Amino acid dipepetide frequency for Circoviridae 6 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.422AlaAla: 17.422 ± 5.435
0.0AlaCys: 0.0 ± 0.0
2.323AlaAsp: 2.323 ± 1.096
6.969AlaGlu: 6.969 ± 0.529
2.323AlaPhe: 2.323 ± 1.465
5.807AlaGly: 5.807 ± 2.22
2.323AlaHis: 2.323 ± 1.318
3.484AlaIle: 3.484 ± 1.672
3.484AlaLys: 3.484 ± 1.977
4.646AlaLeu: 4.646 ± 1.614
5.807AlaMet: 5.807 ± 2.083
1.161AlaAsn: 1.161 ± 0.659
8.13AlaPro: 8.13 ± 1.055
4.646AlaGln: 4.646 ± 0.299
5.807AlaArg: 5.807 ± 0.603
4.646AlaSer: 4.646 ± 3.774
6.969AlaThr: 6.969 ± 2.198
6.969AlaVal: 6.969 ± 2.198
0.0AlaTrp: 0.0 ± 0.0
1.161AlaTyr: 1.161 ± 0.659
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.161CysAsp: 1.161 ± 0.659
1.161CysGlu: 1.161 ± 0.982
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
1.161CysMet: 1.161 ± 0.982
0.0CysAsn: 0.0 ± 0.0
2.323CysPro: 2.323 ± 0.807
1.161CysGln: 1.161 ± 1.385
0.0CysArg: 0.0 ± 0.0
1.161CysSer: 1.161 ± 0.982
0.0CysThr: 0.0 ± 0.0
2.323CysVal: 2.323 ± 1.465
1.161CysTrp: 1.161 ± 0.982
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.484AspAla: 3.484 ± 1.164
0.0AspCys: 0.0 ± 0.0
3.484AspAsp: 3.484 ± 1.099
1.161AspGlu: 1.161 ± 0.659
4.646AspPhe: 4.646 ± 1.623
4.646AspGly: 4.646 ± 2.896
1.161AspHis: 1.161 ± 0.659
0.0AspIle: 0.0 ± 0.0
1.161AspLys: 1.161 ± 1.385
3.484AspLeu: 3.484 ± 1.099
1.161AspMet: 1.161 ± 1.385
0.0AspAsn: 0.0 ± 0.0
1.161AspPro: 1.161 ± 0.659
2.323AspGln: 2.323 ± 0.807
1.161AspArg: 1.161 ± 0.659
1.161AspSer: 1.161 ± 1.385
5.807AspThr: 5.807 ± 3.296
8.13AspVal: 8.13 ± 1.055
0.0AspTrp: 0.0 ± 0.0
1.161AspTyr: 1.161 ± 0.982
0.0AspXaa: 0.0 ± 0.0
Glu
9.292GluAla: 9.292 ± 4.338
0.0GluCys: 0.0 ± 0.0
4.646GluAsp: 4.646 ± 2.637
3.484GluGlu: 3.484 ± 2.409
2.323GluPhe: 2.323 ± 1.465
2.323GluGly: 2.323 ± 1.465
2.323GluHis: 2.323 ± 1.963
1.161GluIle: 1.161 ± 0.982
1.161GluLys: 1.161 ± 1.385
1.161GluLeu: 1.161 ± 0.659
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
2.323GluPro: 2.323 ± 1.318
1.161GluGln: 1.161 ± 0.982
1.161GluArg: 1.161 ± 0.659
4.646GluSer: 4.646 ± 1.623
3.484GluThr: 3.484 ± 0.827
2.323GluVal: 2.323 ± 0.807
0.0GluTrp: 0.0 ± 0.0
1.161GluTyr: 1.161 ± 0.982
0.0GluXaa: 0.0 ± 0.0
Phe
1.161PheAla: 1.161 ± 0.982
0.0PheCys: 0.0 ± 0.0
3.484PheAsp: 3.484 ± 0.827
1.161PheGlu: 1.161 ± 1.385
3.484PhePhe: 3.484 ± 1.977
3.484PheGly: 3.484 ± 1.672
0.0PheHis: 0.0 ± 0.0
1.161PheIle: 1.161 ± 0.659
0.0PheLys: 0.0 ± 0.0
3.484PheLeu: 3.484 ± 4.155
0.0PheMet: 0.0 ± 0.0
3.484PheAsn: 3.484 ± 1.164
3.484PhePro: 3.484 ± 1.099
0.0PheGln: 0.0 ± 0.0
3.484PheArg: 3.484 ± 1.164
2.323PheSer: 2.323 ± 1.318
3.484PheThr: 3.484 ± 1.099
3.484PheVal: 3.484 ± 0.827
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.807GlyAla: 5.807 ± 2.066
1.161GlyCys: 1.161 ± 0.982
1.161GlyAsp: 1.161 ± 0.982
0.0GlyGlu: 0.0 ± 0.0
1.161GlyPhe: 1.161 ± 0.659
8.13GlyGly: 8.13 ± 0.822
1.161GlyHis: 1.161 ± 0.982
4.646GlyIle: 4.646 ± 1.614
4.646GlyLys: 4.646 ± 1.447
4.646GlyLeu: 4.646 ± 1.614
3.484GlyMet: 3.484 ± 1.164
4.646GlyAsn: 4.646 ± 1.614
5.807GlyPro: 5.807 ± 1.676
5.807GlyGln: 5.807 ± 1.676
9.292GlyArg: 9.292 ± 2.886
13.937GlySer: 13.937 ± 5.092
4.646GlyThr: 4.646 ± 0.299
3.484GlyVal: 3.484 ± 0.827
2.323GlyTrp: 2.323 ± 0.807
2.323GlyTyr: 2.323 ± 1.096
0.0GlyXaa: 0.0 ± 0.0
His
1.161HisAla: 1.161 ± 0.659
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
2.323HisPhe: 2.323 ± 1.318
1.161HisGly: 1.161 ± 0.982
1.161HisHis: 1.161 ± 1.385
2.323HisIle: 2.323 ± 1.318
1.161HisLys: 1.161 ± 1.385
3.484HisLeu: 3.484 ± 0.827
1.161HisMet: 1.161 ± 0.659
0.0HisAsn: 0.0 ± 0.0
2.323HisPro: 2.323 ± 1.465
0.0HisGln: 0.0 ± 0.0
2.323HisArg: 2.323 ± 1.465
1.161HisSer: 1.161 ± 0.659
5.807HisThr: 5.807 ± 1.676
1.161HisVal: 1.161 ± 1.385
1.161HisTrp: 1.161 ± 1.385
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.323IleAla: 2.323 ± 1.318
0.0IleCys: 0.0 ± 0.0
2.323IleAsp: 2.323 ± 1.318
1.161IleGlu: 1.161 ± 0.982
1.161IlePhe: 1.161 ± 1.385
2.323IleGly: 2.323 ± 0.807
1.161IleHis: 1.161 ± 1.385
0.0IleIle: 0.0 ± 0.0
1.161IleLys: 1.161 ± 0.659
2.323IleLeu: 2.323 ± 0.807
0.0IleMet: 0.0 ± 0.0
0.0IleAsn: 0.0 ± 0.0
3.484IlePro: 3.484 ± 0.827
1.161IleGln: 1.161 ± 0.659
3.484IleArg: 3.484 ± 1.164
2.323IleSer: 2.323 ± 1.318
8.13IleThr: 8.13 ± 1.876
2.323IleVal: 2.323 ± 1.318
1.161IleTrp: 1.161 ± 1.385
1.161IleTyr: 1.161 ± 0.659
0.0IleXaa: 0.0 ± 0.0
Lys
1.161LysAla: 1.161 ± 0.659
0.0LysCys: 0.0 ± 0.0
3.484LysAsp: 3.484 ± 1.099
1.161LysGlu: 1.161 ± 0.982
1.161LysPhe: 1.161 ± 0.659
3.484LysGly: 3.484 ± 0.827
1.161LysHis: 1.161 ± 0.982
1.161LysIle: 1.161 ± 0.659
3.484LysLys: 3.484 ± 1.164
3.484LysLeu: 3.484 ± 1.164
1.161LysMet: 1.161 ± 0.659
0.0LysAsn: 0.0 ± 0.0
1.161LysPro: 1.161 ± 0.659
1.161LysGln: 1.161 ± 0.659
4.646LysArg: 4.646 ± 0.299
3.484LysSer: 3.484 ± 2.409
1.161LysThr: 1.161 ± 0.659
1.161LysVal: 1.161 ± 0.659
0.0LysTrp: 0.0 ± 0.0
6.969LysTyr: 6.969 ± 1.39
0.0LysXaa: 0.0 ± 0.0
Leu
9.292LeuAla: 9.292 ± 1.49
2.323LeuCys: 2.323 ± 1.465
2.323LeuAsp: 2.323 ± 1.465
5.807LeuGlu: 5.807 ± 2.287
1.161LeuPhe: 1.161 ± 0.659
5.807LeuGly: 5.807 ± 2.435
2.323LeuHis: 2.323 ± 2.77
1.161LeuIle: 1.161 ± 1.385
2.323LeuLys: 2.323 ± 1.318
5.807LeuLeu: 5.807 ± 5.15
1.161LeuMet: 1.161 ± 1.385
1.161LeuAsn: 1.161 ± 0.659
4.646LeuPro: 4.646 ± 1.623
2.323LeuGln: 2.323 ± 0.807
5.807LeuArg: 5.807 ± 2.066
3.484LeuSer: 3.484 ± 1.164
4.646LeuThr: 4.646 ± 0.299
2.323LeuVal: 2.323 ± 1.096
1.161LeuTrp: 1.161 ± 1.385
2.323LeuTyr: 2.323 ± 1.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.161MetAla: 1.161 ± 0.659
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
2.323MetGlu: 2.323 ± 1.465
2.323MetPhe: 2.323 ± 0.807
4.646MetGly: 4.646 ± 2.134
0.0MetHis: 0.0 ± 0.0
2.323MetIle: 2.323 ± 1.318
0.0MetLys: 0.0 ± 0.0
1.161MetLeu: 1.161 ± 1.385
1.161MetMet: 1.161 ± 0.659
0.0MetAsn: 0.0 ± 0.0
1.161MetPro: 1.161 ± 0.659
2.323MetGln: 2.323 ± 1.318
3.484MetArg: 3.484 ± 1.164
3.484MetSer: 3.484 ± 1.099
1.161MetThr: 1.161 ± 0.659
1.161MetVal: 1.161 ± 0.982
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.161AsnAla: 1.161 ± 0.982
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
1.161AsnGlu: 1.161 ± 0.659
0.0AsnPhe: 0.0 ± 0.0
3.484AsnGly: 3.484 ± 1.164
0.0AsnHis: 0.0 ± 0.0
2.323AsnIle: 2.323 ± 1.096
1.161AsnLys: 1.161 ± 0.659
4.646AsnLeu: 4.646 ± 0.299
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
0.0AsnPro: 0.0 ± 0.0
0.0AsnGln: 0.0 ± 0.0
0.0AsnArg: 0.0 ± 0.0
1.161AsnSer: 1.161 ± 0.659
2.323AsnThr: 2.323 ± 1.318
1.161AsnVal: 1.161 ± 0.659
3.484AsnTrp: 3.484 ± 1.099
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.969ProAla: 6.969 ± 2.421
1.161ProCys: 1.161 ± 1.385
4.646ProAsp: 4.646 ± 1.623
0.0ProGlu: 0.0 ± 0.0
4.646ProPhe: 4.646 ± 0.299
4.646ProGly: 4.646 ± 0.299
2.323ProHis: 2.323 ± 1.096
1.161ProIle: 1.161 ± 0.659
3.484ProLys: 3.484 ± 1.099
5.807ProLeu: 5.807 ± 0.603
1.161ProMet: 1.161 ± 0.659
1.161ProAsn: 1.161 ± 0.659
6.969ProPro: 6.969 ± 4.56
3.484ProGln: 3.484 ± 1.672
4.646ProArg: 4.646 ± 1.614
4.646ProSer: 4.646 ± 0.299
6.969ProThr: 6.969 ± 1.828
5.807ProVal: 5.807 ± 1.676
2.323ProTrp: 2.323 ± 1.318
3.484ProTyr: 3.484 ± 0.827
0.0ProXaa: 0.0 ± 0.0
Gln
2.323GlnAla: 2.323 ± 0.807
1.161GlnCys: 1.161 ± 0.982
1.161GlnAsp: 1.161 ± 0.659
3.484GlnGlu: 3.484 ± 1.099
1.161GlnPhe: 1.161 ± 1.385
1.161GlnGly: 1.161 ± 0.982
1.161GlnHis: 1.161 ± 0.659
1.161GlnIle: 1.161 ± 1.385
0.0GlnLys: 0.0 ± 0.0
2.323GlnLeu: 2.323 ± 1.096
0.0GlnMet: 0.0 ± 0.0
1.161GlnAsn: 1.161 ± 1.385
4.646GlnPro: 4.646 ± 1.623
0.0GlnGln: 0.0 ± 0.0
5.807GlnArg: 5.807 ± 2.33
2.323GlnSer: 2.323 ± 1.318
1.161GlnThr: 1.161 ± 1.385
3.484GlnVal: 3.484 ± 1.164
5.807GlnTrp: 5.807 ± 1.676
1.161GlnTyr: 1.161 ± 0.982
0.0GlnXaa: 0.0 ± 0.0
Arg
10.453ArgAla: 10.453 ± 3.186
0.0ArgCys: 0.0 ± 0.0
2.323ArgAsp: 2.323 ± 0.807
1.161ArgGlu: 1.161 ± 0.659
3.484ArgPhe: 3.484 ± 0.827
8.13ArgGly: 8.13 ± 3.219
3.484ArgHis: 3.484 ± 0.827
2.323ArgIle: 2.323 ± 1.096
4.646ArgLys: 4.646 ± 0.299
6.969ArgLeu: 6.969 ± 3.493
2.323ArgMet: 2.323 ± 1.318
3.484ArgAsn: 3.484 ± 1.164
6.969ArgPro: 6.969 ± 1.228
1.161ArgGln: 1.161 ± 1.385
10.453ArgArg: 10.453 ± 2.427
4.646ArgSer: 4.646 ± 1.614
3.484ArgThr: 3.484 ± 1.977
4.646ArgVal: 4.646 ± 1.614
1.161ArgTrp: 1.161 ± 0.659
1.161ArgTyr: 1.161 ± 0.982
0.0ArgXaa: 0.0 ± 0.0
Ser
5.807SerAla: 5.807 ± 2.066
1.161SerCys: 1.161 ± 0.659
3.484SerAsp: 3.484 ± 1.672
4.646SerGlu: 4.646 ± 1.447
0.0SerPhe: 0.0 ± 0.0
3.484SerGly: 3.484 ± 1.099
2.323SerHis: 2.323 ± 2.77
5.807SerIle: 5.807 ± 3.296
2.323SerLys: 2.323 ± 1.465
5.807SerLeu: 5.807 ± 1.676
3.484SerMet: 3.484 ± 1.672
1.161SerAsn: 1.161 ± 0.659
8.13SerPro: 8.13 ± 2.143
4.646SerGln: 4.646 ± 3.774
3.484SerArg: 3.484 ± 1.099
1.161SerSer: 1.161 ± 0.659
3.484SerThr: 3.484 ± 1.099
2.323SerVal: 2.323 ± 1.963
0.0SerTrp: 0.0 ± 0.0
2.323SerTyr: 2.323 ± 1.318
0.0SerXaa: 0.0 ± 0.0
Thr
5.807ThrAla: 5.807 ± 0.603
1.161ThrCys: 1.161 ± 0.659
3.484ThrAsp: 3.484 ± 2.409
2.323ThrGlu: 2.323 ± 0.807
1.161ThrPhe: 1.161 ± 0.982
15.099ThrGly: 15.099 ± 3.102
3.484ThrHis: 3.484 ± 1.977
2.323ThrIle: 2.323 ± 1.318
3.484ThrLys: 3.484 ± 1.164
3.484ThrLeu: 3.484 ± 1.099
0.0ThrMet: 0.0 ± 0.999
2.323ThrAsn: 2.323 ± 0.807
5.807ThrPro: 5.807 ± 1.812
2.323ThrGln: 2.323 ± 0.807
4.646ThrArg: 4.646 ± 2.62
6.969ThrSer: 6.969 ± 0.529
4.646ThrThr: 4.646 ± 1.623
2.323ThrVal: 2.323 ± 0.807
1.161ThrTrp: 1.161 ± 0.659
1.161ThrTyr: 1.161 ± 0.659
0.0ThrXaa: 0.0 ± 0.0
Val
6.969ValAla: 6.969 ± 2.844
2.323ValCys: 2.323 ± 1.963
1.161ValAsp: 1.161 ± 1.385
3.484ValGlu: 3.484 ± 1.099
2.323ValPhe: 2.323 ± 1.096
1.161ValGly: 1.161 ± 0.982
2.323ValHis: 2.323 ± 1.096
3.484ValIle: 3.484 ± 1.164
4.646ValLys: 4.646 ± 1.623
1.161ValLeu: 1.161 ± 1.385
3.484ValMet: 3.484 ± 0.979
2.323ValAsn: 2.323 ± 1.318
4.646ValPro: 4.646 ± 1.614
3.484ValGln: 3.484 ± 0.827
6.969ValArg: 6.969 ± 1.654
2.323ValSer: 2.323 ± 1.465
3.484ValThr: 3.484 ± 2.945
5.807ValVal: 5.807 ± 3.501
1.161ValTrp: 1.161 ± 1.385
2.323ValTyr: 2.323 ± 0.807
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.323TrpGlu: 2.323 ± 0.807
1.161TrpPhe: 1.161 ± 1.385
5.807TrpGly: 5.807 ± 3.478
0.0TrpHis: 0.0 ± 0.0
1.161TrpIle: 1.161 ± 1.385
1.161TrpLys: 1.161 ± 0.659
1.161TrpLeu: 1.161 ± 0.659
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.161TrpGln: 1.161 ± 0.982
3.484TrpArg: 3.484 ± 1.164
0.0TrpSer: 0.0 ± 0.0
2.323TrpThr: 2.323 ± 0.807
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
3.484TrpTyr: 3.484 ± 0.827
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 1.096
1.161TyrCys: 1.161 ± 0.982
4.646TyrAsp: 4.646 ± 0.299
1.161TyrGlu: 1.161 ± 0.982
1.161TyrPhe: 1.161 ± 0.659
3.484TyrGly: 3.484 ± 1.672
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
1.161TyrLys: 1.161 ± 0.659
2.323TyrLeu: 2.323 ± 1.096
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
2.323TyrPro: 2.323 ± 1.465
2.323TyrGln: 2.323 ± 1.318
2.323TyrArg: 2.323 ± 1.318
0.0TyrSer: 0.0 ± 0.0
1.161TyrThr: 1.161 ± 0.659
4.646TyrVal: 4.646 ± 1.447
1.161TyrTrp: 1.161 ± 1.385
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (862 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski