Amino acid dipepetide frequency for Altericroceibacterium endophyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.309AlaAla: 15.309 ± 0.205	1.041AlaCys: 1.041 ± 0.039	7.11AlaAsp: 7.11 ± 0.102	7.695AlaGlu: 7.695 ± 0.118	4.054AlaPhe: 4.054 ± 0.074	10.235AlaGly: 10.235 ± 0.161	2.043AlaHis: 2.043 ± 0.05	6.341AlaIle: 6.341 ± 0.084	3.929AlaLys: 3.929 ± 0.087	12.753AlaLeu: 12.753 ± 0.158	3.558AlaMet: 3.558 ± 0.076	3.411AlaAsn: 3.411 ± 0.084	5.555AlaPro: 5.555 ± 0.095	4.852AlaGln: 4.852 ± 0.083	7.83AlaArg: 7.83 ± 0.144	6.597AlaSer: 6.597 ± 0.102	5.411AlaThr: 5.411 ± 0.093	7.268AlaVal: 7.268 ± 0.106	1.372AlaTrp: 1.372 ± 0.041	2.502AlaTyr: 2.502 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.008CysAla: 1.008 ± 0.038	0.097CysCys: 0.097 ± 0.008	0.548CysAsp: 0.548 ± 0.023	0.465CysGlu: 0.465 ± 0.021	0.301CysPhe: 0.301 ± 0.018	0.878CysGly: 0.878 ± 0.029	0.209CysHis: 0.209 ± 0.015	0.381CysIle: 0.381 ± 0.018	0.167CysLys: 0.167 ± 0.012	0.761CysLeu: 0.761 ± 0.029	0.163CysMet: 0.163 ± 0.013	0.216CysAsn: 0.216 ± 0.015	0.411CysPro: 0.411 ± 0.021	0.22CysGln: 0.22 ± 0.014	0.508CysArg: 0.508 ± 0.022	0.534CysSer: 0.534 ± 0.021	0.42CysThr: 0.42 ± 0.018	0.588CysVal: 0.588 ± 0.026	0.101CysTrp: 0.101 ± 0.009	0.192CysTyr: 0.192 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.127AspAla: 7.127 ± 0.122	0.522AspCys: 0.522 ± 0.023	4.077AspAsp: 4.077 ± 0.129	3.751AspGlu: 3.751 ± 0.072	2.504AspPhe: 2.504 ± 0.059	5.888AspGly: 5.888 ± 0.17	1.411AspHis: 1.411 ± 0.041	3.239AspIle: 3.239 ± 0.071	2.026AspLys: 2.026 ± 0.055	6.118AspLeu: 6.118 ± 0.088	1.594AspMet: 1.594 ± 0.043	1.895AspAsn: 1.895 ± 0.044	3.601AspPro: 3.601 ± 0.054	2.215AspGln: 2.215 ± 0.049	4.448AspArg: 4.448 ± 0.082	2.981AspSer: 2.981 ± 0.063	2.93AspThr: 2.93 ± 0.079	4.086AspVal: 4.086 ± 0.079	1.201AspTrp: 1.201 ± 0.038	1.948AspTyr: 1.948 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.326GluAla: 7.326 ± 0.099	0.369GluCys: 0.369 ± 0.019	3.55GluAsp: 3.55 ± 0.065	3.974GluGlu: 3.974 ± 0.075	1.789GluPhe: 1.789 ± 0.042	4.706GluGly: 4.706 ± 0.072	1.09GluHis: 1.09 ± 0.038	3.302GluIle: 3.302 ± 0.063	2.512GluLys: 2.512 ± 0.062	5.463GluLeu: 5.463 ± 0.083	1.62GluMet: 1.62 ± 0.051	2.159GluAsn: 2.159 ± 0.057	2.65GluPro: 2.65 ± 0.058	2.53GluGln: 2.53 ± 0.06	4.571GluArg: 4.571 ± 0.082	2.884GluSer: 2.884 ± 0.052	3.352GluThr: 3.352 ± 0.063	3.618GluVal: 3.618 ± 0.065	0.998GluTrp: 0.998 ± 0.037	1.194GluTyr: 1.194 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.661PheAla: 4.661 ± 0.078	0.356PheCys: 0.356 ± 0.018	2.869PheAsp: 2.869 ± 0.063	2.131PheGlu: 2.131 ± 0.054	1.333PhePhe: 1.333 ± 0.037	3.817PheGly: 3.817 ± 0.062	0.74PheHis: 0.74 ± 0.026	1.735PheIle: 1.735 ± 0.044	0.946PheLys: 0.946 ± 0.032	3.166PheLeu: 3.166 ± 0.064	0.788PheMet: 0.788 ± 0.028	1.184PheAsn: 1.184 ± 0.035	1.526PhePro: 1.526 ± 0.044	1.016PheGln: 1.016 ± 0.036	2.132PheArg: 2.132 ± 0.051	2.427PheSer: 2.427 ± 0.048	2.236PheThr: 2.236 ± 0.049	2.436PheVal: 2.436 ± 0.048	0.536PheTrp: 0.536 ± 0.026	1.089PheTyr: 1.089 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.141GlyAla: 9.141 ± 0.155	0.816GlyCys: 0.816 ± 0.029	5.345GlyAsp: 5.345 ± 0.198	5.122GlyGlu: 5.122 ± 0.084	3.702GlyPhe: 3.702 ± 0.09	8.159GlyGly: 8.159 ± 0.529	1.783GlyHis: 1.783 ± 0.045	4.649GlyIle: 4.649 ± 0.073	3.467GlyLys: 3.467 ± 0.065	8.264GlyLeu: 8.264 ± 0.106	2.378GlyMet: 2.378 ± 0.048	2.638GlyAsn: 2.638 ± 0.122	3.492GlyPro: 3.492 ± 0.066	3.167GlyGln: 3.167 ± 0.056	5.46GlyArg: 5.46 ± 0.067	5.248GlySer: 5.248 ± 0.128	4.912GlyThr: 4.912 ± 0.103	5.753GlyVal: 5.753 ± 0.093	1.533GlyTrp: 1.533 ± 0.043	2.362GlyTyr: 2.362 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.044HisAla: 2.044 ± 0.048	0.242HisCys: 0.242 ± 0.016	1.232HisAsp: 1.232 ± 0.036	1.048HisGlu: 1.048 ± 0.034	0.898HisPhe: 0.898 ± 0.035	1.785HisGly: 1.785 ± 0.05	0.526HisHis: 0.526 ± 0.029	0.963HisIle: 0.963 ± 0.028	0.492HisLys: 0.492 ± 0.023	1.823HisLeu: 1.823 ± 0.048	0.45HisMet: 0.45 ± 0.021	0.488HisAsn: 0.488 ± 0.024	1.229HisPro: 1.229 ± 0.04	0.575HisGln: 0.575 ± 0.023	1.362HisArg: 1.362 ± 0.041	1.14HisSer: 1.14 ± 0.038	0.776HisThr: 0.776 ± 0.025	1.319HisVal: 1.319 ± 0.035	0.389HisTrp: 0.389 ± 0.019	0.627HisTyr: 0.627 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.257IleAla: 7.257 ± 0.093	0.517IleCys: 0.517 ± 0.024	3.807IleAsp: 3.807 ± 0.074	3.464IleGlu: 3.464 ± 0.065	1.925IlePhe: 1.925 ± 0.054	5.163IleGly: 5.163 ± 0.088	0.951IleHis: 0.951 ± 0.036	2.505IleIle: 2.505 ± 0.073	1.315IleLys: 1.315 ± 0.042	4.209IleLeu: 4.209 ± 0.074	1.131IleMet: 1.131 ± 0.037	1.571IleAsn: 1.571 ± 0.047	2.4IlePro: 2.4 ± 0.051	1.241IleGln: 1.241 ± 0.039	3.271IleArg: 3.271 ± 0.061	3.297IleSer: 3.297 ± 0.065	3.027IleThr: 3.027 ± 0.067	3.759IleVal: 3.759 ± 0.067	0.72IleTrp: 0.72 ± 0.029	1.254IleTyr: 1.254 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.814LysAla: 3.814 ± 0.078	0.185LysCys: 0.185 ± 0.015	1.802LysAsp: 1.802 ± 0.047	1.641LysGlu: 1.641 ± 0.047	0.907LysPhe: 0.907 ± 0.029	2.657LysGly: 2.657 ± 0.053	0.602LysHis: 0.602 ± 0.028	1.663LysIle: 1.663 ± 0.045	1.263LysLys: 1.263 ± 0.053	3.385LysLeu: 3.385 ± 0.066	0.787LysMet: 0.787 ± 0.028	0.993LysAsn: 0.993 ± 0.036	1.972LysPro: 1.972 ± 0.054	1.203LysGln: 1.203 ± 0.039	2.446LysArg: 2.446 ± 0.055	1.869LysSer: 1.869 ± 0.043	1.73LysThr: 1.73 ± 0.041	2.116LysVal: 2.116 ± 0.055	0.466LysTrp: 0.466 ± 0.023	0.701LysTyr: 0.701 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.542LeuAla: 12.542 ± 0.167	0.826LeuCys: 0.826 ± 0.031	6.139LeuAsp: 6.139 ± 0.089	5.347LeuGlu: 5.347 ± 0.089	3.628LeuPhe: 3.628 ± 0.068	7.951LeuGly: 7.951 ± 0.103	1.783LeuHis: 1.783 ± 0.045	5.15LeuIle: 5.15 ± 0.082	3.162LeuLys: 3.162 ± 0.063	9.196LeuLeu: 9.196 ± 0.147	2.184LeuMet: 2.184 ± 0.054	2.731LeuAsn: 2.731 ± 0.057	5.38LeuPro: 5.38 ± 0.085	2.958LeuGln: 2.958 ± 0.059	6.53LeuArg: 6.53 ± 0.112	6.765LeuSer: 6.765 ± 0.097	5.832LeuThr: 5.832 ± 0.084	6.405LeuVal: 6.405 ± 0.099	1.147LeuTrp: 1.147 ± 0.04	2.095LeuTyr: 2.095 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.126MetAla: 3.126 ± 0.06	0.158MetCys: 0.158 ± 0.012	1.323MetAsp: 1.323 ± 0.04	1.336MetGlu: 1.336 ± 0.043	0.687MetPhe: 0.687 ± 0.027	2.005MetGly: 2.005 ± 0.048	0.474MetHis: 0.474 ± 0.022	1.35MetIle: 1.35 ± 0.039	1.01MetLys: 1.01 ± 0.038	2.676MetLeu: 2.676 ± 0.063	0.725MetMet: 0.725 ± 0.029	0.801MetAsn: 0.801 ± 0.028	1.486MetPro: 1.486 ± 0.039	0.902MetGln: 0.902 ± 0.033	1.758MetArg: 1.758 ± 0.043	1.629MetSer: 1.629 ± 0.043	1.575MetThr: 1.575 ± 0.037	1.688MetVal: 1.688 ± 0.037	0.226MetTrp: 0.226 ± 0.016	0.307MetTyr: 0.307 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.477AsnAla: 3.477 ± 0.076	0.276AsnCys: 0.276 ± 0.019	1.774AsnAsp: 1.774 ± 0.063	1.318AsnGlu: 1.318 ± 0.041	1.142AsnPhe: 1.142 ± 0.035	2.84AsnGly: 2.84 ± 0.11	0.546AsnHis: 0.546 ± 0.02	1.59AsnIle: 1.59 ± 0.048	0.753AsnLys: 0.753 ± 0.028	2.892AsnLeu: 2.892 ± 0.058	0.708AsnMet: 0.708 ± 0.027	0.897AsnAsn: 0.897 ± 0.044	1.925AsnPro: 1.925 ± 0.051	0.932AsnGln: 0.932 ± 0.034	1.978AsnArg: 1.978 ± 0.045	1.778AsnSer: 1.778 ± 0.058	1.421AsnThr: 1.421 ± 0.046	2.167AsnVal: 2.167 ± 0.058	0.501AsnTrp: 0.501 ± 0.022	0.91AsnTyr: 0.91 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.989ProAla: 5.989 ± 0.106	0.319ProCys: 0.319 ± 0.017	4.0ProAsp: 4.0 ± 0.07	3.991ProGlu: 3.991 ± 0.065	1.922ProPhe: 1.922 ± 0.05	4.351ProGly: 4.351 ± 0.078	0.979ProHis: 0.979 ± 0.032	2.351ProIle: 2.351 ± 0.053	1.483ProLys: 1.483 ± 0.043	4.777ProLeu: 4.777 ± 0.086	1.148ProMet: 1.148 ± 0.035	1.307ProAsn: 1.307 ± 0.039	2.358ProPro: 2.358 ± 0.07	1.971ProGln: 1.971 ± 0.049	2.709ProArg: 2.709 ± 0.057	2.911ProSer: 2.911 ± 0.058	2.371ProThr: 2.371 ± 0.048	3.836ProVal: 3.836 ± 0.067	0.666ProTrp: 0.666 ± 0.029	1.152ProTyr: 1.152 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.273GlnAla: 4.273 ± 0.076	0.252GlnCys: 0.252 ± 0.015	2.105GlnAsp: 2.105 ± 0.051	1.809GlnGlu: 1.809 ± 0.051	1.253GlnPhe: 1.253 ± 0.041	2.675GlnGly: 2.675 ± 0.053	0.679GlnHis: 0.679 ± 0.025	2.073GlnIle: 2.073 ± 0.044	1.067GlnLys: 1.067 ± 0.036	3.503GlnLeu: 3.503 ± 0.069	0.953GlnMet: 0.953 ± 0.031	1.043GlnAsn: 1.043 ± 0.033	1.867GlnPro: 1.867 ± 0.046	1.513GlnGln: 1.513 ± 0.048	2.572GlnArg: 2.572 ± 0.062	2.253GlnSer: 2.253 ± 0.072	1.762GlnThr: 1.762 ± 0.043	2.232GlnVal: 2.232 ± 0.046	0.515GlnTrp: 0.515 ± 0.021	0.744GlnTyr: 0.744 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.128ArgAla: 7.128 ± 0.114	0.458ArgCys: 0.458 ± 0.021	4.161ArgAsp: 4.161 ± 0.07	4.165ArgGlu: 4.165 ± 0.076	2.976ArgPhe: 2.976 ± 0.065	4.556ArgGly: 4.556 ± 0.075	1.506ArgHis: 1.506 ± 0.049	3.987ArgIle: 3.987 ± 0.073	2.421ArgLys: 2.421 ± 0.055	7.017ArgLeu: 7.017 ± 0.12	1.848ArgMet: 1.848 ± 0.042	2.046ArgAsn: 2.046 ± 0.047	3.086ArgPro: 3.086 ± 0.066	2.538ArgGln: 2.538 ± 0.052	4.77ArgArg: 4.77 ± 0.097	3.732ArgSer: 3.732 ± 0.071	2.823ArgThr: 2.823 ± 0.062	4.082ArgVal: 4.082 ± 0.059	1.023ArgTrp: 1.023 ± 0.032	1.777ArgTyr: 1.777 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	7.202SerAla: 7.202 ± 0.107	0.469SerCys: 0.469 ± 0.019	3.977SerAsp: 3.977 ± 0.088	3.364SerGlu: 3.364 ± 0.06	2.452SerPhe: 2.452 ± 0.05	6.063SerGly: 6.063 ± 0.116	1.084SerHis: 1.084 ± 0.037	2.94SerIle: 2.94 ± 0.068	1.592SerLys: 1.592 ± 0.042	5.812SerLeu: 5.812 ± 0.089	1.394SerMet: 1.394 ± 0.038	1.633SerAsn: 1.633 ± 0.04	2.938SerPro: 2.938 ± 0.058	1.922SerGln: 1.922 ± 0.042	3.596SerArg: 3.596 ± 0.061	3.548SerSer: 3.548 ± 0.076	2.889SerThr: 2.889 ± 0.059	4.005SerVal: 4.005 ± 0.101	0.889SerTrp: 0.889 ± 0.027	1.624SerTyr: 1.624 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.841ThrAla: 5.841 ± 0.082	0.381ThrCys: 0.381 ± 0.018	2.977ThrAsp: 2.977 ± 0.065	2.644ThrGlu: 2.644 ± 0.048	1.866ThrPhe: 1.866 ± 0.044	5.35ThrGly: 5.35 ± 0.107	1.013ThrHis: 1.013 ± 0.036	3.086ThrIle: 3.086 ± 0.063	1.37ThrLys: 1.37 ± 0.035	5.64ThrLeu: 5.64 ± 0.086	1.237ThrMet: 1.237 ± 0.036	1.483ThrAsn: 1.483 ± 0.051	3.309ThrPro: 3.309 ± 0.062	1.738ThrGln: 1.738 ± 0.041	3.115ThrArg: 3.115 ± 0.059	2.916ThrSer: 2.916 ± 0.068	2.584ThrThr: 2.584 ± 0.061	3.787ThrVal: 3.787 ± 0.085	0.54ThrTrp: 0.54 ± 0.024	1.371ThrTyr: 1.371 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	7.672ValAla: 7.672 ± 0.104	0.498ValCys: 0.498 ± 0.023	4.229ValAsp: 4.229 ± 0.069	4.319ValGlu: 4.319 ± 0.073	2.228ValPhe: 2.228 ± 0.053	5.038ValGly: 5.038 ± 0.1	1.135ValHis: 1.135 ± 0.036	3.702ValIle: 3.702 ± 0.076	2.136ValLys: 2.136 ± 0.049	6.355ValLeu: 6.355 ± 0.082	1.729ValMet: 1.729 ± 0.051	2.044ValAsn: 2.044 ± 0.061	3.527ValPro: 3.527 ± 0.067	2.133ValGln: 2.133 ± 0.046	3.904ValArg: 3.904 ± 0.074	4.398ValSer: 4.398 ± 0.088	4.336ValThr: 4.336 ± 0.093	4.543ValVal: 4.543 ± 0.077	0.808ValTrp: 0.808 ± 0.034	1.314ValTyr: 1.314 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.285TrpAla: 1.285 ± 0.041	0.134TrpCys: 0.134 ± 0.011	0.761TrpAsp: 0.761 ± 0.03	0.664TrpGlu: 0.664 ± 0.028	0.562TrpPhe: 0.562 ± 0.024	0.951TrpGly: 0.951 ± 0.033	0.356TrpHis: 0.356 ± 0.019	0.733TrpIle: 0.733 ± 0.026	0.484TrpLys: 0.484 ± 0.022	1.738TrpLeu: 1.738 ± 0.057	0.379TrpMet: 0.379 ± 0.019	0.497TrpAsn: 0.497 ± 0.025	0.713TrpPro: 0.713 ± 0.03	0.69TrpGln: 0.69 ± 0.03	1.23TrpArg: 1.23 ± 0.038	0.953TrpSer: 0.953 ± 0.029	0.746TrpThr: 0.746 ± 0.028	0.832TrpVal: 0.832 ± 0.033	0.254TrpTrp: 0.254 ± 0.018	0.289TrpTyr: 0.289 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.642TyrAla: 2.642 ± 0.061	0.25TyrCys: 0.25 ± 0.015	1.779TyrAsp: 1.779 ± 0.045	1.407TyrGlu: 1.407 ± 0.048	0.995TyrPhe: 0.995 ± 0.031	2.318TyrGly: 2.318 ± 0.062	0.498TyrHis: 0.498 ± 0.023	1.045TyrIle: 1.045 ± 0.032	0.608TyrLys: 0.608 ± 0.027	2.203TyrLeu: 2.203 ± 0.049	0.467TyrMet: 0.467 ± 0.022	0.79TyrAsn: 0.79 ± 0.032	1.164TyrPro: 1.164 ± 0.037	0.829TyrGln: 0.829 ± 0.032	1.912TyrArg: 1.912 ± 0.054	1.535TyrSer: 1.535 ± 0.052	1.114TyrThr: 1.114 ± 0.038	1.526TyrVal: 1.526 ± 0.042	0.368TyrTrp: 0.368 ± 0.019	0.79TyrTyr: 0.79 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3079 proteins (1041826 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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