Amino acid dipepetide frequency for Aeribacillus pallidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.062AlaAla: 6.062 ± 0.097	0.666AlaCys: 0.666 ± 0.025	3.228AlaAsp: 3.228 ± 0.059	4.826AlaGlu: 4.826 ± 0.075	3.309AlaPhe: 3.309 ± 0.058	5.054AlaGly: 5.054 ± 0.082	1.224AlaHis: 1.224 ± 0.034	5.85AlaIle: 5.85 ± 0.083	5.386AlaLys: 5.386 ± 0.078	6.951AlaLeu: 6.951 ± 0.089	1.829AlaMet: 1.829 ± 0.039	2.817AlaAsn: 2.817 ± 0.051	1.96AlaPro: 1.96 ± 0.039	2.103AlaGln: 2.103 ± 0.048	2.618AlaArg: 2.618 ± 0.057	3.835AlaSer: 3.835 ± 0.067	2.903AlaThr: 2.903 ± 0.057	5.709AlaVal: 5.709 ± 0.077	0.537AlaTrp: 0.537 ± 0.023	2.246AlaTyr: 2.246 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.024	0.104CysCys: 0.104 ± 0.011	0.391CysAsp: 0.391 ± 0.019	0.509CysGlu: 0.509 ± 0.025	0.349CysPhe: 0.349 ± 0.018	0.757CysGly: 0.757 ± 0.029	0.22CysHis: 0.22 ± 0.016	0.589CysIle: 0.589 ± 0.023	0.429CysLys: 0.429 ± 0.021	0.779CysLeu: 0.779 ± 0.028	0.19CysMet: 0.19 ± 0.013	0.276CysAsn: 0.276 ± 0.016	0.398CysPro: 0.398 ± 0.022	0.281CysGln: 0.281 ± 0.017	0.359CysArg: 0.359 ± 0.021	0.555CysSer: 0.555 ± 0.025	0.438CysThr: 0.438 ± 0.021	0.417CysVal: 0.417 ± 0.02	0.081CysTrp: 0.081 ± 0.009	0.272CysTyr: 0.272 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.049AspAla: 3.049 ± 0.054	0.379AspCys: 0.379 ± 0.02	2.387AspAsp: 2.387 ± 0.058	4.708AspGlu: 4.708 ± 0.081	2.27AspPhe: 2.27 ± 0.05	3.197AspGly: 3.197 ± 0.056	1.219AspHis: 1.219 ± 0.036	4.062AspIle: 4.062 ± 0.074	2.792AspLys: 2.792 ± 0.056	4.951AspLeu: 4.951 ± 0.071	1.137AspMet: 1.137 ± 0.037	1.431AspAsn: 1.431 ± 0.037	2.03AspPro: 2.03 ± 0.05	2.132AspGln: 2.132 ± 0.051	2.326AspArg: 2.326 ± 0.047	2.188AspSer: 2.188 ± 0.044	1.876AspThr: 1.876 ± 0.041	3.696AspVal: 3.696 ± 0.063	0.576AspTrp: 0.576 ± 0.028	1.931AspTyr: 1.931 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.516GluAla: 5.516 ± 0.082	0.432GluCys: 0.432 ± 0.024	3.458GluAsp: 3.458 ± 0.059	7.312GluGlu: 7.312 ± 0.107	2.602GluPhe: 2.602 ± 0.056	4.276GluGly: 4.276 ± 0.073	1.744GluHis: 1.744 ± 0.041	6.366GluIle: 6.366 ± 0.077	8.245GluLys: 8.245 ± 0.124	7.359GluLeu: 7.359 ± 0.108	2.303GluMet: 2.303 ± 0.056	4.125GluAsn: 4.125 ± 0.077	2.003GluPro: 2.003 ± 0.045	3.685GluGln: 3.685 ± 0.072	3.817GluArg: 3.817 ± 0.055	3.26GluSer: 3.26 ± 0.06	3.787GluThr: 3.787 ± 0.063	4.812GluVal: 4.812 ± 0.076	0.817GluTrp: 0.817 ± 0.025	2.29GluTyr: 2.29 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.137PheAla: 3.137 ± 0.057	0.411PheCys: 0.411 ± 0.018	2.348PheAsp: 2.348 ± 0.049	2.986PheGlu: 2.986 ± 0.058	2.662PhePhe: 2.662 ± 0.079	3.268PheGly: 3.268 ± 0.068	1.303PheHis: 1.303 ± 0.04	4.066PheIle: 4.066 ± 0.085	2.362PheLys: 2.362 ± 0.046	4.848PheLeu: 4.848 ± 0.095	1.139PheMet: 1.139 ± 0.037	1.62PheAsn: 1.62 ± 0.04	1.833PhePro: 1.833 ± 0.042	1.948PheGln: 1.948 ± 0.047	1.675PheArg: 1.675 ± 0.039	3.315PheSer: 3.315 ± 0.065	2.326PheThr: 2.326 ± 0.045	3.284PheVal: 3.284 ± 0.065	0.506PheTrp: 0.506 ± 0.024	1.789PheTyr: 1.789 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.749GlyAla: 4.749 ± 0.075	0.672GlyCys: 0.672 ± 0.026	3.007GlyAsp: 3.007 ± 0.055	4.519GlyGlu: 4.519 ± 0.08	3.329GlyPhe: 3.329 ± 0.066	4.639GlyGly: 4.639 ± 0.095	1.403GlyHis: 1.403 ± 0.045	6.108GlyIle: 6.108 ± 0.091	5.478GlyLys: 5.478 ± 0.079	6.306GlyLeu: 6.306 ± 0.089	1.925GlyMet: 1.925 ± 0.044	2.636GlyAsn: 2.636 ± 0.056	1.736GlyPro: 1.736 ± 0.047	2.145GlyGln: 2.145 ± 0.045	2.705GlyArg: 2.705 ± 0.052	3.795GlySer: 3.795 ± 0.068	3.759GlyThr: 3.759 ± 0.071	4.771GlyVal: 4.771 ± 0.08	0.73GlyTrp: 0.73 ± 0.031	2.622GlyTyr: 2.622 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.302HisAla: 1.302 ± 0.04	0.227HisCys: 0.227 ± 0.015	1.039HisAsp: 1.039 ± 0.032	1.533HisGlu: 1.533 ± 0.043	1.185HisPhe: 1.185 ± 0.035	1.399HisGly: 1.399 ± 0.036	0.709HisHis: 0.709 ± 0.03	1.71HisIle: 1.71 ± 0.04	1.168HisLys: 1.168 ± 0.033	2.239HisLeu: 2.239 ± 0.056	0.47HisMet: 0.47 ± 0.022	0.752HisAsn: 0.752 ± 0.028	1.252HisPro: 1.252 ± 0.037	0.909HisGln: 0.909 ± 0.03	0.995HisArg: 0.995 ± 0.036	1.303HisSer: 1.303 ± 0.039	0.961HisThr: 0.961 ± 0.029	1.488HisVal: 1.488 ± 0.034	0.23HisTrp: 0.23 ± 0.017	0.94HisTyr: 0.94 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.27IleAla: 6.27 ± 0.099	0.74IleCys: 0.74 ± 0.032	4.524IleAsp: 4.524 ± 0.062	6.358IleGlu: 6.358 ± 0.083	3.744IlePhe: 3.744 ± 0.081	6.532IleGly: 6.532 ± 0.101	1.913IleHis: 1.913 ± 0.049	6.316IleIle: 6.316 ± 0.09	5.027IleLys: 5.027 ± 0.071	7.477IleLeu: 7.477 ± 0.101	1.861IleMet: 1.861 ± 0.042	3.186IleAsn: 3.186 ± 0.06	3.54IlePro: 3.54 ± 0.048	3.188IleGln: 3.188 ± 0.062	3.395IleArg: 3.395 ± 0.06	5.138IleSer: 5.138 ± 0.079	4.033IleThr: 4.033 ± 0.062	6.042IleVal: 6.042 ± 0.087	0.715IleTrp: 0.715 ± 0.03	2.644IleTyr: 2.644 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.891LysAla: 4.891 ± 0.08	0.399LysCys: 0.399 ± 0.022	3.696LysAsp: 3.696 ± 0.066	8.018LysGlu: 8.018 ± 0.117	2.157LysPhe: 2.157 ± 0.048	4.979LysGly: 4.979 ± 0.071	1.495LysHis: 1.495 ± 0.038	5.901LysIle: 5.901 ± 0.082	7.373LysLys: 7.373 ± 0.106	6.415LysLeu: 6.415 ± 0.084	2.348LysMet: 2.348 ± 0.041	3.885LysAsn: 3.885 ± 0.062	2.42LysPro: 2.42 ± 0.052	3.495LysGln: 3.495 ± 0.058	3.806LysArg: 3.806 ± 0.066	3.454LysSer: 3.454 ± 0.061	3.947LysThr: 3.947 ± 0.059	4.749LysVal: 4.749 ± 0.078	0.899LysTrp: 0.899 ± 0.028	2.393LysTyr: 2.393 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.273LeuAla: 7.273 ± 0.085	0.755LeuCys: 0.755 ± 0.024	4.565LeuAsp: 4.565 ± 0.07	6.925LeuGlu: 6.925 ± 0.093	4.975LeuPhe: 4.975 ± 0.1	6.081LeuGly: 6.081 ± 0.093	2.058LeuHis: 2.058 ± 0.044	7.273LeuIle: 7.273 ± 0.102	7.822LeuLys: 7.822 ± 0.103	10.248LeuLeu: 10.248 ± 0.14	2.345LeuMet: 2.345 ± 0.048	4.276LeuAsn: 4.276 ± 0.061	3.96LeuPro: 3.96 ± 0.058	3.483LeuGln: 3.483 ± 0.057	3.553LeuArg: 3.553 ± 0.066	6.689LeuSer: 6.689 ± 0.095	5.192LeuThr: 5.192 ± 0.074	5.885LeuVal: 5.885 ± 0.078	0.821LeuTrp: 0.821 ± 0.03	3.222LeuTyr: 3.222 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.918MetAla: 1.918 ± 0.044	0.15MetCys: 0.15 ± 0.013	1.342MetAsp: 1.342 ± 0.04	2.061MetGlu: 2.061 ± 0.044	1.082MetPhe: 1.082 ± 0.034	1.565MetGly: 1.565 ± 0.039	0.421MetHis: 0.421 ± 0.02	2.209MetIle: 2.209 ± 0.056	2.606MetLys: 2.606 ± 0.053	2.43MetLeu: 2.43 ± 0.05	0.78MetMet: 0.78 ± 0.029	1.473MetAsn: 1.473 ± 0.04	0.942MetPro: 0.942 ± 0.032	0.731MetGln: 0.731 ± 0.028	1.039MetArg: 1.039 ± 0.035	1.483MetSer: 1.483 ± 0.039	1.476MetThr: 1.476 ± 0.038	1.54MetVal: 1.54 ± 0.044	0.163MetTrp: 0.163 ± 0.013	0.691MetTyr: 0.691 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.718AsnAla: 2.718 ± 0.054	0.314AsnCys: 0.314 ± 0.018	2.12AsnAsp: 2.12 ± 0.049	3.698AsnGlu: 3.698 ± 0.065	1.678AsnPhe: 1.678 ± 0.04	3.43AsnGly: 3.43 ± 0.067	0.987AsnHis: 0.987 ± 0.032	3.892AsnIle: 3.892 ± 0.063	2.967AsnLys: 2.967 ± 0.056	3.679AsnLeu: 3.679 ± 0.059	1.127AsnMet: 1.127 ± 0.037	1.803AsnAsn: 1.803 ± 0.05	2.05AsnPro: 2.05 ± 0.043	1.722AsnGln: 1.722 ± 0.047	2.128AsnArg: 2.128 ± 0.048	2.187AsnSer: 2.187 ± 0.047	1.753AsnThr: 1.753 ± 0.046	3.159AsnVal: 3.159 ± 0.056	0.55AsnTrp: 0.55 ± 0.025	1.38AsnTyr: 1.38 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.165ProAla: 2.165 ± 0.046	0.231ProCys: 0.231 ± 0.015	2.019ProAsp: 2.019 ± 0.054	3.048ProGlu: 3.048 ± 0.067	2.187ProPhe: 2.187 ± 0.053	2.249ProGly: 2.249 ± 0.049	0.829ProHis: 0.829 ± 0.031	2.987ProIle: 2.987 ± 0.051	2.552ProLys: 2.552 ± 0.053	3.518ProLeu: 3.518 ± 0.058	0.758ProMet: 0.758 ± 0.029	1.823ProAsn: 1.823 ± 0.043	1.025ProPro: 1.025 ± 0.036	1.011ProGln: 1.011 ± 0.032	1.095ProArg: 1.095 ± 0.032	2.237ProSer: 2.237 ± 0.043	1.832ProThr: 1.832 ± 0.044	2.833ProVal: 2.833 ± 0.053	0.386ProTrp: 0.386 ± 0.02	1.477ProTyr: 1.477 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.575GlnAla: 2.575 ± 0.055	0.239GlnCys: 0.239 ± 0.016	1.453GlnAsp: 1.453 ± 0.033	2.835GlnGlu: 2.835 ± 0.055	1.769GlnPhe: 1.769 ± 0.043	1.915GlnGly: 1.915 ± 0.048	0.811GlnHis: 0.811 ± 0.026	2.911GlnIle: 2.911 ± 0.057	3.252GlnLys: 3.252 ± 0.065	4.056GlnLeu: 4.056 ± 0.067	1.139GlnMet: 1.139 ± 0.031	1.862GlnAsn: 1.862 ± 0.043	1.144GlnPro: 1.144 ± 0.034	1.758GlnGln: 1.758 ± 0.047	1.397GlnArg: 1.397 ± 0.036	2.11GlnSer: 2.11 ± 0.052	1.883GlnThr: 1.883 ± 0.037	2.258GlnVal: 2.258 ± 0.053	0.371GlnTrp: 0.371 ± 0.02	1.404GlnTyr: 1.404 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.47ArgAla: 2.47 ± 0.05	0.276ArgCys: 0.276 ± 0.016	1.947ArgAsp: 1.947 ± 0.047	3.34ArgGlu: 3.34 ± 0.067	1.996ArgPhe: 1.996 ± 0.047	2.29ArgGly: 2.29 ± 0.056	0.807ArgHis: 0.807 ± 0.028	3.364ArgIle: 3.364 ± 0.062	3.639ArgLys: 3.639 ± 0.054	4.222ArgLeu: 4.222 ± 0.064	1.264ArgMet: 1.264 ± 0.033	1.953ArgAsn: 1.953 ± 0.049	1.362ArgPro: 1.362 ± 0.039	1.587ArgGln: 1.587 ± 0.041	1.813ArgArg: 1.813 ± 0.04	2.298ArgSer: 2.298 ± 0.047	2.115ArgThr: 2.115 ± 0.043	2.539ArgVal: 2.539 ± 0.051	0.389ArgTrp: 0.389 ± 0.02	1.593ArgTyr: 1.593 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.663SerAla: 3.663 ± 0.063	0.469SerCys: 0.469 ± 0.025	2.633SerAsp: 2.633 ± 0.052	3.848SerGlu: 3.848 ± 0.06	3.468SerPhe: 3.468 ± 0.068	4.224SerGly: 4.224 ± 0.077	1.142SerHis: 1.142 ± 0.035	5.175SerIle: 5.175 ± 0.087	3.904SerLys: 3.904 ± 0.062	5.842SerLeu: 5.842 ± 0.095	1.556SerMet: 1.556 ± 0.04	2.334SerAsn: 2.334 ± 0.048	2.158SerPro: 2.158 ± 0.051	1.717SerGln: 1.717 ± 0.039	2.069SerArg: 2.069 ± 0.041	3.77SerSer: 3.77 ± 0.082	2.706SerThr: 2.706 ± 0.051	3.846SerVal: 3.846 ± 0.063	0.576SerTrp: 0.576 ± 0.025	2.062SerTyr: 2.062 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.613ThrAla: 3.613 ± 0.063	0.369ThrCys: 0.369 ± 0.019	2.394ThrAsp: 2.394 ± 0.052	3.264ThrGlu: 3.264 ± 0.058	2.58ThrPhe: 2.58 ± 0.055	3.838ThrGly: 3.838 ± 0.067	0.93ThrHis: 0.93 ± 0.031	4.576ThrIle: 4.576 ± 0.069	3.372ThrLys: 3.372 ± 0.061	4.613ThrLeu: 4.613 ± 0.067	1.17ThrMet: 1.17 ± 0.037	2.287ThrAsn: 2.287 ± 0.045	2.043ThrPro: 2.043 ± 0.047	1.032ThrGln: 1.032 ± 0.03	1.624ThrArg: 1.624 ± 0.042	2.757ThrSer: 2.757 ± 0.053	2.501ThrThr: 2.501 ± 0.066	4.082ThrVal: 4.082 ± 0.053	0.426ThrTrp: 0.426 ± 0.023	1.726ThrTyr: 1.726 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.658ValAla: 4.658 ± 0.076	0.581ValCys: 0.581 ± 0.024	3.44ValAsp: 3.44 ± 0.069	5.052ValGlu: 5.052 ± 0.08	3.156ValPhe: 3.156 ± 0.065	4.332ValGly: 4.332 ± 0.072	1.542ValHis: 1.542 ± 0.037	5.842ValIle: 5.842 ± 0.087	5.206ValLys: 5.206 ± 0.081	6.901ValLeu: 6.901 ± 0.078	1.639ValMet: 1.639 ± 0.037	2.881ValAsn: 2.881 ± 0.054	2.745ValPro: 2.745 ± 0.056	2.496ValGln: 2.496 ± 0.051	2.771ValArg: 2.771 ± 0.056	4.307ValSer: 4.307 ± 0.068	3.571ValThr: 3.571 ± 0.058	4.925ValVal: 4.925 ± 0.074	0.623ValTrp: 0.623 ± 0.03	2.289ValTyr: 2.289 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.555TrpAla: 0.555 ± 0.025	0.091TrpCys: 0.091 ± 0.009	0.469TrpAsp: 0.469 ± 0.024	0.696TrpGlu: 0.696 ± 0.025	0.502TrpPhe: 0.502 ± 0.027	0.641TrpGly: 0.641 ± 0.028	0.223TrpHis: 0.223 ± 0.015	0.857TrpIle: 0.857 ± 0.033	0.836TrpLys: 0.836 ± 0.027	1.108TrpLeu: 1.108 ± 0.035	0.346TrpMet: 0.346 ± 0.017	0.549TrpAsn: 0.549 ± 0.025	0.283TrpPro: 0.283 ± 0.017	0.328TrpGln: 0.328 ± 0.019	0.409TrpArg: 0.409 ± 0.019	0.513TrpSer: 0.513 ± 0.024	0.483TrpThr: 0.483 ± 0.02	0.588TrpVal: 0.588 ± 0.025	0.133TrpTrp: 0.133 ± 0.014	0.317TrpTyr: 0.317 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.067TyrAla: 2.067 ± 0.04	0.35TyrCys: 0.35 ± 0.019	1.879TyrAsp: 1.879 ± 0.043	2.672TyrGlu: 2.672 ± 0.055	1.822TyrPhe: 1.822 ± 0.044	2.365TyrGly: 2.365 ± 0.054	0.83TyrHis: 0.83 ± 0.026	2.592TyrIle: 2.592 ± 0.053	2.304TyrLys: 2.304 ± 0.052	3.462TyrLeu: 3.462 ± 0.061	0.776TyrMet: 0.776 ± 0.029	1.375TyrAsn: 1.375 ± 0.042	1.378TyrPro: 1.378 ± 0.039	1.389TyrGln: 1.389 ± 0.039	1.673TyrArg: 1.673 ± 0.042	1.966TyrSer: 1.966 ± 0.05	1.655TyrThr: 1.655 ± 0.04	2.336TyrVal: 2.336 ± 0.048	0.397TyrTrp: 0.397 ± 0.022	1.411TyrTyr: 1.411 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3519 proteins (1010804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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