Amino acid dipepetide frequency for Methylomonas lenta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.136AlaAla: 9.136 ± 0.116	1.095AlaCys: 1.095 ± 0.029	5.535AlaAsp: 5.535 ± 0.075	6.497AlaGlu: 6.497 ± 0.093	3.52AlaPhe: 3.52 ± 0.06	6.713AlaGly: 6.713 ± 0.089	1.791AlaHis: 1.791 ± 0.038	6.177AlaIle: 6.177 ± 0.073	4.697AlaLys: 4.697 ± 0.079	10.362AlaLeu: 10.362 ± 0.12	2.595AlaMet: 2.595 ± 0.041	3.674AlaAsn: 3.674 ± 0.051	2.845AlaPro: 2.845 ± 0.056	3.876AlaGln: 3.876 ± 0.068	4.052AlaArg: 4.052 ± 0.049	5.203AlaSer: 5.203 ± 0.067	4.307AlaThr: 4.307 ± 0.064	6.16AlaVal: 6.16 ± 0.064	1.188AlaTrp: 1.188 ± 0.029	2.539AlaTyr: 2.539 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.813CysAla: 0.813 ± 0.024	0.173CysCys: 0.173 ± 0.012	0.587CysAsp: 0.587 ± 0.025	0.561CysGlu: 0.561 ± 0.021	0.452CysPhe: 0.452 ± 0.02	0.883CysGly: 0.883 ± 0.026	0.373CysHis: 0.373 ± 0.019	0.594CysIle: 0.594 ± 0.023	0.461CysLys: 0.461 ± 0.015	1.158CysLeu: 1.158 ± 0.029	0.233CysMet: 0.233 ± 0.013	0.388CysAsn: 0.388 ± 0.017	0.497CysPro: 0.497 ± 0.025	0.49CysGln: 0.49 ± 0.019	0.564CysArg: 0.564 ± 0.019	0.724CysSer: 0.724 ± 0.026	0.463CysThr: 0.463 ± 0.02	0.706CysVal: 0.706 ± 0.024	0.141CysTrp: 0.141 ± 0.01	0.353CysTyr: 0.353 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.913AspAla: 4.913 ± 0.07	0.648AspCys: 0.648 ± 0.021	3.135AspAsp: 3.135 ± 0.057	3.468AspGlu: 3.468 ± 0.055	2.656AspPhe: 2.656 ± 0.05	3.697AspGly: 3.697 ± 0.072	1.176AspHis: 1.176 ± 0.031	3.981AspIle: 3.981 ± 0.059	3.032AspLys: 3.032 ± 0.054	5.703AspLeu: 5.703 ± 0.072	1.367AspMet: 1.367 ± 0.03	2.456AspAsn: 2.456 ± 0.046	2.312AspPro: 2.312 ± 0.04	2.44AspGln: 2.44 ± 0.075	2.531AspArg: 2.531 ± 0.046	3.269AspSer: 3.269 ± 0.057	2.73AspThr: 2.73 ± 0.052	3.598AspVal: 3.598 ± 0.062	0.974AspTrp: 0.974 ± 0.03	2.046AspTyr: 2.046 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.22GluAla: 5.22 ± 0.074	0.49GluCys: 0.49 ± 0.02	2.662GluAsp: 2.662 ± 0.049	2.946GluGlu: 2.946 ± 0.055	2.374GluPhe: 2.374 ± 0.041	3.065GluGly: 3.065 ± 0.052	1.41GluHis: 1.41 ± 0.033	4.116GluIle: 4.116 ± 0.058	3.448GluLys: 3.448 ± 0.067	6.508GluLeu: 6.508 ± 0.07	1.542GluMet: 1.542 ± 0.035	2.593GluAsn: 2.593 ± 0.042	1.919GluPro: 1.919 ± 0.043	3.73GluGln: 3.73 ± 0.054	3.143GluArg: 3.143 ± 0.054	3.274GluSer: 3.274 ± 0.052	3.153GluThr: 3.153 ± 0.052	3.727GluVal: 3.727 ± 0.054	0.718GluTrp: 0.718 ± 0.023	1.617GluTyr: 1.617 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.053	0.535PheCys: 0.535 ± 0.02	2.697PheAsp: 2.697 ± 0.052	2.282PheGlu: 2.282 ± 0.043	1.886PhePhe: 1.886 ± 0.043	3.012PheGly: 3.012 ± 0.052	0.818PheHis: 0.818 ± 0.025	2.566PheIle: 2.566 ± 0.046	2.068PheLys: 2.068 ± 0.043	3.981PheLeu: 3.981 ± 0.071	0.984PheMet: 0.984 ± 0.029	2.001PheAsn: 2.001 ± 0.041	1.55PhePro: 1.55 ± 0.033	1.44PheGln: 1.44 ± 0.031	1.789PheArg: 1.789 ± 0.037	3.211PheSer: 3.211 ± 0.05	2.126PheThr: 2.126 ± 0.036	2.775PheVal: 2.775 ± 0.051	0.619PheTrp: 0.619 ± 0.021	1.401PheTyr: 1.401 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.915GlyAla: 4.915 ± 0.063	0.928GlyCys: 0.928 ± 0.029	3.609GlyAsp: 3.609 ± 0.07	3.712GlyGlu: 3.712 ± 0.059	3.404GlyPhe: 3.404 ± 0.064	4.644GlyGly: 4.644 ± 0.095	1.614GlyHis: 1.614 ± 0.034	4.594GlyIle: 4.594 ± 0.063	3.887GlyLys: 3.887 ± 0.048	7.455GlyLeu: 7.455 ± 0.088	1.875GlyMet: 1.875 ± 0.042	2.658GlyAsn: 2.658 ± 0.062	1.78GlyPro: 1.78 ± 0.039	2.981GlyGln: 2.981 ± 0.051	3.324GlyArg: 3.324 ± 0.057	4.138GlySer: 4.138 ± 0.07	3.012GlyThr: 3.012 ± 0.056	4.771GlyVal: 4.771 ± 0.067	1.019GlyTrp: 1.019 ± 0.028	2.509GlyTyr: 2.509 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.011HisAla: 2.011 ± 0.036	0.346HisCys: 0.346 ± 0.016	1.266HisAsp: 1.266 ± 0.034	1.2HisGlu: 1.2 ± 0.032	1.14HisPhe: 1.14 ± 0.032	1.585HisGly: 1.585 ± 0.04	0.725HisHis: 0.725 ± 0.026	1.455HisIle: 1.455 ± 0.038	1.031HisLys: 1.031 ± 0.027	2.401HisLeu: 2.401 ± 0.048	0.482HisMet: 0.482 ± 0.02	0.858HisAsn: 0.858 ± 0.026	1.296HisPro: 1.296 ± 0.036	1.154HisGln: 1.154 ± 0.026	1.126HisArg: 1.126 ± 0.031	1.338HisSer: 1.338 ± 0.033	1.001HisThr: 1.001 ± 0.031	1.281HisVal: 1.281 ± 0.037	0.41HisTrp: 0.41 ± 0.018	0.879HisTyr: 0.879 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.476IleAla: 6.476 ± 0.072	0.716IleCys: 0.716 ± 0.022	4.455IleAsp: 4.455 ± 0.06	4.299IleGlu: 4.299 ± 0.05	2.229IlePhe: 2.229 ± 0.05	4.56IleGly: 4.56 ± 0.07	1.394IleHis: 1.394 ± 0.033	3.686IleIle: 3.686 ± 0.069	3.543IleLys: 3.543 ± 0.055	5.727IleLeu: 5.727 ± 0.081	1.324IleMet: 1.324 ± 0.036	3.107IleAsn: 3.107 ± 0.052	2.839IlePro: 2.839 ± 0.048	2.508IleGln: 2.508 ± 0.043	3.072IleArg: 3.072 ± 0.054	4.428IleSer: 4.428 ± 0.057	3.439IleThr: 3.439 ± 0.06	4.002IleVal: 4.002 ± 0.062	0.721IleTrp: 0.721 ± 0.026	1.762IleTyr: 1.762 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.619LysAla: 4.619 ± 0.088	0.35LysCys: 0.35 ± 0.017	2.472LysAsp: 2.472 ± 0.05	2.443LysGlu: 2.443 ± 0.05	1.451LysPhe: 1.451 ± 0.033	2.744LysGly: 2.744 ± 0.047	1.235LysHis: 1.235 ± 0.033	3.382LysIle: 3.382 ± 0.059	2.756LysLys: 2.756 ± 0.058	5.483LysLeu: 5.483 ± 0.071	1.232LysMet: 1.232 ± 0.035	2.354LysAsn: 2.354 ± 0.045	2.655LysPro: 2.655 ± 0.051	3.216LysGln: 3.216 ± 0.056	2.5LysArg: 2.5 ± 0.046	3.003LysSer: 3.003 ± 0.055	3.174LysThr: 3.174 ± 0.049	3.132LysVal: 3.132 ± 0.051	0.501LysTrp: 0.501 ± 0.019	1.271LysTyr: 1.271 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.004LeuAla: 11.004 ± 0.114	1.141LeuCys: 1.141 ± 0.032	5.994LeuAsp: 5.994 ± 0.075	6.15LeuGlu: 6.15 ± 0.08	4.606LeuPhe: 4.606 ± 0.073	6.918LeuGly: 6.918 ± 0.082	2.327LeuHis: 2.327 ± 0.044	6.797LeuIle: 6.797 ± 0.092	5.571LeuLys: 5.571 ± 0.067	12.232LeuLeu: 12.232 ± 0.134	2.671LeuMet: 2.671 ± 0.049	4.631LeuAsn: 4.631 ± 0.061	5.414LeuPro: 5.414 ± 0.08	5.305LeuGln: 5.305 ± 0.075	5.212LeuArg: 5.212 ± 0.074	7.631LeuSer: 7.631 ± 0.099	5.909LeuThr: 5.909 ± 0.079	6.455LeuVal: 6.455 ± 0.084	1.197LeuTrp: 1.197 ± 0.033	2.652LeuTyr: 2.652 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.534MetAla: 2.534 ± 0.045	0.15MetCys: 0.15 ± 0.011	1.227MetAsp: 1.227 ± 0.031	1.182MetGlu: 1.182 ± 0.034	0.74MetPhe: 0.74 ± 0.022	1.587MetGly: 1.587 ± 0.04	0.549MetHis: 0.549 ± 0.022	1.433MetIle: 1.433 ± 0.038	1.2MetLys: 1.2 ± 0.035	2.822MetLeu: 2.822 ± 0.047	0.623MetMet: 0.623 ± 0.025	1.062MetAsn: 1.062 ± 0.029	1.403MetPro: 1.403 ± 0.037	1.336MetGln: 1.336 ± 0.028	1.287MetArg: 1.287 ± 0.033	1.606MetSer: 1.606 ± 0.034	1.555MetThr: 1.555 ± 0.039	1.538MetVal: 1.538 ± 0.036	0.168MetTrp: 0.168 ± 0.011	0.454MetTyr: 0.454 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.666AsnAla: 3.666 ± 0.062	0.454AsnCys: 0.454 ± 0.02	2.28AsnAsp: 2.28 ± 0.054	2.01AsnGlu: 2.01 ± 0.038	1.546AsnPhe: 1.546 ± 0.038	2.841AsnGly: 2.841 ± 0.052	0.985AsnHis: 0.985 ± 0.028	2.695AsnIle: 2.695 ± 0.05	2.073AsnLys: 2.073 ± 0.042	4.46AsnLeu: 4.46 ± 0.073	0.965AsnMet: 0.965 ± 0.026	1.958AsnAsn: 1.958 ± 0.045	2.423AsnPro: 2.423 ± 0.045	2.318AsnGln: 2.318 ± 0.053	2.284AsnArg: 2.284 ± 0.041	2.543AsnSer: 2.543 ± 0.053	2.192AsnThr: 2.192 ± 0.047	2.41AsnVal: 2.41 ± 0.044	0.675AsnTrp: 0.675 ± 0.022	1.277AsnTyr: 1.277 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.991ProAla: 3.991 ± 0.057	0.373ProCys: 0.373 ± 0.016	2.858ProAsp: 2.858 ± 0.051	3.292ProGlu: 3.292 ± 0.059	1.759ProPhe: 1.759 ± 0.033	3.006ProGly: 3.006 ± 0.056	0.917ProHis: 0.917 ± 0.028	2.59ProIle: 2.59 ± 0.045	1.87ProLys: 1.87 ± 0.042	4.384ProLeu: 4.384 ± 0.065	1.007ProMet: 1.007 ± 0.03	1.753ProAsn: 1.753 ± 0.035	1.64ProPro: 1.64 ± 0.043	1.748ProGln: 1.748 ± 0.042	1.571ProArg: 1.571 ± 0.033	2.379ProSer: 2.379 ± 0.04	2.146ProThr: 2.146 ± 0.046	3.305ProVal: 3.305 ± 0.057	0.555ProTrp: 0.555 ± 0.022	1.222ProTyr: 1.222 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.401GlnAla: 5.401 ± 0.079	0.382GlnCys: 0.382 ± 0.019	2.27GlnAsp: 2.27 ± 0.041	2.333GlnGlu: 2.333 ± 0.052	1.798GlnPhe: 1.798 ± 0.039	2.851GlnGly: 2.851 ± 0.053	1.431GlnHis: 1.431 ± 0.038	3.008GlnIle: 3.008 ± 0.073	2.168GlnLys: 2.168 ± 0.043	5.49GlnLeu: 5.49 ± 0.076	1.112GlnMet: 1.112 ± 0.032	1.968GlnAsn: 1.968 ± 0.043	2.215GlnPro: 2.215 ± 0.045	3.688GlnGln: 3.688 ± 0.07	2.849GlnArg: 2.849 ± 0.057	2.787GlnSer: 2.787 ± 0.046	2.738GlnThr: 2.738 ± 0.05	3.036GlnVal: 3.036 ± 0.052	0.608GlnTrp: 0.608 ± 0.021	1.298GlnTyr: 1.298 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.676ArgAla: 3.676 ± 0.06	0.52ArgCys: 0.52 ± 0.019	2.552ArgAsp: 2.552 ± 0.046	2.848ArgGlu: 2.848 ± 0.055	2.405ArgPhe: 2.405 ± 0.044	2.677ArgGly: 2.677 ± 0.044	1.325ArgHis: 1.325 ± 0.03	3.375ArgIle: 3.375 ± 0.055	2.388ArgLys: 2.388 ± 0.043	5.926ArgLeu: 5.926 ± 0.074	1.312ArgMet: 1.312 ± 0.032	2.024ArgAsn: 2.024 ± 0.038	1.84ArgPro: 1.84 ± 0.039	2.829ArgGln: 2.829 ± 0.051	2.7ArgArg: 2.7 ± 0.053	2.679ArgSer: 2.679 ± 0.049	2.07ArgThr: 2.07 ± 0.041	3.177ArgVal: 3.177 ± 0.048	0.778ArgTrp: 0.778 ± 0.028	1.906ArgTyr: 1.906 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.551SerAla: 5.551 ± 0.076	0.634SerCys: 0.634 ± 0.022	3.389SerAsp: 3.389 ± 0.057	3.475SerGlu: 3.475 ± 0.052	2.626SerPhe: 2.626 ± 0.049	4.851SerGly: 4.851 ± 0.077	1.443SerHis: 1.443 ± 0.033	4.057SerIle: 4.057 ± 0.064	2.952SerLys: 2.952 ± 0.049	7.038SerLeu: 7.038 ± 0.087	1.513SerMet: 1.513 ± 0.036	2.495SerAsn: 2.495 ± 0.049	2.457SerPro: 2.457 ± 0.042	2.878SerGln: 2.878 ± 0.05	3.079SerArg: 3.079 ± 0.047	4.073SerSer: 4.073 ± 0.073	3.098SerThr: 3.098 ± 0.06	4.215SerVal: 4.215 ± 0.06	0.789SerTrp: 0.789 ± 0.026	1.737SerTyr: 1.737 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.892ThrAla: 4.892 ± 0.07	0.437ThrCys: 0.437 ± 0.017	3.042ThrAsp: 3.042 ± 0.066	2.972ThrGlu: 2.972 ± 0.055	1.864ThrPhe: 1.864 ± 0.041	4.165ThrGly: 4.165 ± 0.058	1.242ThrHis: 1.242 ± 0.033	3.12ThrIle: 3.12 ± 0.055	1.887ThrLys: 1.887 ± 0.042	6.157ThrLeu: 6.157 ± 0.071	1.002ThrMet: 1.002 ± 0.028	1.776ThrAsn: 1.776 ± 0.042	2.699ThrPro: 2.699 ± 0.048	2.386ThrGln: 2.386 ± 0.052	2.368ThrArg: 2.368 ± 0.044	2.987ThrSer: 2.987 ± 0.061	2.766ThrThr: 2.766 ± 0.073	3.603ThrVal: 3.603 ± 0.054	0.589ThrTrp: 0.589 ± 0.023	1.264ThrTyr: 1.264 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.979ValAla: 5.979 ± 0.064	0.703ValCys: 0.703 ± 0.024	3.901ValAsp: 3.901 ± 0.068	3.972ValGlu: 3.972 ± 0.051	2.967ValPhe: 2.967 ± 0.054	4.22ValGly: 4.22 ± 0.067	1.219ValHis: 1.219 ± 0.031	4.474ValIle: 4.474 ± 0.066	3.216ValLys: 3.216 ± 0.053	6.997ValLeu: 6.997 ± 0.081	1.786ValMet: 1.786 ± 0.042	2.778ValAsn: 2.778 ± 0.057	2.551ValPro: 2.551 ± 0.044	2.218ValGln: 2.218 ± 0.044	2.962ValArg: 2.962 ± 0.053	4.422ValSer: 4.422 ± 0.06	3.474ValThr: 3.474 ± 0.055	4.544ValVal: 4.544 ± 0.072	0.789ValTrp: 0.789 ± 0.024	1.797ValTyr: 1.797 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.904TrpAla: 0.904 ± 0.027	0.151TrpCys: 0.151 ± 0.01	0.644TrpAsp: 0.644 ± 0.021	0.607TrpGlu: 0.607 ± 0.023	0.576TrpPhe: 0.576 ± 0.022	0.778TrpGly: 0.778 ± 0.026	0.342TrpHis: 0.342 ± 0.015	0.732TrpIle: 0.732 ± 0.022	0.524TrpLys: 0.524 ± 0.019	2.058TrpLeu: 2.058 ± 0.049	0.323TrpMet: 0.323 ± 0.016	0.488TrpAsn: 0.488 ± 0.02	0.571TrpPro: 0.571 ± 0.02	0.975TrpGln: 0.975 ± 0.027	0.771TrpArg: 0.771 ± 0.026	0.773TrpSer: 0.773 ± 0.025	0.559TrpThr: 0.559 ± 0.022	0.824TrpVal: 0.824 ± 0.027	0.19TrpTrp: 0.19 ± 0.013	0.335TrpTyr: 0.335 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.045	0.39TyrCys: 0.39 ± 0.019	1.555TyrAsp: 1.555 ± 0.036	1.408TyrGlu: 1.408 ± 0.033	1.472TyrPhe: 1.472 ± 0.036	2.031TyrGly: 2.031 ± 0.047	0.667TyrHis: 0.667 ± 0.023	1.455TyrIle: 1.455 ± 0.035	1.201TyrLys: 1.201 ± 0.033	3.478TyrLeu: 3.478 ± 0.054	0.507TyrMet: 0.507 ± 0.021	1.035TyrAsn: 1.035 ± 0.034	1.46TyrPro: 1.46 ± 0.035	1.916TyrGln: 1.916 ± 0.04	1.822TyrArg: 1.822 ± 0.036	1.878TyrSer: 1.878 ± 0.043	1.308TyrThr: 1.308 ± 0.033	1.709TyrVal: 1.709 ± 0.039	0.495TyrTrp: 0.495 ± 0.02	0.975TyrTyr: 0.975 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4162 proteins (1337950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---