37 ± 0.037	3.195LysGly: 3.195 ± 0.064	1.39LysHis: 1.39 ± 0.034	2.79LysIle: 2.79 ± 0.054	3.043LysLys: 3.043 ± 0.069	4.826LysLeu: 4.826 ± 0.074	1.428LysMet: 1.428 ± 0.037	2.168LysAsn: 2.168 ± 0.05	2.305LysPro: 2.305 ± 0.051	3.038LysGln: 3.038 ± 0.07	2.803LysArg: 2.803 ± 0.063	3.022LysSer: 3.022 ± 0.053	3.017LysThr: 3.017 ± 0.059	3.59LysVal: 3.59 ± 0.059	0.525LysTrp: 0.525 ± 0.024	1.325LysTyr: 1.325 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	9.483LeuAla: 9.483 ± 0.095	1.185LeuCys: 1.185 ± 0.035	5.773LeuAsp: 5.773 ± 0.089	5.568LeuGlu: 5.568 ± 0.091	4.034LeuPhe: 4.034 ± 0.08	6.874LeuGly: 6.874 ± 0.095	2.39LeuHis: 2.39 ± 0.045	6.135LeuIle: 6.135 ± 0.094	5.024LeuLys: 5.024 ± 0.068	10.249LeuLeu: 10.249 ± 0.139	2.827LeuMet: 2.827 ± 0.054	4.533LeuAsn: 4.533 ± 0.075	4.673LeuPro: 4.673 ± 0.073	3.942LeuGln: 3.942 ± 0.066	4.533LeuArg: 4.533 ± 0.077	7.957LeuSer: 7.957 ± 0.094	6.177LeuThr: 6.177 ± 0.087	6.822LeuVal: 6.822 ± 0.086	1.088LeuTrp: 1.088 ± 0.035	2.652LeuTyr: 2.652 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.646MetAla: 2.646 ± 0.044	0.253MetCys: 0.253 ± 0.013	1.335MetAsp: 1.335 ± 0.035	1.327MetGlu: 1.327 ± 0.031	0.934MetPhe: 0.934 ± 0.033	1.871MetGly: 1.871 ± 0.05	0.538MetHis: 0.538 ± 0.024	1.67MetIle: 1.67 ± 0.048	1.594MetLys: 1.594 ± 0.042	2.833MetLeu: 2.833 ± 0.058	0.89MetMet: 0.89 ± 0.031	1.264MetAsn: 1.264 ± 0.033	1.297MetPro: 1.297 ± 0.042	1.294MetGln: 1.294 ± 0.03	1.267MetArg: 1.267 ± 0.034	2.174MetSer: 2.174 ± 0.047	1.901MetThr: 1.901 ± 0.043	1.929MetVal: 1.929 ± 0.044	0.251MetTrp: 0.251 ± 0.016	0.623MetTyr: 0.623 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.425AsnAla: 3.425 ± 0.061	0.354AsnCys: 0.354 ± 0.018	2.471AsnAsp: 2.471 ± 0.048	2.341AsnGlu: 2.341 ± 0.052	1.435AsnPhe: 1.435 ± 0.036	2.881AsnGly: 2.881 ± 0.056	1.128AsnHis: 1.128 ± 0.036	2.852AsnIle: 2.852 ± 0.062	2.109AsnLys: 2.109 ± 0.047	3.705AsnLeu: 3.705 ± 0.061	1.047AsnMet: 1.047 ± 0.036	1.915AsnAsn: 1.915 ± 0.052	1.999AsnPro: 1.999 ± 0.045	2.169AsnGln: 2.169 ± 0.047	1.94AsnArg: 1.94 ± 0.048	2.348AsnSer: 2.348 ± 0.046	2.479AsnThr: 2.479 ± 0.049	2.97AsnVal: 2.97 ± 0.058	0.547AsnTrp: 0.547 ± 0.024	1.384AsnTyr: 1.384 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.008ProAla: 3.008 ± 0.06	0.347ProCys: 0.347 ± 0.017	2.399ProAsp: 2.399 ± 0.057	2.909ProGlu: 2.909 ± 0.058	1.682ProPhe: 1.682 ± 0.045	2.235ProGly: 2.235 ± 0.052	1.041ProHis: 1.041 ± 0.031	2.506ProIle: 2.506 ± 0.052	2.048ProLys: 2.048 ± 0.052	4.113ProLeu: 4.113 ± 0.067	1.103ProMet: 1.103 ± 0.031	1.793ProAsn: 1.793 ± 0.044	1.124ProPro: 1.124 ± 0.038	2.038ProGln: 2.038 ± 0.052	1.424ProArg: 1.424 ± 0.043	2.571ProSer: 2.571 ± 0.049	2.34ProThr: 2.34 ± 0.048	2.991ProVal: 2.991 ± 0.056	0.532ProTrp: 0.532 ± 0.025	1.285ProTyr: 1.285 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.846GlnAla: 4.846 ± 0.091	0.519GlnCys: 0.519 ± 0.026	2.317GlnAsp: 2.317 ± 0.046	2.67GlnGlu: 2.67 ± 0.058	1.812GlnPhe: 1.812 ± 0.04	3.197GlnGly: 3.197 ± 0.059	1.52GlnHis: 1.52 ± 0.044	2.352GlnIle: 2.352 ± 0.045	2.135GlnLys: 2.135 ± 0.049	5.395GlnLeu: 5.395 ± 0.09	1.188GlnMet: 1.188 ± 0.034	1.594GlnAsn: 1.594 ± 0.04	2.053GlnPro: 2.053 ± 0.05	3.431GlnGln: 3.431 ± 0.081	2.843GlnArg: 2.843 ± 0.062	3.003GlnSer: 3.003 ± 0.066	2.507GlnThr: 2.507 ± 0.048	3.242GlnVal: 3.242 ± 0.06	0.85GlnTrp: 0.85 ± 0.031	1.601GlnTyr: 1.601 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.433ArgAla: 3.433 ± 0.056	0.518ArgCys: 0.518 ± 0.026	2.606ArgAsp: 2.606 ± 0.056	2.908ArgGlu: 2.908 ± 0.053	2.204ArgPhe: 2.204 ± 0.049	2.645ArgGly: 2.645 ± 0.051	1.403ArgHis: 1.403 ± 0.041	3.155ArgIle: 3.155 ± 0.058	2.213ArgLys: 2.213 ± 0.055	5.144ArgLeu: 5.144 ± 0.077	1.282ArgMet: 1.282 ± 0.037	1.888ArgAsn: 1.888 ± 0.039	1.646ArgPro: 1.646 ± 0.04	2.544ArgGln: 2.544 ± 0.061	2.657ArgArg: 2.657 ± 0.058	2.836ArgSer: 2.836 ± 0.051	2.194ArgThr: 2.194 ± 0.044	3.151ArgVal: 3.151 ± 0.055	0.69ArgTrp: 0.69 ± 0.026	1.941ArgTyr: 1.941 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.368SerAla: 5.368 ± 0.071	0.6SerCys: 0.6 ± 0.023	3.818SerAsp: 3.818 ± 0.078	3.8SerGlu: 3.8 ± 0.069	2.698SerPhe: 2.698 ± 0.06	4.93SerGly: 4.93 ± 0.073	1.813SerHis: 1.813 ± 0.047	4.265SerIle: 4.265 ± 0.078	2.994SerLys: 2.994 ± 0.054	7.059SerLeu: 7.059 ± 0.083	1.843SerMet: 1.843 ± 0.042	2.546SerAsn: 2.546 ± 0.059	2.496SerPro: 2.496 ± 0.058	3.338SerGln: 3.338 ± 0.065	2.91SerArg: 2.91 ± 0.048	4.359SerSer: 4.359 ± 0.073	3.393SerThr: 3.393 ± 0.058	4.634SerVal: 4.634 ± 0.069	0.836SerTrp: 0.836 ± 0.032	1.993SerTyr: 1.993 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.509ThrAla: 4.509 ± 0.069	0.496ThrCys: 0.496 ± 0.023	2.946ThrAsp: 2.946 ± 0.058	2.946ThrGlu: 2.946 ± 0.058	2.19ThrPhe: 2.19 ± 0.049	3.962ThrGly: 3.962 ± 0.064	1.594ThrHis: 1.594 ± 0.042	3.724ThrIle: 3.724 ± 0.056	2.297ThrLys: 2.297 ± 0.057	6.574ThrLeu: 6.574 ± 0.078	1.459ThrMet: 1.459 ± 0.036	2.004ThrAsn: 2.004 ± 0.046	2.885ThrPro: 2.885 ± 0.051	2.853ThrGln: 2.853 ± 0.056	2.461ThrArg: 2.461 ± 0.05	3.506ThrSer: 3.506 ± 0.056	3.045ThrThr: 3.045 ± 0.061	3.963ThrVal: 3.963 ± 0.06	0.646ThrTrp: 0.646 ± 0.029	1.556ThrTyr: 1.556 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.286ValAla: 6.286 ± 0.094	0.796ValCys: 0.796 ± 0.026	4.117ValAsp: 4.117 ± 0.065	4.133ValGlu: 4.133 ± 0.074	2.76ValPhe: 2.76 ± 0.063	4.709ValGly: 4.709 ± 0.082	1.414ValHis: 1.414 ± 0.034	4.891ValIle: 4.891 ± 0.08	3.507ValLys: 3.507 ± 0.066	6.719ValLeu: 6.719 ± 0.089	2.134ValMet: 2.134 ± 0.047	2.942ValAsn: 2.942 ± 0.059	2.654ValPro: 2.654 ± 0.056	2.304ValGln: 2.304 ± 0.048	3.065ValArg: 3.065 ± 0.051	4.977ValSer: 4.977 ± 0.074	4.333ValThr: 4.333 ± 0.069	5.393ValVal: 5.393 ± 0.072	0.775ValTrp: 0.775 ± 0.031	1.879ValTyr: 1.879 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.857TrpAla: 0.857 ± 0.029	0.152TrpCys: 0.152 ± 0.012	0.618TrpAsp: 0.618 ± 0.024	0.54TrpGlu: 0.54 ± 0.025	0.605TrpPhe: 0.605 ± 0.028	0.81TrpGly: 0.81 ± 0.03	0.402TrpHis: 0.402 ± 0.023	0.757TrpIle: 0.757 ± 0.028	0.526TrpLys: 0.526 ± 0.024	1.718TrpLeu: 1.718 ± 0.046	0.381TrpMet: 0.381 ± 0.02	0.494TrpAsn: 0.494 ± 0.022	0.517TrpPro: 0.517 ± 0.022	0.942TrpGln: 0.942 ± 0.033	0.645TrpArg: 0.645 ± 0.022	0.781TrpSer: 0.781 ± 0.027	0.517TrpThr: 0.517 ± 0.021	0.897TrpVal: 0.897 ± 0.027	0.218TrpTrp: 0.218 ± 0.015	0.403TrpTyr: 0.403 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.431TyrAla: 2.431 ± 0.049	0.42TyrCys: 0.42 ± 0.019	1.739TyrAsp: 1.739 ± 0.047	1.569TyrGlu: 1.569 ± 0.038	1.318TyrPhe: 1.318 ± 0.036	2.109TyrGly: 2.109 ± 0.048	0.975TyrHis: 0.975 ± 0.029	1.627TyrIle: 1.627 ± 0.042	1.332TyrLys: 1.332 ± 0.039	3.286TyrLeu: 3.286 ± 0.059	0.712TyrMet: 0.712 ± 0.026	1.157TyrAsn: 1.157 ± 0.04	1.417TyrPro: 1.417 ± 0.036	2.033TyrGln: 2.033 ± 0.045	1.776TyrArg: 1.776 ± 0.042	2.057TyrSer: 2.057 ± 0.051	1.646TyrThr: 1.646 ± 0.039	1.91TyrVal: 1.91 ± 0.039	0.491TyrTrp: 0.491 ± 0.023	1.051TyrTyr: 1.051 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3328 proteins (1057203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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