Amino acid dipepetide frequency for Rhodococcus sp. LHW51113

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.212AlaAla: 18.212 ± 0.203
0.88AlaCys: 0.88 ± 0.026
8.044AlaAsp: 8.044 ± 0.105
7.827AlaGlu: 7.827 ± 0.092
3.352AlaPhe: 3.352 ± 0.066
11.641AlaGly: 11.641 ± 0.129
2.347AlaHis: 2.347 ± 0.048
5.044AlaIle: 5.044 ± 0.079
2.811AlaLys: 2.811 ± 0.068
12.857AlaLeu: 12.857 ± 0.148
2.559AlaMet: 2.559 ± 0.051
2.442AlaAsn: 2.442 ± 0.053
6.054AlaPro: 6.054 ± 0.086
3.646AlaGln: 3.646 ± 0.058
8.718AlaArg: 8.718 ± 0.106
6.467AlaSer: 6.467 ± 0.086
7.226AlaThr: 7.226 ± 0.094
11.62AlaVal: 11.62 ± 0.129
1.489AlaTrp: 1.489 ± 0.042
2.299AlaTyr: 2.299 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.947CysAla: 0.947 ± 0.032
0.079CysCys: 0.079 ± 0.009
0.427CysAsp: 0.427 ± 0.02
0.396CysGlu: 0.396 ± 0.019
0.223CysPhe: 0.223 ± 0.017
0.843CysGly: 0.843 ± 0.03
0.171CysHis: 0.171 ± 0.014
0.255CysIle: 0.255 ± 0.016
0.123CysLys: 0.123 ± 0.011
0.6CysLeu: 0.6 ± 0.024
0.116CysMet: 0.116 ± 0.011
0.143CysAsn: 0.143 ± 0.01
0.441CysPro: 0.441 ± 0.024
0.167CysGln: 0.167 ± 0.013
0.505CysArg: 0.505 ± 0.022
0.51CysSer: 0.51 ± 0.02
0.438CysThr: 0.438 ± 0.02
0.6CysVal: 0.6 ± 0.024
0.102CysTrp: 0.102 ± 0.009
0.124CysTyr: 0.124 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.814AspAla: 7.814 ± 0.105
0.402AspCys: 0.402 ± 0.018
4.064AspAsp: 4.064 ± 0.077
4.138AspGlu: 4.138 ± 0.073
1.727AspPhe: 1.727 ± 0.042
6.332AspGly: 6.332 ± 0.083
1.325AspHis: 1.325 ± 0.039
2.407AspIle: 2.407 ± 0.051
1.189AspLys: 1.189 ± 0.042
6.582AspLeu: 6.582 ± 0.111
0.944AspMet: 0.944 ± 0.031
1.177AspAsn: 1.177 ± 0.036
4.53AspPro: 4.53 ± 0.081
1.669AspGln: 1.669 ± 0.045
4.872AspArg: 4.872 ± 0.075
3.139AspSer: 3.139 ± 0.054
3.492AspThr: 3.492 ± 0.067
5.531AspVal: 5.531 ± 0.089
0.887AspTrp: 0.887 ± 0.032
1.245AspTyr: 1.245 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.559GluAla: 6.559 ± 0.097
0.387GluCys: 0.387 ± 0.019
2.829GluAsp: 2.829 ± 0.053
3.013GluGlu: 3.013 ± 0.059
1.974GluPhe: 1.974 ± 0.041
3.992GluGly: 3.992 ± 0.071
1.537GluHis: 1.537 ± 0.039
2.897GluIle: 2.897 ± 0.053
1.486GluLys: 1.486 ± 0.049
6.722GluLeu: 6.722 ± 0.098
1.143GluMet: 1.143 ± 0.032
1.286GluAsn: 1.286 ± 0.039
3.135GluPro: 3.135 ± 0.064
2.363GluGln: 2.363 ± 0.057
5.029GluArg: 5.029 ± 0.078
3.391GluSer: 3.391 ± 0.054
3.092GluThr: 3.092 ± 0.056
5.022GluVal: 5.022 ± 0.069
0.793GluTrp: 0.793 ± 0.027
1.163GluTyr: 1.163 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.981PheAla: 3.981 ± 0.081
0.244PheCys: 0.244 ± 0.015
2.454PheAsp: 2.454 ± 0.052
1.739PheGlu: 1.739 ± 0.045
0.955PhePhe: 0.955 ± 0.033
3.538PheGly: 3.538 ± 0.064
0.587PheHis: 0.587 ± 0.024
0.869PheIle: 0.869 ± 0.034
0.511PheLys: 0.511 ± 0.023
2.504PheLeu: 2.504 ± 0.054
0.471PheMet: 0.471 ± 0.021
0.595PheAsn: 0.595 ± 0.021
1.371PhePro: 1.371 ± 0.038
0.662PheGln: 0.662 ± 0.027
1.755PheArg: 1.755 ± 0.044
1.643PheSer: 1.643 ± 0.041
2.034PheThr: 2.034 ± 0.044
2.853PheVal: 2.853 ± 0.052
0.396PheTrp: 0.396 ± 0.02
0.649PheTyr: 0.649 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.295GlyAla: 10.295 ± 0.119
0.74GlyCys: 0.74 ± 0.029
5.138GlyAsp: 5.138 ± 0.069
4.952GlyGlu: 4.952 ± 0.068
3.116GlyPhe: 3.116 ± 0.055
8.145GlyGly: 8.145 ± 0.124
1.961GlyHis: 1.961 ± 0.044
4.352GlyIle: 4.352 ± 0.071
2.329GlyLys: 2.329 ± 0.05
8.801GlyLeu: 8.801 ± 0.111
2.129GlyMet: 2.129 ± 0.041
1.97GlyAsn: 1.97 ± 0.053
4.634GlyPro: 4.634 ± 0.065
2.547GlyGln: 2.547 ± 0.046
6.819GlyArg: 6.819 ± 0.091
6.113GlySer: 6.113 ± 0.084
5.863GlyThr: 5.863 ± 0.074
8.009GlyVal: 8.009 ± 0.083
1.552GlyTrp: 1.552 ± 0.04
2.235GlyTyr: 2.235 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.29HisAla: 2.29 ± 0.052
0.191HisCys: 0.191 ± 0.013
1.281HisAsp: 1.281 ± 0.033
1.074HisGlu: 1.074 ± 0.038
0.58HisPhe: 0.58 ± 0.024
2.017HisGly: 2.017 ± 0.048
0.626HisHis: 0.626 ± 0.029
0.69HisIle: 0.69 ± 0.026
0.33HisLys: 0.33 ± 0.018
2.054HisLeu: 2.054 ± 0.039
0.344HisMet: 0.344 ± 0.019
0.421HisAsn: 0.421 ± 0.02
1.592HisPro: 1.592 ± 0.044
0.574HisGln: 0.574 ± 0.025
1.739HisArg: 1.739 ± 0.047
1.08HisSer: 1.08 ± 0.034
1.124HisThr: 1.124 ± 0.035
1.666HisVal: 1.666 ± 0.037
0.298HisTrp: 0.298 ± 0.017
0.446HisTyr: 0.446 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.13IleAla: 6.13 ± 0.092
0.317IleCys: 0.317 ± 0.017
3.47IleAsp: 3.47 ± 0.054
2.874IleGlu: 2.874 ± 0.048
0.956IlePhe: 0.956 ± 0.038
4.574IleGly: 4.574 ± 0.077
0.705IleHis: 0.705 ± 0.027
1.251IleIle: 1.251 ± 0.035
0.798IleLys: 0.798 ± 0.03
3.432IleLeu: 3.432 ± 0.063
0.586IleMet: 0.586 ± 0.024
0.921IleAsn: 0.921 ± 0.034
2.393IlePro: 2.393 ± 0.049
0.872IleGln: 0.872 ± 0.031
2.616IleArg: 2.616 ± 0.048
2.318IleSer: 2.318 ± 0.05
2.713IleThr: 2.713 ± 0.056
3.924IleVal: 3.924 ± 0.064
0.412IleTrp: 0.412 ± 0.024
0.744IleTyr: 0.744 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.547LysAla: 2.547 ± 0.061
0.128LysCys: 0.128 ± 0.011
1.106LysAsp: 1.106 ± 0.038
1.012LysGlu: 1.012 ± 0.038
0.611LysPhe: 0.611 ± 0.024
1.576LysGly: 1.576 ± 0.041
0.437LysHis: 0.437 ± 0.023
1.062LysIle: 1.062 ± 0.038
0.717LysLys: 0.717 ± 0.04
2.072LysLeu: 2.072 ± 0.048
0.484LysMet: 0.484 ± 0.022
0.506LysAsn: 0.506 ± 0.024
1.293LysPro: 1.293 ± 0.04
0.656LysGln: 0.656 ± 0.028
1.514LysArg: 1.514 ± 0.044
1.226LysSer: 1.226 ± 0.033
1.287LysThr: 1.287 ± 0.037
1.963LysVal: 1.963 ± 0.047
0.292LysTrp: 0.292 ± 0.017
0.48LysTyr: 0.48 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.789LeuAla: 13.789 ± 0.139
0.706LeuCys: 0.706 ± 0.027
7.086LeuAsp: 7.086 ± 0.11
5.474LeuGlu: 5.474 ± 0.068
2.749LeuPhe: 2.749 ± 0.056
9.219LeuGly: 9.219 ± 0.094
1.977LeuHis: 1.977 ± 0.049
3.825LeuIle: 3.825 ± 0.074
1.498LeuLys: 1.498 ± 0.044
9.511LeuLeu: 9.511 ± 0.127
1.594LeuMet: 1.594 ± 0.04
1.705LeuAsn: 1.705 ± 0.04
5.708LeuPro: 5.708 ± 0.084
2.325LeuGln: 2.325 ± 0.043
7.49LeuArg: 7.49 ± 0.099
5.695LeuSer: 5.695 ± 0.08
6.298LeuThr: 6.298 ± 0.078
9.193LeuVal: 9.193 ± 0.109
1.163LeuTrp: 1.163 ± 0.035
1.585LeuTyr: 1.585 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.219MetAla: 2.219 ± 0.043
0.165MetCys: 0.165 ± 0.014
0.893MetAsp: 0.893 ± 0.028
0.731MetGlu: 0.731 ± 0.026
0.63MetPhe: 0.63 ± 0.024
1.457MetGly: 1.457 ± 0.043
0.375MetHis: 0.375 ± 0.02
0.958MetIle: 0.958 ± 0.031
0.406MetLys: 0.406 ± 0.02
1.992MetLeu: 1.992 ± 0.043
0.37MetMet: 0.37 ± 0.021
0.462MetAsn: 0.462 ± 0.02
1.183MetPro: 1.183 ± 0.031
0.545MetGln: 0.545 ± 0.024
1.485MetArg: 1.485 ± 0.04
1.572MetSer: 1.572 ± 0.036
1.634MetThr: 1.634 ± 0.037
1.613MetVal: 1.613 ± 0.04
0.267MetTrp: 0.267 ± 0.017
0.346MetTyr: 0.346 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.463AsnAla: 2.463 ± 0.058
0.157AsnCys: 0.157 ± 0.013
1.044AsnAsp: 1.044 ± 0.034
1.107AsnGlu: 1.107 ± 0.036
0.626AsnPhe: 0.626 ± 0.025
1.959AsnGly: 1.959 ± 0.047
0.404AsnHis: 0.404 ± 0.02
0.874AsnIle: 0.874 ± 0.025
0.468AsnLys: 0.468 ± 0.023
2.039AsnLeu: 2.039 ± 0.053
0.426AsnMet: 0.426 ± 0.021
0.506AsnAsn: 0.506 ± 0.018
1.67AsnPro: 1.67 ± 0.039
0.605AsnGln: 0.605 ± 0.022
1.499AsnArg: 1.499 ± 0.041
1.185AsnSer: 1.185 ± 0.036
1.316AsnThr: 1.316 ± 0.041
1.672AsnVal: 1.672 ± 0.042
0.343AsnTrp: 0.343 ± 0.017
0.526AsnTyr: 0.526 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.58ProAla: 6.58 ± 0.106
0.265ProCys: 0.265 ± 0.015
4.435ProAsp: 4.435 ± 0.078
4.122ProGlu: 4.122 ± 0.069
1.644ProPhe: 1.644 ± 0.035
5.581ProGly: 5.581 ± 0.074
1.108ProHis: 1.108 ± 0.031
2.282ProIle: 2.282 ± 0.047
1.154ProLys: 1.154 ± 0.034
4.785ProLeu: 4.785 ± 0.072
1.069ProMet: 1.069 ± 0.032
1.268ProAsn: 1.268 ± 0.04
2.786ProPro: 2.786 ± 0.073
1.651ProGln: 1.651 ± 0.049
3.396ProArg: 3.396 ± 0.058
3.346ProSer: 3.346 ± 0.057
3.638ProThr: 3.638 ± 0.057
5.288ProVal: 5.288 ± 0.083
0.773ProTrp: 0.773 ± 0.028
1.085ProTyr: 1.085 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.273GlnAla: 3.273 ± 0.065
0.178GlnCys: 0.178 ± 0.013
1.213GlnAsp: 1.213 ± 0.034
1.265GlnGlu: 1.265 ± 0.033
0.967GlnPhe: 0.967 ± 0.029
1.987GlnGly: 1.987 ± 0.047
0.582GlnHis: 0.582 ± 0.025
1.499GlnIle: 1.499 ± 0.042
0.62GlnLys: 0.62 ± 0.026
3.222GlnLeu: 3.222 ± 0.061
0.605GlnMet: 0.605 ± 0.026
0.604GlnAsn: 0.604 ± 0.024
1.546GlnPro: 1.546 ± 0.038
1.179GlnGln: 1.179 ± 0.039
2.347GlnArg: 2.347 ± 0.047
1.398GlnSer: 1.398 ± 0.035
1.455GlnThr: 1.455 ± 0.039
2.737GlnVal: 2.737 ± 0.048
0.489GlnTrp: 0.489 ± 0.026
0.597GlnTyr: 0.597 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.144ArgAla: 8.144 ± 0.094
0.554ArgCys: 0.554 ± 0.025
4.257ArgAsp: 4.257 ± 0.077
4.414ArgGlu: 4.414 ± 0.068
2.375ArgPhe: 2.375 ± 0.047
5.574ArgGly: 5.574 ± 0.078
1.55ArgHis: 1.55 ± 0.04
3.637ArgIle: 3.637 ± 0.066
1.727ArgLys: 1.727 ± 0.047
7.22ArgLeu: 7.22 ± 0.092
1.843ArgMet: 1.843 ± 0.041
1.567ArgAsn: 1.567 ± 0.041
3.861ArgPro: 3.861 ± 0.064
2.042ArgGln: 2.042 ± 0.049
6.678ArgArg: 6.678 ± 0.111
4.389ArgSer: 4.389 ± 0.067
4.566ArgThr: 4.566 ± 0.067
6.05ArgVal: 6.05 ± 0.083
1.222ArgTrp: 1.222 ± 0.034
1.704ArgTyr: 1.704 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.066SerAla: 7.066 ± 0.088
0.376SerCys: 0.376 ± 0.022
3.622SerAsp: 3.622 ± 0.061
3.096SerGlu: 3.096 ± 0.051
1.721SerPhe: 1.721 ± 0.038
6.291SerGly: 6.291 ± 0.087
0.984SerHis: 0.984 ± 0.029
2.44SerIle: 2.44 ± 0.049
1.237SerLys: 1.237 ± 0.037
5.171SerLeu: 5.171 ± 0.085
1.367SerMet: 1.367 ± 0.034
1.288SerAsn: 1.288 ± 0.033
3.188SerPro: 3.188 ± 0.057
1.372SerGln: 1.372 ± 0.038
3.91SerArg: 3.91 ± 0.066
3.459SerSer: 3.459 ± 0.064
3.653SerThr: 3.653 ± 0.059
5.304SerVal: 5.304 ± 0.079
0.914SerTrp: 0.914 ± 0.031
1.174SerTyr: 1.174 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.765ThrAla: 7.765 ± 0.09
0.397ThrCys: 0.397 ± 0.021
3.819ThrAsp: 3.819 ± 0.062
3.485ThrGlu: 3.485 ± 0.059
1.808ThrPhe: 1.808 ± 0.047
6.037ThrGly: 6.037 ± 0.083
1.139ThrHis: 1.139 ± 0.032
2.616ThrIle: 2.616 ± 0.053
1.23ThrLys: 1.23 ± 0.041
5.818ThrLeu: 5.818 ± 0.059
1.128ThrMet: 1.128 ± 0.029
1.364ThrAsn: 1.364 ± 0.047
3.899ThrPro: 3.899 ± 0.077
1.459ThrGln: 1.459 ± 0.038
3.855ThrArg: 3.855 ± 0.059
3.459ThrSer: 3.459 ± 0.063
3.986ThrThr: 3.986 ± 0.069
6.501ThrVal: 6.501 ± 0.094
0.763ThrTrp: 0.763 ± 0.029
1.24ThrTyr: 1.24 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
11.713ValAla: 11.713 ± 0.137
0.724ValCys: 0.724 ± 0.028
6.359ValAsp: 6.359 ± 0.088
5.338ValGlu: 5.338 ± 0.081
2.581ValPhe: 2.581 ± 0.046
7.998ValGly: 7.998 ± 0.099
1.907ValHis: 1.907 ± 0.044
3.725ValIle: 3.725 ± 0.067
1.676ValLys: 1.676 ± 0.047
9.529ValLeu: 9.529 ± 0.099
1.519ValMet: 1.519 ± 0.037
1.867ValAsn: 1.867 ± 0.041
5.126ValPro: 5.126 ± 0.088
2.264ValGln: 2.264 ± 0.046
6.348ValArg: 6.348 ± 0.095
5.174ValSer: 5.174 ± 0.078
5.932ValThr: 5.932 ± 0.087
9.297ValVal: 9.297 ± 0.146
1.047ValTrp: 1.047 ± 0.031
1.566ValTyr: 1.566 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.51TrpAla: 1.51 ± 0.041
0.137TrpCys: 0.137 ± 0.012
0.705TrpAsp: 0.705 ± 0.026
0.63TrpGlu: 0.63 ± 0.025
0.509TrpPhe: 0.509 ± 0.025
1.016TrpGly: 1.016 ± 0.033
0.296TrpHis: 0.296 ± 0.019
0.668TrpIle: 0.668 ± 0.027
0.308TrpLys: 0.308 ± 0.016
1.507TrpLeu: 1.507 ± 0.043
0.315TrpMet: 0.315 ± 0.014
0.382TrpAsn: 0.382 ± 0.021
0.711TrpPro: 0.711 ± 0.022
0.536TrpGln: 0.536 ± 0.022
1.096TrpArg: 1.096 ± 0.033
0.924TrpSer: 0.924 ± 0.03
0.892TrpThr: 0.892 ± 0.031
1.107TrpVal: 1.107 ± 0.037
0.323TrpTrp: 0.323 ± 0.018
0.29TrpTyr: 0.29 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.237TyrAla: 2.237 ± 0.051
0.178TyrCys: 0.178 ± 0.014
1.218TyrAsp: 1.218 ± 0.035
1.125TyrGlu: 1.125 ± 0.035
0.709TyrPhe: 0.709 ± 0.029
1.927TyrGly: 1.927 ± 0.046
0.402TyrHis: 0.402 ± 0.024
0.652TyrIle: 0.652 ± 0.025
0.348TyrLys: 0.348 ± 0.018
2.172TyrLeu: 2.172 ± 0.048
0.292TyrMet: 0.292 ± 0.017
0.416TyrAsn: 0.416 ± 0.019
1.134TyrPro: 1.134 ± 0.032
0.629TyrGln: 0.629 ± 0.027
1.704TyrArg: 1.704 ± 0.038
1.148TyrSer: 1.148 ± 0.03
1.13TyrThr: 1.13 ± 0.035
1.74TyrVal: 1.74 ± 0.057
0.337TyrTrp: 0.337 ± 0.017
0.443TyrTyr: 0.443 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3281 proteins (1087130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski