Amino acid dipepetide frequency for Corynebacterium flavescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.692AlaAla: 16.692 ± 0.236
0.963AlaCys: 0.963 ± 0.037
6.682AlaAsp: 6.682 ± 0.094
7.953AlaGlu: 7.953 ± 0.129
3.784AlaPhe: 3.784 ± 0.084
10.333AlaGly: 10.333 ± 0.145
2.459AlaHis: 2.459 ± 0.062
5.677AlaIle: 5.677 ± 0.096
3.871AlaLys: 3.871 ± 0.095
12.017AlaLeu: 12.017 ± 0.179
2.712AlaMet: 2.712 ± 0.055
2.766AlaAsn: 2.766 ± 0.063
5.13AlaPro: 5.13 ± 0.103
5.307AlaGln: 5.307 ± 0.124
7.558AlaArg: 7.558 ± 0.126
6.331AlaSer: 6.331 ± 0.107
6.549AlaThr: 6.549 ± 0.117
9.363AlaVal: 9.363 ± 0.135
1.581AlaTrp: 1.581 ± 0.048
2.356AlaTyr: 2.356 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.028CysAla: 1.028 ± 0.046
0.073CysCys: 0.073 ± 0.011
0.407CysAsp: 0.407 ± 0.022
0.405CysGlu: 0.405 ± 0.025
0.251CysPhe: 0.251 ± 0.017
0.795CysGly: 0.795 ± 0.035
0.169CysHis: 0.169 ± 0.017
0.352CysIle: 0.352 ± 0.022
0.13CysLys: 0.13 ± 0.012
0.596CysLeu: 0.596 ± 0.028
0.113CysMet: 0.113 ± 0.011
0.208CysAsn: 0.208 ± 0.019
0.435CysPro: 0.435 ± 0.027
0.205CysGln: 0.205 ± 0.017
0.346CysArg: 0.346 ± 0.022
0.535CysSer: 0.535 ± 0.035
0.434CysThr: 0.434 ± 0.027
0.545CysVal: 0.545 ± 0.025
0.079CysTrp: 0.079 ± 0.01
0.184CysTyr: 0.184 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.576AspAla: 6.576 ± 0.109
0.384AspCys: 0.384 ± 0.026
3.028AspAsp: 3.028 ± 0.071
3.928AspGlu: 3.928 ± 0.077
2.246AspPhe: 2.246 ± 0.065
4.532AspGly: 4.532 ± 0.079
1.192AspHis: 1.192 ± 0.044
3.202AspIle: 3.202 ± 0.067
2.096AspLys: 2.096 ± 0.059
5.653AspLeu: 5.653 ± 0.084
1.202AspMet: 1.202 ± 0.042
1.689AspAsn: 1.689 ± 0.052
3.572AspPro: 3.572 ± 0.08
1.419AspGln: 1.419 ± 0.045
3.239AspArg: 3.239 ± 0.07
3.78AspSer: 3.78 ± 0.081
3.062AspThr: 3.062 ± 0.062
4.54AspVal: 4.54 ± 0.07
0.79AspTrp: 0.79 ± 0.032
1.62AspTyr: 1.62 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
7.147GluAla: 7.147 ± 0.132
0.369GluCys: 0.369 ± 0.027
3.951GluAsp: 3.951 ± 0.072
4.754GluGlu: 4.754 ± 0.099
2.195GluPhe: 2.195 ± 0.058
4.694GluGly: 4.694 ± 0.086
1.634GluHis: 1.634 ± 0.049
3.448GluIle: 3.448 ± 0.07
2.672GluLys: 2.672 ± 0.064
7.075GluLeu: 7.075 ± 0.112
1.316GluMet: 1.316 ± 0.043
1.791GluAsn: 1.791 ± 0.061
2.672GluPro: 2.672 ± 0.074
2.5GluGln: 2.5 ± 0.065
4.127GluArg: 4.127 ± 0.082
3.651GluSer: 3.651 ± 0.073
3.082GluThr: 3.082 ± 0.069
5.192GluVal: 5.192 ± 0.098
0.842GluTrp: 0.842 ± 0.042
1.482GluTyr: 1.482 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.912PheAla: 3.912 ± 0.081
0.282PheCys: 0.282 ± 0.022
2.35PheAsp: 2.35 ± 0.061
1.956PheGlu: 1.956 ± 0.049
1.284PhePhe: 1.284 ± 0.05
3.479PheGly: 3.479 ± 0.07
0.754PheHis: 0.754 ± 0.034
1.815PheIle: 1.815 ± 0.061
0.921PheLys: 0.921 ± 0.041
3.201PheLeu: 3.201 ± 0.079
0.694PheMet: 0.694 ± 0.035
1.018PheAsn: 1.018 ± 0.043
1.528PhePro: 1.528 ± 0.048
0.907PheGln: 0.907 ± 0.039
1.804PheArg: 1.804 ± 0.051
2.466PheSer: 2.466 ± 0.066
1.781PheThr: 1.781 ± 0.059
2.455PheVal: 2.455 ± 0.07
0.48PheTrp: 0.48 ± 0.028
0.839PheTyr: 0.839 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
8.953GlyAla: 8.953 ± 0.118
0.719GlyCys: 0.719 ± 0.037
4.305GlyAsp: 4.305 ± 0.083
5.191GlyGlu: 5.191 ± 0.091
3.131GlyPhe: 3.131 ± 0.065
6.719GlyGly: 6.719 ± 0.132
1.915GlyHis: 1.915 ± 0.048
4.918GlyIle: 4.918 ± 0.084
3.308GlyLys: 3.308 ± 0.084
8.326GlyLeu: 8.326 ± 0.127
2.064GlyMet: 2.064 ± 0.051
2.284GlyAsn: 2.284 ± 0.059
3.331GlyPro: 3.331 ± 0.078
2.91GlyGln: 2.91 ± 0.065
4.818GlyArg: 4.818 ± 0.092
5.112GlySer: 5.112 ± 0.098
4.993GlyThr: 4.993 ± 0.101
6.835GlyVal: 6.835 ± 0.111
1.338GlyTrp: 1.338 ± 0.047
2.182GlyTyr: 2.182 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.258HisAla: 2.258 ± 0.063
0.191HisCys: 0.191 ± 0.017
1.249HisAsp: 1.249 ± 0.042
1.242HisGlu: 1.242 ± 0.043
0.727HisPhe: 0.727 ± 0.033
1.977HisGly: 1.977 ± 0.054
0.645HisHis: 0.645 ± 0.033
1.027HisIle: 1.027 ± 0.038
0.586HisLys: 0.586 ± 0.027
2.151HisLeu: 2.151 ± 0.053
0.451HisMet: 0.451 ± 0.024
0.706HisAsn: 0.706 ± 0.035
1.534HisPro: 1.534 ± 0.048
0.636HisGln: 0.636 ± 0.031
1.422HisArg: 1.422 ± 0.047
1.379HisSer: 1.379 ± 0.046
1.254HisThr: 1.254 ± 0.045
1.532HisVal: 1.532 ± 0.052
0.28HisTrp: 0.28 ± 0.021
0.527HisTyr: 0.527 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.616IleAla: 6.616 ± 0.092
0.412IleCys: 0.412 ± 0.024
3.64IleAsp: 3.64 ± 0.077
3.312IleGlu: 3.312 ± 0.067
1.712IlePhe: 1.712 ± 0.056
4.366IleGly: 4.366 ± 0.087
1.028IleHis: 1.028 ± 0.038
2.777IleIle: 2.777 ± 0.077
1.589IleLys: 1.589 ± 0.045
4.373IleLeu: 4.373 ± 0.099
1.016IleMet: 1.016 ± 0.046
1.661IleAsn: 1.661 ± 0.053
2.606IlePro: 2.606 ± 0.062
1.184IleGln: 1.184 ± 0.043
2.549IleArg: 2.549 ± 0.057
3.312IleSer: 3.312 ± 0.073
3.117IleThr: 3.117 ± 0.063
4.318IleVal: 4.318 ± 0.076
0.473IleTrp: 0.473 ± 0.026
1.092IleTyr: 1.092 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
3.897LysAla: 3.897 ± 0.097
0.117LysCys: 0.117 ± 0.013
1.908LysAsp: 1.908 ± 0.055
2.198LysGlu: 2.198 ± 0.066
0.922LysPhe: 0.922 ± 0.039
2.342LysGly: 2.342 ± 0.063
0.688LysHis: 0.688 ± 0.026
1.699LysIle: 1.699 ± 0.051
1.77LysLys: 1.77 ± 0.071
3.12LysLeu: 3.12 ± 0.077
0.737LysMet: 0.737 ± 0.033
1.035LysAsn: 1.035 ± 0.049
1.554LysPro: 1.554 ± 0.056
1.343LysGln: 1.343 ± 0.045
2.164LysArg: 2.164 ± 0.061
1.849LysSer: 1.849 ± 0.051
1.75LysThr: 1.75 ± 0.06
2.596LysVal: 2.596 ± 0.059
0.415LysTrp: 0.415 ± 0.024
0.777LysTyr: 0.777 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
12.229LeuAla: 12.229 ± 0.167
0.784LeuCys: 0.784 ± 0.036
6.086LeuAsp: 6.086 ± 0.099
5.845LeuGlu: 5.845 ± 0.115
2.939LeuPhe: 2.939 ± 0.078
8.651LeuGly: 8.651 ± 0.126
2.093LeuHis: 2.093 ± 0.054
5.045LeuIle: 5.045 ± 0.102
2.866LeuLys: 2.866 ± 0.08
9.106LeuLeu: 9.106 ± 0.159
1.857LeuMet: 1.857 ± 0.059
2.664LeuAsn: 2.664 ± 0.059
5.082LeuPro: 5.082 ± 0.087
2.76LeuGln: 2.76 ± 0.063
6.767LeuArg: 6.767 ± 0.1
6.833LeuSer: 6.833 ± 0.116
5.205LeuThr: 5.205 ± 0.095
7.866LeuVal: 7.866 ± 0.118
1.182LeuTrp: 1.182 ± 0.045
1.914LeuTyr: 1.914 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.637MetAla: 2.637 ± 0.065
0.162MetCys: 0.162 ± 0.016
1.092MetAsp: 1.092 ± 0.035
1.11MetGlu: 1.11 ± 0.037
0.65MetPhe: 0.65 ± 0.031
1.746MetGly: 1.746 ± 0.046
0.442MetHis: 0.442 ± 0.027
1.02MetIle: 1.02 ± 0.039
0.696MetLys: 0.696 ± 0.031
2.102MetLeu: 2.102 ± 0.062
0.463MetMet: 0.463 ± 0.03
0.658MetAsn: 0.658 ± 0.03
1.117MetPro: 1.117 ± 0.04
0.665MetGln: 0.665 ± 0.032
1.4MetArg: 1.4 ± 0.044
1.751MetSer: 1.751 ± 0.057
1.427MetThr: 1.427 ± 0.042
1.606MetVal: 1.606 ± 0.044
0.29MetTrp: 0.29 ± 0.018
0.356MetTyr: 0.356 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.061AsnAla: 3.061 ± 0.058
0.182AsnCys: 0.182 ± 0.014
1.419AsnAsp: 1.419 ± 0.054
1.654AsnGlu: 1.654 ± 0.058
0.927AsnPhe: 0.927 ± 0.039
2.257AsnGly: 2.257 ± 0.062
0.6AsnHis: 0.6 ± 0.026
1.371AsnIle: 1.371 ± 0.042
0.987AsnLys: 0.987 ± 0.039
2.681AsnLeu: 2.681 ± 0.056
0.599AsnMet: 0.599 ± 0.031
0.938AsnAsn: 0.938 ± 0.044
1.901AsnPro: 1.901 ± 0.058
0.959AsnGln: 0.959 ± 0.035
1.634AsnArg: 1.634 ± 0.054
1.802AsnSer: 1.802 ± 0.057
1.496AsnThr: 1.496 ± 0.047
2.097AsnVal: 2.097 ± 0.057
0.391AsnTrp: 0.391 ± 0.024
0.812AsnTyr: 0.812 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
6.267ProAla: 6.267 ± 0.11
0.256ProCys: 0.256 ± 0.019
3.02ProAsp: 3.02 ± 0.062
4.0ProGlu: 4.0 ± 0.082
1.629ProPhe: 1.629 ± 0.052
4.449ProGly: 4.449 ± 0.087
1.164ProHis: 1.164 ± 0.044
1.976ProIle: 1.976 ± 0.051
1.381ProLys: 1.381 ± 0.045
4.431ProLeu: 4.431 ± 0.092
0.843ProMet: 0.843 ± 0.038
1.411ProAsn: 1.411 ± 0.056
1.822ProPro: 1.822 ± 0.063
2.208ProGln: 2.208 ± 0.052
2.898ProArg: 2.898 ± 0.066
2.919ProSer: 2.919 ± 0.077
2.903ProThr: 2.903 ± 0.069
4.133ProVal: 4.133 ± 0.075
0.761ProTrp: 0.761 ± 0.034
1.045ProTyr: 1.045 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.446GlnAla: 4.446 ± 0.091
0.179GlnCys: 0.179 ± 0.014
1.764GlnAsp: 1.764 ± 0.052
2.27GlnGlu: 2.27 ± 0.058
1.011GlnPhe: 1.011 ± 0.039
2.504GlnGly: 2.504 ± 0.061
0.764GlnHis: 0.764 ± 0.034
1.664GlnIle: 1.664 ± 0.055
1.025GlnLys: 1.025 ± 0.041
3.886GlnLeu: 3.886 ± 0.079
0.753GlnMet: 0.753 ± 0.038
0.692GlnAsn: 0.692 ± 0.031
1.682GlnPro: 1.682 ± 0.058
1.427GlnGln: 1.427 ± 0.045
2.686GlnArg: 2.686 ± 0.068
1.847GlnSer: 1.847 ± 0.051
1.431GlnThr: 1.431 ± 0.044
2.826GlnVal: 2.826 ± 0.069
0.571GlnTrp: 0.571 ± 0.031
0.658GlnTyr: 0.658 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
6.805ArgAla: 6.805 ± 0.105
0.355ArgCys: 0.355 ± 0.022
3.451ArgAsp: 3.451 ± 0.075
4.53ArgGlu: 4.53 ± 0.077
2.169ArgPhe: 2.169 ± 0.057
4.727ArgGly: 4.727 ± 0.093
1.407ArgHis: 1.407 ± 0.046
3.281ArgIle: 3.281 ± 0.077
2.045ArgLys: 2.045 ± 0.056
6.093ArgLeu: 6.093 ± 0.09
1.64ArgMet: 1.64 ± 0.051
1.764ArgAsn: 1.764 ± 0.051
2.949ArgPro: 2.949 ± 0.062
2.22ArgGln: 2.22 ± 0.059
5.007ArgArg: 5.007 ± 0.119
3.473ArgSer: 3.473 ± 0.073
3.528ArgThr: 3.528 ± 0.073
4.672ArgVal: 4.672 ± 0.105
0.907ArgTrp: 0.907 ± 0.037
1.527ArgTyr: 1.527 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
7.513SerAla: 7.513 ± 0.118
0.405SerCys: 0.405 ± 0.025
3.105SerAsp: 3.105 ± 0.07
3.723SerGlu: 3.723 ± 0.079
2.271SerPhe: 2.271 ± 0.062
5.432SerGly: 5.432 ± 0.098
1.232SerHis: 1.232 ± 0.044
2.973SerIle: 2.973 ± 0.062
1.938SerLys: 1.938 ± 0.058
5.886SerLeu: 5.886 ± 0.106
1.469SerMet: 1.469 ± 0.047
1.665SerAsn: 1.665 ± 0.045
3.321SerPro: 3.321 ± 0.074
2.291SerGln: 2.291 ± 0.062
3.845SerArg: 3.845 ± 0.076
4.018SerSer: 4.018 ± 0.09
3.969SerThr: 3.969 ± 0.082
4.554SerVal: 4.554 ± 0.08
0.927SerTrp: 0.927 ± 0.039
1.517SerTyr: 1.517 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.425ThrAla: 6.425 ± 0.106
0.449ThrCys: 0.449 ± 0.028
2.85ThrAsp: 2.85 ± 0.058
3.072ThrGlu: 3.072 ± 0.069
1.847ThrPhe: 1.847 ± 0.058
5.113ThrGly: 5.113 ± 0.087
1.185ThrHis: 1.185 ± 0.039
2.917ThrIle: 2.917 ± 0.07
1.71ThrLys: 1.71 ± 0.052
5.486ThrLeu: 5.486 ± 0.089
1.201ThrMet: 1.201 ± 0.042
1.469ThrAsn: 1.469 ± 0.054
3.455ThrPro: 3.455 ± 0.071
1.815ThrGln: 1.815 ± 0.05
3.189ThrArg: 3.189 ± 0.077
3.436ThrSer: 3.436 ± 0.065
3.377ThrThr: 3.377 ± 0.075
5.021ThrVal: 5.021 ± 0.09
0.79ThrTrp: 0.79 ± 0.037
1.298ThrTyr: 1.298 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
9.814ValAla: 9.814 ± 0.142
0.667ValCys: 0.667 ± 0.029
5.411ValAsp: 5.411 ± 0.087
5.352ValGlu: 5.352 ± 0.108
2.719ValPhe: 2.719 ± 0.074
6.244ValGly: 6.244 ± 0.122
1.619ValHis: 1.619 ± 0.049
4.38ValIle: 4.38 ± 0.083
2.242ValLys: 2.242 ± 0.056
7.734ValLeu: 7.734 ± 0.121
1.528ValMet: 1.528 ± 0.048
2.165ValAsn: 2.165 ± 0.059
3.904ValPro: 3.904 ± 0.073
1.97ValGln: 1.97 ± 0.051
4.468ValArg: 4.468 ± 0.073
5.144ValSer: 5.144 ± 0.095
4.805ValThr: 4.805 ± 0.1
6.839ValVal: 6.839 ± 0.13
1.013ValTrp: 1.013 ± 0.041
1.592ValTyr: 1.592 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.475TrpAla: 1.475 ± 0.044
0.126TrpCys: 0.126 ± 0.012
0.722TrpAsp: 0.722 ± 0.037
0.78TrpGlu: 0.78 ± 0.035
0.531TrpPhe: 0.531 ± 0.033
0.922TrpGly: 0.922 ± 0.036
0.316TrpHis: 0.316 ± 0.022
0.702TrpIle: 0.702 ± 0.031
0.462TrpLys: 0.462 ± 0.023
1.473TrpLeu: 1.473 ± 0.056
0.342TrpMet: 0.342 ± 0.025
0.537TrpAsn: 0.537 ± 0.026
0.692TrpPro: 0.692 ± 0.032
0.606TrpGln: 0.606 ± 0.029
0.951TrpArg: 0.951 ± 0.036
0.823TrpSer: 0.823 ± 0.036
0.669TrpThr: 0.669 ± 0.031
1.018TrpVal: 1.018 ± 0.035
0.322TrpTrp: 0.322 ± 0.021
0.281TrpTyr: 0.281 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.332TyrAla: 2.332 ± 0.058
0.215TyrCys: 0.215 ± 0.018
1.311TyrAsp: 1.311 ± 0.047
1.319TyrGlu: 1.319 ± 0.042
0.98TyrPhe: 0.98 ± 0.046
2.066TyrGly: 2.066 ± 0.061
0.466TyrHis: 0.466 ± 0.025
0.91TyrIle: 0.91 ± 0.033
0.585TyrLys: 0.585 ± 0.031
2.387TyrLeu: 2.387 ± 0.066
0.39TyrMet: 0.39 ± 0.026
0.648TyrAsn: 0.648 ± 0.034
1.229TyrPro: 1.229 ± 0.052
0.757TyrGln: 0.757 ± 0.037
1.679TyrArg: 1.679 ± 0.053
1.589TyrSer: 1.589 ± 0.048
1.274TyrThr: 1.274 ± 0.041
1.6TyrVal: 1.6 ± 0.05
0.321TyrTrp: 0.321 ± 0.02
0.534TyrTyr: 0.534 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2152 proteins (708000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski