Amino acid dipepetide frequency for Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990) (Eubacterium rectale)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.688AlaAla: 6.688 ± 0.116
1.079AlaCys: 1.079 ± 0.035
5.032AlaAsp: 5.032 ± 0.091
4.683AlaGlu: 4.683 ± 0.071
2.921AlaPhe: 2.921 ± 0.057
5.657AlaGly: 5.657 ± 0.085
1.145AlaHis: 1.145 ± 0.036
5.304AlaIle: 5.304 ± 0.083
5.287AlaLys: 5.287 ± 0.084
6.369AlaLeu: 6.369 ± 0.152
2.336AlaMet: 2.336 ± 0.047
2.85AlaAsn: 2.85 ± 0.054
1.775AlaPro: 1.775 ± 0.048
2.317AlaGln: 2.317 ± 0.054
2.627AlaArg: 2.627 ± 0.051
3.934AlaSer: 3.934 ± 0.068
3.444AlaThr: 3.444 ± 0.067
5.798AlaVal: 5.798 ± 0.089
0.542AlaTrp: 0.542 ± 0.024
2.858AlaTyr: 2.858 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.99CysAla: 0.99 ± 0.029
0.26CysCys: 0.26 ± 0.018
1.051CysAsp: 1.051 ± 0.034
0.934CysGlu: 0.934 ± 0.033
0.687CysPhe: 0.687 ± 0.029
1.406CysGly: 1.406 ± 0.043
0.336CysHis: 0.336 ± 0.02
1.306CysIle: 1.306 ± 0.039
0.909CysLys: 0.909 ± 0.035
1.083CysLeu: 1.083 ± 0.032
0.497CysMet: 0.497 ± 0.021
0.741CysAsn: 0.741 ± 0.03
0.549CysPro: 0.549 ± 0.025
0.397CysGln: 0.397 ± 0.019
0.662CysArg: 0.662 ± 0.026
0.918CysSer: 0.918 ± 0.034
0.755CysThr: 0.755 ± 0.027
1.02CysVal: 1.02 ± 0.031
0.112CysTrp: 0.112 ± 0.01
0.59CysTyr: 0.59 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.571AspAla: 4.571 ± 0.084
0.869AspCys: 0.869 ± 0.027
4.09AspAsp: 4.09 ± 0.082
5.696AspGlu: 5.696 ± 0.088
2.85AspPhe: 2.85 ± 0.052
4.591AspGly: 4.591 ± 0.084
0.785AspHis: 0.785 ± 0.03
5.533AspIle: 5.533 ± 0.075
4.694AspLys: 4.694 ± 0.078
4.196AspLeu: 4.196 ± 0.069
2.2AspMet: 2.2 ± 0.054
3.119AspAsn: 3.119 ± 0.06
1.501AspPro: 1.501 ± 0.042
1.105AspGln: 1.105 ± 0.039
2.398AspArg: 2.398 ± 0.049
3.74AspSer: 3.74 ± 0.071
3.625AspThr: 3.625 ± 0.064
4.203AspVal: 4.203 ± 0.08
0.573AspTrp: 0.573 ± 0.027
3.112AspTyr: 3.112 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.145GluAla: 5.145 ± 0.077
0.91GluCys: 0.91 ± 0.031
3.884GluAsp: 3.884 ± 0.068
5.336GluGlu: 5.336 ± 0.103
2.57GluPhe: 2.57 ± 0.049
3.642GluGly: 3.642 ± 0.063
1.45GluHis: 1.45 ± 0.043
5.477GluIle: 5.477 ± 0.078
6.532GluLys: 6.532 ± 0.092
6.732GluLeu: 6.732 ± 0.092
2.157GluMet: 2.157 ± 0.039
4.337GluAsn: 4.337 ± 0.069
1.726GluPro: 1.726 ± 0.048
2.836GluGln: 2.836 ± 0.06
3.011GluArg: 3.011 ± 0.062
3.56GluSer: 3.56 ± 0.056
3.272GluThr: 3.272 ± 0.056
4.06GluVal: 4.06 ± 0.078
0.655GluTrp: 0.655 ± 0.028
3.273GluTyr: 3.273 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.912PheAla: 2.912 ± 0.061
0.766PheCys: 0.766 ± 0.028
2.916PheAsp: 2.916 ± 0.052
2.641PheGlu: 2.641 ± 0.049
1.871PhePhe: 1.871 ± 0.046
2.914PheGly: 2.914 ± 0.052
0.743PheHis: 0.743 ± 0.026
3.222PheIle: 3.222 ± 0.069
2.478PheLys: 2.478 ± 0.052
3.438PheLeu: 3.438 ± 0.071
1.365PheMet: 1.365 ± 0.038
1.768PheAsn: 1.768 ± 0.038
1.198PhePro: 1.198 ± 0.036
0.999PheGln: 0.999 ± 0.033
1.477PheArg: 1.477 ± 0.042
2.961PheSer: 2.961 ± 0.062
2.444PheThr: 2.444 ± 0.049
3.002PheVal: 3.002 ± 0.057
0.419PheTrp: 0.419 ± 0.021
1.858PheTyr: 1.858 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.631GlyAla: 4.631 ± 0.085
1.21GlyCys: 1.21 ± 0.034
3.516GlyAsp: 3.516 ± 0.068
4.036GlyGlu: 4.036 ± 0.067
3.032GlyPhe: 3.032 ± 0.05
4.242GlyGly: 4.242 ± 0.077
1.213GlyHis: 1.213 ± 0.039
5.951GlyIle: 5.951 ± 0.092
5.252GlyLys: 5.252 ± 0.074
5.226GlyLeu: 5.226 ± 0.082
2.326GlyMet: 2.326 ± 0.044
3.276GlyAsn: 3.276 ± 0.077
1.099GlyPro: 1.099 ± 0.036
1.885GlyGln: 1.885 ± 0.044
2.904GlyArg: 2.904 ± 0.059
3.959GlySer: 3.959 ± 0.068
3.906GlyThr: 3.906 ± 0.079
4.603GlyVal: 4.603 ± 0.078
0.621GlyTrp: 0.621 ± 0.032
3.232GlyTyr: 3.232 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.012HisAla: 1.012 ± 0.036
0.289HisCys: 0.289 ± 0.017
1.054HisAsp: 1.054 ± 0.034
1.064HisGlu: 1.064 ± 0.038
0.883HisPhe: 0.883 ± 0.03
1.242HisGly: 1.242 ± 0.037
0.384HisHis: 0.384 ± 0.022
1.461HisIle: 1.461 ± 0.04
1.062HisLys: 1.062 ± 0.036
1.376HisLeu: 1.376 ± 0.044
0.563HisMet: 0.563 ± 0.023
0.826HisAsn: 0.826 ± 0.025
0.702HisPro: 0.702 ± 0.03
0.487HisGln: 0.487 ± 0.022
0.798HisArg: 0.798 ± 0.033
1.01HisSer: 1.01 ± 0.033
0.99HisThr: 0.99 ± 0.031
1.173HisVal: 1.173 ± 0.032
0.156HisTrp: 0.156 ± 0.012
0.741HisTyr: 0.741 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.86IleAla: 5.86 ± 0.077
1.41IleCys: 1.41 ± 0.035
5.115IleAsp: 5.115 ± 0.078
5.303IleGlu: 5.303 ± 0.069
3.203IlePhe: 3.203 ± 0.068
4.958IleGly: 4.958 ± 0.082
1.291IleHis: 1.291 ± 0.035
6.21IleIle: 6.21 ± 0.102
5.365IleLys: 5.365 ± 0.076
6.436IleLeu: 6.436 ± 0.104
2.28IleMet: 2.28 ± 0.058
3.744IleAsn: 3.744 ± 0.058
2.892IlePro: 2.892 ± 0.063
2.042IleGln: 2.042 ± 0.047
3.327IleArg: 3.327 ± 0.06
5.478IleSer: 5.478 ± 0.08
4.455IleThr: 4.455 ± 0.066
5.432IleVal: 5.432 ± 0.084
0.634IleTrp: 0.634 ± 0.026
3.163IleTyr: 3.163 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.419LysAla: 5.419 ± 0.085
0.903LysCys: 0.903 ± 0.034
4.573LysAsp: 4.573 ± 0.074
6.51LysGlu: 6.51 ± 0.084
2.14LysPhe: 2.14 ± 0.046
4.086LysGly: 4.086 ± 0.066
1.242LysHis: 1.242 ± 0.034
5.151LysIle: 5.151 ± 0.08
6.756LysLys: 6.756 ± 0.092
6.082LysLeu: 6.082 ± 0.089
2.186LysMet: 2.186 ± 0.046
4.378LysAsn: 4.378 ± 0.075
2.144LysPro: 2.144 ± 0.052
2.619LysGln: 2.619 ± 0.055
3.13LysArg: 3.13 ± 0.063
4.206LysSer: 4.206 ± 0.067
3.947LysThr: 3.947 ± 0.062
4.311LysVal: 4.311 ± 0.069
0.692LysTrp: 0.692 ± 0.031
3.463LysTyr: 3.463 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
5.983LeuAla: 5.983 ± 0.149
1.544LeuCys: 1.544 ± 0.04
5.198LeuAsp: 5.198 ± 0.077
5.469LeuGlu: 5.469 ± 0.073
3.835LeuPhe: 3.835 ± 0.066
5.189LeuGly: 5.189 ± 0.088
1.475LeuHis: 1.475 ± 0.041
6.173LeuIle: 6.173 ± 0.096
5.95LeuLys: 5.95 ± 0.076
7.418LeuLeu: 7.418 ± 0.114
2.492LeuMet: 2.492 ± 0.045
3.951LeuAsn: 3.951 ± 0.062
2.953LeuPro: 2.953 ± 0.058
2.467LeuGln: 2.467 ± 0.059
3.319LeuArg: 3.319 ± 0.066
6.136LeuSer: 6.136 ± 0.082
4.626LeuThr: 4.626 ± 0.065
5.254LeuVal: 5.254 ± 0.156
0.708LeuTrp: 0.708 ± 0.029
3.315LeuTyr: 3.315 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.436MetAla: 2.436 ± 0.047
0.412MetCys: 0.412 ± 0.019
2.062MetAsp: 2.062 ± 0.045
2.216MetGlu: 2.216 ± 0.049
1.092MetPhe: 1.092 ± 0.032
1.966MetGly: 1.966 ± 0.05
0.517MetHis: 0.517 ± 0.022
2.321MetIle: 2.321 ± 0.051
2.587MetLys: 2.587 ± 0.048
2.802MetLeu: 2.802 ± 0.059
0.916MetMet: 0.916 ± 0.033
1.626MetAsn: 1.626 ± 0.043
1.096MetPro: 1.096 ± 0.029
1.13MetGln: 1.13 ± 0.035
1.247MetArg: 1.247 ± 0.033
1.962MetSer: 1.962 ± 0.039
1.777MetThr: 1.777 ± 0.04
1.915MetVal: 1.915 ± 0.045
0.232MetTrp: 0.232 ± 0.016
1.138MetTyr: 1.138 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.397AsnAla: 3.397 ± 0.067
0.653AsnCys: 0.653 ± 0.023
2.931AsnAsp: 2.931 ± 0.055
3.452AsnGlu: 3.452 ± 0.058
1.694AsnPhe: 1.694 ± 0.042
3.641AsnGly: 3.641 ± 0.08
0.897AsnHis: 0.897 ± 0.029
4.106AsnIle: 4.106 ± 0.063
3.329AsnLys: 3.329 ± 0.069
3.803AsnLeu: 3.803 ± 0.071
1.696AsnMet: 1.696 ± 0.039
2.691AsnAsn: 2.691 ± 0.066
2.058AsnPro: 2.058 ± 0.046
1.479AsnGln: 1.479 ± 0.045
2.106AsnArg: 2.106 ± 0.05
2.929AsnSer: 2.929 ± 0.067
2.807AsnThr: 2.807 ± 0.06
3.172AsnVal: 3.172 ± 0.063
0.447AsnTrp: 0.447 ± 0.026
2.13AsnTyr: 2.13 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.166ProAla: 2.166 ± 0.051
0.434ProCys: 0.434 ± 0.021
2.283ProAsp: 2.283 ± 0.053
2.53ProGlu: 2.53 ± 0.048
1.408ProPhe: 1.408 ± 0.041
1.931ProGly: 1.931 ± 0.054
0.547ProHis: 0.547 ± 0.03
1.991ProIle: 1.991 ± 0.047
1.966ProLys: 1.966 ± 0.051
2.343ProLeu: 2.343 ± 0.054
0.833ProMet: 0.833 ± 0.027
1.199ProAsn: 1.199 ± 0.036
0.62ProPro: 0.62 ± 0.026
1.151ProGln: 1.151 ± 0.042
0.901ProArg: 0.901 ± 0.031
1.568ProSer: 1.568 ± 0.045
1.408ProThr: 1.408 ± 0.037
2.644ProVal: 2.644 ± 0.053
0.322ProTrp: 0.322 ± 0.019
1.341ProTyr: 1.341 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.191GlnAla: 2.191 ± 0.048
0.35GlnCys: 0.35 ± 0.019
1.53GlnAsp: 1.53 ± 0.037
2.044GlnGlu: 2.044 ± 0.052
1.185GlnPhe: 1.185 ± 0.03
1.647GlnGly: 1.647 ± 0.04
0.444GlnHis: 0.444 ± 0.022
2.696GlnIle: 2.696 ± 0.047
2.677GlnLys: 2.677 ± 0.056
2.717GlnLeu: 2.717 ± 0.053
1.152GlnMet: 1.152 ± 0.031
1.654GlnAsn: 1.654 ± 0.042
0.808GlnPro: 0.808 ± 0.031
1.236GlnGln: 1.236 ± 0.04
1.34GlnArg: 1.34 ± 0.037
1.802GlnSer: 1.802 ± 0.047
1.703GlnThr: 1.703 ± 0.042
1.899GlnVal: 1.899 ± 0.045
0.292GlnTrp: 0.292 ± 0.019
1.373GlnTyr: 1.373 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.599ArgAla: 2.599 ± 0.049
0.57ArgCys: 0.57 ± 0.023
2.2ArgAsp: 2.2 ± 0.045
3.106ArgGlu: 3.106 ± 0.062
1.772ArgPhe: 1.772 ± 0.038
2.219ArgGly: 2.219 ± 0.056
0.756ArgHis: 0.756 ± 0.027
3.431ArgIle: 3.431 ± 0.064
3.383ArgLys: 3.383 ± 0.067
3.561ArgLeu: 3.561 ± 0.071
1.429ArgMet: 1.429 ± 0.039
2.053ArgAsn: 2.053 ± 0.041
1.188ArgPro: 1.188 ± 0.036
1.563ArgGln: 1.563 ± 0.04
1.991ArgArg: 1.991 ± 0.046
1.882ArgSer: 1.882 ± 0.043
2.0ArgThr: 2.0 ± 0.048
2.633ArgVal: 2.633 ± 0.051
0.325ArgTrp: 0.325 ± 0.019
1.851ArgTyr: 1.851 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.202SerAla: 4.202 ± 0.076
0.857SerCys: 0.857 ± 0.033
4.294SerAsp: 4.294 ± 0.076
3.872SerGlu: 3.872 ± 0.058
2.809SerPhe: 2.809 ± 0.063
4.861SerGly: 4.861 ± 0.087
1.064SerHis: 1.064 ± 0.036
4.505SerIle: 4.505 ± 0.076
4.15SerLys: 4.15 ± 0.077
4.868SerLeu: 4.868 ± 0.073
1.918SerMet: 1.918 ± 0.044
2.757SerAsn: 2.757 ± 0.059
1.546SerPro: 1.546 ± 0.044
1.962SerGln: 1.962 ± 0.043
2.502SerArg: 2.502 ± 0.048
3.78SerSer: 3.78 ± 0.077
3.114SerThr: 3.114 ± 0.056
4.573SerVal: 4.573 ± 0.073
0.542SerTrp: 0.542 ± 0.02
2.784SerTyr: 2.784 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.371ThrAla: 4.371 ± 0.077
0.653ThrCys: 0.653 ± 0.028
3.781ThrAsp: 3.781 ± 0.073
3.618ThrGlu: 3.618 ± 0.066
2.185ThrPhe: 2.185 ± 0.051
4.528ThrGly: 4.528 ± 0.082
0.879ThrHis: 0.879 ± 0.028
4.173ThrIle: 4.173 ± 0.069
3.387ThrLys: 3.387 ± 0.058
4.372ThrLeu: 4.372 ± 0.071
1.468ThrMet: 1.468 ± 0.036
2.376ThrAsn: 2.376 ± 0.052
1.975ThrPro: 1.975 ± 0.041
1.632ThrGln: 1.632 ± 0.04
1.867ThrArg: 1.867 ± 0.046
3.062ThrSer: 3.062 ± 0.061
2.957ThrThr: 2.957 ± 0.068
4.228ThrVal: 4.228 ± 0.075
0.428ThrTrp: 0.428 ± 0.022
2.242ThrTyr: 2.242 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.752ValAla: 4.752 ± 0.08
1.18ValCys: 1.18 ± 0.036
4.247ValAsp: 4.247 ± 0.091
4.353ValGlu: 4.353 ± 0.07
2.955ValPhe: 2.955 ± 0.053
3.908ValGly: 3.908 ± 0.072
1.056ValHis: 1.056 ± 0.03
5.515ValIle: 5.515 ± 0.079
4.722ValLys: 4.722 ± 0.073
6.269ValLeu: 6.269 ± 0.153
2.105ValMet: 2.105 ± 0.048
3.167ValAsn: 3.167 ± 0.061
2.251ValPro: 2.251 ± 0.046
1.746ValGln: 1.746 ± 0.045
2.616ValArg: 2.616 ± 0.06
4.768ValSer: 4.768 ± 0.082
4.131ValThr: 4.131 ± 0.07
4.721ValVal: 4.721 ± 0.078
0.567ValTrp: 0.567 ± 0.025
2.845ValTyr: 2.845 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.492TrpAla: 0.492 ± 0.022
0.158TrpCys: 0.158 ± 0.012
0.563TrpAsp: 0.563 ± 0.021
0.587TrpGlu: 0.587 ± 0.024
0.352TrpPhe: 0.352 ± 0.021
0.596TrpGly: 0.596 ± 0.028
0.212TrpHis: 0.212 ± 0.015
0.703TrpIle: 0.703 ± 0.033
0.687TrpLys: 0.687 ± 0.029
0.764TrpLeu: 0.764 ± 0.026
0.256TrpMet: 0.256 ± 0.016
0.555TrpAsn: 0.555 ± 0.027
0.181TrpPro: 0.181 ± 0.015
0.376TrpGln: 0.376 ± 0.019
0.313TrpArg: 0.313 ± 0.017
0.498TrpSer: 0.498 ± 0.023
0.476TrpThr: 0.476 ± 0.026
0.464TrpVal: 0.464 ± 0.021
0.115TrpTrp: 0.115 ± 0.01
0.406TrpTyr: 0.406 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.829TyrAla: 2.829 ± 0.052
0.697TyrCys: 0.697 ± 0.025
3.129TyrAsp: 3.129 ± 0.057
3.114TyrGlu: 3.114 ± 0.059
1.948TyrPhe: 1.948 ± 0.048
2.894TyrGly: 2.894 ± 0.058
0.837TyrHis: 0.837 ± 0.032
3.37TyrIle: 3.37 ± 0.062
2.765TyrLys: 2.765 ± 0.047
3.602TyrLeu: 3.602 ± 0.065
1.272TyrMet: 1.272 ± 0.033
2.351TyrAsn: 2.351 ± 0.056
1.326TyrPro: 1.326 ± 0.042
1.312TyrGln: 1.312 ± 0.035
1.978TyrArg: 1.978 ± 0.05
2.806TyrSer: 2.806 ± 0.062
2.346TyrThr: 2.346 ± 0.052
2.769TyrVal: 2.769 ± 0.056
0.37TyrTrp: 0.37 ± 0.019
2.16TyrTyr: 2.16 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3545 proteins (1016923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski