Amino acid dipepetide frequency for Streptomyces inhibens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.165AlaAla: 22.165 ± 0.138	1.1AlaCys: 1.1 ± 0.022	8.372AlaAsp: 8.372 ± 0.07	8.581AlaGlu: 8.581 ± 0.093	3.57AlaPhe: 3.57 ± 0.039	13.337AlaGly: 13.337 ± 0.068	3.095AlaHis: 3.095 ± 0.035	3.684AlaIle: 3.684 ± 0.048	3.049AlaLys: 3.049 ± 0.054	15.027AlaLeu: 15.027 ± 0.111	2.636AlaMet: 2.636 ± 0.028	1.936AlaAsn: 1.936 ± 0.029	7.543AlaPro: 7.543 ± 0.066	4.001AlaGln: 4.001 ± 0.044	10.327AlaArg: 10.327 ± 0.077	5.67AlaSer: 5.67 ± 0.044	7.159AlaThr: 7.159 ± 0.06	11.931AlaVal: 11.931 ± 0.091	1.813AlaTrp: 1.813 ± 0.03	2.728AlaTyr: 2.728 ± 0.034	0.001AlaXaa: 0.001 ± 0.001
Cys	1.194CysAla: 1.194 ± 0.02	0.115CysCys: 0.115 ± 0.007	0.484CysAsp: 0.484 ± 0.015	0.404CysGlu: 0.404 ± 0.013	0.242CysPhe: 0.242 ± 0.01	1.019CysGly: 1.019 ± 0.021	0.208CysHis: 0.208 ± 0.01	0.22CysIle: 0.22 ± 0.009	0.123CysLys: 0.123 ± 0.007	0.778CysLeu: 0.778 ± 0.019	0.129CysMet: 0.129 ± 0.007	0.138CysAsn: 0.138 ± 0.007	0.509CysPro: 0.509 ± 0.016	0.19CysGln: 0.19 ± 0.008	0.657CysArg: 0.657 ± 0.016	0.45CysSer: 0.45 ± 0.011	0.577CysThr: 0.577 ± 0.016	0.658CysVal: 0.658 ± 0.017	0.136CysTrp: 0.136 ± 0.007	0.179CysTyr: 0.179 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.706AspAla: 7.706 ± 0.061	0.454AspCys: 0.454 ± 0.014	3.425AspAsp: 3.425 ± 0.041	3.755AspGlu: 3.755 ± 0.044	1.624AspPhe: 1.624 ± 0.026	6.38AspGly: 6.38 ± 0.053	1.484AspHis: 1.484 ± 0.025	1.977AspIle: 1.977 ± 0.03	1.242AspLys: 1.242 ± 0.029	6.029AspLeu: 6.029 ± 0.056	0.771AspMet: 0.771 ± 0.018	0.974AspAsn: 0.974 ± 0.02	4.434AspPro: 4.434 ± 0.044	1.569AspGln: 1.569 ± 0.028	4.901AspArg: 4.901 ± 0.048	2.479AspSer: 2.479 ± 0.039	3.114AspThr: 3.114 ± 0.039	4.182AspVal: 4.182 ± 0.042	0.995AspTrp: 0.995 ± 0.022	1.113AspTyr: 1.113 ± 0.021	0.002AspXaa: 0.002 ± 0.001
Glu	7.185GluAla: 7.185 ± 0.077	0.372GluCys: 0.372 ± 0.01	2.642GluAsp: 2.642 ± 0.037	3.353GluGlu: 3.353 ± 0.051	1.439GluPhe: 1.439 ± 0.025	4.108GluGly: 4.108 ± 0.044	1.491GluHis: 1.491 ± 0.026	2.28GluIle: 2.28 ± 0.033	1.369GluLys: 1.369 ± 0.029	6.913GluLeu: 6.913 ± 0.066	0.918GluMet: 0.918 ± 0.02	0.977GluAsn: 0.977 ± 0.022	3.287GluPro: 3.287 ± 0.043	2.298GluGln: 2.298 ± 0.031	5.483GluArg: 5.483 ± 0.058	2.486GluSer: 2.486 ± 0.035	2.75GluThr: 2.75 ± 0.034	4.287GluVal: 4.287 ± 0.05	0.75GluTrp: 0.75 ± 0.017	0.988GluTyr: 0.988 ± 0.023	0.001GluXaa: 0.001 ± 0.001
Phe	3.746PheAla: 3.746 ± 0.041	0.278PheCys: 0.278 ± 0.01	1.893PheAsp: 1.893 ± 0.03	1.353PheGlu: 1.353 ± 0.025	0.881PhePhe: 0.881 ± 0.022	3.008PheGly: 3.008 ± 0.039	0.673PheHis: 0.673 ± 0.018	0.804PheIle: 0.804 ± 0.021	0.519PheLys: 0.519 ± 0.016	2.63PheLeu: 2.63 ± 0.037	0.392PheMet: 0.392 ± 0.012	0.558PheAsn: 0.558 ± 0.017	1.417PhePro: 1.417 ± 0.023	0.669PheGln: 0.669 ± 0.014	1.862PheArg: 1.862 ± 0.028	1.471PheSer: 1.471 ± 0.029	2.006PheThr: 2.006 ± 0.027	2.107PheVal: 2.107 ± 0.03	0.423PheTrp: 0.423 ± 0.014	0.568PheTyr: 0.568 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.45GlyAla: 11.45 ± 0.068	0.908GlyCys: 0.908 ± 0.017	4.936GlyAsp: 4.936 ± 0.046	5.054GlyGlu: 5.054 ± 0.042	2.811GlyPhe: 2.811 ± 0.04	8.95GlyGly: 8.95 ± 0.103	2.418GlyHis: 2.418 ± 0.036	3.626GlyIle: 3.626 ± 0.041	2.585GlyLys: 2.585 ± 0.039	9.406GlyLeu: 9.406 ± 0.075	2.01GlyMet: 2.01 ± 0.032	1.754GlyAsn: 1.754 ± 0.029	5.42GlyPro: 5.42 ± 0.052	2.759GlyGln: 2.759 ± 0.04	7.886GlyArg: 7.886 ± 0.056	5.405GlySer: 5.405 ± 0.054	6.102GlyThr: 6.102 ± 0.061	7.057GlyVal: 7.057 ± 0.055	1.682GlyTrp: 1.682 ± 0.029	2.27GlyTyr: 2.27 ± 0.034	0.002GlyXaa: 0.002 ± 0.001
His	2.77HisAla: 2.77 ± 0.038	0.246HisCys: 0.246 ± 0.01	1.423HisAsp: 1.423 ± 0.025	1.228HisGlu: 1.228 ± 0.022	0.712HisPhe: 0.712 ± 0.016	2.554HisGly: 2.554 ± 0.035	0.8HisHis: 0.8 ± 0.021	0.79HisIle: 0.79 ± 0.021	0.399HisLys: 0.399 ± 0.012	2.574HisLeu: 2.574 ± 0.033	0.348HisMet: 0.348 ± 0.012	0.403HisAsn: 0.403 ± 0.012	1.989HisPro: 1.989 ± 0.025	0.731HisGln: 0.731 ± 0.02	2.248HisArg: 2.248 ± 0.032	1.131HisSer: 1.131 ± 0.024	1.535HisThr: 1.535 ± 0.03	1.525HisVal: 1.525 ± 0.026	0.402HisTrp: 0.402 ± 0.013	0.493HisTyr: 0.493 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.158IleAla: 5.158 ± 0.056	0.322IleCys: 0.322 ± 0.012	2.355IleAsp: 2.355 ± 0.033	2.11IleGlu: 2.11 ± 0.031	0.764IlePhe: 0.764 ± 0.02	3.813IleGly: 3.813 ± 0.046	0.664IleHis: 0.664 ± 0.016	0.942IleIle: 0.942 ± 0.025	0.811IleLys: 0.811 ± 0.021	2.391IleLeu: 2.391 ± 0.036	0.464IleMet: 0.464 ± 0.017	0.764IleAsn: 0.764 ± 0.02	1.884IlePro: 1.884 ± 0.028	0.734IleGln: 0.734 ± 0.017	2.343IleArg: 2.343 ± 0.034	1.775IleSer: 1.775 ± 0.03	2.273IleThr: 2.273 ± 0.03	2.846IleVal: 2.846 ± 0.038	0.413IleTrp: 0.413 ± 0.013	0.553IleTyr: 0.553 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.94LysAla: 2.94 ± 0.046	0.119LysCys: 0.119 ± 0.008	1.435LysAsp: 1.435 ± 0.031	1.226LysGlu: 1.226 ± 0.025	0.491LysPhe: 0.491 ± 0.013	1.868LysGly: 1.868 ± 0.036	0.479LysHis: 0.479 ± 0.013	0.966LysIle: 0.966 ± 0.021	0.966LysLys: 0.966 ± 0.035	2.101LysLeu: 2.101 ± 0.032	0.41LysMet: 0.41 ± 0.016	0.565LysAsn: 0.565 ± 0.018	1.401LysPro: 1.401 ± 0.032	0.74LysGln: 0.74 ± 0.02	1.473LysArg: 1.473 ± 0.029	1.166LysSer: 1.166 ± 0.023	1.317LysThr: 1.317 ± 0.027	1.873LysVal: 1.873 ± 0.033	0.283LysTrp: 0.283 ± 0.013	0.459LysTyr: 0.459 ± 0.016	0.001LysXaa: 0.001 ± 0.001
Leu	15.477LeuAla: 15.477 ± 0.112	0.916LeuCys: 0.916 ± 0.021	6.61LeuAsp: 6.61 ± 0.061	4.482LeuGlu: 4.482 ± 0.051	2.612LeuPhe: 2.612 ± 0.041	9.253LeuGly: 9.253 ± 0.068	2.464LeuHis: 2.464 ± 0.037	3.549LeuIle: 3.549 ± 0.043	2.024LeuLys: 2.024 ± 0.034	11.535LeuLeu: 11.535 ± 0.105	1.656LeuMet: 1.656 ± 0.026	1.709LeuAsn: 1.709 ± 0.027	6.702LeuPro: 6.702 ± 0.065	2.339LeuGln: 2.339 ± 0.033	8.842LeuArg: 8.842 ± 0.074	5.45LeuSer: 5.45 ± 0.055	7.054LeuThr: 7.054 ± 0.052	8.311LeuVal: 8.311 ± 0.067	1.302LeuTrp: 1.302 ± 0.024	1.817LeuTyr: 1.817 ± 0.025	0.002LeuXaa: 0.002 ± 0.001
Met	2.407MetAla: 2.407 ± 0.033	0.139MetCys: 0.139 ± 0.007	0.909MetAsp: 0.909 ± 0.02	0.754MetGlu: 0.754 ± 0.018	0.439MetPhe: 0.439 ± 0.014	1.372MetGly: 1.372 ± 0.024	0.396MetHis: 0.396 ± 0.013	0.669MetIle: 0.669 ± 0.015	0.427MetLys: 0.427 ± 0.013	1.739MetLeu: 1.739 ± 0.032	0.316MetMet: 0.316 ± 0.012	0.458MetAsn: 0.458 ± 0.015	1.193MetPro: 1.193 ± 0.022	0.468MetGln: 0.468 ± 0.013	1.45MetArg: 1.45 ± 0.028	1.277MetSer: 1.277 ± 0.025	1.478MetThr: 1.478 ± 0.023	1.293MetVal: 1.293 ± 0.022	0.229MetTrp: 0.229 ± 0.01	0.317MetTyr: 0.317 ± 0.011	0.001MetXaa: 0.001 ± 0.001
Asn	2.201AsnAla: 2.201 ± 0.034	0.179AsnCys: 0.179 ± 0.008	0.988AsnAsp: 0.988 ± 0.026	0.811AsnGlu: 0.811 ± 0.022	0.487AsnPhe: 0.487 ± 0.015	1.885AsnGly: 1.885 ± 0.031	0.413AsnHis: 0.413 ± 0.013	0.667AsnIle: 0.667 ± 0.016	0.446AsnLys: 0.446 ± 0.015	1.584AsnLeu: 1.584 ± 0.026	0.304AsnMet: 0.304 ± 0.01	0.449AsnAsn: 0.449 ± 0.016	1.337AsnPro: 1.337 ± 0.024	0.523AsnGln: 0.523 ± 0.015	1.236AsnArg: 1.236 ± 0.025	0.99AsnSer: 0.99 ± 0.02	1.105AsnThr: 1.105 ± 0.021	1.294AsnVal: 1.294 ± 0.022	0.316AsnTrp: 0.316 ± 0.012	0.419AsnTyr: 0.419 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.925ProAla: 8.925 ± 0.086	0.366ProCys: 0.366 ± 0.011	4.594ProAsp: 4.594 ± 0.047	4.243ProGlu: 4.243 ± 0.039	1.556ProPhe: 1.556 ± 0.026	6.771ProGly: 6.771 ± 0.057	1.552ProHis: 1.552 ± 0.027	1.32ProIle: 1.32 ± 0.023	1.291ProLys: 1.291 ± 0.029	5.533ProLeu: 5.533 ± 0.053	1.038ProMet: 1.038 ± 0.02	0.928ProAsn: 0.928 ± 0.018	3.721ProPro: 3.721 ± 0.058	2.047ProGln: 2.047 ± 0.035	4.046ProArg: 4.046 ± 0.047	3.237ProSer: 3.237 ± 0.042	3.34ProThr: 3.34 ± 0.043	5.39ProVal: 5.39 ± 0.051	0.926ProTrp: 0.926 ± 0.02	1.445ProTyr: 1.445 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	3.866GlnAla: 3.866 ± 0.047	0.197GlnCys: 0.197 ± 0.008	1.476GlnAsp: 1.476 ± 0.027	1.558GlnGlu: 1.558 ± 0.028	0.722GlnPhe: 0.722 ± 0.018	2.378GlnGly: 2.378 ± 0.034	0.754GlnHis: 0.754 ± 0.017	1.159GlnIle: 1.159 ± 0.02	0.642GlnLys: 0.642 ± 0.018	3.398GlnLeu: 3.398 ± 0.037	0.552GlnMet: 0.552 ± 0.015	0.488GlnAsn: 0.488 ± 0.016	1.817GlnPro: 1.817 ± 0.035	1.479GlnGln: 1.479 ± 0.044	2.53GlnArg: 2.53 ± 0.035	1.29GlnSer: 1.29 ± 0.024	1.364GlnThr: 1.364 ± 0.028	2.358GlnVal: 2.358 ± 0.032	0.496GlnTrp: 0.496 ± 0.015	0.576GlnTyr: 0.576 ± 0.015	0.001GlnXaa: 0.001 ± 0.001
Arg	10.009ArgAla: 10.009 ± 0.076	0.638ArgCys: 0.638 ± 0.018	4.11ArgAsp: 4.11 ± 0.041	4.552ArgGlu: 4.552 ± 0.042	2.324ArgPhe: 2.324 ± 0.029	5.791ArgGly: 5.791 ± 0.054	2.232ArgHis: 2.232 ± 0.033	3.49ArgIle: 3.49 ± 0.041	1.731ArgLys: 1.731 ± 0.027	8.749ArgLeu: 8.749 ± 0.081	1.818ArgMet: 1.818 ± 0.027	1.374ArgAsn: 1.374 ± 0.027	5.265ArgPro: 5.265 ± 0.057	2.469ArgGln: 2.469 ± 0.034	7.872ArgArg: 7.872 ± 0.069	4.111ArgSer: 4.111 ± 0.042	5.528ArgThr: 5.528 ± 0.046	5.328ArgVal: 5.328 ± 0.049	1.395ArgTrp: 1.395 ± 0.026	1.793ArgTyr: 1.793 ± 0.03	0.001ArgXaa: 0.001 ± 0.001
Ser	6.806SerAla: 6.806 ± 0.055	0.46SerCys: 0.46 ± 0.014	2.644SerAsp: 2.644 ± 0.035	2.334SerGlu: 2.334 ± 0.034	1.547SerPhe: 1.547 ± 0.031	5.914SerGly: 5.914 ± 0.055	1.095SerHis: 1.095 ± 0.02	1.435SerIle: 1.435 ± 0.026	1.055SerLys: 1.055 ± 0.025	4.786SerLeu: 4.786 ± 0.049	1.069SerMet: 1.069 ± 0.023	0.842SerAsn: 0.842 ± 0.022	3.208SerPro: 3.208 ± 0.039	1.33SerGln: 1.33 ± 0.023	3.656SerArg: 3.656 ± 0.04	2.834SerSer: 2.834 ± 0.045	2.987SerThr: 2.987 ± 0.038	4.046SerVal: 4.046 ± 0.044	0.931SerTrp: 0.931 ± 0.02	1.223SerTyr: 1.223 ± 0.025	0.002SerXaa: 0.002 ± 0.001
Thr	9.07ThrAla: 9.07 ± 0.076	0.446ThrCys: 0.446 ± 0.013	3.573ThrAsp: 3.573 ± 0.035	3.231ThrGlu: 3.231 ± 0.036	1.641ThrPhe: 1.641 ± 0.024	6.534ThrGly: 6.534 ± 0.062	1.277ThrHis: 1.277 ± 0.022	1.759ThrIle: 1.759 ± 0.026	1.192ThrLys: 1.192 ± 0.027	5.73ThrLeu: 5.73 ± 0.046	0.951ThrMet: 0.951 ± 0.02	0.992ThrAsn: 0.992 ± 0.021	4.227ThrPro: 4.227 ± 0.046	1.324ThrGln: 1.324 ± 0.025	3.772ThrArg: 3.772 ± 0.041	3.124ThrSer: 3.124 ± 0.035	3.869ThrThr: 3.869 ± 0.057	5.943ThrVal: 5.943 ± 0.056	0.85ThrTrp: 0.85 ± 0.02	1.294ThrTyr: 1.294 ± 0.027	0.001ThrXaa: 0.001 ± 0.001
Val	10.238ValAla: 10.238 ± 0.077	0.802ValCys: 0.802 ± 0.017	4.502ValAsp: 4.502 ± 0.042	4.384ValGlu: 4.384 ± 0.049	2.244ValPhe: 2.244 ± 0.036	6.238ValGly: 6.238 ± 0.057	2.0ValHis: 2.0 ± 0.028	2.981ValIle: 2.981 ± 0.036	1.661ValLys: 1.661 ± 0.033	9.228ValLeu: 9.228 ± 0.07	1.38ValMet: 1.38 ± 0.025	1.567ValAsn: 1.567 ± 0.027	5.037ValPro: 5.037 ± 0.044	2.146ValGln: 2.146 ± 0.028	6.815ValArg: 6.815 ± 0.054	4.028ValSer: 4.028 ± 0.039	5.171ValThr: 5.171 ± 0.054	7.19ValVal: 7.19 ± 0.065	1.085ValTrp: 1.085 ± 0.022	1.446ValTyr: 1.446 ± 0.024	0.001ValXaa: 0.001 ± 0.001
Trp	1.663TrpAla: 1.663 ± 0.025	0.175TrpCys: 0.175 ± 0.008	0.798TrpAsp: 0.798 ± 0.019	0.723TrpGlu: 0.723 ± 0.016	0.509TrpPhe: 0.509 ± 0.015	1.055TrpGly: 1.055 ± 0.023	0.406TrpHis: 0.406 ± 0.013	0.568TrpIle: 0.568 ± 0.014	0.365TrpLys: 0.365 ± 0.012	1.818TrpLeu: 1.818 ± 0.033	0.321TrpMet: 0.321 ± 0.01	0.38TrpAsn: 0.38 ± 0.014	0.809TrpPro: 0.809 ± 0.018	0.679TrpGln: 0.679 ± 0.019	1.342TrpArg: 1.342 ± 0.026	0.935TrpSer: 0.935 ± 0.02	0.951TrpThr: 0.951 ± 0.019	0.935TrpVal: 0.935 ± 0.02	0.342TrpTrp: 0.342 ± 0.012	0.333TrpTyr: 0.333 ± 0.012	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.747TyrAla: 2.747 ± 0.032	0.174TyrCys: 0.174 ± 0.009	1.44TyrAsp: 1.44 ± 0.027	1.238TyrGlu: 1.238 ± 0.025	0.642TyrPhe: 0.642 ± 0.018	2.262TyrGly: 2.262 ± 0.028	0.4TyrHis: 0.4 ± 0.013	0.494TyrIle: 0.494 ± 0.014	0.382TyrLys: 0.382 ± 0.015	2.157TyrLeu: 2.157 ± 0.031	0.248TyrMet: 0.248 ± 0.01	0.382TyrAsn: 0.382 ± 0.013	1.067TyrPro: 1.067 ± 0.02	0.604TyrGln: 0.604 ± 0.016	1.84TyrArg: 1.84 ± 0.028	0.893TyrSer: 0.893 ± 0.018	1.117TyrThr: 1.117 ± 0.024	1.587TyrVal: 1.587 ± 0.03	0.341TyrTrp: 0.341 ± 0.013	0.443TyrTyr: 0.443 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7955 proteins (2512952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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