Amino acid dipepetide frequency for Moraxella phage Mcat17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.717AlaAla: 4.717 ± 1.459
1.101AlaCys: 1.101 ± 0.411
5.504AlaAsp: 5.504 ± 0.651
6.211AlaGlu: 6.211 ± 1.016
3.617AlaPhe: 3.617 ± 0.857
5.268AlaGly: 5.268 ± 0.632
1.101AlaHis: 1.101 ± 0.372
6.604AlaIle: 6.604 ± 1.019
8.098AlaLys: 8.098 ± 0.904
7.312AlaLeu: 7.312 ± 0.75
2.28AlaMet: 2.28 ± 0.533
4.56AlaAsn: 4.56 ± 0.547
1.887AlaPro: 1.887 ± 0.438
3.853AlaGln: 3.853 ± 0.611
3.381AlaArg: 3.381 ± 0.415
6.211AlaSer: 6.211 ± 0.604
5.582AlaThr: 5.582 ± 0.654
5.268AlaVal: 5.268 ± 0.707
1.022AlaTrp: 1.022 ± 0.287
2.123AlaTyr: 2.123 ± 0.399
0.0AlaXaa: 0.0 ± 0.0
Cys
0.393CysAla: 0.393 ± 0.199
0.157CysCys: 0.157 ± 0.103
0.314CysAsp: 0.314 ± 0.141
0.55CysGlu: 0.55 ± 0.314
0.157CysPhe: 0.157 ± 0.119
1.101CysGly: 1.101 ± 0.374
0.55CysHis: 0.55 ± 0.25
0.472CysIle: 0.472 ± 0.168
0.708CysLys: 0.708 ± 0.255
0.786CysLeu: 0.786 ± 0.297
0.079CysMet: 0.079 ± 0.085
0.157CysAsn: 0.157 ± 0.09
0.786CysPro: 0.786 ± 0.287
0.943CysGln: 0.943 ± 0.326
0.865CysArg: 0.865 ± 0.252
0.708CysSer: 0.708 ± 0.357
0.314CysThr: 0.314 ± 0.168
0.629CysVal: 0.629 ± 0.309
0.0CysTrp: 0.0 ± 0.0
0.314CysTyr: 0.314 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
4.717AspAla: 4.717 ± 0.525
0.472AspCys: 0.472 ± 0.271
5.189AspAsp: 5.189 ± 0.785
4.953AspGlu: 4.953 ± 0.417
1.966AspPhe: 1.966 ± 0.313
5.504AspGly: 5.504 ± 0.472
1.101AspHis: 1.101 ± 0.273
3.931AspIle: 3.931 ± 0.597
4.953AspLys: 4.953 ± 0.59
4.953AspLeu: 4.953 ± 0.699
1.101AspMet: 1.101 ± 0.308
3.538AspAsn: 3.538 ± 0.594
1.101AspPro: 1.101 ± 0.369
0.943AspGln: 0.943 ± 0.247
2.123AspArg: 2.123 ± 0.385
3.774AspSer: 3.774 ± 0.445
3.224AspThr: 3.224 ± 0.504
4.246AspVal: 4.246 ± 0.637
0.708AspTrp: 0.708 ± 0.281
2.201AspTyr: 2.201 ± 0.497
0.0AspXaa: 0.0 ± 0.0
Glu
4.403GluAla: 4.403 ± 1.132
0.865GluCys: 0.865 ± 0.321
1.808GluAsp: 1.808 ± 0.461
2.201GluGlu: 2.201 ± 0.51
2.752GluPhe: 2.752 ± 0.464
2.044GluGly: 2.044 ± 0.37
1.101GluHis: 1.101 ± 0.338
4.875GluIle: 4.875 ± 0.551
4.403GluLys: 4.403 ± 0.9
6.762GluLeu: 6.762 ± 0.833
1.887GluMet: 1.887 ± 0.328
2.909GluAsn: 2.909 ± 0.546
2.516GluPro: 2.516 ± 0.465
4.246GluGln: 4.246 ± 0.608
4.167GluArg: 4.167 ± 0.422
3.302GluSer: 3.302 ± 0.635
2.988GluThr: 2.988 ± 0.429
3.459GluVal: 3.459 ± 0.499
0.55GluTrp: 0.55 ± 0.185
2.516GluTyr: 2.516 ± 0.317
0.0GluXaa: 0.0 ± 0.0
Phe
2.673PheAla: 2.673 ± 0.468
0.708PheCys: 0.708 ± 0.248
3.381PheAsp: 3.381 ± 0.533
2.673PheGlu: 2.673 ± 0.48
0.943PhePhe: 0.943 ± 0.275
4.01PheGly: 4.01 ± 0.56
0.55PheHis: 0.55 ± 0.263
2.123PheIle: 2.123 ± 0.507
1.808PheLys: 1.808 ± 0.352
1.887PheLeu: 1.887 ± 0.455
0.943PheMet: 0.943 ± 0.322
2.123PheAsn: 2.123 ± 0.406
0.708PhePro: 0.708 ± 0.187
0.786PheGln: 0.786 ± 0.344
1.887PheArg: 1.887 ± 0.332
1.73PheSer: 1.73 ± 0.354
1.887PheThr: 1.887 ± 0.368
1.808PheVal: 1.808 ± 0.383
0.629PheTrp: 0.629 ± 0.213
1.258PheTyr: 1.258 ± 0.289
0.0PheXaa: 0.0 ± 0.0
Gly
4.56GlyAla: 4.56 ± 0.699
0.314GlyCys: 0.314 ± 0.141
4.56GlyAsp: 4.56 ± 0.715
4.403GlyGlu: 4.403 ± 0.62
3.302GlyPhe: 3.302 ± 0.639
4.403GlyGly: 4.403 ± 0.719
1.022GlyHis: 1.022 ± 0.338
4.088GlyIle: 4.088 ± 0.735
5.897GlyLys: 5.897 ± 0.998
6.133GlyLeu: 6.133 ± 0.872
1.808GlyMet: 1.808 ± 0.335
3.853GlyAsn: 3.853 ± 0.497
0.314GlyPro: 0.314 ± 0.188
2.359GlyGln: 2.359 ± 0.466
4.167GlyArg: 4.167 ± 0.702
3.145GlySer: 3.145 ± 0.49
3.459GlyThr: 3.459 ± 0.594
6.526GlyVal: 6.526 ± 0.688
1.258GlyTrp: 1.258 ± 0.324
2.044GlyTyr: 2.044 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
2.201HisAla: 2.201 ± 0.457
0.314HisCys: 0.314 ± 0.168
1.415HisAsp: 1.415 ± 0.282
1.101HisGlu: 1.101 ± 0.24
0.472HisPhe: 0.472 ± 0.172
2.201HisGly: 2.201 ± 0.338
0.629HisHis: 0.629 ± 0.257
1.494HisIle: 1.494 ± 0.361
0.943HisLys: 0.943 ± 0.295
1.73HisLeu: 1.73 ± 0.382
0.314HisMet: 0.314 ± 0.148
1.022HisAsn: 1.022 ± 0.288
0.629HisPro: 0.629 ± 0.263
0.786HisGln: 0.786 ± 0.228
0.55HisArg: 0.55 ± 0.197
0.943HisSer: 0.943 ± 0.308
1.415HisThr: 1.415 ± 0.294
0.629HisVal: 0.629 ± 0.215
0.314HisTrp: 0.314 ± 0.163
0.55HisTyr: 0.55 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.661IleAla: 5.661 ± 0.748
0.629IleCys: 0.629 ± 0.23
5.975IleAsp: 5.975 ± 0.62
4.01IleGlu: 4.01 ± 0.369
1.651IlePhe: 1.651 ± 0.395
5.11IleGly: 5.11 ± 0.626
0.865IleHis: 0.865 ± 0.233
5.346IleIle: 5.346 ± 0.832
6.211IleLys: 6.211 ± 1.179
4.246IleLeu: 4.246 ± 0.698
1.179IleMet: 1.179 ± 0.335
5.975IleAsn: 5.975 ± 1.335
2.516IlePro: 2.516 ± 0.647
2.359IleGln: 2.359 ± 0.436
2.359IleArg: 2.359 ± 0.342
5.11IleSer: 5.11 ± 1.01
5.504IleThr: 5.504 ± 0.99
2.595IleVal: 2.595 ± 0.401
0.472IleTrp: 0.472 ± 0.19
1.415IleTyr: 1.415 ± 0.293
0.0IleXaa: 0.0 ± 0.0
Lys
6.762LysAla: 6.762 ± 0.916
0.314LysCys: 0.314 ± 0.224
3.853LysAsp: 3.853 ± 0.702
3.617LysGlu: 3.617 ± 0.679
2.595LysPhe: 2.595 ± 0.438
4.01LysGly: 4.01 ± 0.592
1.808LysHis: 1.808 ± 0.345
5.346LysIle: 5.346 ± 0.797
4.717LysLys: 4.717 ± 0.922
6.211LysLeu: 6.211 ± 0.815
2.044LysMet: 2.044 ± 0.397
2.909LysAsn: 2.909 ± 0.528
2.359LysPro: 2.359 ± 0.422
3.695LysGln: 3.695 ± 0.676
4.01LysArg: 4.01 ± 0.838
5.346LysSer: 5.346 ± 0.708
4.481LysThr: 4.481 ± 0.727
3.695LysVal: 3.695 ± 0.522
1.101LysTrp: 1.101 ± 0.278
2.595LysTyr: 2.595 ± 0.469
0.0LysXaa: 0.0 ± 0.0
Leu
7.469LeuAla: 7.469 ± 0.782
1.258LeuCys: 1.258 ± 0.396
5.425LeuAsp: 5.425 ± 0.568
5.582LeuGlu: 5.582 ± 1.113
1.887LeuPhe: 1.887 ± 0.351
6.133LeuGly: 6.133 ± 0.718
2.123LeuHis: 2.123 ± 0.462
4.56LeuIle: 4.56 ± 0.734
7.233LeuLys: 7.233 ± 1.034
5.897LeuLeu: 5.897 ± 0.989
1.808LeuMet: 1.808 ± 0.564
3.302LeuAsn: 3.302 ± 0.518
3.931LeuPro: 3.931 ± 0.592
4.167LeuGln: 4.167 ± 0.56
4.01LeuArg: 4.01 ± 0.373
6.368LeuSer: 6.368 ± 0.645
5.739LeuThr: 5.739 ± 0.724
3.774LeuVal: 3.774 ± 0.498
1.179LeuTrp: 1.179 ± 0.263
3.145LeuTyr: 3.145 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
2.83MetAla: 2.83 ± 0.518
0.157MetCys: 0.157 ± 0.119
1.101MetAsp: 1.101 ± 0.279
0.629MetGlu: 0.629 ± 0.228
0.786MetPhe: 0.786 ± 0.225
1.494MetGly: 1.494 ± 0.302
0.55MetHis: 0.55 ± 0.292
1.651MetIle: 1.651 ± 0.536
1.494MetLys: 1.494 ± 0.349
1.73MetLeu: 1.73 ± 0.502
0.943MetMet: 0.943 ± 0.331
1.808MetAsn: 1.808 ± 0.416
0.865MetPro: 0.865 ± 0.254
1.808MetGln: 1.808 ± 0.472
1.415MetArg: 1.415 ± 0.319
2.044MetSer: 2.044 ± 0.419
1.494MetThr: 1.494 ± 0.413
1.572MetVal: 1.572 ± 0.525
0.079MetTrp: 0.079 ± 0.085
0.786MetTyr: 0.786 ± 0.293
0.0MetXaa: 0.0 ± 0.0
Asn
4.717AsnAla: 4.717 ± 0.881
0.157AsnCys: 0.157 ± 0.111
2.673AsnAsp: 2.673 ± 0.405
2.595AsnGlu: 2.595 ± 0.364
1.494AsnPhe: 1.494 ± 0.331
3.853AsnGly: 3.853 ± 0.767
0.865AsnHis: 0.865 ± 0.275
3.381AsnIle: 3.381 ± 0.746
3.617AsnLys: 3.617 ± 0.659
4.639AsnLeu: 4.639 ± 0.568
1.494AsnMet: 1.494 ± 0.473
2.988AsnAsn: 2.988 ± 0.691
2.752AsnPro: 2.752 ± 0.521
2.044AsnGln: 2.044 ± 0.377
2.516AsnArg: 2.516 ± 0.418
4.167AsnSer: 4.167 ± 1.273
3.066AsnThr: 3.066 ± 0.749
2.359AsnVal: 2.359 ± 0.528
0.708AsnTrp: 0.708 ± 0.183
1.808AsnTyr: 1.808 ± 0.357
0.0AsnXaa: 0.0 ± 0.0
Pro
3.224ProAla: 3.224 ± 0.42
0.55ProCys: 0.55 ± 0.245
2.044ProAsp: 2.044 ± 0.438
1.258ProGlu: 1.258 ± 0.305
1.337ProPhe: 1.337 ± 0.32
0.472ProGly: 0.472 ± 0.211
0.865ProHis: 0.865 ± 0.262
3.066ProIle: 3.066 ± 0.406
1.966ProLys: 1.966 ± 0.412
2.044ProLeu: 2.044 ± 0.336
1.179ProMet: 1.179 ± 0.307
1.887ProAsn: 1.887 ± 0.295
1.494ProPro: 1.494 ± 0.345
0.943ProGln: 0.943 ± 0.268
1.179ProArg: 1.179 ± 0.303
2.516ProSer: 2.516 ± 0.496
2.752ProThr: 2.752 ± 0.573
2.044ProVal: 2.044 ± 0.5
0.55ProTrp: 0.55 ± 0.196
0.629ProTyr: 0.629 ± 0.202
0.0ProXaa: 0.0 ± 0.0
Gln
6.368GlnAla: 6.368 ± 0.648
0.236GlnCys: 0.236 ± 0.162
1.808GlnAsp: 1.808 ± 0.473
2.123GlnGlu: 2.123 ± 0.377
1.415GlnPhe: 1.415 ± 0.433
2.437GlnGly: 2.437 ± 0.482
0.865GlnHis: 0.865 ± 0.214
3.695GlnIle: 3.695 ± 0.453
3.145GlnLys: 3.145 ± 0.521
4.796GlnLeu: 4.796 ± 0.64
1.101GlnMet: 1.101 ± 0.326
1.966GlnAsn: 1.966 ± 0.308
0.786GlnPro: 0.786 ± 0.296
2.201GlnGln: 2.201 ± 0.491
1.494GlnArg: 1.494 ± 0.323
3.695GlnSer: 3.695 ± 0.711
3.302GlnThr: 3.302 ± 0.553
2.359GlnVal: 2.359 ± 0.404
0.786GlnTrp: 0.786 ± 0.232
1.258GlnTyr: 1.258 ± 0.24
0.0GlnXaa: 0.0 ± 0.0
Arg
3.931ArgAla: 3.931 ± 0.671
0.236ArgCys: 0.236 ± 0.113
2.359ArgAsp: 2.359 ± 0.345
3.617ArgGlu: 3.617 ± 0.627
2.201ArgPhe: 2.201 ± 0.617
3.224ArgGly: 3.224 ± 0.46
1.337ArgHis: 1.337 ± 0.239
3.381ArgIle: 3.381 ± 0.693
2.201ArgLys: 2.201 ± 0.456
5.032ArgLeu: 5.032 ± 0.828
0.786ArgMet: 0.786 ± 0.212
1.73ArgAsn: 1.73 ± 0.516
1.258ArgPro: 1.258 ± 0.297
2.909ArgGln: 2.909 ± 0.441
1.73ArgArg: 1.73 ± 0.393
2.83ArgSer: 2.83 ± 0.372
3.381ArgThr: 3.381 ± 0.745
3.145ArgVal: 3.145 ± 0.456
0.393ArgTrp: 0.393 ± 0.209
2.201ArgTyr: 2.201 ± 0.464
0.0ArgXaa: 0.0 ± 0.0
Ser
5.425SerAla: 5.425 ± 0.522
0.472SerCys: 0.472 ± 0.217
4.088SerAsp: 4.088 ± 0.528
5.032SerGlu: 5.032 ± 0.73
2.673SerPhe: 2.673 ± 0.438
4.167SerGly: 4.167 ± 0.648
1.101SerHis: 1.101 ± 0.268
4.639SerIle: 4.639 ± 0.894
4.167SerLys: 4.167 ± 0.619
5.897SerLeu: 5.897 ± 0.757
1.572SerMet: 1.572 ± 0.327
4.01SerAsn: 4.01 ± 0.73
1.966SerPro: 1.966 ± 0.428
3.853SerGln: 3.853 ± 0.535
2.909SerArg: 2.909 ± 0.44
3.695SerSer: 3.695 ± 0.719
2.988SerThr: 2.988 ± 0.489
4.403SerVal: 4.403 ± 0.891
0.472SerTrp: 0.472 ± 0.19
1.887SerTyr: 1.887 ± 0.328
0.0SerXaa: 0.0 ± 0.0
Thr
7.233ThrAla: 7.233 ± 0.845
0.472ThrCys: 0.472 ± 0.21
3.145ThrAsp: 3.145 ± 0.496
3.224ThrGlu: 3.224 ± 0.649
1.572ThrPhe: 1.572 ± 0.39
5.189ThrGly: 5.189 ± 0.793
1.179ThrHis: 1.179 ± 0.337
4.639ThrIle: 4.639 ± 0.771
3.853ThrLys: 3.853 ± 0.492
5.504ThrLeu: 5.504 ± 0.86
1.494ThrMet: 1.494 ± 0.39
2.595ThrAsn: 2.595 ± 0.728
3.145ThrPro: 3.145 ± 0.511
2.752ThrGln: 2.752 ± 0.656
1.966ThrArg: 1.966 ± 0.56
3.538ThrSer: 3.538 ± 0.875
4.246ThrThr: 4.246 ± 0.9
4.403ThrVal: 4.403 ± 0.837
0.708ThrTrp: 0.708 ± 0.173
1.337ThrTyr: 1.337 ± 0.293
0.0ThrXaa: 0.0 ± 0.0
Val
4.56ValAla: 4.56 ± 0.45
0.865ValCys: 0.865 ± 0.37
3.224ValAsp: 3.224 ± 0.515
3.459ValGlu: 3.459 ± 0.521
2.201ValPhe: 2.201 ± 0.413
3.538ValGly: 3.538 ± 0.582
1.179ValHis: 1.179 ± 0.264
3.853ValIle: 3.853 ± 0.462
3.617ValLys: 3.617 ± 0.622
5.818ValLeu: 5.818 ± 0.607
1.887ValMet: 1.887 ± 0.452
3.145ValAsn: 3.145 ± 0.546
1.808ValPro: 1.808 ± 0.38
2.909ValGln: 2.909 ± 0.422
3.617ValArg: 3.617 ± 0.39
3.853ValSer: 3.853 ± 0.612
3.774ValThr: 3.774 ± 0.57
3.224ValVal: 3.224 ± 0.634
1.337ValTrp: 1.337 ± 0.299
2.516ValTyr: 2.516 ± 0.412
0.0ValXaa: 0.0 ± 0.0
Trp
1.258TrpAla: 1.258 ± 0.306
0.079TrpCys: 0.079 ± 0.082
0.629TrpAsp: 0.629 ± 0.223
0.708TrpGlu: 0.708 ± 0.207
0.55TrpPhe: 0.55 ± 0.237
0.786TrpGly: 0.786 ± 0.221
0.236TrpHis: 0.236 ± 0.115
0.472TrpIle: 0.472 ± 0.154
0.393TrpLys: 0.393 ± 0.223
1.415TrpLeu: 1.415 ± 0.378
0.314TrpMet: 0.314 ± 0.157
0.393TrpAsn: 0.393 ± 0.197
0.079TrpPro: 0.079 ± 0.085
1.179TrpGln: 1.179 ± 0.281
0.708TrpArg: 0.708 ± 0.253
1.022TrpSer: 1.022 ± 0.29
0.629TrpThr: 0.629 ± 0.233
1.572TrpVal: 1.572 ± 0.386
0.314TrpTrp: 0.314 ± 0.156
0.393TrpTyr: 0.393 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.595TyrAla: 2.595 ± 0.519
0.629TyrCys: 0.629 ± 0.209
2.201TyrAsp: 2.201 ± 0.342
1.808TyrGlu: 1.808 ± 0.39
0.943TyrPhe: 0.943 ± 0.363
2.673TyrGly: 2.673 ± 0.494
0.629TyrHis: 0.629 ± 0.253
1.572TyrIle: 1.572 ± 0.428
2.044TyrLys: 2.044 ± 0.494
2.201TyrLeu: 2.201 ± 0.362
0.943TyrMet: 0.943 ± 0.29
1.101TyrAsn: 1.101 ± 0.263
1.101TyrPro: 1.101 ± 0.279
1.101TyrGln: 1.101 ± 0.396
2.83TyrArg: 2.83 ± 0.346
1.415TyrSer: 1.415 ± 0.332
1.966TyrThr: 1.966 ± 0.352
2.673TyrVal: 2.673 ± 0.544
0.55TyrTrp: 0.55 ± 0.164
1.494TyrTyr: 1.494 ± 0.369
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12720 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski