Amino acid dipepetide frequency for Natronospirillum operosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.109AlaAla: 12.109 ± 0.134	0.991AlaCys: 0.991 ± 0.031	6.606AlaAsp: 6.606 ± 0.074	7.367AlaGlu: 7.367 ± 0.088	3.568AlaPhe: 3.568 ± 0.063	8.612AlaGly: 8.612 ± 0.103	2.152AlaHis: 2.152 ± 0.045	5.119AlaIle: 5.119 ± 0.071	1.902AlaLys: 1.902 ± 0.049	12.812AlaLeu: 12.812 ± 0.134	2.993AlaMet: 2.993 ± 0.051	2.451AlaAsn: 2.451 ± 0.044	4.089AlaPro: 4.089 ± 0.063	4.38AlaGln: 4.38 ± 0.06	7.633AlaArg: 7.633 ± 0.083	5.31AlaSer: 5.31 ± 0.072	5.041AlaThr: 5.041 ± 0.069	7.607AlaVal: 7.607 ± 0.095	1.615AlaTrp: 1.615 ± 0.041	2.24AlaTyr: 2.24 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.026	0.128CysCys: 0.128 ± 0.011	0.477CysAsp: 0.477 ± 0.021	0.449CysGlu: 0.449 ± 0.02	0.317CysPhe: 0.317 ± 0.013	0.812CysGly: 0.812 ± 0.027	0.28CysHis: 0.28 ± 0.015	0.424CysIle: 0.424 ± 0.018	0.192CysLys: 0.192 ± 0.012	0.991CysLeu: 0.991 ± 0.03	0.195CysMet: 0.195 ± 0.012	0.243CysAsn: 0.243 ± 0.012	0.439CysPro: 0.439 ± 0.021	0.393CysGln: 0.393 ± 0.018	0.698CysArg: 0.698 ± 0.025	0.536CysSer: 0.536 ± 0.022	0.448CysThr: 0.448 ± 0.02	0.546CysVal: 0.546 ± 0.02	0.14CysTrp: 0.14 ± 0.012	0.218CysTyr: 0.218 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.412AspAla: 5.412 ± 0.071	0.512AspCys: 0.512 ± 0.019	3.788AspAsp: 3.788 ± 0.066	3.809AspGlu: 3.809 ± 0.061	2.21AspPhe: 2.21 ± 0.051	4.225AspGly: 4.225 ± 0.069	1.544AspHis: 1.544 ± 0.042	3.421AspIle: 3.421 ± 0.06	1.378AspLys: 1.378 ± 0.033	6.502AspLeu: 6.502 ± 0.087	1.533AspMet: 1.533 ± 0.036	1.836AspAsn: 1.836 ± 0.046	3.131AspPro: 3.131 ± 0.056	2.758AspGln: 2.758 ± 0.054	4.04AspArg: 4.04 ± 0.066	3.167AspSer: 3.167 ± 0.053	3.101AspThr: 3.101 ± 0.057	3.672AspVal: 3.672 ± 0.063	1.307AspTrp: 1.307 ± 0.036	1.919AspTyr: 1.919 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.936GluAla: 6.936 ± 0.081	0.398GluCys: 0.398 ± 0.018	3.368GluAsp: 3.368 ± 0.056	3.566GluGlu: 3.566 ± 0.062	2.033GluPhe: 2.033 ± 0.044	3.923GluGly: 3.923 ± 0.062	1.716GluHis: 1.716 ± 0.036	2.935GluIle: 2.935 ± 0.051	1.824GluLys: 1.824 ± 0.05	7.121GluLeu: 7.121 ± 0.088	1.442GluMet: 1.442 ± 0.034	1.575GluAsn: 1.575 ± 0.037	3.042GluPro: 3.042 ± 0.059	4.11GluGln: 4.11 ± 0.065	5.065GluArg: 5.065 ± 0.068	3.124GluSer: 3.124 ± 0.05	3.147GluThr: 3.147 ± 0.06	4.363GluVal: 4.363 ± 0.065	0.81GluTrp: 0.81 ± 0.022	1.361GluTyr: 1.361 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.418PheAla: 3.418 ± 0.057	0.382PheCys: 0.382 ± 0.018	2.331PheAsp: 2.331 ± 0.043	2.112PheGlu: 2.112 ± 0.043	1.407PhePhe: 1.407 ± 0.042	3.06PheGly: 3.06 ± 0.049	0.851PheHis: 0.851 ± 0.026	1.81PheIle: 1.81 ± 0.045	0.826PheLys: 0.826 ± 0.027	3.383PheLeu: 3.383 ± 0.058	0.956PheMet: 0.956 ± 0.026	1.317PheAsn: 1.317 ± 0.033	1.526PhePro: 1.526 ± 0.032	1.231PheGln: 1.231 ± 0.031	2.381PheArg: 2.381 ± 0.042	2.495PheSer: 2.495 ± 0.047	1.843PheThr: 1.843 ± 0.036	2.559PheVal: 2.559 ± 0.047	0.606PheTrp: 0.606 ± 0.026	1.038PheTyr: 1.038 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.812GlyAla: 6.812 ± 0.099	0.812GlyCys: 0.812 ± 0.029	4.269GlyAsp: 4.269 ± 0.073	4.6GlyGlu: 4.6 ± 0.071	3.156GlyPhe: 3.156 ± 0.058	5.712GlyGly: 5.712 ± 0.083	1.911GlyHis: 1.911 ± 0.044	4.218GlyIle: 4.218 ± 0.066	2.268GlyLys: 2.268 ± 0.053	8.997GlyLeu: 8.997 ± 0.105	2.23GlyMet: 2.23 ± 0.04	2.197GlyAsn: 2.197 ± 0.075	2.79GlyPro: 2.79 ± 0.052	3.582GlyGln: 3.582 ± 0.054	5.227GlyArg: 5.227 ± 0.069	4.321GlySer: 4.321 ± 0.069	4.111GlyThr: 4.111 ± 0.07	5.628GlyVal: 5.628 ± 0.069	1.306GlyTrp: 1.306 ± 0.04	2.446GlyTyr: 2.446 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.086HisAla: 2.086 ± 0.039	0.342HisCys: 0.342 ± 0.018	1.41HisAsp: 1.41 ± 0.033	1.413HisGlu: 1.413 ± 0.033	1.059HisPhe: 1.059 ± 0.03	1.864HisGly: 1.864 ± 0.046	0.755HisHis: 0.755 ± 0.025	1.132HisIle: 1.132 ± 0.028	0.563HisLys: 0.563 ± 0.023	2.698HisLeu: 2.698 ± 0.048	0.531HisMet: 0.531 ± 0.02	0.708HisAsn: 0.708 ± 0.025	1.532HisPro: 1.532 ± 0.04	1.22HisGln: 1.22 ± 0.034	1.76HisArg: 1.76 ± 0.045	1.312HisSer: 1.312 ± 0.031	1.089HisThr: 1.089 ± 0.033	1.326HisVal: 1.326 ± 0.036	0.595HisTrp: 0.595 ± 0.021	0.833HisTyr: 0.833 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.217IleAla: 5.217 ± 0.073	0.477IleCys: 0.477 ± 0.021	3.228IleAsp: 3.228 ± 0.052	3.527IleGlu: 3.527 ± 0.051	1.555IlePhe: 1.555 ± 0.045	4.07IleGly: 4.07 ± 0.058	1.076IleHis: 1.076 ± 0.03	2.476IleIle: 2.476 ± 0.05	1.327IleLys: 1.327 ± 0.036	4.65IleLeu: 4.65 ± 0.076	1.28IleMet: 1.28 ± 0.035	1.846IleAsn: 1.846 ± 0.042	2.367IlePro: 2.367 ± 0.048	1.757IleGln: 1.757 ± 0.036	3.438IleArg: 3.438 ± 0.051	3.05IleSer: 3.05 ± 0.05	2.832IleThr: 2.832 ± 0.07	3.352IleVal: 3.352 ± 0.062	0.649IleTrp: 0.649 ± 0.024	1.17IleTyr: 1.17 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.935LysAla: 2.935 ± 0.053	0.152LysCys: 0.152 ± 0.012	1.312LysAsp: 1.312 ± 0.035	1.324LysGlu: 1.324 ± 0.037	0.574LysPhe: 0.574 ± 0.022	1.881LysGly: 1.881 ± 0.04	0.576LysHis: 0.576 ± 0.023	1.079LysIle: 1.079 ± 0.033	1.054LysLys: 1.054 ± 0.038	2.468LysLeu: 2.468 ± 0.058	0.545LysMet: 0.545 ± 0.02	0.711LysAsn: 0.711 ± 0.026	1.42LysPro: 1.42 ± 0.039	1.138LysGln: 1.138 ± 0.033	1.764LysArg: 1.764 ± 0.046	1.432LysSer: 1.432 ± 0.039	1.485LysThr: 1.485 ± 0.035	1.889LysVal: 1.889 ± 0.046	0.268LysTrp: 0.268 ± 0.016	0.557LysTyr: 0.557 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.843LeuAla: 12.843 ± 0.129	1.023LeuCys: 1.023 ± 0.029	6.743LeuAsp: 6.743 ± 0.075	6.509LeuGlu: 6.509 ± 0.086	3.96LeuPhe: 3.96 ± 0.069	8.537LeuGly: 8.537 ± 0.104	2.601LeuHis: 2.601 ± 0.055	5.465LeuIle: 5.465 ± 0.079	3.03LeuLys: 3.03 ± 0.059	12.627LeuLeu: 12.627 ± 0.175	2.757LeuMet: 2.757 ± 0.047	3.55LeuAsn: 3.55 ± 0.051	5.851LeuPro: 5.851 ± 0.067	5.305LeuGln: 5.305 ± 0.072	7.194LeuArg: 7.194 ± 0.087	7.006LeuSer: 7.006 ± 0.088	6.539LeuThr: 6.539 ± 0.093	7.921LeuVal: 7.921 ± 0.088	1.558LeuTrp: 1.558 ± 0.044	2.618LeuTyr: 2.618 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.063MetAla: 3.063 ± 0.049	0.14MetCys: 0.14 ± 0.011	1.344MetAsp: 1.344 ± 0.037	1.269MetGlu: 1.269 ± 0.031	0.679MetPhe: 0.679 ± 0.022	1.917MetGly: 1.917 ± 0.038	0.521MetHis: 0.521 ± 0.021	1.353MetIle: 1.353 ± 0.039	0.839MetLys: 0.839 ± 0.026	2.723MetLeu: 2.723 ± 0.052	0.706MetMet: 0.706 ± 0.023	0.849MetAsn: 0.849 ± 0.024	1.424MetPro: 1.424 ± 0.032	1.138MetGln: 1.138 ± 0.032	1.558MetArg: 1.558 ± 0.032	1.631MetSer: 1.631 ± 0.039	1.937MetThr: 1.937 ± 0.038	1.86MetVal: 1.86 ± 0.042	0.211MetTrp: 0.211 ± 0.014	0.416MetTyr: 0.416 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.834AsnAla: 2.834 ± 0.057	0.252AsnCys: 0.252 ± 0.014	1.655AsnAsp: 1.655 ± 0.044	1.636AsnGlu: 1.636 ± 0.041	0.933AsnPhe: 0.933 ± 0.029	2.213AsnGly: 2.213 ± 0.058	0.682AsnHis: 0.682 ± 0.026	1.538AsnIle: 1.538 ± 0.044	0.686AsnLys: 0.686 ± 0.024	3.238AsnLeu: 3.238 ± 0.054	0.729AsnMet: 0.729 ± 0.026	0.978AsnAsn: 0.978 ± 0.035	1.919AsnPro: 1.919 ± 0.039	1.272AsnGln: 1.272 ± 0.034	2.193AsnArg: 2.193 ± 0.044	1.527AsnSer: 1.527 ± 0.04	1.534AsnThr: 1.534 ± 0.04	1.827AsnVal: 1.827 ± 0.044	0.528AsnTrp: 0.528 ± 0.021	0.758AsnTyr: 0.758 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.225ProAla: 5.225 ± 0.084	0.323ProCys: 0.323 ± 0.015	3.775ProAsp: 3.775 ± 0.07	4.312ProGlu: 4.312 ± 0.07	1.757ProPhe: 1.757 ± 0.037	4.113ProGly: 4.113 ± 0.062	1.041ProHis: 1.041 ± 0.029	1.981ProIle: 1.981 ± 0.041	1.02ProLys: 1.02 ± 0.034	5.133ProLeu: 5.133 ± 0.067	1.208ProMet: 1.208 ± 0.033	1.287ProAsn: 1.287 ± 0.03	2.122ProPro: 2.122 ± 0.046	1.906ProGln: 1.906 ± 0.039	2.508ProArg: 2.508 ± 0.041	2.312ProSer: 2.312 ± 0.042	2.373ProThr: 2.373 ± 0.047	4.097ProVal: 4.097 ± 0.064	0.864ProTrp: 0.864 ± 0.028	1.165ProTyr: 1.165 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.831GlnAla: 5.831 ± 0.075	0.352GlnCys: 0.352 ± 0.017	2.242GlnAsp: 2.242 ± 0.044	2.354GlnGlu: 2.354 ± 0.048	1.407GlnPhe: 1.407 ± 0.036	3.504GlnGly: 3.504 ± 0.047	1.253GlnHis: 1.253 ± 0.034	2.02GlnIle: 2.02 ± 0.037	1.115GlnLys: 1.115 ± 0.03	4.96GlnLeu: 4.96 ± 0.077	1.098GlnMet: 1.098 ± 0.029	1.156GlnAsn: 1.156 ± 0.033	2.544GlnPro: 2.544 ± 0.041	3.048GlnGln: 3.048 ± 0.062	3.67GlnArg: 3.67 ± 0.067	2.525GlnSer: 2.525 ± 0.055	2.48GlnThr: 2.48 ± 0.05	3.371GlnVal: 3.371 ± 0.052	0.845GlnTrp: 0.845 ± 0.027	1.108GlnTyr: 1.108 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.577ArgAla: 6.577 ± 0.084	0.586ArgCys: 0.586 ± 0.023	3.85ArgAsp: 3.85 ± 0.059	4.382ArgGlu: 4.382 ± 0.062	2.768ArgPhe: 2.768 ± 0.046	3.96ArgGly: 3.96 ± 0.058	2.149ArgHis: 2.149 ± 0.041	3.65ArgIle: 3.65 ± 0.052	1.956ArgLys: 1.956 ± 0.05	8.66ArgLeu: 8.66 ± 0.1	1.828ArgMet: 1.828 ± 0.037	2.022ArgAsn: 2.022 ± 0.042	3.129ArgPro: 3.129 ± 0.059	4.081ArgGln: 4.081 ± 0.06	5.097ArgArg: 5.097 ± 0.075	3.605ArgSer: 3.605 ± 0.058	3.353ArgThr: 3.353 ± 0.05	4.877ArgVal: 4.877 ± 0.063	1.24ArgTrp: 1.24 ± 0.037	2.078ArgTyr: 2.078 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.967SerAla: 5.967 ± 0.067	0.388SerCys: 0.388 ± 0.017	3.23SerAsp: 3.23 ± 0.054	3.362SerGlu: 3.362 ± 0.054	2.032SerPhe: 2.032 ± 0.041	5.342SerGly: 5.342 ± 0.074	1.236SerHis: 1.236 ± 0.028	2.683SerIle: 2.683 ± 0.045	1.279SerLys: 1.279 ± 0.036	6.265SerLeu: 6.265 ± 0.078	1.549SerMet: 1.549 ± 0.039	1.597SerAsn: 1.597 ± 0.044	2.649SerPro: 2.649 ± 0.05	2.262SerGln: 2.262 ± 0.045	3.816SerArg: 3.816 ± 0.056	3.224SerSer: 3.224 ± 0.058	3.022SerThr: 3.022 ± 0.05	4.158SerVal: 4.158 ± 0.056	0.811SerTrp: 0.811 ± 0.027	1.301SerTyr: 1.301 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.504ThrAla: 5.504 ± 0.08	0.422ThrCys: 0.422 ± 0.019	3.22ThrAsp: 3.22 ± 0.061	3.385ThrGlu: 3.385 ± 0.057	1.797ThrPhe: 1.797 ± 0.042	4.918ThrGly: 4.918 ± 0.095	1.209ThrHis: 1.209 ± 0.029	2.421ThrIle: 2.421 ± 0.049	0.814ThrLys: 0.814 ± 0.029	7.156ThrLeu: 7.156 ± 0.104	1.127ThrMet: 1.127 ± 0.031	1.303ThrAsn: 1.303 ± 0.038	3.055ThrPro: 3.055 ± 0.051	1.994ThrGln: 1.994 ± 0.041	3.638ThrArg: 3.638 ± 0.05	2.694ThrSer: 2.694 ± 0.05	2.854ThrThr: 2.854 ± 0.064	3.985ThrVal: 3.985 ± 0.057	0.764ThrTrp: 0.764 ± 0.028	1.142ThrTyr: 1.142 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.474ValAla: 7.474 ± 0.082	0.674ValCys: 0.674 ± 0.023	4.254ValAsp: 4.254 ± 0.063	4.277ValGlu: 4.277 ± 0.063	2.615ValPhe: 2.615 ± 0.044	5.004ValGly: 5.004 ± 0.067	1.535ValHis: 1.535 ± 0.042	3.847ValIle: 3.847 ± 0.057	1.625ValLys: 1.625 ± 0.045	7.933ValLeu: 7.933 ± 0.093	1.93ValMet: 1.93 ± 0.041	2.155ValAsn: 2.155 ± 0.041	3.429ValPro: 3.429 ± 0.05	2.804ValGln: 2.804 ± 0.052	4.786ValArg: 4.786 ± 0.063	4.555ValSer: 4.555 ± 0.058	4.199ValThr: 4.199 ± 0.07	5.603ValVal: 5.603 ± 0.076	0.94ValTrp: 0.94 ± 0.029	1.626ValTyr: 1.626 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.287TrpAla: 1.287 ± 0.034	0.151TrpCys: 0.151 ± 0.01	0.704TrpAsp: 0.704 ± 0.025	0.729TrpGlu: 0.729 ± 0.025	0.623TrpPhe: 0.623 ± 0.024	0.926TrpGly: 0.926 ± 0.028	0.483TrpHis: 0.483 ± 0.019	0.673TrpIle: 0.673 ± 0.025	0.323TrpLys: 0.323 ± 0.016	2.466TrpLeu: 2.466 ± 0.055	0.392TrpMet: 0.392 ± 0.019	0.416TrpAsn: 0.416 ± 0.02	0.84TrpPro: 0.84 ± 0.032	1.145TrpGln: 1.145 ± 0.034	1.19TrpArg: 1.19 ± 0.032	0.91TrpSer: 0.91 ± 0.029	0.758TrpThr: 0.758 ± 0.026	1.122TrpVal: 1.122 ± 0.033	0.301TrpTrp: 0.301 ± 0.018	0.399TrpTyr: 0.399 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.205TyrAla: 2.205 ± 0.037	0.284TyrCys: 0.284 ± 0.014	1.459TyrAsp: 1.459 ± 0.041	1.478TyrGlu: 1.478 ± 0.036	1.079TyrPhe: 1.079 ± 0.028	2.001TyrGly: 2.001 ± 0.048	0.659TyrHis: 0.659 ± 0.022	1.099TyrIle: 1.099 ± 0.029	0.539TyrLys: 0.539 ± 0.02	2.854TyrLeu: 2.854 ± 0.048	0.547TyrMet: 0.547 ± 0.02	0.738TyrAsn: 0.738 ± 0.027	1.224TyrPro: 1.224 ± 0.034	1.36TyrGln: 1.36 ± 0.034	2.192TyrArg: 2.192 ± 0.041	1.436TyrSer: 1.436 ± 0.035	1.256TyrThr: 1.256 ± 0.031	1.504TyrVal: 1.504 ± 0.033	0.48TyrTrp: 0.48 ± 0.02	0.76TyrTyr: 0.76 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3948 proteins (1311596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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