Amino acid dipepetide frequency for Cecembia lonarensis LW9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.163AlaAla: 5.163 ± 0.076
0.622AlaCys: 0.622 ± 0.02
3.466AlaAsp: 3.466 ± 0.049
4.357AlaGlu: 4.357 ± 0.065
3.942AlaPhe: 3.942 ± 0.053
4.985AlaGly: 4.985 ± 0.067
1.274AlaHis: 1.274 ± 0.031
5.089AlaIle: 5.089 ± 0.069
4.295AlaLys: 4.295 ± 0.066
6.915AlaLeu: 6.915 ± 0.087
1.795AlaMet: 1.795 ± 0.037
3.036AlaAsn: 3.036 ± 0.052
2.232AlaPro: 2.232 ± 0.049
2.678AlaGln: 2.678 ± 0.052
2.453AlaArg: 2.453 ± 0.046
4.078AlaSer: 4.078 ± 0.053
3.023AlaThr: 3.023 ± 0.05
4.441AlaVal: 4.441 ± 0.059
0.855AlaTrp: 0.855 ± 0.027
2.75AlaTyr: 2.75 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.439CysAla: 0.439 ± 0.017
0.102CysCys: 0.102 ± 0.008
0.363CysAsp: 0.363 ± 0.018
0.416CysGlu: 0.416 ± 0.018
0.411CysPhe: 0.411 ± 0.02
0.566CysGly: 0.566 ± 0.024
0.213CysHis: 0.213 ± 0.015
0.478CysIle: 0.478 ± 0.019
0.382CysLys: 0.382 ± 0.015
0.65CysLeu: 0.65 ± 0.022
0.157CysMet: 0.157 ± 0.01
0.3CysAsn: 0.3 ± 0.016
0.331CysPro: 0.331 ± 0.02
0.298CysGln: 0.298 ± 0.015
0.251CysArg: 0.251 ± 0.014
0.488CysSer: 0.488 ± 0.021
0.364CysThr: 0.364 ± 0.016
0.365CysVal: 0.365 ± 0.017
0.079CysTrp: 0.079 ± 0.007
0.227CysTyr: 0.227 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.469AspAla: 3.469 ± 0.053
0.377AspCys: 0.377 ± 0.016
2.343AspAsp: 2.343 ± 0.044
3.552AspGlu: 3.552 ± 0.053
3.833AspPhe: 3.833 ± 0.054
3.837AspGly: 3.837 ± 0.078
1.063AspHis: 1.063 ± 0.029
4.048AspIle: 4.048 ± 0.053
3.5AspLys: 3.5 ± 0.057
5.789AspLeu: 5.789 ± 0.08
1.346AspMet: 1.346 ± 0.032
2.414AspAsn: 2.414 ± 0.046
2.487AspPro: 2.487 ± 0.044
2.111AspGln: 2.111 ± 0.039
2.495AspArg: 2.495 ± 0.046
2.515AspSer: 2.515 ± 0.046
2.189AspThr: 2.189 ± 0.04
2.977AspVal: 2.977 ± 0.052
0.945AspTrp: 0.945 ± 0.024
2.41AspTyr: 2.41 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.045GluAla: 5.045 ± 0.065
0.277GluCys: 0.277 ± 0.014
3.765GluAsp: 3.765 ± 0.061
5.908GluGlu: 5.908 ± 0.085
3.193GluPhe: 3.193 ± 0.059
4.752GluGly: 4.752 ± 0.062
1.104GluHis: 1.104 ± 0.03
5.554GluIle: 5.554 ± 0.07
6.091GluLys: 6.091 ± 0.092
6.397GluLeu: 6.397 ± 0.075
1.945GluMet: 1.945 ± 0.038
4.137GluAsn: 4.137 ± 0.051
1.906GluPro: 1.906 ± 0.041
2.438GluGln: 2.438 ± 0.046
3.146GluArg: 3.146 ± 0.047
3.546GluSer: 3.546 ± 0.056
3.038GluThr: 3.038 ± 0.05
4.846GluVal: 4.846 ± 0.066
0.838GluTrp: 0.838 ± 0.025
2.087GluTyr: 2.087 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.283PheAla: 3.283 ± 0.055
0.416PheCys: 0.416 ± 0.017
3.308PheAsp: 3.308 ± 0.055
3.888PheGlu: 3.888 ± 0.053
3.268PhePhe: 3.268 ± 0.07
4.015PheGly: 4.015 ± 0.058
1.048PheHis: 1.048 ± 0.029
3.711PheIle: 3.711 ± 0.061
3.075PheLys: 3.075 ± 0.045
5.56PheLeu: 5.56 ± 0.088
1.255PheMet: 1.255 ± 0.031
2.794PheAsn: 2.794 ± 0.05
2.198PhePro: 2.198 ± 0.042
2.099PheGln: 2.099 ± 0.041
2.362PheArg: 2.362 ± 0.046
4.13PheSer: 4.13 ± 0.058
2.833PheThr: 2.833 ± 0.047
3.092PheVal: 3.092 ± 0.051
0.741PheTrp: 0.741 ± 0.025
2.088PheTyr: 2.088 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.553GlyAla: 4.553 ± 0.067
0.555GlyCys: 0.555 ± 0.024
3.54GlyAsp: 3.54 ± 0.057
4.429GlyGlu: 4.429 ± 0.069
4.026GlyPhe: 4.026 ± 0.057
4.988GlyGly: 4.988 ± 0.092
1.298GlyHis: 1.298 ± 0.033
5.61GlyIle: 5.61 ± 0.074
5.269GlyLys: 5.269 ± 0.07
7.095GlyLeu: 7.095 ± 0.077
2.031GlyMet: 2.031 ± 0.043
3.69GlyAsn: 3.69 ± 0.065
2.054GlyPro: 2.054 ± 0.039
2.482GlyGln: 2.482 ± 0.052
3.074GlyArg: 3.074 ± 0.05
3.997GlySer: 3.997 ± 0.063
3.636GlyThr: 3.636 ± 0.056
4.599GlyVal: 4.599 ± 0.064
0.954GlyTrp: 0.954 ± 0.026
2.819GlyTyr: 2.819 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.24HisAla: 1.24 ± 0.032
0.18HisCys: 0.18 ± 0.012
0.91HisAsp: 0.91 ± 0.027
1.153HisGlu: 1.153 ± 0.029
1.23HisPhe: 1.23 ± 0.026
1.323HisGly: 1.323 ± 0.032
0.565HisHis: 0.565 ± 0.023
1.352HisIle: 1.352 ± 0.034
0.949HisLys: 0.949 ± 0.026
2.106HisLeu: 2.106 ± 0.04
0.446HisMet: 0.446 ± 0.018
0.761HisAsn: 0.761 ± 0.024
1.129HisPro: 1.129 ± 0.033
1.015HisGln: 1.015 ± 0.027
0.803HisArg: 0.803 ± 0.024
1.065HisSer: 1.065 ± 0.029
0.871HisThr: 0.871 ± 0.028
1.155HisVal: 1.155 ± 0.026
0.302HisTrp: 0.302 ± 0.017
0.837HisTyr: 0.837 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.051IleAla: 5.051 ± 0.066
0.606IleCys: 0.606 ± 0.022
4.061IleAsp: 4.061 ± 0.06
4.718IleGlu: 4.718 ± 0.069
3.797IlePhe: 3.797 ± 0.057
5.22IleGly: 5.22 ± 0.071
1.562IleHis: 1.562 ± 0.032
4.965IleIle: 4.965 ± 0.072
4.677IleLys: 4.677 ± 0.08
7.035IleLeu: 7.035 ± 0.095
1.511IleMet: 1.511 ± 0.034
3.724IleAsn: 3.724 ± 0.056
3.523IlePro: 3.523 ± 0.053
3.046IleGln: 3.046 ± 0.045
3.307IleArg: 3.307 ± 0.053
5.166IleSer: 5.166 ± 0.071
3.628IleThr: 3.628 ± 0.055
3.886IleVal: 3.886 ± 0.058
0.865IleTrp: 0.865 ± 0.027
2.479IleTyr: 2.479 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.759LysAla: 4.759 ± 0.064
0.271LysCys: 0.271 ± 0.014
3.738LysAsp: 3.738 ± 0.051
5.598LysGlu: 5.598 ± 0.075
2.642LysPhe: 2.642 ± 0.049
4.486LysGly: 4.486 ± 0.069
1.195LysHis: 1.195 ± 0.032
5.036LysIle: 5.036 ± 0.071
5.251LysLys: 5.251 ± 0.082
5.816LysLeu: 5.816 ± 0.08
1.771LysMet: 1.771 ± 0.035
3.734LysAsn: 3.734 ± 0.059
2.428LysPro: 2.428 ± 0.043
2.076LysGln: 2.076 ± 0.038
2.777LysArg: 2.777 ± 0.049
4.146LysSer: 4.146 ± 0.057
3.393LysThr: 3.393 ± 0.052
4.617LysVal: 4.617 ± 0.067
0.738LysTrp: 0.738 ± 0.026
2.389LysTyr: 2.389 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
6.851LeuAla: 6.851 ± 0.092
0.638LeuCys: 0.638 ± 0.021
5.603LeuAsp: 5.603 ± 0.066
7.276LeuGlu: 7.276 ± 0.086
5.21LeuPhe: 5.21 ± 0.077
6.934LeuGly: 6.934 ± 0.078
1.778LeuHis: 1.778 ± 0.035
7.146LeuIle: 7.146 ± 0.103
6.688LeuLys: 6.688 ± 0.085
9.71LeuLeu: 9.71 ± 0.119
2.51LeuMet: 2.51 ± 0.046
4.938LeuAsn: 4.938 ± 0.061
4.192LeuPro: 4.192 ± 0.057
3.466LeuGln: 3.466 ± 0.056
4.041LeuArg: 4.041 ± 0.058
6.907LeuSer: 6.907 ± 0.076
4.818LeuThr: 4.818 ± 0.061
6.099LeuVal: 6.099 ± 0.072
1.062LeuTrp: 1.062 ± 0.028
3.162LeuTyr: 3.162 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.104MetAla: 2.104 ± 0.041
0.134MetCys: 0.134 ± 0.009
1.563MetAsp: 1.563 ± 0.035
1.951MetGlu: 1.951 ± 0.043
0.877MetPhe: 0.877 ± 0.026
1.944MetGly: 1.944 ± 0.045
0.483MetHis: 0.483 ± 0.017
1.673MetIle: 1.673 ± 0.034
2.069MetLys: 2.069 ± 0.038
2.253MetLeu: 2.253 ± 0.044
0.753MetMet: 0.753 ± 0.025
1.233MetAsn: 1.233 ± 0.029
1.09MetPro: 1.09 ± 0.03
0.862MetGln: 0.862 ± 0.026
1.124MetArg: 1.124 ± 0.026
1.359MetSer: 1.359 ± 0.034
1.184MetThr: 1.184 ± 0.029
1.784MetVal: 1.784 ± 0.036
0.206MetTrp: 0.206 ± 0.013
0.652MetTyr: 0.652 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.322AsnAla: 3.322 ± 0.053
0.334AsnCys: 0.334 ± 0.016
2.295AsnAsp: 2.295 ± 0.044
3.04AsnGlu: 3.04 ± 0.048
2.901AsnPhe: 2.901 ± 0.044
3.382AsnGly: 3.382 ± 0.063
1.027AsnHis: 1.027 ± 0.03
3.622AsnIle: 3.622 ± 0.055
2.925AsnLys: 2.925 ± 0.051
5.277AsnLeu: 5.277 ± 0.069
1.214AsnMet: 1.214 ± 0.03
2.541AsnAsn: 2.541 ± 0.052
2.91AsnPro: 2.91 ± 0.053
2.222AsnGln: 2.222 ± 0.046
2.521AsnArg: 2.521 ± 0.04
2.831AsnSer: 2.831 ± 0.049
2.531AsnThr: 2.531 ± 0.045
2.765AsnVal: 2.765 ± 0.046
0.819AsnTrp: 0.819 ± 0.024
2.175AsnTyr: 2.175 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.513ProAla: 2.513 ± 0.044
0.22ProCys: 0.22 ± 0.013
2.597ProAsp: 2.597 ± 0.045
3.575ProGlu: 3.575 ± 0.057
2.288ProPhe: 2.288 ± 0.04
2.785ProGly: 2.785 ± 0.055
0.787ProHis: 0.787 ± 0.025
2.824ProIle: 2.824 ± 0.045
2.423ProLys: 2.423 ± 0.04
3.587ProLeu: 3.587 ± 0.051
0.99ProMet: 0.99 ± 0.029
2.189ProAsn: 2.189 ± 0.043
1.093ProPro: 1.093 ± 0.035
1.423ProGln: 1.423 ± 0.037
1.369ProArg: 1.369 ± 0.033
2.611ProSer: 2.611 ± 0.051
1.781ProThr: 1.781 ± 0.035
2.813ProVal: 2.813 ± 0.052
0.484ProTrp: 0.484 ± 0.02
1.546ProTyr: 1.546 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.604GlnAla: 2.604 ± 0.043
0.191GlnCys: 0.191 ± 0.012
1.802GlnAsp: 1.802 ± 0.035
2.987GlnGlu: 2.987 ± 0.047
1.818GlnPhe: 1.818 ± 0.04
2.354GlnGly: 2.354 ± 0.039
0.685GlnHis: 0.685 ± 0.021
2.707GlnIle: 2.707 ± 0.05
2.659GlnLys: 2.659 ± 0.047
3.77GlnLeu: 3.77 ± 0.057
0.98GlnMet: 0.98 ± 0.028
1.909GlnAsn: 1.909 ± 0.035
1.338GlnPro: 1.338 ± 0.033
1.573GlnGln: 1.573 ± 0.038
1.735GlnArg: 1.735 ± 0.038
2.16GlnSer: 2.16 ± 0.042
1.75GlnThr: 1.75 ± 0.036
2.727GlnVal: 2.727 ± 0.042
0.482GlnTrp: 0.482 ± 0.02
1.294GlnTyr: 1.294 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.59ArgAla: 2.59 ± 0.044
0.217ArgCys: 0.217 ± 0.012
2.333ArgAsp: 2.333 ± 0.042
3.051ArgGlu: 3.051 ± 0.051
2.428ArgPhe: 2.428 ± 0.044
2.619ArgGly: 2.619 ± 0.049
0.735ArgHis: 0.735 ± 0.024
3.373ArgIle: 3.373 ± 0.054
3.064ArgLys: 3.064 ± 0.048
4.241ArgLeu: 4.241 ± 0.064
1.261ArgMet: 1.261 ± 0.028
2.384ArgAsn: 2.384 ± 0.045
1.664ArgPro: 1.664 ± 0.039
1.552ArgGln: 1.552 ± 0.031
1.978ArgArg: 1.978 ± 0.047
2.411ArgSer: 2.411 ± 0.046
2.067ArgThr: 2.067 ± 0.041
2.649ArgVal: 2.649 ± 0.041
0.56ArgTrp: 0.56 ± 0.023
1.75ArgTyr: 1.75 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
3.738SerAla: 3.738 ± 0.05
0.562SerCys: 0.562 ± 0.021
3.063SerAsp: 3.063 ± 0.045
3.794SerGlu: 3.794 ± 0.057
3.662SerPhe: 3.662 ± 0.055
4.793SerGly: 4.793 ± 0.066
1.223SerHis: 1.223 ± 0.029
4.597SerIle: 4.597 ± 0.055
3.984SerLys: 3.984 ± 0.054
6.223SerLeu: 6.223 ± 0.073
1.554SerMet: 1.554 ± 0.037
3.108SerAsn: 3.108 ± 0.057
2.655SerPro: 2.655 ± 0.045
2.237SerGln: 2.237 ± 0.043
2.701SerArg: 2.701 ± 0.05
3.88SerSer: 3.88 ± 0.067
3.015SerThr: 3.015 ± 0.048
3.414SerVal: 3.414 ± 0.065
0.818SerTrp: 0.818 ± 0.028
2.287SerTyr: 2.287 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
3.454ThrAla: 3.454 ± 0.057
0.331ThrCys: 0.331 ± 0.018
2.67ThrAsp: 2.67 ± 0.048
2.935ThrGlu: 2.935 ± 0.04
2.768ThrPhe: 2.768 ± 0.052
4.006ThrGly: 4.006 ± 0.063
0.938ThrHis: 0.938 ± 0.024
3.465ThrIle: 3.465 ± 0.046
2.627ThrLys: 2.627 ± 0.052
4.939ThrLeu: 4.939 ± 0.063
0.973ThrMet: 0.973 ± 0.026
2.069ThrAsn: 2.069 ± 0.041
2.175ThrPro: 2.175 ± 0.039
1.644ThrGln: 1.644 ± 0.033
1.78ThrArg: 1.78 ± 0.036
2.922ThrSer: 2.922 ± 0.046
2.332ThrThr: 2.332 ± 0.045
3.298ThrVal: 3.298 ± 0.053
0.662ThrTrp: 0.662 ± 0.021
1.991ThrTyr: 1.991 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
4.118ValAla: 4.118 ± 0.064
0.484ValCys: 0.484 ± 0.021
3.542ValAsp: 3.542 ± 0.051
4.121ValGlu: 4.121 ± 0.056
3.705ValPhe: 3.705 ± 0.062
4.18ValGly: 4.18 ± 0.064
1.212ValHis: 1.212 ± 0.026
4.474ValIle: 4.474 ± 0.059
4.044ValLys: 4.044 ± 0.057
6.32ValLeu: 6.32 ± 0.066
1.576ValMet: 1.576 ± 0.035
3.242ValAsn: 3.242 ± 0.049
2.509ValPro: 2.509 ± 0.042
2.105ValGln: 2.105 ± 0.039
2.575ValArg: 2.575 ± 0.05
4.088ValSer: 4.088 ± 0.053
3.046ValThr: 3.046 ± 0.052
3.932ValVal: 3.932 ± 0.055
0.743ValTrp: 0.743 ± 0.023
2.267ValTyr: 2.267 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.775TrpAla: 0.775 ± 0.023
0.089TrpCys: 0.089 ± 0.008
0.759TrpAsp: 0.759 ± 0.027
0.982TrpGlu: 0.982 ± 0.026
0.627TrpPhe: 0.627 ± 0.022
0.875TrpGly: 0.875 ± 0.029
0.282TrpHis: 0.282 ± 0.013
0.903TrpIle: 0.903 ± 0.028
0.838TrpLys: 0.838 ± 0.025
1.223TrpLeu: 1.223 ± 0.032
0.432TrpMet: 0.432 ± 0.019
0.674TrpAsn: 0.674 ± 0.022
0.383TrpPro: 0.383 ± 0.018
0.495TrpGln: 0.495 ± 0.023
0.583TrpArg: 0.583 ± 0.023
0.759TrpSer: 0.759 ± 0.026
0.679TrpThr: 0.679 ± 0.023
0.842TrpVal: 0.842 ± 0.028
0.2TrpTrp: 0.2 ± 0.013
0.494TrpTyr: 0.494 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.379TyrAla: 2.379 ± 0.044
0.274TyrCys: 0.274 ± 0.016
1.982TyrAsp: 1.982 ± 0.035
2.283TyrGlu: 2.283 ± 0.039
2.537TyrPhe: 2.537 ± 0.047
2.655TyrGly: 2.655 ± 0.043
0.916TyrHis: 0.916 ± 0.024
2.202TyrIle: 2.202 ± 0.039
2.052TyrLys: 2.052 ± 0.039
4.12TyrLeu: 4.12 ± 0.068
0.797TyrMet: 0.797 ± 0.025
1.777TyrAsn: 1.777 ± 0.036
1.603TyrPro: 1.603 ± 0.033
1.706TyrGln: 1.706 ± 0.036
1.849TyrArg: 1.849 ± 0.036
2.248TyrSer: 2.248 ± 0.043
1.801TyrThr: 1.801 ± 0.045
1.982TyrVal: 1.982 ± 0.034
0.541TyrTrp: 0.541 ± 0.022
1.524TyrTyr: 1.524 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4213 proteins (1388209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski