Amino acid dipepetide frequency for Capronia epimyces CBS 606.96

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.34AlaAla: 9.34 ± 0.067	1.063AlaCys: 1.063 ± 0.016	4.561AlaAsp: 4.561 ± 0.03	5.385AlaGlu: 5.385 ± 0.042	3.182AlaPhe: 3.182 ± 0.028	6.246AlaGly: 6.246 ± 0.04	1.894AlaHis: 1.894 ± 0.023	4.273AlaIle: 4.273 ± 0.032	3.98AlaLys: 3.98 ± 0.037	7.953AlaLeu: 7.953 ± 0.047	1.896AlaMet: 1.896 ± 0.02	2.945AlaAsn: 2.945 ± 0.023	4.662AlaPro: 4.662 ± 0.035	3.666AlaGln: 3.666 ± 0.03	5.333AlaArg: 5.333 ± 0.033	7.453AlaSer: 7.453 ± 0.047	5.611AlaThr: 5.611 ± 0.041	5.773AlaVal: 5.773 ± 0.041	1.197AlaTrp: 1.197 ± 0.017	2.229AlaTyr: 2.229 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.924CysAla: 0.924 ± 0.016	0.208CysCys: 0.208 ± 0.007	0.602CysAsp: 0.602 ± 0.011	0.541CysGlu: 0.541 ± 0.011	0.511CysPhe: 0.511 ± 0.01	0.856CysGly: 0.856 ± 0.016	0.332CysHis: 0.332 ± 0.008	0.665CysIle: 0.665 ± 0.012	0.47CysLys: 0.47 ± 0.011	1.283CysLeu: 1.283 ± 0.017	0.242CysMet: 0.242 ± 0.007	0.386CysAsn: 0.386 ± 0.009	0.641CysPro: 0.641 ± 0.013	0.432CysGln: 0.432 ± 0.008	0.735CysArg: 0.735 ± 0.014	0.823CysSer: 0.823 ± 0.014	0.641CysThr: 0.641 ± 0.012	0.768CysVal: 0.768 ± 0.013	0.191CysTrp: 0.191 ± 0.006	0.347CysTyr: 0.347 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.788AspAla: 4.788 ± 0.033	0.603AspCys: 0.603 ± 0.013	4.323AspAsp: 4.323 ± 0.045	4.514AspGlu: 4.514 ± 0.041	2.224AspPhe: 2.224 ± 0.023	4.16AspGly: 4.16 ± 0.034	1.429AspHis: 1.429 ± 0.019	2.886AspIle: 2.886 ± 0.03	2.382AspLys: 2.382 ± 0.023	5.393AspLeu: 5.393 ± 0.038	1.187AspMet: 1.187 ± 0.017	1.784AspAsn: 1.784 ± 0.019	3.511AspPro: 3.511 ± 0.028	2.15AspGln: 2.15 ± 0.021	3.265AspArg: 3.265 ± 0.029	4.046AspSer: 4.046 ± 0.032	3.017AspThr: 3.017 ± 0.027	3.773AspVal: 3.773 ± 0.031	0.887AspTrp: 0.887 ± 0.015	1.569AspTyr: 1.569 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.57GluAla: 5.57 ± 0.042	0.566GluCys: 0.566 ± 0.012	4.153GluAsp: 4.153 ± 0.042	5.116GluGlu: 5.116 ± 0.046	1.844GluPhe: 1.844 ± 0.019	3.605GluGly: 3.605 ± 0.028	1.471GluHis: 1.471 ± 0.02	2.983GluIle: 2.983 ± 0.027	3.444GluLys: 3.444 ± 0.033	5.158GluLeu: 5.158 ± 0.037	1.364GluMet: 1.364 ± 0.016	2.055GluAsn: 2.055 ± 0.022	2.771GluPro: 2.771 ± 0.028	2.614GluGln: 2.614 ± 0.027	3.932GluArg: 3.932 ± 0.032	4.137GluSer: 4.137 ± 0.033	3.47GluThr: 3.47 ± 0.029	3.699GluVal: 3.699 ± 0.031	0.848GluTrp: 0.848 ± 0.013	1.599GluTyr: 1.599 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.103PheAla: 3.103 ± 0.029	0.538PheCys: 0.538 ± 0.011	2.29PheAsp: 2.29 ± 0.023	2.111PheGlu: 2.111 ± 0.022	1.578PhePhe: 1.578 ± 0.022	2.862PheGly: 2.862 ± 0.03	0.911PheHis: 0.911 ± 0.014	1.703PheIle: 1.703 ± 0.021	1.388PheLys: 1.388 ± 0.016	3.483PheLeu: 3.483 ± 0.036	0.739PheMet: 0.739 ± 0.013	1.329PheAsn: 1.329 ± 0.016	1.933PhePro: 1.933 ± 0.018	1.415PheGln: 1.415 ± 0.017	1.958PheArg: 1.958 ± 0.02	2.851PheSer: 2.851 ± 0.028	2.018PheThr: 2.018 ± 0.018	2.396PheVal: 2.396 ± 0.024	0.655PheTrp: 0.655 ± 0.013	1.075PheTyr: 1.075 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.436GlyAla: 5.436 ± 0.039	0.811GlyCys: 0.811 ± 0.014	3.643GlyAsp: 3.643 ± 0.034	3.523GlyGlu: 3.523 ± 0.028	2.824GlyPhe: 2.824 ± 0.027	5.751GlyGly: 5.751 ± 0.051	1.838GlyHis: 1.838 ± 0.022	3.449GlyIle: 3.449 ± 0.03	3.323GlyLys: 3.323 ± 0.031	6.41GlyLeu: 6.41 ± 0.039	1.551GlyMet: 1.551 ± 0.019	2.346GlyAsn: 2.346 ± 0.021	3.582GlyPro: 3.582 ± 0.027	2.82GlyGln: 2.82 ± 0.025	4.335GlyArg: 4.335 ± 0.035	5.72GlySer: 5.72 ± 0.045	4.101GlyThr: 4.101 ± 0.036	4.437GlyVal: 4.437 ± 0.036	1.176GlyTrp: 1.176 ± 0.018	2.097GlyTyr: 2.097 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.011HisAla: 2.011 ± 0.022	0.31HisCys: 0.31 ± 0.008	1.5HisAsp: 1.5 ± 0.019	1.45HisGlu: 1.45 ± 0.018	0.922HisPhe: 0.922 ± 0.014	1.89HisGly: 1.89 ± 0.02	0.911HisHis: 0.911 ± 0.02	1.194HisIle: 1.194 ± 0.017	0.926HisLys: 0.926 ± 0.013	2.372HisLeu: 2.372 ± 0.023	0.468HisMet: 0.468 ± 0.011	0.836HisAsn: 0.836 ± 0.015	1.763HisPro: 1.763 ± 0.02	1.07HisGln: 1.07 ± 0.015	1.608HisArg: 1.608 ± 0.016	1.888HisSer: 1.888 ± 0.02	1.307HisThr: 1.307 ± 0.015	1.586HisVal: 1.586 ± 0.018	0.351HisTrp: 0.351 ± 0.009	0.725HisTyr: 0.725 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.113IleAla: 4.113 ± 0.034	0.726IleCys: 0.726 ± 0.013	2.833IleAsp: 2.833 ± 0.026	2.72IleGlu: 2.72 ± 0.024	1.875IlePhe: 1.875 ± 0.021	3.151IleGly: 3.151 ± 0.033	1.176IleHis: 1.176 ± 0.017	2.273IleIle: 2.273 ± 0.027	2.06IleLys: 2.06 ± 0.02	4.527IleLeu: 4.527 ± 0.034	0.925IleMet: 0.925 ± 0.013	1.682IleAsn: 1.682 ± 0.018	3.013IlePro: 3.013 ± 0.024	1.881IleGln: 1.881 ± 0.02	2.72IleArg: 2.72 ± 0.02	3.65IleSer: 3.65 ± 0.025	2.663IleThr: 2.663 ± 0.025	3.15IleVal: 3.15 ± 0.029	0.701IleTrp: 0.701 ± 0.013	1.37IleTyr: 1.37 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.278LysAla: 4.278 ± 0.037	0.451LysCys: 0.451 ± 0.011	2.688LysAsp: 2.688 ± 0.024	3.139LysGlu: 3.139 ± 0.028	1.383LysPhe: 1.383 ± 0.02	2.791LysGly: 2.791 ± 0.027	1.172LysHis: 1.172 ± 0.016	2.177LysIle: 2.177 ± 0.024	2.972LysLys: 2.972 ± 0.044	3.944LysLeu: 3.944 ± 0.033	0.934LysMet: 0.934 ± 0.016	1.546LysAsn: 1.546 ± 0.02	2.624LysPro: 2.624 ± 0.025	1.885LysGln: 1.885 ± 0.02	3.307LysArg: 3.307 ± 0.028	3.361LysSer: 3.361 ± 0.028	2.735LysThr: 2.735 ± 0.024	2.804LysVal: 2.804 ± 0.026	0.64LysTrp: 0.64 ± 0.011	1.368LysTyr: 1.368 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.292LeuAla: 8.292 ± 0.048	1.217LeuCys: 1.217 ± 0.018	5.536LeuAsp: 5.536 ± 0.038	5.573LeuGlu: 5.573 ± 0.035	3.304LeuPhe: 3.304 ± 0.033	6.119LeuGly: 6.119 ± 0.036	2.312LeuHis: 2.312 ± 0.023	3.827LeuIle: 3.827 ± 0.028	4.18LeuLys: 4.18 ± 0.032	8.55LeuLeu: 8.55 ± 0.062	1.736LeuMet: 1.736 ± 0.019	3.067LeuAsn: 3.067 ± 0.026	5.608LeuPro: 5.608 ± 0.039	4.026LeuGln: 4.026 ± 0.027	5.847LeuArg: 5.847 ± 0.041	7.281LeuSer: 7.281 ± 0.045	4.982LeuThr: 4.982 ± 0.035	5.714LeuVal: 5.714 ± 0.032	1.233LeuTrp: 1.233 ± 0.019	2.379LeuTyr: 2.379 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.26MetAla: 2.26 ± 0.02	0.224MetCys: 0.224 ± 0.007	1.155MetAsp: 1.155 ± 0.015	1.095MetGlu: 1.095 ± 0.016	0.714MetPhe: 0.714 ± 0.011	1.346MetGly: 1.346 ± 0.019	0.482MetHis: 0.482 ± 0.01	0.927MetIle: 0.927 ± 0.013	0.866MetLys: 0.866 ± 0.014	1.797MetLeu: 1.797 ± 0.022	0.503MetMet: 0.503 ± 0.01	0.718MetAsn: 0.718 ± 0.011	1.229MetPro: 1.229 ± 0.016	0.831MetGln: 0.831 ± 0.013	1.149MetArg: 1.149 ± 0.014	1.775MetSer: 1.775 ± 0.019	1.262MetThr: 1.262 ± 0.017	1.272MetVal: 1.272 ± 0.017	0.234MetTrp: 0.234 ± 0.007	0.516MetTyr: 0.516 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.027	0.399AsnCys: 0.399 ± 0.01	1.833AsnAsp: 1.833 ± 0.023	1.854AsnGlu: 1.854 ± 0.016	1.246AsnPhe: 1.246 ± 0.015	2.824AsnGly: 2.824 ± 0.028	0.865AsnHis: 0.865 ± 0.012	1.862AsnIle: 1.862 ± 0.019	1.409AsnLys: 1.409 ± 0.015	3.176AsnLeu: 3.176 ± 0.025	0.751AsnMet: 0.751 ± 0.012	1.304AsnAsn: 1.304 ± 0.02	2.369AsnPro: 2.369 ± 0.022	1.303AsnGln: 1.303 ± 0.016	1.857AsnArg: 1.857 ± 0.018	2.5AsnSer: 2.5 ± 0.021	2.096AsnThr: 2.096 ± 0.024	2.303AsnVal: 2.303 ± 0.021	0.511AsnTrp: 0.511 ± 0.011	0.969AsnTyr: 0.969 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.444ProAla: 5.444 ± 0.045	0.479ProCys: 0.479 ± 0.009	3.459ProAsp: 3.459 ± 0.03	3.734ProGlu: 3.734 ± 0.029	2.052ProPhe: 2.052 ± 0.023	4.178ProGly: 4.178 ± 0.03	1.38ProHis: 1.38 ± 0.019	2.408ProIle: 2.408 ± 0.022	2.542ProLys: 2.542 ± 0.025	4.851ProLeu: 4.851 ± 0.031	1.0ProMet: 1.0 ± 0.014	2.12ProAsn: 2.12 ± 0.021	5.17ProPro: 5.17 ± 0.062	2.6ProGln: 2.6 ± 0.032	3.54ProArg: 3.54 ± 0.031	6.036ProSer: 6.036 ± 0.043	4.137ProThr: 4.137 ± 0.033	3.758ProVal: 3.758 ± 0.032	0.751ProTrp: 0.751 ± 0.011	1.53ProTyr: 1.53 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.841GlnAla: 3.841 ± 0.028	0.432GlnCys: 0.432 ± 0.011	2.265GlnAsp: 2.265 ± 0.022	2.537GlnGlu: 2.537 ± 0.021	1.284GlnPhe: 1.284 ± 0.017	2.583GlnGly: 2.583 ± 0.026	1.204GlnHis: 1.204 ± 0.015	1.973GlnIle: 1.973 ± 0.021	1.961GlnLys: 1.961 ± 0.022	3.595GlnLeu: 3.595 ± 0.03	0.854GlnMet: 0.854 ± 0.015	1.524GlnAsn: 1.524 ± 0.018	2.729GlnPro: 2.729 ± 0.032	2.43GlnGln: 2.43 ± 0.037	2.708GlnArg: 2.708 ± 0.027	3.254GlnSer: 3.254 ± 0.034	2.515GlnThr: 2.515 ± 0.026	2.342GlnVal: 2.342 ± 0.02	0.572GlnTrp: 0.572 ± 0.01	1.213GlnTyr: 1.213 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.951ArgAla: 4.951 ± 0.033	0.673ArgCys: 0.673 ± 0.012	3.507ArgAsp: 3.507 ± 0.032	3.794ArgGlu: 3.794 ± 0.034	2.108ArgPhe: 2.108 ± 0.019	3.721ArgGly: 3.721 ± 0.036	1.729ArgHis: 1.729 ± 0.02	2.809ArgIle: 2.809 ± 0.023	3.478ArgLys: 3.478 ± 0.03	5.773ArgLeu: 5.773 ± 0.036	1.237ArgMet: 1.237 ± 0.015	2.147ArgAsn: 2.147 ± 0.019	3.851ArgPro: 3.851 ± 0.029	2.828ArgGln: 2.828 ± 0.028	5.374ArgArg: 5.374 ± 0.043	4.85ArgSer: 4.85 ± 0.04	3.409ArgThr: 3.409 ± 0.025	3.378ArgVal: 3.378 ± 0.028	0.954ArgTrp: 0.954 ± 0.013	1.703ArgTyr: 1.703 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.782SerAla: 6.782 ± 0.044	0.798SerCys: 0.798 ± 0.011	4.169SerAsp: 4.169 ± 0.036	4.032SerGlu: 4.032 ± 0.032	2.882SerPhe: 2.882 ± 0.026	5.522SerGly: 5.522 ± 0.039	2.021SerHis: 2.021 ± 0.023	3.837SerIle: 3.837 ± 0.031	3.555SerLys: 3.555 ± 0.03	7.26SerLeu: 7.26 ± 0.044	1.619SerMet: 1.619 ± 0.018	2.828SerAsn: 2.828 ± 0.026	5.581SerPro: 5.581 ± 0.051	3.391SerGln: 3.391 ± 0.031	5.106SerArg: 5.106 ± 0.041	8.611SerSer: 8.611 ± 0.074	5.837SerThr: 5.837 ± 0.052	4.623SerVal: 4.623 ± 0.032	1.09SerTrp: 1.09 ± 0.013	1.968SerTyr: 1.968 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.567ThrAla: 5.567 ± 0.037	0.695ThrCys: 0.695 ± 0.013	2.912ThrAsp: 2.912 ± 0.027	3.086ThrGlu: 3.086 ± 0.024	2.198ThrPhe: 2.198 ± 0.019	4.394ThrGly: 4.394 ± 0.038	1.319ThrHis: 1.319 ± 0.016	3.016ThrIle: 3.016 ± 0.028	2.566ThrLys: 2.566 ± 0.022	5.282ThrLeu: 5.282 ± 0.036	1.15ThrMet: 1.15 ± 0.013	2.1ThrAsn: 2.1 ± 0.022	4.327ThrPro: 4.327 ± 0.037	2.173ThrGln: 2.173 ± 0.021	3.277ThrArg: 3.277 ± 0.025	5.586ThrSer: 5.586 ± 0.048	4.608ThrThr: 4.608 ± 0.074	3.913ThrVal: 3.913 ± 0.03	0.848ThrTrp: 0.848 ± 0.013	1.575ThrTyr: 1.575 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.559ValAla: 5.559 ± 0.039	0.821ValCys: 0.821 ± 0.014	3.956ValAsp: 3.956 ± 0.034	3.9ValGlu: 3.9 ± 0.03	2.471ValPhe: 2.471 ± 0.024	4.228ValGly: 4.228 ± 0.032	1.497ValHis: 1.497 ± 0.017	2.853ValIle: 2.853 ± 0.023	2.871ValLys: 2.871 ± 0.024	5.829ValLeu: 5.829 ± 0.043	1.248ValMet: 1.248 ± 0.016	2.155ValAsn: 2.155 ± 0.024	3.695ValPro: 3.695 ± 0.029	2.565ValGln: 2.565 ± 0.024	3.628ValArg: 3.628 ± 0.024	4.679ValSer: 4.679 ± 0.029	3.619ValThr: 3.619 ± 0.032	4.581ValVal: 4.581 ± 0.033	0.913ValTrp: 0.913 ± 0.014	1.71ValTyr: 1.71 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.146TrpAla: 1.146 ± 0.016	0.196TrpCys: 0.196 ± 0.007	0.858TrpAsp: 0.858 ± 0.015	0.809TrpGlu: 0.809 ± 0.013	0.538TrpPhe: 0.538 ± 0.011	0.858TrpGly: 0.858 ± 0.015	0.369TrpHis: 0.369 ± 0.007	0.768TrpIle: 0.768 ± 0.013	0.776TrpLys: 0.776 ± 0.012	1.408TrpLeu: 1.408 ± 0.018	0.361TrpMet: 0.361 ± 0.009	0.578TrpAsn: 0.578 ± 0.01	0.628TrpPro: 0.628 ± 0.011	0.588TrpGln: 0.588 ± 0.011	0.98TrpArg: 0.98 ± 0.012	1.054TrpSer: 1.054 ± 0.015	0.984TrpThr: 0.984 ± 0.014	0.841TrpVal: 0.841 ± 0.012	0.266TrpTrp: 0.266 ± 0.006	0.45TrpTyr: 0.45 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.211TyrAla: 2.211 ± 0.022	0.388TyrCys: 0.388 ± 0.008	1.646TyrAsp: 1.646 ± 0.019	1.485TyrGlu: 1.485 ± 0.018	1.197TyrPhe: 1.197 ± 0.017	2.086TyrGly: 2.086 ± 0.02	0.779TyrHis: 0.779 ± 0.014	1.325TyrIle: 1.325 ± 0.016	1.052TyrLys: 1.052 ± 0.014	2.737TyrLeu: 2.737 ± 0.024	0.592TyrMet: 0.592 ± 0.011	1.005TyrAsn: 1.005 ± 0.015	1.485TyrPro: 1.485 ± 0.02	1.148TyrGln: 1.148 ± 0.015	1.616TyrArg: 1.616 ± 0.019	1.958TyrSer: 1.958 ± 0.021	1.58TyrThr: 1.58 ± 0.018	1.667TyrVal: 1.667 ± 0.019	0.436TyrTrp: 0.436 ± 0.009	0.888TyrTyr: 0.888 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10469 proteins (5150417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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