Amino acid dipepetide frequency for Acinetobacter calcoaceticus (strain PHEA-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.663AlaAla: 7.663 ± 0.122	0.944AlaCys: 0.944 ± 0.032	4.266AlaAsp: 4.266 ± 0.082	5.357AlaGlu: 5.357 ± 0.082	3.436AlaPhe: 3.436 ± 0.067	6.181AlaGly: 6.181 ± 0.099	1.821AlaHis: 1.821 ± 0.038	6.069AlaIle: 6.069 ± 0.08	5.006AlaLys: 5.006 ± 0.075	9.567AlaLeu: 9.567 ± 0.105	2.304AlaMet: 2.304 ± 0.054	3.482AlaAsn: 3.482 ± 0.068	3.126AlaPro: 3.126 ± 0.065	4.492AlaGln: 4.492 ± 0.063	3.368AlaArg: 3.368 ± 0.062	4.913AlaSer: 4.913 ± 0.077	4.582AlaThr: 4.582 ± 0.061	5.705AlaVal: 5.705 ± 0.083	1.105AlaTrp: 1.105 ± 0.034	2.695AlaTyr: 2.695 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.733CysAla: 0.733 ± 0.029	0.13CysCys: 0.13 ± 0.012	0.495CysAsp: 0.495 ± 0.023	0.496CysGlu: 0.496 ± 0.021	0.432CysPhe: 0.432 ± 0.022	0.815CysGly: 0.815 ± 0.027	0.278CysHis: 0.278 ± 0.017	0.648CysIle: 0.648 ± 0.027	0.371CysLys: 0.371 ± 0.019	1.025CysLeu: 1.025 ± 0.028	0.232CysMet: 0.232 ± 0.018	0.328CysAsn: 0.328 ± 0.018	0.421CysPro: 0.421 ± 0.021	0.413CysGln: 0.413 ± 0.019	0.395CysArg: 0.395 ± 0.019	0.636CysSer: 0.636 ± 0.023	0.455CysThr: 0.455 ± 0.019	0.655CysVal: 0.655 ± 0.026	0.105CysTrp: 0.105 ± 0.009	0.282CysTyr: 0.282 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.355AspAla: 4.355 ± 0.079	0.399AspCys: 0.399 ± 0.019	2.537AspAsp: 2.537 ± 0.077	3.394AspGlu: 3.394 ± 0.06	2.366AspPhe: 2.366 ± 0.048	3.194AspGly: 3.194 ± 0.068	1.327AspHis: 1.327 ± 0.035	3.641AspIle: 3.641 ± 0.062	2.552AspLys: 2.552 ± 0.054	5.492AspLeu: 5.492 ± 0.078	1.092AspMet: 1.092 ± 0.033	1.857AspAsn: 1.857 ± 0.051	2.05AspPro: 2.05 ± 0.052	2.722AspGln: 2.722 ± 0.058	2.26AspArg: 2.26 ± 0.044	2.628AspSer: 2.628 ± 0.058	2.405AspThr: 2.405 ± 0.065	3.61AspVal: 3.61 ± 0.063	0.801AspTrp: 0.801 ± 0.026	1.98AspTyr: 1.98 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.772GluAla: 4.772 ± 0.086	0.418GluCys: 0.418 ± 0.019	2.631GluAsp: 2.631 ± 0.059	3.209GluGlu: 3.209 ± 0.063	2.272GluPhe: 2.272 ± 0.051	3.323GluGly: 3.323 ± 0.062	1.653GluHis: 1.653 ± 0.039	4.155GluIle: 4.155 ± 0.062	4.056GluLys: 4.056 ± 0.068	6.235GluLeu: 6.235 ± 0.094	1.423GluMet: 1.423 ± 0.039	2.948GluAsn: 2.948 ± 0.051	1.853GluPro: 1.853 ± 0.048	4.361GluGln: 4.361 ± 0.086	2.929GluArg: 2.929 ± 0.053	2.945GluSer: 2.945 ± 0.054	2.978GluThr: 2.978 ± 0.061	3.791GluVal: 3.791 ± 0.059	0.821GluTrp: 0.821 ± 0.024	1.843GluTyr: 1.843 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.704PheAla: 3.704 ± 0.068	0.477PheCys: 0.477 ± 0.019	2.585PheAsp: 2.585 ± 0.054	2.636PheGlu: 2.636 ± 0.06	2.023PhePhe: 2.023 ± 0.055	3.352PheGly: 3.352 ± 0.068	0.876PheHis: 0.876 ± 0.025	3.17PheIle: 3.17 ± 0.063	2.525PheLys: 2.525 ± 0.055	4.003PheLeu: 4.003 ± 0.078	1.092PheMet: 1.092 ± 0.036	2.2PheAsn: 2.2 ± 0.044	1.478PhePro: 1.478 ± 0.038	1.626PheGln: 1.626 ± 0.048	1.398PheArg: 1.398 ± 0.039	3.18PheSer: 3.18 ± 0.059	2.228PheThr: 2.228 ± 0.048	2.657PheVal: 2.657 ± 0.052	0.627PheTrp: 0.627 ± 0.026	1.565PheTyr: 1.565 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.329GlyAla: 5.329 ± 0.09	0.853GlyCys: 0.853 ± 0.028	2.91GlyAsp: 2.91 ± 0.061	3.676GlyGlu: 3.676 ± 0.06	3.38GlyPhe: 3.38 ± 0.072	4.846GlyGly: 4.846 ± 0.128	1.576GlyHis: 1.576 ± 0.042	4.9GlyIle: 4.9 ± 0.08	3.761GlyLys: 3.761 ± 0.066	7.363GlyLeu: 7.363 ± 0.107	1.808GlyMet: 1.808 ± 0.044	2.552GlyAsn: 2.552 ± 0.067	1.692GlyPro: 1.692 ± 0.039	3.277GlyGln: 3.277 ± 0.078	2.85GlyArg: 2.85 ± 0.064	4.021GlySer: 4.021 ± 0.068	3.673GlyThr: 3.673 ± 0.08	5.135GlyVal: 5.135 ± 0.081	0.978GlyTrp: 0.978 ± 0.037	2.552GlyTyr: 2.552 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.911HisAla: 1.911 ± 0.04	0.246HisCys: 0.246 ± 0.015	1.145HisAsp: 1.145 ± 0.033	1.27HisGlu: 1.27 ± 0.034	1.219HisPhe: 1.219 ± 0.037	1.572HisGly: 1.572 ± 0.038	0.791HisHis: 0.791 ± 0.029	1.634HisIle: 1.634 ± 0.035	0.982HisLys: 0.982 ± 0.032	2.541HisLeu: 2.541 ± 0.045	0.524HisMet: 0.524 ± 0.021	0.815HisAsn: 0.815 ± 0.029	1.354HisPro: 1.354 ± 0.029	1.242HisGln: 1.242 ± 0.036	1.012HisArg: 1.012 ± 0.03	1.391HisSer: 1.391 ± 0.037	1.082HisThr: 1.082 ± 0.029	1.47HisVal: 1.47 ± 0.03	0.36HisTrp: 0.36 ± 0.017	0.892HisTyr: 0.892 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.636IleAla: 6.636 ± 0.079	0.756IleCys: 0.756 ± 0.026	4.022IleAsp: 4.022 ± 0.07	4.688IleGlu: 4.688 ± 0.068	2.878IlePhe: 2.878 ± 0.068	5.02IleGly: 5.02 ± 0.081	1.535IleHis: 1.535 ± 0.038	4.19IleIle: 4.19 ± 0.067	3.502IleLys: 3.502 ± 0.059	6.411IleLeu: 6.411 ± 0.094	1.346IleMet: 1.346 ± 0.031	3.0IleAsn: 3.0 ± 0.062	2.953IlePro: 2.953 ± 0.048	3.429IleGln: 3.429 ± 0.067	2.929IleArg: 2.929 ± 0.051	4.408IleSer: 4.408 ± 0.063	3.551IleThr: 3.551 ± 0.062	4.334IleVal: 4.334 ± 0.066	0.742IleTrp: 0.742 ± 0.029	2.217IleTyr: 2.217 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.042LysAla: 5.042 ± 0.089	0.302LysCys: 0.302 ± 0.019	3.108LysAsp: 3.108 ± 0.064	3.223LysGlu: 3.223 ± 0.061	1.973LysPhe: 1.973 ± 0.044	3.082LysGly: 3.082 ± 0.055	1.257LysHis: 1.257 ± 0.035	3.928LysIle: 3.928 ± 0.06	3.519LysLys: 3.519 ± 0.065	5.449LysLeu: 5.449 ± 0.074	1.389LysMet: 1.389 ± 0.037	2.969LysAsn: 2.969 ± 0.057	2.301LysPro: 2.301 ± 0.048	3.435LysGln: 3.435 ± 0.06	2.477LysArg: 2.477 ± 0.055	3.098LysSer: 3.098 ± 0.052	3.347LysThr: 3.347 ± 0.06	3.878LysVal: 3.878 ± 0.066	0.62LysTrp: 0.62 ± 0.025	1.696LysTyr: 1.696 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.357LeuAla: 9.357 ± 0.1	1.065LeuCys: 1.065 ± 0.035	5.485LeuAsp: 5.485 ± 0.076	5.924LeuGlu: 5.924 ± 0.1	4.439LeuPhe: 4.439 ± 0.081	7.252LeuGly: 7.252 ± 0.087	2.119LeuHis: 2.119 ± 0.045	7.117LeuIle: 7.117 ± 0.092	6.728LeuLys: 6.728 ± 0.081	10.105LeuLeu: 10.105 ± 0.14	2.541LeuMet: 2.541 ± 0.057	5.392LeuAsn: 5.392 ± 0.075	4.784LeuPro: 4.784 ± 0.074	4.52LeuGln: 4.52 ± 0.076	4.076LeuArg: 4.076 ± 0.062	7.403LeuSer: 7.403 ± 0.085	5.928LeuThr: 5.928 ± 0.072	6.457LeuVal: 6.457 ± 0.086	1.226LeuTrp: 1.226 ± 0.037	2.811LeuTyr: 2.811 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.201MetAla: 2.201 ± 0.046	0.204MetCys: 0.204 ± 0.012	1.02MetAsp: 1.02 ± 0.031	0.973MetGlu: 0.973 ± 0.03	0.917MetPhe: 0.917 ± 0.033	1.703MetGly: 1.703 ± 0.044	0.512MetHis: 0.512 ± 0.022	1.52MetIle: 1.52 ± 0.038	1.355MetLys: 1.355 ± 0.036	2.423MetLeu: 2.423 ± 0.047	0.72MetMet: 0.72 ± 0.028	1.24MetAsn: 1.24 ± 0.035	1.124MetPro: 1.124 ± 0.031	1.356MetGln: 1.356 ± 0.042	1.05MetArg: 1.05 ± 0.031	1.821MetSer: 1.821 ± 0.042	1.476MetThr: 1.476 ± 0.041	1.61MetVal: 1.61 ± 0.037	0.221MetTrp: 0.221 ± 0.014	0.512MetTyr: 0.512 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.741AsnAla: 3.741 ± 0.067	0.357AsnCys: 0.357 ± 0.02	2.188AsnAsp: 2.188 ± 0.049	2.426AsnGlu: 2.426 ± 0.055	1.961AsnPhe: 1.961 ± 0.045	2.944AsnGly: 2.944 ± 0.063	0.995AsnHis: 0.995 ± 0.03	3.366AsnIle: 3.366 ± 0.057	2.372AsnLys: 2.372 ± 0.062	4.613AsnLeu: 4.613 ± 0.077	1.035AsnMet: 1.035 ± 0.029	2.15AsnAsn: 2.15 ± 0.073	2.274AsnPro: 2.274 ± 0.052	2.465AsnGln: 2.465 ± 0.06	1.835AsnArg: 1.835 ± 0.043	2.684AsnSer: 2.684 ± 0.067	2.499AsnThr: 2.499 ± 0.055	2.714AsnVal: 2.714 ± 0.05	0.59AsnTrp: 0.59 ± 0.021	1.638AsnTyr: 1.638 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.221ProAla: 3.221 ± 0.063	0.291ProCys: 0.291 ± 0.015	2.23ProAsp: 2.23 ± 0.049	3.36ProGlu: 3.36 ± 0.055	1.788ProPhe: 1.788 ± 0.039	1.735ProGly: 1.735 ± 0.05	0.948ProHis: 0.948 ± 0.028	2.586ProIle: 2.586 ± 0.049	2.468ProLys: 2.468 ± 0.051	4.149ProLeu: 4.149 ± 0.062	0.923ProMet: 0.923 ± 0.029	2.055ProAsn: 2.055 ± 0.047	1.13ProPro: 1.13 ± 0.039	1.968ProGln: 1.968 ± 0.045	1.42ProArg: 1.42 ± 0.039	2.421ProSer: 2.421 ± 0.048	2.432ProThr: 2.432 ± 0.047	3.159ProVal: 3.159 ± 0.06	0.487ProTrp: 0.487 ± 0.021	1.44ProTyr: 1.44 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.839GlnAla: 4.839 ± 0.083	0.347GlnCys: 0.347 ± 0.015	2.341GlnAsp: 2.341 ± 0.052	2.65GlnGlu: 2.65 ± 0.058	2.093GlnPhe: 2.093 ± 0.049	3.207GlnGly: 3.207 ± 0.071	1.614GlnHis: 1.614 ± 0.045	3.47GlnIle: 3.47 ± 0.059	3.07GlnLys: 3.07 ± 0.059	5.647GlnLeu: 5.647 ± 0.091	1.151GlnMet: 1.151 ± 0.034	2.43GlnAsn: 2.43 ± 0.054	2.182GlnPro: 2.182 ± 0.049	3.812GlnGln: 3.812 ± 0.096	2.23GlnArg: 2.23 ± 0.045	2.953GlnSer: 2.953 ± 0.058	2.74GlnThr: 2.74 ± 0.052	3.494GlnVal: 3.494 ± 0.053	0.684GlnTrp: 0.684 ± 0.023	1.724GlnTyr: 1.724 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.193ArgAla: 3.193 ± 0.055	0.352ArgCys: 0.352 ± 0.018	2.142ArgAsp: 2.142 ± 0.046	2.576ArgGlu: 2.576 ± 0.052	2.102ArgPhe: 2.102 ± 0.045	2.415ArgGly: 2.415 ± 0.054	1.07ArgHis: 1.07 ± 0.033	2.973ArgIle: 2.973 ± 0.048	2.193ArgLys: 2.193 ± 0.046	4.75ArgLeu: 4.75 ± 0.072	1.038ArgMet: 1.038 ± 0.033	1.75ArgAsn: 1.75 ± 0.037	1.652ArgPro: 1.652 ± 0.043	2.23ArgGln: 2.23 ± 0.049	2.002ArgArg: 2.002 ± 0.05	2.321ArgSer: 2.321 ± 0.04	1.992ArgThr: 1.992 ± 0.035	2.856ArgVal: 2.856 ± 0.056	0.528ArgTrp: 0.528 ± 0.021	1.773ArgTyr: 1.773 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.907SerAla: 4.907 ± 0.08	0.541SerCys: 0.541 ± 0.025	2.878SerAsp: 2.878 ± 0.055	3.404SerGlu: 3.404 ± 0.056	2.897SerPhe: 2.897 ± 0.055	4.514SerGly: 4.514 ± 0.086	1.434SerHis: 1.434 ± 0.034	4.248SerIle: 4.248 ± 0.064	3.23SerLys: 3.23 ± 0.057	6.609SerLeu: 6.609 ± 0.088	1.526SerMet: 1.526 ± 0.04	2.787SerAsn: 2.787 ± 0.057	2.506SerPro: 2.506 ± 0.052	2.855SerGln: 2.855 ± 0.057	2.559SerArg: 2.559 ± 0.056	4.213SerSer: 4.213 ± 0.07	3.533SerThr: 3.533 ± 0.054	3.924SerVal: 3.924 ± 0.069	0.744SerTrp: 0.744 ± 0.027	2.104SerTyr: 2.104 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.853ThrAla: 4.853 ± 0.07	0.462ThrCys: 0.462 ± 0.019	2.754ThrAsp: 2.754 ± 0.064	2.993ThrGlu: 2.993 ± 0.055	2.13ThrPhe: 2.13 ± 0.04	4.223ThrGly: 4.223 ± 0.078	1.267ThrHis: 1.267 ± 0.034	3.415ThrIle: 3.415 ± 0.054	2.456ThrLys: 2.456 ± 0.05	5.971ThrLeu: 5.971 ± 0.074	1.034ThrMet: 1.034 ± 0.029	2.059ThrAsn: 2.059 ± 0.048	2.816ThrPro: 2.816 ± 0.052	2.787ThrGln: 2.787 ± 0.056	2.129ThrArg: 2.129 ± 0.052	3.256ThrSer: 3.256 ± 0.063	3.275ThrThr: 3.275 ± 0.068	3.871ThrVal: 3.871 ± 0.077	0.677ThrTrp: 0.677 ± 0.025	1.671ThrTyr: 1.671 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.934ValAla: 5.934 ± 0.076	0.704ValCys: 0.704 ± 0.029	3.649ValAsp: 3.649 ± 0.068	4.221ValGlu: 4.221 ± 0.069	2.799ValPhe: 2.799 ± 0.056	4.739ValGly: 4.739 ± 0.067	1.292ValHis: 1.292 ± 0.033	4.744ValIle: 4.744 ± 0.068	3.559ValLys: 3.559 ± 0.062	6.967ValLeu: 6.967 ± 0.087	1.739ValMet: 1.739 ± 0.042	2.934ValAsn: 2.934 ± 0.058	2.73ValPro: 2.73 ± 0.05	2.888ValGln: 2.888 ± 0.057	2.726ValArg: 2.726 ± 0.052	4.233ValSer: 4.233 ± 0.067	3.723ValThr: 3.723 ± 0.075	5.124ValVal: 5.124 ± 0.087	0.793ValTrp: 0.793 ± 0.029	1.836ValTyr: 1.836 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.843TrpAla: 0.843 ± 0.025	0.153TrpCys: 0.153 ± 0.01	0.549TrpAsp: 0.549 ± 0.024	0.499TrpGlu: 0.499 ± 0.021	0.684TrpPhe: 0.684 ± 0.027	0.759TrpGly: 0.759 ± 0.027	0.355TrpHis: 0.355 ± 0.019	0.876TrpIle: 0.876 ± 0.03	0.718TrpLys: 0.718 ± 0.026	1.705TrpLeu: 1.705 ± 0.044	0.393TrpMet: 0.393 ± 0.022	0.581TrpAsn: 0.581 ± 0.024	0.358TrpPro: 0.358 ± 0.019	0.869TrpGln: 0.869 ± 0.027	0.589TrpArg: 0.589 ± 0.023	0.801TrpSer: 0.801 ± 0.031	0.602TrpThr: 0.602 ± 0.023	0.9TrpVal: 0.9 ± 0.034	0.174TrpTrp: 0.174 ± 0.013	0.381TrpTyr: 0.381 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.849TyrAla: 2.849 ± 0.049	0.343TyrCys: 0.343 ± 0.018	1.73TyrAsp: 1.73 ± 0.043	1.641TyrGlu: 1.641 ± 0.04	1.612TyrPhe: 1.612 ± 0.038	2.256TyrGly: 2.256 ± 0.045	0.735TyrHis: 0.735 ± 0.027	1.895TyrIle: 1.895 ± 0.047	1.669TyrLys: 1.669 ± 0.04	3.703TyrLeu: 3.703 ± 0.066	0.648TyrMet: 0.648 ± 0.025	1.318TyrAsn: 1.318 ± 0.039	1.428TyrPro: 1.428 ± 0.037	1.932TyrGln: 1.932 ± 0.046	1.676TyrArg: 1.676 ± 0.048	2.083TyrSer: 2.083 ± 0.051	1.598TyrThr: 1.598 ± 0.042	1.989TyrVal: 1.989 ± 0.047	0.507TyrTrp: 0.507 ± 0.023	1.086TyrTyr: 1.086 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3598 proteins (1122070 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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