Amino acid dipepetide frequency for Acyrthosiphon pisum virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.711AlaAla: 4.711 ± 1.227
1.256AlaCys: 1.256 ± 0.616
3.455AlaAsp: 3.455 ± 0.81
4.711AlaGlu: 4.711 ± 0.541
5.339AlaPhe: 5.339 ± 0.035
4.711AlaGly: 4.711 ± 0.541
1.256AlaHis: 1.256 ± 0.268
4.083AlaIle: 4.083 ± 0.233
2.827AlaLys: 2.827 ± 1.386
7.224AlaLeu: 7.224 ± 0.889
2.198AlaMet: 2.198 ± 0.194
3.769AlaAsn: 3.769 ± 0.079
2.198AlaPro: 2.198 ± 2.459
2.513AlaGln: 2.513 ± 1.421
2.198AlaArg: 2.198 ± 0.691
4.711AlaSer: 4.711 ± 0.343
2.827AlaThr: 2.827 ± 0.383
3.455AlaVal: 3.455 ± 0.81
0.0AlaTrp: 0.0 ± 0.0
1.884AlaTyr: 1.884 ± 0.845
0.0AlaXaa: 0.0 ± 0.0
Cys
0.628CysAla: 0.628 ± 0.308
0.0CysCys: 0.0 ± 0.0
0.314CysAsp: 0.314 ± 0.73
0.942CysGlu: 0.942 ± 0.462
0.628CysPhe: 0.628 ± 0.308
1.256CysGly: 1.256 ± 0.616
0.0CysHis: 0.0 ± 0.0
1.256CysIle: 1.256 ± 0.268
1.256CysLys: 1.256 ± 0.268
1.57CysLeu: 1.57 ± 0.77
0.314CysMet: 0.314 ± 0.154
1.256CysAsn: 1.256 ± 0.616
0.628CysPro: 0.628 ± 0.308
0.314CysGln: 0.314 ± 0.154
0.314CysArg: 0.314 ± 0.154
2.198CysSer: 2.198 ± 1.078
0.942CysThr: 0.942 ± 0.462
0.942CysVal: 0.942 ± 0.422
0.314CysTrp: 0.314 ± 0.154
0.942CysTyr: 0.942 ± 0.462
0.0CysXaa: 0.0 ± 0.0
Asp
3.455AspAla: 3.455 ± 0.959
0.314AspCys: 0.314 ± 0.154
4.711AspAsp: 4.711 ± 0.541
3.141AspGlu: 3.141 ± 1.113
3.455AspPhe: 3.455 ± 0.81
1.884AspGly: 1.884 ± 0.924
0.942AspHis: 0.942 ± 0.462
4.711AspIle: 4.711 ± 0.343
3.769AspLys: 3.769 ± 0.805
4.397AspLeu: 4.397 ± 0.497
0.942AspMet: 0.942 ± 0.422
2.198AspAsn: 2.198 ± 0.194
3.769AspPro: 3.769 ± 1.848
0.314AspGln: 0.314 ± 0.154
3.455AspArg: 3.455 ± 0.81
5.025AspSer: 5.025 ± 0.695
2.198AspThr: 2.198 ± 0.194
1.57AspVal: 1.57 ± 0.77
2.198AspTrp: 2.198 ± 1.575
3.141AspTyr: 3.141 ± 1.997
0.0AspXaa: 0.0 ± 0.0
Glu
4.083GluAla: 4.083 ± 0.233
0.628GluCys: 0.628 ± 0.308
3.141GluAsp: 3.141 ± 0.656
3.769GluGlu: 3.769 ± 1.848
3.455GluPhe: 3.455 ± 0.959
2.827GluGly: 2.827 ± 0.502
0.628GluHis: 0.628 ± 0.308
2.827GluIle: 2.827 ± 0.383
5.967GluLys: 5.967 ± 0.273
6.91GluLeu: 6.91 ± 1.619
0.942GluMet: 0.942 ± 0.462
5.025GluAsn: 5.025 ± 1.58
1.256GluPro: 1.256 ± 0.616
1.884GluGln: 1.884 ± 0.845
3.455GluArg: 3.455 ± 0.075
2.827GluSer: 2.827 ± 0.502
2.198GluThr: 2.198 ± 0.691
2.827GluVal: 2.827 ± 0.502
0.942GluTrp: 0.942 ± 0.422
3.141GluTyr: 3.141 ± 0.656
0.0GluXaa: 0.0 ± 0.0
Phe
1.884PheAla: 1.884 ± 0.924
2.198PheCys: 2.198 ± 0.146
3.141PheAsp: 3.141 ± 1.997
3.455PheGlu: 3.455 ± 0.81
1.57PhePhe: 1.57 ± 0.999
3.455PheGly: 3.455 ± 0.81
0.628PheHis: 0.628 ± 0.308
4.083PheIle: 4.083 ± 1.535
2.827PheLys: 2.827 ± 0.383
1.884PheLeu: 1.884 ± 0.04
0.628PheMet: 0.628 ± 0.542
2.827PheAsn: 2.827 ± 0.383
1.256PhePro: 1.256 ± 0.268
1.256PheGln: 1.256 ± 2.037
2.513PheArg: 2.513 ± 0.348
4.711PheSer: 4.711 ± 2.111
2.827PheThr: 2.827 ± 1.267
2.827PheVal: 2.827 ± 0.502
0.314PheTrp: 0.314 ± 0.154
2.513PheTyr: 2.513 ± 0.537
0.0PheXaa: 0.0 ± 0.0
Gly
2.827GlyAla: 2.827 ± 1.267
0.942GlyCys: 0.942 ± 0.462
1.884GlyAsp: 1.884 ± 0.04
2.198GlyGlu: 2.198 ± 1.078
2.827GlyPhe: 2.827 ± 0.502
3.769GlyGly: 3.769 ± 0.805
0.314GlyHis: 0.314 ± 0.73
2.198GlyIle: 2.198 ± 0.691
4.711GlyLys: 4.711 ± 1.426
5.967GlyLeu: 5.967 ± 1.495
1.256GlyMet: 1.256 ± 0.268
3.141GlyAsn: 3.141 ± 0.229
2.198GlyPro: 2.198 ± 0.194
1.256GlyGln: 1.256 ± 1.153
4.083GlyArg: 4.083 ± 0.233
2.827GlySer: 2.827 ± 0.383
3.455GlyThr: 3.455 ± 0.81
4.711GlyVal: 4.711 ± 2.31
0.314GlyTrp: 0.314 ± 0.154
2.827GlyTyr: 2.827 ± 1.267
0.0GlyXaa: 0.0 ± 0.0
His
1.57HisAla: 1.57 ± 0.77
0.314HisCys: 0.314 ± 0.154
0.942HisAsp: 0.942 ± 0.422
1.256HisGlu: 1.256 ± 0.268
1.256HisPhe: 1.256 ± 0.268
0.628HisGly: 0.628 ± 0.308
0.314HisHis: 0.314 ± 0.154
3.455HisIle: 3.455 ± 0.075
0.942HisLys: 0.942 ± 0.462
0.942HisLeu: 0.942 ± 0.462
0.628HisMet: 0.628 ± 0.576
0.628HisAsn: 0.628 ± 0.308
0.942HisPro: 0.942 ± 0.422
0.314HisGln: 0.314 ± 0.154
1.57HisArg: 1.57 ± 0.77
0.628HisSer: 0.628 ± 0.308
2.198HisThr: 2.198 ± 0.194
0.628HisVal: 0.628 ± 0.308
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.455IleAla: 3.455 ± 0.959
0.628IleCys: 0.628 ± 0.117
2.198IleAsp: 2.198 ± 1.575
3.769IleGlu: 3.769 ± 0.805
2.513IlePhe: 2.513 ± 2.305
3.455IleGly: 3.455 ± 0.81
1.256IleHis: 1.256 ± 0.616
7.852IleIle: 7.852 ± 2.081
5.339IleLys: 5.339 ± 0.035
5.339IleLeu: 5.339 ± 1.734
1.256IleMet: 1.256 ± 0.671
3.769IleAsn: 3.769 ± 0.964
2.827IlePro: 2.827 ± 0.383
3.141IleGln: 3.141 ± 0.656
3.141IleArg: 3.141 ± 0.229
5.339IleSer: 5.339 ± 1.803
6.281IleThr: 6.281 ± 3.08
3.455IleVal: 3.455 ± 0.81
0.628IleTrp: 0.628 ± 0.308
2.827IleTyr: 2.827 ± 2.151
0.0IleXaa: 0.0 ± 0.0
Lys
4.397LysAla: 4.397 ± 0.387
0.942LysCys: 0.942 ± 0.462
4.083LysAsp: 4.083 ± 0.233
4.711LysGlu: 4.711 ± 0.541
4.083LysPhe: 4.083 ± 0.651
3.141LysGly: 3.141 ± 0.229
0.942LysHis: 0.942 ± 0.462
3.769LysIle: 3.769 ± 0.964
4.397LysLys: 4.397 ± 1.272
6.595LysLeu: 6.595 ± 0.581
0.942LysMet: 0.942 ± 0.422
3.769LysAsn: 3.769 ± 0.079
3.455LysPro: 3.455 ± 0.81
3.455LysGln: 3.455 ± 0.075
2.513LysArg: 2.513 ± 1.232
4.083LysSer: 4.083 ± 1.118
4.083LysThr: 4.083 ± 0.651
4.083LysVal: 4.083 ± 0.233
0.0LysTrp: 0.0 ± 0.0
3.455LysTyr: 3.455 ± 1.694
0.0LysXaa: 0.0 ± 0.0
Leu
5.967LeuAla: 5.967 ± 1.157
1.57LeuCys: 1.57 ± 0.77
2.827LeuAsp: 2.827 ± 0.502
4.711LeuGlu: 4.711 ± 1.426
4.083LeuPhe: 4.083 ± 2.419
4.397LeuGly: 4.397 ± 0.497
2.198LeuHis: 2.198 ± 0.194
5.025LeuIle: 5.025 ± 0.695
4.397LeuLys: 4.397 ± 1.272
9.108LeuLeu: 9.108 ± 1.724
1.884LeuMet: 1.884 ± 0.924
5.025LeuAsn: 5.025 ± 0.695
3.141LeuPro: 3.141 ± 1.997
3.141LeuGln: 3.141 ± 0.229
3.455LeuArg: 3.455 ± 0.075
6.91LeuSer: 6.91 ± 1.918
6.91LeuThr: 6.91 ± 0.735
5.025LeuVal: 5.025 ± 1.58
0.628LeuTrp: 0.628 ± 0.308
3.141LeuTyr: 3.141 ± 0.229
0.0LeuXaa: 0.0 ± 0.0
Met
1.256MetAla: 1.256 ± 0.268
0.314MetCys: 0.314 ± 0.154
0.942MetAsp: 0.942 ± 0.462
2.513MetGlu: 2.513 ± 1.232
0.942MetPhe: 0.942 ± 0.422
0.628MetGly: 0.628 ± 0.576
0.314MetHis: 0.314 ± 0.73
0.942MetIle: 0.942 ± 0.462
1.884MetLys: 1.884 ± 0.924
1.256MetLeu: 1.256 ± 0.268
0.314MetMet: 0.314 ± 0.154
1.256MetAsn: 1.256 ± 0.616
1.57MetPro: 1.57 ± 0.77
1.57MetGln: 1.57 ± 2.767
1.57MetArg: 1.57 ± 0.77
1.57MetSer: 1.57 ± 0.999
1.57MetThr: 1.57 ± 0.77
0.942MetVal: 0.942 ± 0.462
0.0MetTrp: 0.0 ± 0.0
0.314MetTyr: 0.314 ± 0.154
0.0MetXaa: 0.0 ± 0.0
Asn
5.339AsnAla: 5.339 ± 0.919
0.942AsnCys: 0.942 ± 0.462
3.141AsnAsp: 3.141 ± 0.656
3.141AsnGlu: 3.141 ± 0.656
2.198AsnPhe: 2.198 ± 0.194
2.827AsnGly: 2.827 ± 0.502
1.57AsnHis: 1.57 ± 0.77
3.141AsnIle: 3.141 ± 0.229
5.025AsnLys: 5.025 ± 0.695
4.083AsnLeu: 4.083 ± 1.535
1.256AsnMet: 1.256 ± 0.616
4.397AsnAsn: 4.397 ± 1.381
4.397AsnPro: 4.397 ± 0.387
2.513AsnGln: 2.513 ± 0.537
2.827AsnArg: 2.827 ± 0.502
4.083AsnSer: 4.083 ± 2.419
2.198AsnThr: 2.198 ± 0.691
2.198AsnVal: 2.198 ± 0.691
0.0AsnTrp: 0.0 ± 0.0
4.083AsnTyr: 4.083 ± 1.118
0.0AsnXaa: 0.0 ± 0.0
Pro
2.198ProAla: 2.198 ± 1.575
0.628ProCys: 0.628 ± 0.308
2.513ProAsp: 2.513 ± 0.537
1.57ProGlu: 1.57 ± 0.114
2.513ProPhe: 2.513 ± 0.348
2.513ProGly: 2.513 ± 1.232
1.57ProHis: 1.57 ± 0.114
2.513ProIle: 2.513 ± 0.348
2.513ProLys: 2.513 ± 1.421
2.827ProLeu: 2.827 ± 0.383
1.57ProMet: 1.57 ± 0.114
2.513ProAsn: 2.513 ± 1.232
2.198ProPro: 2.198 ± 0.194
1.256ProGln: 1.256 ± 0.268
0.942ProArg: 0.942 ± 1.307
3.455ProSer: 3.455 ± 0.81
3.769ProThr: 3.769 ± 0.079
1.884ProVal: 1.884 ± 0.924
0.314ProTrp: 0.314 ± 0.154
3.141ProTyr: 3.141 ± 0.656
0.0ProXaa: 0.0 ± 0.0
Gln
1.884GlnAla: 1.884 ± 0.04
0.314GlnCys: 0.314 ± 0.154
1.256GlnAsp: 1.256 ± 0.268
1.884GlnGlu: 1.884 ± 0.04
0.942GlnPhe: 0.942 ± 1.307
1.884GlnGly: 1.884 ± 0.845
0.314GlnHis: 0.314 ± 0.73
3.455GlnIle: 3.455 ± 0.959
2.198GlnLys: 2.198 ± 1.078
1.884GlnLeu: 1.884 ± 0.845
0.942GlnMet: 0.942 ± 2.191
3.769GlnAsn: 3.769 ± 3.458
1.256GlnPro: 1.256 ± 0.268
2.513GlnGln: 2.513 ± 4.074
3.141GlnArg: 3.141 ± 1.997
2.198GlnSer: 2.198 ± 0.691
1.256GlnThr: 1.256 ± 2.037
3.455GlnVal: 3.455 ± 0.075
0.0GlnTrp: 0.0 ± 0.0
0.942GlnTyr: 0.942 ± 0.422
0.0GlnXaa: 0.0 ± 0.0
Arg
3.141ArgAla: 3.141 ± 0.656
0.314ArgCys: 0.314 ± 0.154
3.455ArgAsp: 3.455 ± 0.81
1.884ArgGlu: 1.884 ± 0.04
1.256ArgPhe: 1.256 ± 0.268
2.513ArgGly: 2.513 ± 2.305
1.57ArgHis: 1.57 ± 0.77
4.083ArgIle: 4.083 ± 1.118
3.141ArgLys: 3.141 ± 1.54
4.397ArgLeu: 4.397 ± 0.497
0.942ArgMet: 0.942 ± 0.462
1.884ArgAsn: 1.884 ± 0.04
1.256ArgPro: 1.256 ± 0.268
2.198ArgGln: 2.198 ± 1.575
2.513ArgArg: 2.513 ± 0.537
2.827ArgSer: 2.827 ± 0.383
2.827ArgThr: 2.827 ± 0.383
3.141ArgVal: 3.141 ± 0.229
0.314ArgTrp: 0.314 ± 0.154
2.513ArgTyr: 2.513 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
6.281SerAla: 6.281 ± 0.427
0.628SerCys: 0.628 ± 0.308
5.339SerAsp: 5.339 ± 0.849
5.025SerGlu: 5.025 ± 1.58
1.884SerPhe: 1.884 ± 0.845
4.083SerGly: 4.083 ± 2.419
1.256SerHis: 1.256 ± 1.153
4.397SerIle: 4.397 ± 1.272
2.827SerLys: 2.827 ± 0.502
5.967SerLeu: 5.967 ± 1.157
1.57SerMet: 1.57 ± 0.114
4.083SerAsn: 4.083 ± 1.535
2.513SerPro: 2.513 ± 0.348
2.198SerGln: 2.198 ± 1.575
2.513SerArg: 2.513 ± 0.537
7.852SerSer: 7.852 ± 0.571
7.538SerThr: 7.538 ± 0.725
5.339SerVal: 5.339 ± 1.734
0.628SerTrp: 0.628 ± 0.576
2.198SerTyr: 2.198 ± 0.691
0.0SerXaa: 0.0 ± 0.0
Thr
4.397ThrAla: 4.397 ± 1.272
1.57ThrCys: 1.57 ± 0.114
4.711ThrAsp: 4.711 ± 1.227
3.455ThrGlu: 3.455 ± 0.81
3.455ThrPhe: 3.455 ± 0.959
2.827ThrGly: 2.827 ± 1.267
0.942ThrHis: 0.942 ± 0.462
5.653ThrIle: 5.653 ± 1.003
5.339ThrLys: 5.339 ± 0.849
3.769ThrLeu: 3.769 ± 0.079
1.57ThrMet: 1.57 ± 0.77
3.455ThrAsn: 3.455 ± 1.843
2.827ThrPro: 2.827 ± 0.383
2.827ThrGln: 2.827 ± 2.151
2.513ThrArg: 2.513 ± 0.348
5.025ThrSer: 5.025 ± 2.464
10.05ThrThr: 10.05 ± 2.275
4.083ThrVal: 4.083 ± 1.535
0.0ThrTrp: 0.0 ± 0.0
2.827ThrTyr: 2.827 ± 0.502
0.0ThrXaa: 0.0 ± 0.0
Val
2.827ValAla: 2.827 ± 0.502
0.942ValCys: 0.942 ± 0.462
3.455ValAsp: 3.455 ± 0.81
5.025ValGlu: 5.025 ± 1.957
2.198ValPhe: 2.198 ± 0.194
5.025ValGly: 5.025 ± 2.464
2.198ValHis: 2.198 ± 1.078
2.198ValIle: 2.198 ± 1.575
3.769ValLys: 3.769 ± 0.964
4.711ValLeu: 4.711 ± 1.426
1.256ValMet: 1.256 ± 0.616
2.513ValAsn: 2.513 ± 0.537
2.513ValPro: 2.513 ± 1.232
0.628ValGln: 0.628 ± 0.308
0.942ValArg: 0.942 ± 0.462
3.769ValSer: 3.769 ± 0.964
4.083ValThr: 4.083 ± 1.118
6.281ValVal: 6.281 ± 2.196
0.314ValTrp: 0.314 ± 0.154
5.339ValTyr: 5.339 ± 0.849
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.314TrpCys: 0.314 ± 0.154
0.628TrpAsp: 0.628 ± 0.308
0.0TrpGlu: 0.0 ± 0.0
0.942TrpPhe: 0.942 ± 0.462
0.0TrpGly: 0.0 ± 0.0
0.314TrpHis: 0.314 ± 0.154
0.628TrpIle: 0.628 ± 0.576
0.314TrpLys: 0.314 ± 0.73
0.314TrpLeu: 0.314 ± 0.154
0.628TrpMet: 0.628 ± 0.308
0.314TrpAsn: 0.314 ± 0.154
0.0TrpPro: 0.0 ± 0.0
0.314TrpGln: 0.314 ± 0.73
0.0TrpArg: 0.0 ± 0.0
0.942TrpSer: 0.942 ± 0.462
0.314TrpThr: 0.314 ± 0.154
0.628TrpVal: 0.628 ± 0.308
0.0TrpTrp: 0.0 ± 0.0
0.628TrpTyr: 0.628 ± 1.461
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.025TyrAla: 5.025 ± 1.073
1.256TyrCys: 1.256 ± 0.268
3.455TyrAsp: 3.455 ± 0.075
1.57TyrGlu: 1.57 ± 0.114
1.256TyrPhe: 1.256 ± 0.616
1.884TyrGly: 1.884 ± 0.845
0.628TyrHis: 0.628 ± 0.308
2.513TyrIle: 2.513 ± 0.537
3.455TyrLys: 3.455 ± 0.959
4.397TyrLeu: 4.397 ± 0.497
0.314TyrMet: 0.314 ± 0.154
3.769TyrAsn: 3.769 ± 0.964
2.198TyrPro: 2.198 ± 0.194
1.884TyrGln: 1.884 ± 0.845
2.513TyrArg: 2.513 ± 0.537
3.141TyrSer: 3.141 ± 0.656
3.769TyrThr: 3.769 ± 1.689
2.513TyrVal: 2.513 ± 1.232
0.314TyrTrp: 0.314 ± 0.154
2.198TyrTyr: 2.198 ± 0.194
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3185 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski